LOCUS       NM_138423               3974 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens golgi membrane protein 2 (GOLM2), transcript variant
            1, mRNA.
ACCESSION   NM_138423
VERSION     NM_138423.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3974)
  AUTHORS   Li,R., Dong,X., Chen,S., Tan,J., Chen,X., Liu,J., Wen,T. and Ru,X.
  TITLE     Tn antigen promotes breast cancer metastasis via impairment of
            CASC4
  JOURNAL   Cell Biol Int 47 (11), 1854-1867 (2023)
   PUBMED   37493437
  REMARK    GeneRIF: Tn antigen promotes breast cancer metastasis via
            impairment of CASC4.
REFERENCE   2  (bases 1 to 3974)
  AUTHORS   Duval,S., Abu-Thuraia,A., Elkholi,I.E., Chen,R., Seebun,D.,
            Mayne,J., Cote,J.F., Figeys,D. and Seidah,N.G.
  TITLE     Shedding of cancer susceptibility candidate 4 by the convertases
            PC7/furin unravels a novel secretory protein implicated in cancer
            progression
  JOURNAL   Cell Death Dis 11 (8), 665 (2020)
   PUBMED   32820145
  REMARK    GeneRIF: Shedding of cancer susceptibility candidate 4 by the
            convertases PC7/furin unravels a novel secretory protein implicated
            in cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3974)
  AUTHORS   Anczukow,O., Akerman,M., Clery,A., Wu,J., Shen,C., Shirole,N.H.,
            Raimer,A., Sun,S., Jensen,M.A., Hua,Y., Allain,F.H. and
            Krainer,A.R.
  TITLE     SRSF1-Regulated Alternative Splicing in Breast Cancer
  JOURNAL   Mol Cell 60 (1), 105-117 (2015)
   PUBMED   26431027
REFERENCE   4  (bases 1 to 3974)
  AUTHORS   Sato,T., Peiper,M., Heinecke,A., Zurakowski,D., Eisenberger,C.F.,
            Hosch,S., Knoefel,W.T. and Izbicki,J.R.
  TITLE     Expression of HER2/neu does not correlate with survival in soft
            tissue sarcoma
  JOURNAL   Onkologie 26 (3), 268-271 (2003)
   PUBMED   12845212
  REMARK    GeneRIF: Of 62 analyzed specimens, 43 tumors were HER2/neu negative
            compared to 19 HER2/neu positive tumors. Kaplan-Meier analysis
            indicated no difference in survival according to HER2/neu
            expression (p = 0.31, log-rank test = 1.10
REFERENCE   5  (bases 1 to 3974)
  AUTHORS   Scheer,M., Prange,W., Petmecky,K., Schirmacher,P., Zoller,J.E. and
            Kubler,A.C.
  TITLE     [Evaluation of her-2/neu amplification/overexpression in OSCC with
            fluorescence in situ hybridization (FISH) and immunohistochemistry]
  JOURNAL   Mund Kiefer Gesichtschir 7 (3), 138-145 (2003)
   PUBMED   12764679
  REMARK    GeneRIF: In spite of missing correlation between survival and
            her-2/ neu overexpression in our study, the predictive value of the
            her-2/ neu protooncogene in adjuvant therapy in OSCC needs further
            investigation.
REFERENCE   6  (bases 1 to 3974)
  AUTHORS   Oh,J.J., Grosshans,D.R., Wong,S.G. and Slamon,D.J.
  TITLE     Identification of differentially expressed genes associated with
            HER-2/neu overexpression in human breast cancer cells
  JOURNAL   Nucleic Acids Res 27 (20), 4008-4017 (1999)
   PUBMED   10497265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB229269.1, BC012124.1,
            AL832840.1 and BI467176.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138423.3.
            
            Summary: The increased expression level of this gene is associated
            with HER-2/neu proto-oncogene overexpression. Amplification and
            resulting overexpression of this proto-oncogene are found in
            approximately 30% of human breast and 20% of human ovarian cancers.
