LOCUS       NM_016548               3046 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens golgi membrane protein 1 (GOLM1), transcript variant
            1, mRNA.
ACCESSION   NM_016548
VERSION     NM_016548.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3046)
  AUTHORS   Lin,Y.F., Liao,L.Z., Wang,S.Y., Zhang,S.Z., Zhong,X.B., Zhou,H.M.,
            Xu,X.F., Xiong,Z.Y., Huang,Y.Q., Liu,M.H., Guo,Y., Liao,X.X. and
            Zhuang,X.D.
  TITLE     Causal Association of Golgi Protein 73 With Coronary Artery
            Disease: Evidence from Proteomics and Mendelian Randomization
  JOURNAL   Int J Med Sci 21 (11), 2127-2138 (2024)
   PUBMED   39239555
  REMARK    GeneRIF: Causal Association of Golgi Protein 73 With Coronary
            Artery Disease: Evidence from Proteomics and Mendelian
            Randomization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3046)
  AUTHORS   Huang,F., Guo,J., Zhao,N., Hou,M., Gai,X., Yang,S., Cai,P.,
            Wang,Y., Ma,Q., Zhao,Q., Li,L., Yang,H., Jing,Y., Jin,D., Hu,Z.,
            Zha,X., Wang,H., Mao,Y., Liu,F. and Zhang,H.
  TITLE     PTEN deficiency potentiates HBV-associated liver cancer development
            through augmented GP73/GOLM1
  JOURNAL   J Transl Med 22 (1), 254 (2024)
   PUBMED   38459588
  REMARK    GeneRIF: PTEN deficiency potentiates HBV-associated liver cancer
            development through augmented GP73/GOLM1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3046)
  AUTHORS   Zhang,Z., Leng,X.K., Zhai,Y.Y., Zhang,X., Sun,Z.W., Xiao,J.Y.,
            Lu,J.F., Liu,K., Xia,B., Gao,Q., Jia,M., Xu,C.Q., Jiang,Y.N.,
            Zhang,X.G., Tao,K.S. and Wu,J.W.
  TITLE     Deficiency of ASGR1 promotes liver injury by increasing
            GP73-mediated hepatic endoplasmic reticulum stress
  JOURNAL   Nat Commun 15 (1), 1908 (2024)
   PUBMED   38459023
  REMARK    GeneRIF: Deficiency of ASGR1 promotes liver injury by increasing
            GP73-mediated hepatic endoplasmic reticulum stress.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3046)
  AUTHORS   Liu,S., Ma,J., Chen,P., Liu,S., Guo,Y., Tan,M., Guo,X., Feng,Y.,
            Wang,Q., Li,W., Yang,C., Gao,B., Hua,Y., Liu,N., Song,H., He,R.,
            Wang,R., Gao,Q., Liu,C. and Qi,X.
  TITLE     Novel serum biomarker of Golgi protein 73 for the diagnosis of
            clinically significant portal hypertension in patients with
            compensated cirrhosis
  JOURNAL   J Med Virol 96 (1), e29380 (2024)
   PUBMED   38235849
  REMARK    GeneRIF: Novel serum biomarker of Golgi protein 73 for the
            diagnosis of clinically significant portal hypertension in patients
            with compensated cirrhosis.
REFERENCE   5  (bases 1 to 3046)
  AUTHORS   Fan,Y., Wang,L., Han,X., Ma,H., Zhang,N. and She,L.
  TITLE     LncRNA ASB16-AS1 accelerates cellular process and chemoresistance
            of ovarian cancer cells by regulating GOLM1 expression via
            targeting miR-3918
  JOURNAL   Biochem Biophys Res Commun 675, 1-9 (2023)
   PUBMED   37429067
  REMARK    GeneRIF: LncRNA ASB16-AS1 accelerates cellular process and
            chemoresistance of ovarian cancer cells by regulating GOLM1
            expression via targeting miR-3918.
REFERENCE   6  (bases 1 to 3046)
  AUTHORS   Kladney,R.D., Tollefson,A.E., Wold,W.S. and Fimmel,C.J.
  TITLE     Upregulation of the Golgi protein GP73 by adenovirus infection
            requires the E1A CtBP interaction domain
  JOURNAL   Virology 301 (2), 236-246 (2002)
   PUBMED   12359426
  REMARK    GeneRIF: GP73 as a novel adenovirus-induced cellular protein whose
            expression is regulated through the CID of the E1A protein
REFERENCE   7  (bases 1 to 3046)
  AUTHORS   Puri,S., Bachert,C., Fimmel,C.J. and Linstedt,A.D.
  TITLE     Cycling of early Golgi proteins via the cell surface and endosomes
            upon lumenal pH disruption
  JOURNAL   Traffic 3 (9), 641-653 (2002)
   PUBMED   12191016
REFERENCE   8  (bases 1 to 3046)
  AUTHORS   Bauer,K., Zemlin,M., Hummel,M., Pfeiffer,S., Karstaedt,J.,
            Steinhauser,G., Xiao,X., Versmold,H. and Berek,C.
