LOCUS       NM_181077               5777 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens golgin A8 family member A (GOLGA8A), transcript
            variant 1, mRNA.
ACCESSION   NM_181077 XM_001128160
VERSION     NM_181077.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5777)
  AUTHORS   Merino-Zamorano,C., Delgado,P., Fernandez de Retana,S.,
            Fernandez-Cadenas,I., Rodriguez-Luna,D., Montaner,J. and
            Hernandez-Guillamon,M.
  TITLE     Identification of Plasma Biomarkers of Human Intracerebral
            Hemorrhage Subtypes through Microarray Technology
  JOURNAL   J Stroke Cerebrovasc Dis 25 (3), 665-671 (2016)
   PUBMED   26738811
  REMARK    GeneRIF: The microarray analysis and the validation study revealed
            an increase in Golgin A8 Family, Member A (GOLGA8A) mRNA and
            protein levels in Intracerebral hemorrhage.
REFERENCE   2  (bases 1 to 5777)
  AUTHORS   Eystathioy,T., Jakymiw,A., Fujita,D.J., Fritzler,M.J. and Chan,E.K.
  TITLE     Human autoantibodies to a novel Golgi protein golgin-67: high
            similarity with golgin-95/gm 130 autoantigen
  JOURNAL   J Autoimmun 14 (2), 179-187 (2000)
   PUBMED   10677249
REFERENCE   3  (bases 1 to 5777)
  AUTHORS   Jakymiw,A., Raharjo,E., Rattner,J.B., Eystathioy,T., Chan,E.K. and
            Fujita,D.J.
  TITLE     Identification and characterization of a novel Golgi protein,
            golgin-67
  JOURNAL   J Biol Chem 275 (6), 4137-4144 (2000)
   PUBMED   10660574
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025678.7.
            
            On Sep 16, 2020 this sequence version replaced NM_181077.4.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked, flattened membrane sacs referred
            to as cisternae. Interactions between the Golgi and microtubules
            are thought to be important for the reorganization of the Golgi
            after it fragments during mitosis. The golgins constitute a family
            of proteins which are localized to the Golgi. This gene encodes a
            golgin which structurally resembles its family member GOLGA2,
            suggesting that they may share a similar function. There are many
            similar copies of this gene on chromosome 15. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR18074968.1767754.1,
                                    SRR14038193.3658576.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359187.5/ ENSP00000352111.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               AC025678.7         169016-169426       c
            412-500             AC025678.7         167001-167089       c
            501-712             AC025678.7         139142-139353       c
            713-909             AC025678.7         138292-138488       c
            910-1048            AC025678.7         136535-136673       c
            1049-1096           AC025678.7         132330-132377       c
            1097-1145           AC025678.7         130773-130821       c
            1146-1241           AC025678.7         130252-130347       c
            1242-1545           AC025678.7         122741-123044       c
            1546-1670           AC025678.7         121262-121386       c
            1671-1790           AC025678.7         119451-119570       c
            1791-1907           AC025678.7         118243-118359       c
            1908-1946           AC025678.7         117358-117396       c
            1947-1994           AC025678.7         117045-117092       c
            1995-2079           AC025678.7         116872-116956       c
            2080-2189           AC025678.7         116666-116775       c
            2190-2276           AC025678.7         115579-115665       c
            2277-2384           AC025678.7         115364-115471       c
            2385-2472           AC025678.7         115059-115146       c
            2473-2729           AC025678.7         114415-114671       c
            2730-2873           AC025678.7         114004-114147       c
            2874-2974           AC025678.7         113769-113869       c
