LOCUS       NM_014498               4310 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens golgi integral membrane protein 4 (GOLIM4), transcript
            variant 1, mRNA.
ACCESSION   NM_014498
VERSION     NM_014498.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4310)
  AUTHORS   Kan,B., Yan,G., Shao,Y., Zhang,Z. and Xue,H.
  TITLE     CircRNA RNF10 inhibits tumorigenicity by targeting
            miR-942-5p/GOLIM4 axis in breast cancer
  JOURNAL   Environ Mol Mutagen 63 (7), 362-372 (2022)
   PUBMED   36054164
  REMARK    GeneRIF: CircRNA RNF10 inhibits tumorigenicity by targeting
            miR-942-5p/GOLIM4 axis in breast cancer.
REFERENCE   2  (bases 1 to 4310)
  AUTHORS   Luo,C.L., Xu,X.C., Liu,C.J., He,S., Chen,J.R., Feng,Y.C., Liu,S.Q.,
            Peng,W., Zhou,Y.Q., Liu,Y.X., Wei,P.P., Li,B., Mai,H.Q., Xia,X.J.
            and Bei,J.X.
  TITLE     RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway
            to Promote Nasopharyngeal Carcinogenesis
  JOURNAL   Adv Sci (Weinh) 8 (16), e2004852 (2021)
   PUBMED   34180133
  REMARK    GeneRIF: RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport
            Pathway to Promote Nasopharyngeal Carcinogenesis.
REFERENCE   3  (bases 1 to 4310)
  AUTHORS   Lin,B., Liu,C., Shi,E., Jin,Q., Zhao,W., Wang,J. and Ji,R.
  TITLE     MiR-105-3p acts as an oncogene to promote the proliferation and
            metastasis of breast cancer cells by targeting GOLIM4
  JOURNAL   BMC Cancer 21 (1), 275 (2021)
   PUBMED   33722196
  REMARK    GeneRIF: MiR-105-3p acts as an oncogene to promote the
            proliferation and metastasis of breast cancer cells by targeting
            GOLIM4.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4310)
  AUTHORS   Bai,Y., Cui,X., Gao,D., Wang,Y., Wang,B. and Wang,W.
  TITLE     Golgi integral membrane protein 4 manipulates cellular
            proliferation, apoptosis, and cell cycle in human head and neck
            cancer
  JOURNAL   Biosci Rep 38 (4) (2018)
   PUBMED   30068697
  REMARK    GeneRIF: This study found that GOLIM4, as the target gene
            downstream of STIM1, inhibited the proliferation of head and neck
            cancer, promoted apoptosis, and regulated cell cycle progression,
            and GOLIM4 is a novel oncogene in head and neck cancer and might
            help in developing promising targetted therapies for head and neck
            cancer patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4310)
  AUTHORS   Venkat,S. and Linstedt,A.D.
  TITLE     Manganese-induced trafficking and turnover of GPP130 is mediated by
            sortilin
  JOURNAL   Mol Biol Cell 28 (19), 2569-2578 (2017)
   PUBMED   28768823
  REMARK    GeneRIF: Authors provide evidence that Mn-induced exit of GPP130
            from the trans-Golgi network (TGN) toward lysosomes is mediated by
            the sorting receptor sortilin interacting with the lumenal stem
            domain of GPP130.
REFERENCE   6  (bases 1 to 4310)
  AUTHORS   Oka,T., Ungar,D., Hughson,F.M. and Krieger,M.
  TITLE     The COG and COPI complexes interact to control the abundance of
            GEARs, a subset of Golgi integral membrane proteins
  JOURNAL   Mol Biol Cell 15 (5), 2423-2435 (2004)
   PUBMED   15004235
REFERENCE   7  (bases 1 to 4310)
  AUTHORS   Puri,S., Bachert,C., Fimmel,C.J. and Linstedt,A.D.
  TITLE     Cycling of early Golgi proteins via the cell surface and endosomes
            upon lumenal pH disruption
  JOURNAL   Traffic 3 (9), 641-653 (2002)
   PUBMED   12191016
REFERENCE   8  (bases 1 to 4310)
  AUTHORS   Doi,K., Noma,S., Yamao,F., Goko,H. and Yagura,T.