  TITLE     Diversification of Ig heavy chain genes in human preterm neonates
            prematurely exposed to environmental antigens
  JOURNAL   J Immunol 169 (3), 1349-1356 (2002)
   PUBMED   12133958
REFERENCE   9  (bases 1 to 3046)
  AUTHORS   Kladney,R.D., Cui,X., Bulla,G.A., Brunt,E.M. and Fimmel,C.J.
  TITLE     Expression of GP73, a resident Golgi membrane protein, in viral and
            nonviral liver disease
  JOURNAL   Hepatology 35 (6), 1431-1440 (2002)
   PUBMED   12029628
  REMARK    GeneRIF: increased expression of GP73 in hepatocytes appears to be
            a general feature of advanced liver disease, and may be regulated
            via distinct pathways that involve hepatotropic viruses or
            cytokines.
REFERENCE   10 (bases 1 to 3046)
  AUTHORS   Kladney,R.D., Bulla,G.A., Guo,L., Mason,A.L., Tollefson,A.E.,
            Simon,D.J., Koutoubi,Z. and Fimmel,C.J.
  TITLE     GP73, a novel Golgi-localized protein upregulated by viral
            infection
  JOURNAL   Gene 249 (1-2), 53-65 (2000)
   PUBMED   10831838
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL533767.3, AK027717.1 and
            BC001740.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016548.3.
            
            Summary: The Golgi complex plays a key role in the sorting and
            modification of proteins exported from the endoplasmic reticulum.
            The protein encoded by this gene is a type II Golgi transmembrane
            protein. It processes proteins synthesized in the rough endoplasmic
            reticulum and assists in the transport of protein cargo through the
            Golgi apparatus. The expression of this gene has been observed to
            be upregulated in response to viral infection. Alternatively
            spliced transcript variants encoding the same protein have been
            described for this gene. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027717.1, BC001740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388712.7/ ENSP00000373364.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AL533767.3         38-85
            49-1429             AK027717.1         49-1429
            1430-3046           BC001740.1         1382-2998
FEATURES             Location/Qualifiers
     source          1..3046
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..3046
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /note="golgi membrane protein 1"
                     /db_xref="GeneID:51280"
                     /db_xref="HGNC:HGNC:15451"
                     /db_xref="MIM:606804"
     exon            1..148
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            149..298
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1375
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /note="golgi phosphoprotein 2; golgi membrane protein
                     GP73; golgi protein, 73-kD; epididymis luminal protein 46"
                     /codon_start=1
                     /product="Golgi membrane protein 1"
                     /protein_id="NP_057632.2"
                     /db_xref="CCDS:CCDS35054.1"
                     /db_xref="GeneID:51280"
                     /db_xref="HGNC:HGNC:15451"
                     /db_xref="MIM:606804"
                     /translation="MMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQT
                     RIMELEGRVRRAAAERGAVELKKNEFQGELEKQREQLDKIQSSHNFQLESVNKLYQDE
                     KAVLVNNITTGERLIRVLQDQLKTLQRNYGRLQQDVLQFQKNQTNLERKFSYDLSQCI
                     NQMKEVKEQCEERIEEVTKKGNEAVASRDLSENNDQRQQLQALSEPQPRLQAAGLPHT
                     EVPQGKGNVLGNSKSQTPAPSSEVVLDSKRQVEKEETNEIQVVNEEPQRDRLPQEPGR
                     EQVVEDRPVGGRGFGGAGELGQTPQVQAALSVSQENPEMEGPERDQLVIPDGQEEEQE
                     AAGEGRNQQKLRGEDDYNMDENEAESETDKQAALAGNDRNIDVFNVEDQKRDTINLLD
                     QREKRNHTL"
     exon            299..478
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            479..533
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            534..636
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            637..766
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            767..926
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1184
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1298