            2975-3075           AC025678.7         113586-113686       c
            3076-3231           AC025678.7         113319-113474       c
            3232-5777           AC025678.7         110686-113231       c
FEATURES             Location/Qualifiers
     source          1..5777
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..5777
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="golgin A8 family member A"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
     exon            1..411
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            412..500
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            501..712
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            713..909
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1048
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1096
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1145
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1241
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1545
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1670
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     CDS             1623..3434
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="isoform 1 is encoded by transcript variant 1; golgi
                     autoantigen, golgin subfamily a, 8A; golgin subfamily A
                     member 8A; GM88 autoantigen; 88-kDa golgi protein;
                     golgin-67; 88 kDa Golgi matrix protein; Golgin subfamily A
                     member 8B"
                     /codon_start=1
                     /product="golgin subfamily A member 8A isoform 1"
                     /protein_id="NP_851422.1"
                     /db_xref="CCDS:CCDS10038.1"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
                     /translation="MAEETGQSKLAAAKKKFKEYWQRNRPGVPAAAKRNTKANGSSPE
                     TAASGGCHSSEASSSASSSLHARQSPCQEQAAVLNSRSIKISRLNDTIKSLKQQKKQV
                     EHQLEEEKKANNEKQKAERELEGQIQRLNTEKKKLNTDLYHMKHSLRYFEEESKDLAG
                     RLQRSSQRIGELEWSLCAVAATQKKKPDGFSSRSKALLKRQLEQSIREQILLKGHVTQ
                     LKESLKEVQLERDQYAEQIKGERAQWQQRMRKMSQEVCTLKEEKKHDTHRVEELERSL
                     SRLKNQMAEPLPPDAPAVSSEVELQDLRKELERVAGELQAQVENNQCISLLNRGQKER
                     LREQEERLQEQQERLREREKRLQQLAEPQSDLEELKHENKSALQLEQQVKELQEKLGQ
                     VMETLTSAEKEPEAAVPASGTGGESSGLMDLLEEKADLREHVEKLELGFIQYRRERCH
                     QKVHRLLTEPGDSAKDASPGGGHHQAGPGQGGEEGEAAGAAGDGVAACGSYSEGHGKF
                     LAAARNPAAEPSPGAPAPQELGAADKHGDLCEASLTNSVEPAQGEAREGSSQDNPTAQ
                     PVVQLLGEMQDHQEHPGLGSNCCVPCFCWAWLPRRRR"
     exon            1671..1790
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1907
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1946
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..1994
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2079
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2189
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2276
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2384
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2472
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2729
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2873
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..2974
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3075
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3231
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..5777
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5754..5759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="hexamer: AATAAA"
     polyA_site      5777
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="major polyA site"
ORIGIN      
        1 gctattcagc tgtcgggcta atcagcagtc gaggtgtgcg gctaggcgcg agctctgcgg
       61 gagctcagcc cccgggagag acccggcagc ggcgcggcga ggacggcggc gcggcgagga
      121 cggcggcgcg gcgaggacgg cggcgcggcg aggacggcgg cgcggcgagg acggcggcgc
      181 ggcgaggacg gcggcgcggc gaggacggcg gcgcggcgag gacggcggcg cggcgaggac
      241 ggcggcgcgg cgaggacggc ggcgcggcga ggacggcggc gcggcgagga cggcggcgcg