  TITLE     Expression of Golgi membrane protein p138 is cell cycle-independent
            and dissociated from centrosome duplication
  JOURNAL   Cell Struct Funct 27 (2), 117-125 (2002)
   PUBMED   12207053
  REMARK    GeneRIF: both the translation and transcription are regulated
            independent of the cell cycle and dissociated from the duplication
            of the centrosome
REFERENCE   9  (bases 1 to 4310)
  AUTHORS   Bachert,C., Lee,T.H. and Linstedt,A.D.
  TITLE     Lumenal endosomal and Golgi-retrieval determinants involved in
            pH-sensitive targeting of an early Golgi protein
  JOURNAL   Mol Biol Cell 12 (10), 3152-3160 (2001)
   PUBMED   11598199
REFERENCE   10 (bases 1 to 4310)
  AUTHORS   Linstedt,A.D., Mehta,A., Suhan,J., Reggio,H. and Hauri,H.P.
  TITLE     Sequence and overexpression of GPP130/GIMPc: evidence for saturable
            pH-sensitive targeting of a type II early Golgi membrane protein
  JOURNAL   Mol Biol Cell 8 (6), 1073-1087 (1997)
   PUBMED   9201717
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM925724.1, AK307557.1,
            BC143232.1, U55853.1, AU310391.1, AC117467.3 and BX097666.1.
            
            On May 17, 2019 this sequence version replaced NM_014498.4.
            
            Summary: The Golgi complex plays a key role in the sorting and
            modification of proteins exported from the endoplasmic reticulum.
            The protein encoded by this gene is a type II Golgi-resident
            protein. It may process proteins synthesized in the rough
            endoplasmic reticulum and assist in the transport of protein cargo
            through the Golgi apparatus. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.150157.1,
                                           SRR1803615.78472.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000470487.6/ ENSP00000417354.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               BM925724.1         33-327
            296-2566            AK307557.1         2-2272
            2567-2764           BC143232.1         1903-2100
            2765-2857           U55853.1           2139-2231
            2858-3133           AU310391.1         72-347
            3134-3734           AC117467.3         40244-40844         c
            3735-4310           BX097666.1         25-600
FEATURES             Location/Qualifiers
     source          1..4310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..4310
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /note="golgi integral membrane protein 4"
                     /db_xref="GeneID:27333"
                     /db_xref="HGNC:HGNC:15448"
                     /db_xref="MIM:606805"
     exon            1..826
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     CDS             640..2730
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /note="isoform 1 is encoded by transcript variant 1; type
                     II Golgi membrane protein; golgi phosphoprotein 4; 130 kDa
                     golgi-localized phosphoprotein; cis Golgi-localized
                     calcium-binding protein; golgi phosphoprotein of 130 kDa;
                     golgi integral membrane protein, cis; golgi-localized
                     phosphoprotein of 130 kDa"
                     /codon_start=1
                     /product="Golgi integral membrane protein 4 isoform 1"
                     /protein_id="NP_055313.1"
                     /db_xref="CCDS:CCDS3204.1"
                     /db_xref="GeneID:27333"
                     /db_xref="HGNC:HGNC:15448"
                     /db_xref="MIM:606805"
                     /translation="MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAE
                     AVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNK
                     GRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQL
                     QQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLE
                     DHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPT
                     REVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQ
                     VEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAE
                     VYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQ
                     QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYER
                     DNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAE
                     QVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQED
                     LTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEED
                     GAAVAEKSHRRAEM"
     exon            827..901
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            902..951
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1005
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1156
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1239
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1323
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1482
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1815
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2072
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2152
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2262
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2430
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2499
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2580
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..4310
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2956..2961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /note="hexamer: AATAAA"
     polyA_site      2978
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /note="major polyA site"
     regulatory      3978..3983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /note="hexamer: AATAAA"
     polyA_site      3999
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /note="major polyA site"
     regulatory      4200..4205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
                     /note="hexamer: AATACA"
     polyA_site      4219
                     /gene="GOLIM4"
                     /gene_synonym="GIMPC; GOLPH4; GPP130; P138"
ORIGIN      
        1 atagccgggc cgtgggtgac acgtaagttg ggcaggaggt ggcggggcgg cagaggcacc
       61 agccgacccg tcagtgacac cgctgtgccg tccccaaaac cagccgagac agctggcccc
      121 cacccttcca cccattgggc aggccgcacg ggggcgcggc ccggagtcct ggtccctttg
      181 ttgggcgcgc accccctccc ttaggtggca acaaagtcgt gcagtgggag ccgccgcgat
      241 agggcgggga gtggccaggg cgggactcca agaactgccc gggggcagcg gggccaaaaa
      301 gtgggaagaa ggaaaaaagg caggaggcat ctggggacag gcgcgagggc agccggctct
      361 gaagtatgcg gagggcctcc tcccggcccc gggcattcgc ggagaacgag cctcgcagaa
      421 gtttggctgc agctgcccgg gcggcgtcga tggctgcgcg ccccgcgccg cgcgggggct
      481 gagcgggcgc cacttcccct ccgggccggc ttttgtgtct ggcatctcct cctcatgctg
      541 cgtctggcca cctactgcgg cggccgctgc tgagacgctc gctcggacca aggggaggag
      601 acggcggggg cggccgcggc tttgggtcca ggcgggacta tgggaaacgg gatgtgctcc
      661 cgaaagcaga agcggatttt ccagacgctg ctgctgctga ccgtcgtgtt cggctttctc
      721 tacggcgcga tgctctacta cgagctgcag acgcagctgc ggaaagccga ggcggtggcg
      781 ctcaagtacc agcagcacca ggagtccctc tccgcccagt tacaagttgt atatgaacac
      841 agatcaagat tagagaaatc cttgcaaaaa gaaagacttg aacataaaaa agcaaaggaa
      901 gattttcttg tttataagtt agaagcacaa gaaacattaa ataaaggaag gcaagattcc
      961 aatagcagat acagtgcact gaatgtccaa catcagatgt tgaaaagcca acacgaggag
     1021 ctaaagaaac agcacagtga cttggaagag gaacatcgca aacaagggga agacttcagt
     1081 agaacattta atgaccataa gcaaaaatac ttgcagctcc agcaagaaaa agaacaagaa
     1141 ctttctaagc taaaagagac tgtatacaat ttgagagaag agaatagaca actaaggaaa
     1201 gcacaccaag acatacatac acagcttcaa gatgtcaagc aacagcataa gaatttactc