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..3046
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3024..3029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /note="hexamer: AATAAA"
     polyA_site      3046
                     /gene="GOLM1"
                     /gene_synonym="bA379P1.3; C9orf155; GOLPH2; GP73; HEL46;
                     PSEC0257"
                     /note="major polyA site"
ORIGIN      
        1 ggagacgcgg cggcgctgga cgcggaggcg ctgggcgcac ggcgcggagc cggccggagc
       61 tcgaggccgg cggcggcggg agagcgaccc gggcggcctc gtagcggggc cccggatccc
      121 cgagtggcgg ccggagcctc gaaaagagat tctcagcgct gattttgaga tgatgggctt
      181 gggaaacggg cgtcgcagca tgaagtcgcc gcccctcgtg ctggccgccc tggtggcctg
      241 catcatcgtc ttgggcttca actactggat tgcgagctcc cggagcgtgg acctccagac
      301 acggatcatg gagctggaag gcagggtccg cagggcggct gcagagagag gcgccgtgga
      361 gctgaagaag aacgagttcc agggagagct ggagaagcag cgggagcagc ttgacaaaat
      421 ccagtccagc cacaacttcc agctggagag cgtcaacaag ctgtaccagg acgaaaaggc
      481 ggttttggtg aataacatca ccacaggtga gaggctcatc cgagtgctgc aagaccagtt
      541 aaagaccctg cagaggaatt acggcaggct gcagcaggat gtcctccagt ttcagaagaa
      601 ccagaccaac ctggagagga agttctccta cgacctgagc cagtgcatca atcagatgaa
      661 ggaggtgaag gaacagtgtg aggagcgaat agaagaggtc accaaaaagg ggaatgaagc
      721 tgtagcttcc agagacctga gtgaaaacaa cgaccagaga cagcagctcc aagccctcag
      781 tgagcctcag cccaggctgc aggcagcagg cctgccacac acagaggtgc cacaagggaa
      841 gggaaacgtg cttggtaaca gcaagtccca gacaccagcc cccagttccg aagtggtttt
      901 ggattcaaag agacaagttg agaaagagga aaccaatgag atccaggtgg tgaatgagga
      961 gcctcagagg gacaggctgc cgcaggagcc aggccgggag caggtggtgg aagacagacc
     1021 tgtaggtgga agaggcttcg ggggagccgg agaactgggc cagaccccac aggtgcaggc
     1081 tgccctgtca gtgagccagg aaaatccaga gatggagggc cctgagcgag accagcttgt
     1141 catccccgac ggacaggagg aggagcagga agctgccggg gaagggagaa accagcagaa
     1201 actgagagga gaagatgact acaacatgga tgaaaatgaa gcagaatctg agacagacaa
     1261 gcaagcagcc ctggcaggga atgacagaaa catagatgtt tttaatgttg aagatcagaa
     1321 aagagacacc ataaatttac ttgatcagcg tgaaaagcgg aatcatacac tctgaattga
     1381 actggaatca catatttcac aacagggccg aagagatgac tataaaatgt tcatgaggga
     1441 ctgaatactg aaaactgtga aatgtactaa ataaaatgta catctgaaga tgattattgt
     1501 gaaattttag tatgcacttt gtgtaggaaa aaatggaatg gtcttttaaa cagcttttgg
     1561 ggggtacttt ggaagtgtct aataaggtgt cacaattttt ggtagtaggt atttcgtgag
     1621 aagttcaaca ccaaaactgg aacatagttc tccttcaagt gttggcgaca gcggggcttc
     1681 ctgattctgg aatataactt tgtgtaaatt aacagccacc tatagaagag tccatctgct
     1741 gtgaaggaga gacagagaac tctgggttcc gtcgtcctgt ccacgtgctg taccaagtgc
     1801 tggtgccagc ctgttacctg ttctcactga aaagtctggc taatgctctt gtgtagtcac
     1861 ttctgattct gacaatcaat caatcaatgg cctagagcac tgactgttaa cacaaacgtc
     1921 actagcaaag tagcaacagc tttaagtcta aatacaaagc tgttctgtgt gagaattttt
     1981 taaaaggcta cttgtataat aacccttgtc atttttaatg tacaaaacgc tattaagtgg
     2041 cttagaattt gaacatttgt ggtctttatt tactttgctt cgtgtgtggg caaagcaaca
     2101 tcttccctaa atatatatta ccaagaaaag caagaagcag attaggtttt tgacaaaaca
     2161 aacaggccaa aagggggctg acctggagca gagcatggtg agaggcaagg catgagaggg
     2221 caagtttgtt gtggacagat ctgtgcctac tttattactg gagtaaaaga aaacaaagtt
     2281 cattgatgtc gaaggatata tacagtgtta gaaattagga ctgtttagaa aaacaggaat
     2341 acaatggttg tttttatcat agtgtacaca tttagcttgt ggtaaatgac tcacaaaact
     2401 gattttaaaa tcaagttaat gtgaattttg aaaattacta cttaatccta attcacaata
     2461 acaatggcat taaggtttga cttgagttgg ttcttagtat tatttatggt aaataggctc
     2521 ttaccacttg caaataactg gccacatcat taatgactga cttcccagta aggctctcta
     2581 aggggtaagt aggaggatcc acaggatttg agatgctaag gccccagaga tcgtttgatc
     2641 caaccctctt attttcagag gggaaaatgg ggcctagaag ttacagagca tctagctggt
     2701 gcgctggcac ccctggcctc acacagactc ccgagtagct gggactacag gcacacagtc
     2761 actgaagcag gccctgtttg caattcacgt tgccacctcc aacttaaaca ttcttcatat
     2821 gtgatgtcct tagtcactaa ggttaaactt tcccacccag aaaaggcaac ttagataaaa
     2881 tcttagagta ctttcatact cttctaagtc ctcttccagc ctcactttga gtcctccttg
     2941 gggttgatag gaattttctc ttgctttctc aataaagtct ctattcatct catgtttaat
     3001 ttgtacgcat agaattgctg agaaataaaa tgttctgttc aactta
//
