LOCUS       NM_018178               3124 bp    mRNA    linear   PRI 08-MAR-2025
DEFINITION  Homo sapiens golgi phosphoprotein 3 like (GOLPH3L), mRNA.
ACCESSION   NM_018178
VERSION     NM_018178.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3124)
  AUTHORS   Welch,L.G., Peak-Chew,S.Y., Begum,F., Stevens,T.J. and Munro,S.
  TITLE     GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting
            into intra-Golgi transport vesicles
  JOURNAL   J Cell Biol 220 (10) (2021)
   PUBMED   34473204
  REMARK    GeneRIF: GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for
            sorting into intra-Golgi transport vesicles.
REFERENCE   2  (bases 1 to 3124)
  AUTHORS   Xu,Y., Chen,W., Liang,J., Zeng,X., Ji,K., Zhou,J., Liao,S., Wu,J.,
            Xing,K., He,Z., Yang,Y., Liu,Q., Zhu,P., Liu,Y., Li,L., Liu,M.,
            Chen,W. and Huang,W.
  TITLE     The miR-1185-2-3p-GOLPH3L pathway promotes glucose metabolism in
            breast cancer by stabilizing p53-induced SERPINE1
  JOURNAL   J Exp Clin Cancer Res 40 (1), 47 (2021)
   PUBMED   33509226
  REMARK    GeneRIF: The miR-1185-2-3p-GOLPH3L pathway promotes glucose
            metabolism in breast cancer by stabilizing p53-induced SERPINE1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3124)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3124)
  AUTHORS   Al Olama,A.A., Kote-Jarai,Z., Berndt,S.I., Conti,D.V.,
            Schumacher,F., Han,Y., Benlloch,S., Hazelett,D.J., Wang,Z.,
            Saunders,E., Leongamornlert,D., Lindstrom,S., Jugurnauth-Little,S.,
            Dadaev,T., Tymrakiewicz,M., Stram,D.O., Rand,K., Wan,P., Stram,A.,
            Sheng,X., Pooler,L.C., Park,K., Xia,L., Tyrer,J., Kolonel,L.N., Le
            Marchand,L., Hoover,R.N., Machiela,M.J., Yeager,M., Burdette,L.,
            Chung,C.C., Hutchinson,A., Yu,K., Goh,C., Ahmed,M., Govindasami,K.,
            Guy,M., Tammela,T.L., Auvinen,A., Wahlfors,T., Schleutker,J.,
            Visakorpi,T., Leinonen,K.A., Xu,J., Aly,M., Donovan,J.,
            Travis,R.C., Key,T.J., Siddiq,A., Canzian,F., Khaw,K.T.,
            Takahashi,A., Kubo,M., Pharoah,P., Pashayan,N., Weischer,M.,
            Nordestgaard,B.G., Nielsen,S.F., Klarskov,P., Roder,M.A.,
            Iversen,P., Thibodeau,S.N., McDonnell,S.K., Schaid,D.J.,
            Stanford,J.L., Kolb,S., Holt,S., Knudsen,B., Coll,A.H.,
            Gapstur,S.M., Diver,W.R., Stevens,V.L., Maier,C., Luedeke,M.,
            Herkommer,K., Rinckleb,A.E., Strom,S.S., Pettaway,C., Yeboah,E.D.,
            Tettey,Y., Biritwum,R.B., Adjei,A.A., Tay,E., Truelove,A., Niwa,S.,
            Chokkalingam,A.P., Cannon-Albright,L., Cybulski,C., Wokolorczyk,D.,
            Kluzniak,W., Park,J., Sellers,T., Lin,H.Y., Isaacs,W.B.,
            Partin,A.W., Brenner,H., Dieffenbach,A.K., Stegmaier,C., Chen,C.,
            Giovannucci,E.L., Ma,J., Stampfer,M., Penney,K.L., Mucci,L.,
            John,E.M., Ingles,S.A., Kittles,R.A., Murphy,A.B., Pandha,H.,
            Michael,A., Kierzek,A.M., Blot,W., Signorello,L.B., Zheng,W.,
            Albanes,D., Virtamo,J., Weinstein,S., Nemesure,B., Carpten,J.,
            Leske,C., Wu,S.Y., Hennis,A., Kibel,A.S., Rybicki,B.A.,
            Neslund-Dudas,C., Hsing,A.W., Chu,L., Goodman,P.J., Klein,E.A.,
            Zheng,S.L., Batra,J., Clements,J., Spurdle,A., Teixeira,M.R.,
            Paulo,P., Maia,S., Slavov,C., Kaneva,R., Mitev,V., Witte,J.S.,
            Casey,G., Gillanders,E.M., Seminara,D., Riboli,E., Hamdy,F.C.,
            Coetzee,G.A., Li,Q., Freedman,M.L., Hunter,D.J., Muir,K.,
            Gronberg,H., Neal,D.E., Southey,M., Giles,G.G., Severi,G.,
            Cook,M.B., Nakagawa,H., Wiklund,F., Kraft,P., Chanock,S.J.,
            Henderson,B.E., Easton,D.F., Eeles,R.A. and Haiman,C.A.