            Alternatively spliced variants encoding different isoforms have
            been identified for this gene. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript, and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.32507.1,
                                           SRR1803611.134875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299957.11/ ENSP00000299957.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DB229269.1         9-20
            13-550              BC012124.1         1-538
            551-3972            AL832840.1         1-3422
            3973-3974           BI467176.1         4-5                 c
FEATURES             Location/Qualifiers
     source          1..3974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..3974
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /note="golgi membrane protein 2"
                     /db_xref="GeneID:113201"
                     /db_xref="HGNC:HGNC:24892"
     exon            1..638
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1622
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /note="isoform a is encoded by transcript variant 1; gene
                     associated with HER-2/neu overexpression; protein CASC4;
                     cancer susceptibility candidate gene 4 protein; cancer
                     susceptibility candidate 4; cancer susceptibility 4;
                     protein GOLM2"
                     /codon_start=1
                     /product="protein GOLM2 isoform a"
                     /protein_id="NP_612432.2"
                     /db_xref="CCDS:CCDS10108.1"
                     /db_xref="GeneID:113201"
                     /db_xref="HGNC:HGNC:24892"
                     /translation="MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQE
                     EVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGRLSSRLQAREGLG
                     KRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEY
                     ESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIP
                     KVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPALRKPPISV
                     SQHESHQAISHLPTGQPLSPNMPPDSHINHNGNPGTSKQNPSSPLQRLIPGSNLDSEP
                     RIQTDILKQATKDRVSDFHKLKQSRFFDENESPVDPQHGSKLADYNGDDGNVGEYEAD
                     KQAELAYNEEEDGDGGEEDVQDDEERELQMDPADYGKQHFNDVL"
     exon            639..693
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /inference="alignment:Splign:2.1.0"
     exon            694..796
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /inference="alignment:Splign:2.1.0"
     exon            797..887
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1032
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1113
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1212
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1383
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1551
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..3974
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3952..3957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /note="hexamer: AATAAA"
     polyA_site      3964
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /note="major polyA site"
     polyA_site      3974
                     /gene="GOLM2"
                     /gene_synonym="CASC4; H63"
                     /note="major polyA site"
ORIGIN      
        1 cccgcctccc aaccgtgagg tgttgggttt gggggacgct ggcagctggg ttctcccggt
       61 tcccttgggc aggtgcaggg tcgggttcaa agcctccgga acgcgttttg gcctgatttg
      121 aggagggggg cggggaggga cctgcggctt gcggccccgc ccccttctcc ggctcgcagc
      181 cgaccggtaa gcccgcctcc tccctcggcc ggccctgggg ccgtgtccgc cgggcaactc
      241 cagccgaggc ctgggcttct gcctgcaggt gtctgcggcg aggcccctag ggtacagccc
      301 gatttggccc catggtgggt ttcggggcca accggcgggc tggccgcctg ccctctctcg
      361 tgctggtggt gctgctggtg gtgatcgtcg tcctcgcctt caactactgg agcatctcct
      421 cccgccacgt cctgcttcag gaggaggtgg ccgagctgca gggccaggtc cagcgcaccg
      481 aagtggcccg cgggcggctg gaaaagcgca attcggacct cttgctgttg gtggacacgc
      541 acaagaaaca gatcgaccag aaggaggccg actacggccg cctcagcagc cggctgcagg
      601 ccagagaggg cctcgggaag agatgcgagg atgacaaggt taaactacag aacaacatat
