LOCUS       NM_198447                776 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens golgi transport 1A (GOLT1A), mRNA.
ACCESSION   NM_198447 XM_059186
VERSION     NM_198447.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Zhang,L., Cheng,A., Yu,Y., Zou,N., Wang,W., Lv,L., Guo,X., Chen,M.
            and Zhang,Y.
  TITLE     GOLT1A-KISS1 fusion is associated with metastasis in adenoid cystic
            carcinomas
  JOURNAL   Biochem Biophys Res Commun 526 (1), 70-77 (2020)
   PUBMED   32192769
  REMARK    GeneRIF: GOLT1A-KISS1 fusion is associated with metastasis in
            adenoid cystic carcinomas.
REFERENCE   2  (bases 1 to 776)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 776)
  AUTHORS   Ikeda,K., Horie-Inoue,K., Ueno,T., Suzuki,T., Sato,W.,
            Shigekawa,T., Osaki,A., Saeki,T., Berezikov,E., Mano,H. and
            Inoue,S.
  TITLE     miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7
            cells through targeting GOLT1A
  JOURNAL   Sci Rep 5, 13170 (2015)
   PUBMED   26255816
  REMARK    GeneRIF: GOLT1A knockdown restored tamoxifen resistance and low
            GOLT1A levels correlate with better survival in patients with
            breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 776)
  AUTHORS   Conchon,S., Cao,X., Barlowe,C. and Pelham,H.R.
  TITLE     Got1p and Sft2p: membrane proteins involved in traffic to the Golgi
            complex
  JOURNAL   EMBO J 18 (14), 3934-3946 (1999)
   PUBMED   10406798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK124645.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198447.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.21467.1, BC058832.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308302.4/ ENSP00000308535.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-776               AK124645.1         105-880
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..776
                     /gene="GOLT1A"
                     /gene_synonym="CGI-141; GOT1; GOT1B; hGOT1b; HMFN1187;
                     YMR292W"
                     /note="golgi transport 1A"
                     /db_xref="GeneID:127845"
                     /db_xref="HGNC:HGNC:24766"
                     /db_xref="MIM:620633"
     exon            1..107
                     /gene="GOLT1A"
                     /gene_synonym="CGI-141; GOT1; GOT1B; hGOT1b; HMFN1187;
                     YMR292W"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..481
                     /gene="GOLT1A"
                     /gene_synonym="CGI-141; GOT1; GOT1B; hGOT1b; HMFN1187;
                     YMR292W"
                     /codon_start=1
                     /product="vesicle transport protein GOT1A"
                     /protein_id="NP_940849.1"
                     /db_xref="CCDS:CCDS1443.1"
                     /db_xref="GeneID:127845"
                     /db_xref="HGNC:HGNC:24766"
                     /db_xref="MIM:620633"
                     /translation="MISITEWQKIGVGITGFGIFFILFGTLLYFDSVLLAFGNLLFLT
                     GLSLIIGLRKTFWFFFQRHKLKGTSFLLGGVVIVLLRWPLLGMFLETYGFFSLFKGFF
                     PVAFGFLGNVCNIPFLGALFRRLQGTSSMV"
     exon            108..199
                     /gene="GOLT1A"
                     /gene_synonym="CGI-141; GOT1; GOT1B; hGOT1b; HMFN1187;
                     YMR292W"
                     /inference="alignment:Splign:2.1.0"
     exon            200..378
                     /gene="GOLT1A"
                     /gene_synonym="CGI-141; GOT1; GOT1B; hGOT1b; HMFN1187;
                     YMR292W"
                     /inference="alignment:Splign:2.1.0"
     exon            379..442
                     /gene="GOLT1A"
                     /gene_synonym="CGI-141; GOT1; GOT1B; hGOT1b; HMFN1187;
                     YMR292W"
                     /inference="alignment:Splign:2.1.0"
     exon            443..776
                     /gene="GOLT1A"
                     /gene_synonym="CGI-141; GOT1; GOT1B; hGOT1b; HMFN1187;
                     YMR292W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      752..757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLT1A"
                     /gene_synonym="CGI-141; GOT1; GOT1B; hGOT1b; HMFN1187;
                     YMR292W"
                     /note="hexamer: ATTAAA"
     polyA_site      776
                     /gene="GOLT1A"
                     /gene_synonym="CGI-141; GOT1; GOT1B; hGOT1b; HMFN1187;
                     YMR292W"
                     /note="major polyA site"
ORIGIN      
        1 gtgaccatgt accagctgcg tcctctgggc cacgctccac ttgcccgctt ccacccggaa
       61 agccccccag gctgagtgcg gcatgatctc catcaccgaa tggcagaaga ttggtgtggg
      121 gatcaccggt ttcggcatct tcttcatcct ctttggaaca ctcctgtact ttgattccgt
      181 gctcctggcc tttggaaacc tgctgttcct gacgggcctg tccctcatca ttggcctgag
      241 gaagaccttt tggttcttct tccaacggca caaactcaag ggaaccagct tcctcctggg
      301 gggtgtggtt atcgtgctcc tacgctggcc cctcctcggc atgttcctgg aaacctacgg
      361 attcttcagc ctctttaagg gctttttccc tgtcgccttc ggcttcctgg gcaatgtctg
      421 caacatcccc ttcctgggtg cgctgttccg gagacttcaa ggcactagct cgatggtctg
      481 aaaaacagag atgagctcct tgaacttgga tcattggttg agggggctag agggagaatg
      541 ggaaccaccc cctcagtccc ctgcactgac tcactccccg acatatccgg acctccccaa
      601 gtccagaagg aaggaatgga gctgagcaac tgacgtcaaa tccccaagtc gactcaagag
      661 gctgccagga agcagagatg cagaccccaa ggagactggg ctggggctgg tatcacaccc
      721 tcactctata tttatgggag gaaaagtgaa gattaaattc ccaagttgtg cgtgtg
//