  CONSRTM   Breast and Prostate Cancer Cohort Consortium (BPC3); PRACTICAL
            (Prostate Cancer Association Group to Investigate Cancer-Associated
            Alterations in the Genome) Consortium; COGS (Collaborative
            Oncological Gene-environment Study) Consortium; GAME-ON/ELLIPSE
            Consortium
  TITLE     A meta-analysis of 87,040 individuals identifies 23 new
            susceptibility loci for prostate cancer
  JOURNAL   Nat Genet 46 (10), 1103-1109 (2014)
   PUBMED   25217961
REFERENCE   5  (bases 1 to 3124)
  AUTHORS   Butland,S.L., Sanders,S.S., Schmidt,M.E., Riechers,S.P., Lin,D.T.,
            Martin,D.D., Vaid,K., Graham,R.K., Singaraja,R.R., Wanker,E.E.,
            Conibear,E. and Hayden,M.R.
  TITLE     The palmitoyl acyltransferase HIP14 shares a high proportion of
            interactors with huntingtin: implications for a role in the
            pathogenesis of Huntington's disease
  JOURNAL   Hum Mol Genet 23 (15), 4142-4160 (2014)
   PUBMED   24705354
REFERENCE   6  (bases 1 to 3124)
  AUTHORS   Kirin,M., Chandra,A., Charteris,D.G., Hayward,C., Campbell,S.,
            Celap,I., Bencic,G., Vatavuk,Z., Kirac,I., Richards,A.J.,
            Tenesa,A., Snead,M.P., Fleck,B.W., Singh,J., Harsum,S.,
            Maclaren,R.E., den Hollander,A.I., Dunlop,M.G., Hoyng,C.B.,
            Wright,A.F., Campbell,H., Vitart,V. and Mitry,D.
  TITLE     Genome-wide association study identifies genetic risk underlying
            primary rhegmatogenous retinal detachment
  JOURNAL   Hum Mol Genet 22 (15), 3174-3185 (2013)
   PUBMED   23585552
REFERENCE   7  (bases 1 to 3124)
  AUTHORS   Ng,M.M., Dippold,H.C., Buschman,M.D., Noakes,C.J. and Field,S.J.
  TITLE     GOLPH3L antagonizes GOLPH3 to determine Golgi morphology
  JOURNAL   Mol Biol Cell 24 (6), 796-808 (2013)
   PUBMED   23345592
  REMARK    GeneRIF: GOLPH3L differs critically from GOLPH3 in that it is
            largely unable to bind to MYO18A; data demonstrate that despite
            their similarities, unexpectedly, GOLPH3L antagonizes GOLPH3/MYO18A
            at the Golgi
REFERENCE   8  (bases 1 to 3124)
  AUTHORS   Suter,B., Fontaine,J.F., Yildirimman,R., Rasko,T., Schaefer,M.H.,
            Rasche,A., Porras,P., Vazquez-Alvarez,B.M., Russ,J., Rau,K.,
            Foulle,R., Zenkner,M., Saar,K., Herwig,R., Andrade-Navarro,M.A. and
            Wanker,E.E.
  TITLE     Development and application of a DNA microarray-based yeast
            two-hybrid system
  JOURNAL   Nucleic Acids Res 41 (3), 1496-1507 (2013)
   PUBMED   23275563
REFERENCE   9  (bases 1 to 3124)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356292.21 and AL356356.17.
            
            On Nov 23, 2018 this sequence version replaced NM_018178.5.
            
            Summary: The Golgi complex plays a key role in the sorting and
            modification of proteins exported from the endoplasmic reticulum.
