LOCUS       NM_022130               2678 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens golgi phosphoprotein 3 (GOLPH3), mRNA.
ACCESSION   NM_022130
VERSION     NM_022130.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2678)
  AUTHORS   Yin,Z., Liu,Q., Gao,Y., Wang,R., Qi,Y., Wang,D., Chen,L., Yin,X.,
            He,M. and Li,W.
  TITLE     GOLPH3 promotes tumor malignancy via inhibition of ferroptosis by
            upregulating SLC7A11 in cholangiocarcinoma
  JOURNAL   Mol Carcinog 63 (5), 912-925 (2024)
   PUBMED   38390729
  REMARK    GeneRIF: GOLPH3 promotes tumor malignancy via inhibition of
            ferroptosis by upregulating SLC7A11 in cholangiocarcinoma.
REFERENCE   2  (bases 1 to 2678)
  AUTHORS   Polanco,C.M., Cavieres,V.A., Galarza,A.J., Jara,C., Torres,A.K.,
            Cancino,J., Varas-Godoy,M., Burgos,P.V., Tapia-Rojas,C. and
            Mardones,G.A.
  TITLE     GOLPH3 Participates in Mitochondrial Fission and Is Necessary to
            Sustain Bioenergetic Function in MDA-MB-231 Breast Cancer Cells
  JOURNAL   Cells 13 (4), 316 (2024)
   PUBMED   38391929
  REMARK    GeneRIF: GOLPH3 Participates in Mitochondrial Fission and Is
            Necessary to Sustain Bioenergetic Function in MDA-MB-231 Breast
            Cancer Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2678)
  AUTHORS   Yang,H., Ma,X., Song,B., Wang,D. and Chai,Z.
  TITLE     Golgi Phosphoprotein 3 Promotes Cervical Cancer Progression via
            Wnt/beta-catenin Mediated Epithelial-Mesenchymal Transition
  JOURNAL   Ann Clin Lab Sci 53 (5), 738-748 (2023)
   PUBMED   37945014
  REMARK    GeneRIF: Golgi Phosphoprotein 3 Promotes Cervical Cancer
            Progression via Wnt/beta-catenin Mediated Epithelial-Mesenchymal
            Transition.
REFERENCE   4  (bases 1 to 2678)
  AUTHORS   Bucurica,S., Gaman,L., Jinga,M., Popa,A.A. and Ionita-Radu,F.
  TITLE     Golgi Apparatus Target Proteins in Gastroenterological Cancers: A
            Comprehensive Review of GOLPH3 and GOLGA Proteins
  JOURNAL   Cells 12 (14), 1823 (2023)
   PUBMED   37508488
  REMARK    GeneRIF: Golgi Apparatus Target Proteins in Gastroenterological
            Cancers: A Comprehensive Review of GOLPH3 and GOLGA Proteins.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2678)
  AUTHORS   Zhu,S., Lin,D., Ye,Z., Chen,X., Jiang,W., Xu,H., Quan,S. and
            Zheng,B.
  TITLE     GOLPH3 modulates expression and alternative splicing of
            transcription factors associated with endometrial decidualization
            in human endometrial stromal cells
  JOURNAL   PeerJ 11, e15048 (2023)
   PUBMED   36967990
  REMARK    GeneRIF: GOLPH3 modulates expression and alternative splicing of
            transcription factors associated with endometrial decidualization
            in human endometrial stromal cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2678)
  AUTHORS   Abraham,R.T.
  TITLE     GOLPH3 links the Golgi network to mTOR signaling and human cancer
  JOURNAL   Pigment Cell Melanoma Res 22 (4), 378-379 (2009)
   PUBMED   19624311
  REMARK    GeneRIF: GOLPH3 links the Golgi network to mTOR signaling and human
            cancer
REFERENCE   7  (bases 1 to 2678)
  AUTHORS   Scott,K.L., Kabbarah,O., Liang,M.C., Ivanova,E., Anagnostou,V.,
            Wu,J., Dhakal,S., Wu,M., Chen,S., Feinberg,T., Huang,J., Saci,A.,
            Widlund,H.R., Fisher,D.E., Xiao,Y., Rimm,D.L., Protopopov,A.,
            Wong,K.K. and Chin,L.
  TITLE     GOLPH3 modulates mTOR signalling and rapamycin sensitivity in
            cancer
  JOURNAL   Nature 459 (7250), 1085-1090 (2009)
   PUBMED   19553991
  REMARK    GeneRIF: Gain- and loss-of-function studies in vitro and in vivo
            validated GOLPH3 as a potent oncogene
REFERENCE   8  (bases 1 to 2678)
  AUTHORS   Schmitz,K.R., Liu,J., Li,S., Setty,T.G., Wood,C.S., Burd,C.G. and
            Ferguson,K.M.