     1261 tccgagcatg aacaacttgt agtgactttg gaagaccaca agagtgcact agctgctgca
     1321 cagactcaag ttgcagaata taaacaactg aaagatactc tgaataggat tccaagcctt
     1381 cgaaaacctg atccagcaga acagcaaaat gtgacccagg tggcacattc tccacaaggt
     1441 tacaacacag caagggagaa gccaacccga gaggtgcagg aggtgtctcg aaataatgat
     1501 gtgtggcaga accatgaagc agttcctgga agagcagaag acacaaaact ctatgctccc
     1561 acccataagg aggcagaatt tcaggctccc ccagagccaa tccaacaaga agtggaacgc
     1621 agagaacctg aggagcatca ggtggaagag gagcacagaa aggccctgga ggaggaagaa
     1681 atggagcagg tcgggcaagc agaacatctt gaggaggaac acgatccatc accagaggag
     1741 caggatcggg agtggaaaga gcagcatgag caacgagaag cagccaacct cctggaaggg
     1801 cacgcgcgtg ctgaggtgta cccttcagcc aagccaatga tcaaattcca atcaccctat
     1861 gaggaacagt tggaacagca gagactggca gtgcagcagg tggaggaggc ccagcagctg
     1921 cgggaacacc aggaagcttt gcaccagcag aggctgcagg ggcacttact acggcagcag
     1981 gaacagcagc agcagcaggt ggcaagagag atggccctgc agaggcaggc tgagcttgag
     2041 gagggccggc cgcagcacca ggagcagctc cggcagcaag ctcattatga tgctatggat
     2101 aatgatatcg ttcagggagc agaggaccag ggaatccaag gagaggaagg agcctatgaa
     2161 agagacaacc agcaccaaga tgaagcagaa ggagatccag gtaatagaca tgagcctcgt
     2221 gaacaaggac cccgagaagc cgacccagaa tctgaggcag atagggcagc tgtagaagat
     2281 ataaacccag cagatgaccc taataatcaa ggtgaggatg aatttgaaga agccgagcaa
     2341 gtgagagaag aaaatttgcc agatgaaaat gaagagcaaa aacaaagtaa tcaaaagcaa
     2401 gagaatacag aagtggagga acatttggtg atggcaggaa atccagacca gcaggaggac
     2461 aatgttgatg aacagtacca ggaagaggca gaagaggagg ttcaggaaga tttgactgaa
     2521 gagaaaaaaa gggaactgga gcataatgct gaagagacct atggtgaaaa tgatgaaaat
     2581 actgatgata aaaataatga tggagaagag caagaagttc gagatgacaa ccgccccaaa
     2641 ggccgagagg aacactacga ggaggaagaa gaggaggaag aagacggggc tgcagttgct
     2701 gagaaatcac atcgaagagc tgaaatgtag cggcacccaa tttctagaca acgctcagcc
     2761 aacggattct tttcaagctg ctcaaacata aatctgccta ctgaactcta ggatatttaa
     2821 ttacaaaaat taagaactta gactttttta aaacttttgt attagaaatg cgcatacatt
     2881 tatatgaata tattttgata acgtaggtct agagcttctt ttatattcaa gctaaacatg
     2941 aaaaagaaga aaaacaataa agtaaacctg agcccccacg tcccaatttt tttaatagat
     3001 tatgtgatgt tggaaagctc attgattttg tatatgtttc agcgtgttac ctttctggct
     3061 tccagttccc aggtgttctt tgtttgcctt tgataaaata caggatttaa gaacagagag
     3121 tactgcaaaa tgccatgcag actttaaaga gaatggcctg tttactaatt gctgcccttc
     3181 tgatgtcttt atgtatagct ctgatagaat tttcaccagt ctatgtatct ctggagtgag
     3241 atctatgtac aaagtgacat acaattggaa atccattttt gttgtaaaga cattgttttt
     3301 cagacttttc agatcaatta gaaaaatgtc attgctttaa aatcatagct gttctgttta
     3361 agaggaattg aatttaaaaa tgagagagta ttaaaactca tgtggcagta tcctggtctt
     3421 aatcaggtat tgcagtgttc aaacaaggta tggacacatc aacatattca ccttttggaa
     3481 ggactagtga cttggttaaa aactaatgag tgtttgcgtg tggtgtttct atgcgagcac
     3541 ccattctcaa tttttttttt ttttttttgt ttgaagccat tgattgatat tcttgtttca
     3601 gtgtctggtt ccctataagt aatatatatt tcctctttaa gctctgtgcc tcaatatgca
     3661 atcactttga taataagtat aaatatgaag acataccaaa ctgcaaatag gattattttt
     3721 caaaactata tggtgaaaca tatggtgata tgatagactt atggtttttc tgtttgctgg
     3781 gattgggtct gctttttgcc tatgtgtaag gcattttaat cattgtgaat ataatagatt
     3841 ccttaaaata agaaaattaa aaatcagaaa cttcccttgg agtagagaca tttcagttgc
     3901 aagcataaag atttttaaat atataacact aggttatata attcatatat gtgtggtttt
     3961 gtattaataa tcaaattaat aaaaacattt cattttctac cattgtatga acgtaatttt
     4021 attttttaat aaccacactc atagatggtt ttgattgttc cagttgagtg attgtgtatg
     4081 tacgcatagg aatgttttgt tcagttgtac tttgtatttc caataatcag aaatcttacc
     4141 tttatgtata aaaacccatt atgtaatgta aaatgtataa tattgtacat aatattcaga
     4201 atacaattat tttggtaaat tagcttgtat ttttaatgtc ccagttgcag tatttaatta
     4261 tttgaaccat actgaaagtt ggtaatagtc aataaagcta aaaaaaaaaa
//