            The protein encoded by this gene is localized at the Golgi stack
            and may have a regulatory role in Golgi trafficking. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.71307.1,
                                           SRR1803613.101362.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271732.8/ ENSP00000271732.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AL356292.21        49704-49866         c
            164-358             AL356292.21        47368-47562         c
            359-490             AL356292.21        16344-16475         c
            491-605             AL356292.21        14526-14640         c
            606-3124            AL356356.17        173492-176010       c
FEATURES             Location/Qualifiers
     source          1..3124
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3124
                     /gene="GOLPH3L"
                     /gene_synonym="GPP34R"
                     /note="golgi phosphoprotein 3 like"
                     /db_xref="GeneID:55204"
                     /db_xref="HGNC:HGNC:24882"
                     /db_xref="MIM:612208"
     exon            1..163
                     /gene="GOLPH3L"
                     /gene_synonym="GPP34R"
                     /inference="alignment:Splign:2.1.0"
     exon            164..358
                     /gene="GOLPH3L"
                     /gene_synonym="GPP34R"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1033
                     /gene="GOLPH3L"
                     /gene_synonym="GPP34R"
                     /note="GPP34-related protein"
                     /codon_start=1
                     /product="Golgi phosphoprotein 3-like"
                     /protein_id="NP_060648.2"
                     /db_xref="CCDS:CCDS966.1"
                     /db_xref="GeneID:55204"
                     /db_xref="HGNC:HGNC:24882"
                     /db_xref="MIM:612208"
                     /translation="MTTLTHRARRTEISKNSEKKMESEEDSNWEKSPDNEDSGDSKDI
                     RLTLMEEVLLLGLKDKEGYTSFWNDCISSGLRGGILIELAMRGRIYLEPPTMRKKRLL
                     DRKVLLKSDSPTGDVLLDETLKHIKATEPTETVQTWIELLTGETWNPFKLQYQLRNVR
                     ERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQDSVLERWVNDPQRM
                     DKRTLALLVLAHSSDVLENVFSSLTDDKYDVAMNRAKDLVELDPEVEGTKPSATEMIW
                     AVLAAFNKS"
     exon            359..490
                     /gene="GOLPH3L"
                     /gene_synonym="GPP34R"
                     /inference="alignment:Splign:2.1.0"
     exon            491..605
                     /gene="GOLPH3L"
                     /gene_synonym="GPP34R"
                     /inference="alignment:Splign:2.1.0"
     exon            606..3124
                     /gene="GOLPH3L"
                     /gene_synonym="GPP34R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3103..3108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLPH3L"
                     /gene_synonym="GPP34R"
                     /note="hexamer: AATAAA"
     polyA_site      3124
                     /gene="GOLPH3L"
                     /gene_synonym="GPP34R"
                     /note="major polyA site"
ORIGIN      
        1 gtgttattcc ttctctgcat cgaaggatca ggaagtttgt gctctctgcg tggctaagtt
       61 tttcacctac taggacgggg gtggggtggg gagaacaggt gtccttctaa aatacagcac
      121 aagctacagc ctgcgtccag ccataaccca ggagtaacat cagaaacagg tgagaatgac
      181 cactttaact caccgggccc gtcgcactga aataagcaag aactctgaaa agaagatgga
      241 aagtgaggaa gacagtaatt gggagaaaag tccagacaat gaagattctg gagactctaa