  TITLE     Golgi localization of glycosyltransferases requires a Vps74p
            oligomer
  JOURNAL   Dev Cell 14 (4), 523-534 (2008)
   PUBMED   18410729
REFERENCE   9  (bases 1 to 2678)
  AUTHORS   Nakashima-Kamimura,N., Asoh,S., Ishibashi,Y., Mukai,Y., Shidara,Y.,
            Oda,H., Munakata,K., Goto,Y. and Ohta,S.
  TITLE     MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial
            mass in response to mitochondrial dysfunction
  JOURNAL   J Cell Sci 118 (Pt 22), 5357-5367 (2005)
   PUBMED   16263763
  REMARK    GeneRIF: MIDAS/GPP34 is involved in the regulation of mitochondrial
            lipids, leading to increases of total mitochondrial mass in
            response to mitochondrial dysfunction.
REFERENCE   10 (bases 1 to 2678)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025181.8 and AC025178.8.
            
            On Nov 25, 2018 this sequence version replaced NM_022130.3.
            
            Summary: The Golgi complex plays a key role in the sorting and
            modification of proteins exported from the endoplasmic reticulum.
            The protein encoded by this gene is a peripheral membrane protein
            of the Golgi stack and may have a regulatory role in Golgi
            trafficking. Several alternatively spliced transcript variants of
            this gene have been described, but the full-length nature of these
            variants has not been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075156.1, BC063586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265070.7/ ENSP00000265070.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               AC025181.8         9602-10111          c
            511-642             AC025178.8         35317-35448
            643-757             AC025178.8         43511-43625
            758-2678            AC025178.8         52561-54481
FEATURES             Location/Qualifiers
     source          1..2678
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.3"
     gene            1..2678
                     /gene="GOLPH3"
                     /gene_synonym="GOPP1; GPP34; MIDAS; Vps74"
                     /note="golgi phosphoprotein 3"
                     /db_xref="GeneID:64083"
                     /db_xref="HGNC:HGNC:15452"
                     /db_xref="MIM:612207"
     exon            1..510
                     /gene="GOLPH3"
                     /gene_synonym="GOPP1; GPP34; MIDAS; Vps74"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1182
                     /gene="GOLPH3"
                     /gene_synonym="GOPP1; GPP34; MIDAS; Vps74"
                     /note="golgi peripheral membrane protein 1, 34 kDa;
                     coat-protein; golgi-associated protein; golgi protein;
                     coat protein GPP34; mitochondrial DNA absence factor"
                     /codon_start=1
                     /product="Golgi phosphoprotein 3"
                     /protein_id="NP_071413.1"
                     /db_xref="CCDS:CCDS3896.1"
                     /db_xref="GeneID:64083"
                     /db_xref="HGNC:HGNC:15452"
                     /db_xref="MIM:612207"
                     /translation="MTSLTQRSSGLVQRRTEASRNAADKERAAGGGAGSSEDDAQSRR
                     DEQDDDDKGDSKETRLTLMEEVLLLGLKDREGYTSFWNDCISSGLRGCMLIELALRGR
                     LQLEACGMRRKSLLTRKVICKSDAPTGDVLLDEALKHVKETQPPETVQNWIELLSGET
                     WNPLKLHYQLRNVRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLTNNNIKQRLIKKVQ
                     EAVLDKWVNDPHRMDRRLLALIYLAHASDVLENAFAPLLDEQYDLATKRVRQLLDLDP
                     EVECLKANTNEVLWAVVAAFTK"
     exon            511..642
                     /gene="GOLPH3"
                     /gene_synonym="GOPP1; GPP34; MIDAS; Vps74"
                     /inference="alignment:Splign:2.1.0"
     exon            643..757
                     /gene="GOLPH3"
                     /gene_synonym="GOPP1; GPP34; MIDAS; Vps74"
                     /inference="alignment:Splign:2.1.0"