      661 cgtatcagat ggcagacata catcatttaa aggagcaact tgctgagctt cgtcaggaat
      721 ttcttcgaca agaagaccag cttcaggact ataggaagaa caatacttac cttgtgaaga
      781 ggttagaata tgaaagtttt cagtgtggac agcagatgaa ggaattgaga gcacagcatg
      841 aagaaaatat taaaaagtta gcagaccagt ttttagagga acaaaagcaa gagacccaaa
      901 agattcaatc aaatgatgga aaggaattgg atataaacaa tcaagtagta cctaaaaata
      961 ttccaaaagt agctgagaat gttgcagata agaatgaaga accctcaagc aatcatattc
     1021 cacatgggaa agaacaaatc aaaagaggtg gtgatgcagg gatgcctgga atagaagaga
     1081 atgacctagc aaaagttgat gatcttcccc ctgctttaag gaagcctcct atttcagttt
     1141 ctcaacatga aagtcatcaa gcaatctccc atcttccaac tggacaacct ctctccccaa
     1201 atatgcctcc agattcacac ataaaccaca atggaaaccc cggtacttca aaacagaatc
     1261 cttccagtcc tcttcagcgt ttaattccag gctcaaactt ggacagtgaa cccagaattc
     1321 aaacagatat actaaagcag gctaccaagg acagagtcag tgatttccat aaattgaagc
     1381 aaagccgatt ctttgatgaa aatgaatccc ctgttgatcc gcagcatggc tctaaactgg
     1441 cggattataa tggggatgat ggtaacgtag gtgagtatga ggcagacaag caggctgagc
     1501 tggcttacaa tgaggaagaa gatggtgatg gtggagagga agacgtccaa gatgatgaag
     1561 aacgagagct tcaaatggat cctgcagact atggaaagca acatttcaat gatgtccttt
     1621 aagtcctaaa ggaatgcttc agaaaaccta aagtgctgta aaatgaaatc attctacttt
     1681 gtcctttctg acttttgttg taaagacgaa ttgtatcagt tgtaaagata cattgagata
     1741 gaattaagga aaaactttaa tgaaggaatg tacccatgta catatgtgaa ctttttcata
     1801 ttgtattatc aaggtataga cttttttggt tatgatacag ttaagccaaa aacagctaat
     1861 ctttgcatct aaagcaaact aatgtatatt tcacatttta ttgagccgac ttatttccac
     1921 aaatagataa acaggacaaa atagttgtac aggttatatg tggcatagca taaccacagt
     1981 aagaacagaa cagatattca gcagaaaact ttttatactc taattctttt tttttttttt
     2041 tttgagacag agttttagtc ttgtttccca ggctggagtg caatggcaca atcttggctc
     2101 actgcaacct ccgcctcctg ggttcaggca attttcctgc ctcagcctcc caagtagctg
     2161 ggattacagg cacccaccac catgcccagc taatttttgt atttttaata gagagctaat
     2221 aattgtatat ttaataaaga cgggtttcac catgttggcc aggctggtct tgaactcctg
     2281 acctcaggtg atcctcctgc attggcctcc caaagtgctg gaattccagg catgagccac
     2341 tgcgcccagt ctacacacta attcttgtta gcccaacagc tgttctgttc tatctacccc
     2401 tcatttcacg ctcaaggagt catacctaga atagttacac acaagaggga aactggaagc
     2461 caaacactgt acagtattgt gtagaaagtc acctccctac tccttttatt ttacatgagt
     2521 gctgatgtgt tttggcagat gagctttcag ctgaggcctg atggaaattg agataacctg
     2581 caaagacata acagtattta tgagttatat cttagttctt gaaattgtgg aatgcatgat
     2641 tgacaatata tttttaattt ttattttttc aagtaatacc agtactgttt aactatagcc
     2701 agaactggct aaaattttta tattttcaga gttgaagttg gtgaagacat tcatgattta
     2761 aacaccagat cctgaaaggg gttaaatcta ctttgaaatg aatctgcaat cagtatttca
     2821 aagcttttct ggtaatttta gtgatcttat ttgattagac tttttcagaa gtactaaata
     2881 aggaatttta acaggttttt attaatgcac agataaatag aagtacagtg aggtctatag
     2941 ccattttatt aaaatagctt aaaagtttgt aaaaaaatga atctttgtaa ttacttaata
     3001 tgttagttaa gaacccgtca agcttatatt tgctagactt acaaattatt ttaaatgcat
     3061 ttatcttttt tgacactatt cagtggaatg tgtaagctag ctaattcttg ttttctgatt
     3121 taaagcactt ttaaatctta tcctgccccc taaaaacaaa aggttttgat cacaagggga
     3181 aatttaagat tgttaaccct gtttttcaga agggctactg ttaattgcac ataaacatga
     3241 aatgtgtttt cccctgtgta ctaacacatt ctaggcaaaa ttcaaactta tagtggtaaa
     3301 gaaacaggtt gttcacttgc tgaggtgcaa aaattcttaa gacttctgtt tgaaattgct
     3361 caatgactag gaaaagatgt agtagtttac taaaattgtt tttctaccat atcaaattaa
     3421 acaattcatg cctttatagg gtcaggccta caatgaatag gtatggtggt ttcacagaat
     3481 tttaaaatag agttaaaggg aagtgatgta catttcgggg gcattagggt agggagatga
     3541 atcaaaaaat acccctagta atgctttata ttttaatact gcaaaagctt tacaaatgga
     3601 aaccatgcaa ttacctgcct tagttctttt gtcataaaaa caatcacttg gttggttgta
     3661 ttgtagctat tacttataca gcaacatttc ttcaattagc agtctagaca ttttataaac
     3721 agaaatcttg gaccaattga taatatttct gactgtatta atattttagt gctataaaat
     3781 actatgtgaa tctcttaaaa atctgacatt ttacagtctg tattagacat actgttttta
     3841 taatgtttta cttctgcctt aagatttagg ttttttaaat gtatttttgc cctgaattaa
     3901 gtgttaattt gatggaaact ctgcttttaa aatcatcatt tactgggttc taataaatta
     3961 aaaattaaac ttgt
//