      301 ggatatccgc cttactctta tggaagaagt attgcttctg ggactaaaag ataaagaggg
      361 gtacacatct ttctggaatg actgcatatc atcaggcctg cgagggggca tcctgataga
      421 gctggccatg cggggtcgaa tctatctgga acccccgacc atgcgtaaga agcgactact
      481 agacagaaag gtactgctaa agtcagacag cccaacaggt gatgttttac tggatgaaac
      541 tctgaaacac atcaaagcaa ctgaacccac agaaactgtc caaacatgga tagagctact
      601 cactggtgag acctggaacc ccttcaaatt acagtaccag ctgagaaatg tacgagagcg
      661 catcgcaaag aacctagtag agaaaggtat tctaaccact gagaagcaga atttcctgct
      721 atttgacatg actactcatc cagtgaccaa tacaacagag aaacagcgac tagtgaaaaa
      781 acttcaagat agtgtactag agcggtgggt aaatgaccct cagcgtatgg acaagcgaac
      841 actagcactc ctggtgctag cccactcctc tgatgtgcta gagaatgtct tctcctctct
      901 gacagatgac aagtatgatg tggcaatgaa tcgagccaag gacttagtag aactggaccc
      961 tgaagtggaa gggacaaagc ctagtgccac agaaatgatc tgggctgtgc tggcagcctt
     1021 caataaatct taaagccggc aggtggattt ctccttttcc cctgctggct ggtgactgtc
     1081 agagacccca tcactgagtt ttgtgtgatg agatgttttc atcatttttg tttccttttc
     1141 ttgaatcaga cttgtgattt ggggagagca acttcagggc ttctccatag accttgacca
     1201 ttataagcag accttatttc tccctacact tccactccat aggtaaataa actgggtgaa
     1261 gccacacaca cccaatgaac attttctccc atttggtggt ttagtttcac ccagtgtgct
     1321 tttggataag cagaaatatc taaatgggat tttgagttct ccagctatag aatgtgaatg
     1381 agataaaaag tgaactatct attatatttt tctgagtttg ttttctatca taaatacatg
     1441 ttttcacagc ctttgtctct cagactctgc taaataatgt agcttattga aataactgtc
     1501 gctgaataag gagcaatgag aaacaaaact aatttttgga gcagatggtc tctggaattg
     1561 catatcctgc tagtgatttt ctcatctttc cttttctaac ctaatgagaa tgtcccagat
     1621 tcaattacct ggatgtcaaa gtcctagagc cagaaatata ttctctcatc cctcttagca
     1681 ttctcttgct ccctcattca ctagggcaaa tgtctaaatg aagaaaagtc tctctcaaca
     1741 cctcgttcat gcaatcagca ttagaatttg taaggaagga aggggggtgg catgaaaatt
     1801 tccattcttg gggtatatga ctgtcctgtt tcccccaggc cacttttttt ttttttttct
     1861 tttgagacag ggtcttgctc ttgcccaggc aggagtacag tagtgcaatc acagctgact
     1921 gcagccttga cctccagggc tcaaggatcc tcctgcctca gtctcccaac taagtgggac
     1981 tacaggcacg tgccaccata ctcagctttt ttttgtttgt tttagacaag agtctcgctt
     2041 tgttgcccag gctggtcttg aattcctggg ctcaagcaat tcttccacct cagcctccca
     2101 aagtgctgag attactggct tgagccactg cacccacccc tccagactac tttaaatgtc
     2161 tctgctctga ctgaattgaa ggaattgtaa gtttcagttg ctgaatatat cagtatatct
     2221 gaactccaga tctttttatt tcctattttt ggcttcctac ataaattaat aaagtctgtc
     2281 tatatttaag gtttctggga gtagttttgt ctatatttaa tccatagatg tgctcctagt
     2341 catcagtctt atttcagtaa aaccatcttt ctggccaaat ctctaacacg ttttttactt
     2401 cagtagtgag ggcaatgaga agctttatta agaaagatcc tatttaaagg gctaatttgg
     2461 tattgaaagc atgctgatat aaagtccagt atttgaggat ataaagagga tgtgcactga
     2521 gctgtgctga tgttcagcat ttattatact ttaatgggat agtgcttctt gaccattata
     2581 gaacaacaaa ctgtcaaagg gttaatacag atgacccaga cctgacatta aatcctcttg
     2641 attagaaata attaaatgaa ttatttattc atttctctcc tctgccaaat ctacttagcc
     2701 ccacaaaaat gccccagctc agttaacatt tttttgtttt tcactttagg tatctcttag
     2761 gcaaatagag atataaattg taataggaaa cagtctctaa atgtgaggct gaatacagct
     2821 tcagtctggc tctctaatag gacaaaagcc agtccatgtg ttgtctctaa ctgatttagc
     2881 tttttctttt ctttgaacaa ttcggcatga attgaaacca ggttttcctg tggaaagtta
     2941 tagcttgatt gggagataga agttgaattg agttctttct tgcaactctt agtgtttatt
     3001 tttatatctc agtaagacga ggataccttc agtttgaatc tgcataatgt tcactgccaa
     3061 actccttctc atttaatgct tatggccttc acatttctgt ataataaaga tcaattatca
     3121 gctc
//