     exon            758..2678
                     /gene="GOLPH3"
                     /gene_synonym="GOPP1; GPP34; MIDAS; Vps74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2650..2655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLPH3"
                     /gene_synonym="GOPP1; GPP34; MIDAS; Vps74"
                     /note="hexamer: AATAAA"
     polyA_site      2678
                     /gene="GOLPH3"
                     /gene_synonym="GOPP1; GPP34; MIDAS; Vps74"
                     /note="major polyA site"
ORIGIN      
        1 atattggaaa ggcgccgccg ccgcctccgc cttggagctc ggggtgtttc ggggactgcg
       61 gccacaggca ggaaggcgct cctctcctgc cccgccgacg cccggccagc ccgcttcgcc
      121 ctgacctgtt tcctcatgac tgcccccggc cctgctgccg acggacgtcg ccccggcgtc
      181 cggatttaac acggaaaccc ggatcggagg ccgcgcgggg aggaggaggg cgacccggtc
      241 ggtcctgcga ccctctcggc ccggctcggc gcctcggcgg gagccatgac ctcgctgacc
      301 cagcgcagct ccggcctggt gcagcggcgc accgaggcct cccgcaacgc cgccgacaag
      361 gagcgggcgg cgggcggcgg cgccggcagc agcgaggacg acgcgcagag ccgccgcgac
      421 gagcaggacg acgacgacaa gggcgactcc aaggaaacgc ggctgaccct gatggaggaa
      481 gtgctcctgc tgggcctcaa ggaccgcgag ggttacacat cattttggaa tgactgtata
      541 tcatctggat tacgtggctg tatgttaatt gaattagcat tgagaggaag gttacaacta
      601 gaggcttgtg gaatgagacg taaaagtcta ttaacaagaa aggtaatctg taagtcagat
      661 gctccaacag gggatgttct tcttgatgaa gctctgaagc atgttaagga aactcagcct
      721 ccagaaacgg tccagaactg gattgaatta cttagtggtg agacatggaa tccattaaaa
      781 ttgcattatc agttaagaaa tgtacgggaa cgattagcta aaaacctggt ggaaaagggt
      841 gtattgacaa cagagaaaca gaacttccta ctttttgaca tgacaacaca tcccctcacc
      901 aataacaaca ttaagcagcg cctcatcaag aaagtacagg aagccgttct tgacaaatgg
      961 gtgaatgacc ctcaccgcat ggacaggcgc ttgctggccc tcatttacct ggctcatgcc
     1021 tcggacgtcc tggagaatgc ttttgctcct cttctggacg agcagtatga tttggctacc
     1081 aagagagtgc ggcagcttct cgacttagac cctgaagtgg aatgtctgaa ggccaacacc
     1141 aatgaggttc tgtgggcggt ggtggcggcg ttcaccaagt aactctgctc ggggtgaacc
     1201 attctccttt ctctcaagta aaccagtagt ttttcttctg ttgacttctg gttttctgta
     1261 atttgtactt tcccacacta taattggctt ctgttttaca aaatggtggg tggctttttc
     1321 ttttttgtac gtgtacagga ttctgctggt acgagaggcc ttcctctttc tgtttttaaa
     1381 aaaagtttta ctgccatatt ggcattccat tccctgttgc catcctcact gttacctgtt
     1441 ttgggtttct ggtctacttt gactttcaaa gtacctccag cctcctcata cgcacagctt
     1501 ttggatgacc tcagcttgag tttctccata tgtgcatgta catctagcat tctgcctaca
     1561 gttcagacag aagtcacaaa aaggccttca actcaccaaa ggtaaatatc tgtatctatt
     1621 aggacatttt ttacatagac ttcagttgag atgtatactt agcaaaatta tttttaaatt
     1681 gaaacagcac agtaaatact taatataaaa tgtcccttgg attttgcttc ccatgtaaat
     1741 ctattgtatt attacacttg ttataatttt aactataaag gtccaattgt ttcacagagc
     1801 cagtttggga tgggctgcat tccatttatg ctgtatatag tttgaattat atataaatta
     1861 ccccttcttc tggccacccc tgctcccatc ttagtatttt gcaagatcta atcagttgta
     1921 cacctggtgc ccctcgcttg cttcaatcat ggttatttga tggcaaaatc gacctcttgt
     1981 cgctgaagga gagagaaaag atgtgtgtct gattggtcct gggatttttt gagctgtgcc
     2041 atttatggta ctctttgcct atgcatcccc ttgttagatt ttttttaaat tttatcttac
     2101 tgtttttata atttctattg ggaagaggct tgtgaccagt accaatcttg agtttctttt
     2161 tctgtccaca agtaaattaa tatctgctct gaaatgtcat ttatctactc acacattctt
     2221 ggggaaaaaa atcaaatgtc agtcctagca gatgttgcat gtaaattggt agcaagtaat
     2281 gattacaacc cagaggatta agaattttgt aacagaaagc tctatgtttt aattttttat
     2341 atacaattag gataattagc attgtcagac tataaacctt tgctttttaa agtttatttt
     2401 tactatttct ttatcacttt attgtatcat caccattggt ttcataatgt aaatactata
     2461 tgttgaacaa attaaatgtc aaaatttttt attaccatag tccatgttaa tagtggggct
     2521 ttcaggtgtt tagagatttt ttttgttgtt gttaacattc attgcaaaag tactagatgg
     2581 tgtataactc tagagttgaa ttttaaggga ttccctaata tgtatactat ctttttatct
     2641 gaagtaataa ataaacaatg atcttgaaag tgcctgaa
//