      301 gcgaggacgg cggcgcggcg aggacggcgg cgcggcgagg acggcggcgc ggcgaggacg
      361 gcggcgcggc gaggacggcg gcggaccggg gcagccccgc gccctggcca ggaataatcg
      421 gtggagatgg attgtgaaat ggaggtgcat aaatatccag tttgccaacc gagctaagaa
      481 atgctggata aaagtaaaag ctctactgag atgaagaaag aaaaagaata cctgctcagc
      541 tccagagaca cgtaaaggga cagagattgg gggacagaag gaagtgcatt aattccttcc
      601 acgacccctg aagagcagcg gtgggtctga gcatcctatc tccaggaagc aggccagcag
      661 gcaagccagc tgccacctcg tcctgtgcaa agcacaggca ccgtccccaa aagatttcca
      721 aagatgatgt taaacccagc cacggttctg atctccagga aagcaattgc tgtggtacaa
      781 aaggacaagg gttaaaagag aacagtggga gctctctttc ccagctaact cacgcagtgt
      841 gacgcagagg ctttcagcac agcccagggt gcccgggact gaaaactcct tcaccagccc
      901 cctccacagg atatagaaga cttagatcac tacgagatga aagcagagcc cattagtggg
      961 aaaaagttgg aggatgaagg aattgaaaaa gaaaatttgg caatattaga gaaattagga
     1021 agactgaaag acaagagcat ttaactgcaa actgttgtcg ttgtcaactg ggttgtcttc
     1081 ctgaagtatg aatccggtat gtattgtgtg gaggagcatt acgtattgaa cttctcacaa
     1141 aacagggctg aagcagtgcc tactcgacag aaccggtcat cgtacaaaga aatgccacgt
     1201 gactcaaagg caaagccaga gtgcagcttg gagcaaagaa gatgatgtct cactctgtca
     1261 cccaagatgg agtgcaatgg cacgatctca gctcactgca acctctgcct cccaggttca
     1321 agcaattatc ctgcctcagc cacccgagta gctgagatta caggcctctg ccaccatgct
     1381 cagctatttt ttgtattttt agtagagacg gggtttcacc atgttgggca ggctagtctt
     1441 ggaactactg acctcaggtg atccgcccac tttggcctcc cgaaagtgct gggattacag
     1501 tcatgagcca ccatgcccag cctatttatt tctgattctt taagggtgac tggatgtgtt
     1561 gatcagcgct cgctgggatt tggctgacgt ggccccagcc ccgcctccct ccccacccca
     1621 caatggcaga agaaactgga cagagtaaat tagctgcagc caagaaaaag ttcaaagaat
     1681 attggcagag aaaccgccct ggtgttccag cagcagcgaa gaggaacacg aaagcaaatg
     1741 gcagtagccc tgagacggcc gcttctggtg gttgccactc atctgaggct tcctcctccg
     1801 cctcctcctc tctgcatgcg cgtcagagcc cgtgccaaga acaagcagca gtcctgaact
     1861 cgaggtccat aaaaatcagt cgactgaatg acaccatcaa atctttgaaa caacagaaga
     1921 aacaagtgga acatcagctg gaagaagaaa agaaagcaaa caatgagaaa cagaaagctg
     1981 aaagggagct agagggtcaa atccagagat tgaacacaga gaaaaagaaa ctaaatacgg
     2041 acctgtatca catgaaacat tctctcagat actttgaaga agagtccaag gatctggccg
     2101 gccgcctgca acgttcatcg cagcgtatag gagagttaga gtggtctctc tgtgctgtcg
     2161 ccgccacaca gaagaagaag ccggatgggt tctcgagccg cagtaaagca cttctcaagc
     2221 ggcagttaga gcagtccata cgggagcaga tactgctgaa aggacacgtg acacagttga
     2281 aggagtcgct taaagaagtc cagctggaga gagatcaata tgctgaacaa ataaaaggag
     2341 agagggccca gtggcagcag aggatgagga aaatgtcgca ggaggtttgc acattgaagg
     2401 aggagaagaa gcatgatacg catcgggtag aggagctgga gaggagcttg tccagactca
     2461 aaaaccagat ggctgagcca ctgcccccgg atgccccagc agtgtcctct gaggtggagc
     2521 tgcaagacct gaggaaggag ctggagagag tggcaggaga gctccaggct caggtggaaa
     2581 acaatcagtg catcagtctc ctgaaccgtg ggcaaaagga gaggcttcgc gagcaggagg
     2641 agaggcttca ggagcagcag gagaggcttc gggaacggga gaagaggctt cagcagctgg
     2701 ccgagccaca gagcgacttg gaggagctga agcacgagaa caagagcgca ctgcagttgg
     2761 agcagcaagt aaaggagctg caggagaagc tgggccaggt gatggagacg ctcacctcgg
     2821 ccgagaagga gccagaggca gcagtcccag cctcagggac tgggggcgag tctagcggcc
     2881 ttatggacct cctggaggag aaggcggacc tgagggagca tgtggagaaa ctggaacttg
     2941 gattcatcca gtaccggaga gagagatgcc atcagaaagt acatcgcctt ctaacagagc
     3001 caggggacag tgccaaagat gcgtcaccgg gaggaggcca tcatcaggct ggcccaggac
     3061 aaggaggaga ggaaggtgaa gctgctggag ctgcaggaga tggtgttgcg gcttgtggca
     3121 gctacagcga ggggcacggc aaattcctgg ccgctgcccg gaaccctgct gctgaaccca
     3181 gtccaggagc cccagccccc caggagctcg gggctgccga caagcatggt gatctttgtg
     3241 aggcgagcct caccaacagc gtggagcctg cacaaggaga agccagggag ggttcttccc
     3301 aggacaaccc tactgcacag ccagtcgtgc agctccttgg tgagatgcag gaccaccagg
     3361 agcacccagg cttgggcagc aactgctgtg tgccatgctt ttgctgggct tggctgccga
     3421 gaagaaggag ataaacacca ccatcatcaa agagctgctc aagaaatttt taaaaacgaa
     3481 acaaagttat ggggttaatc tcctacacaa ttcatttact tcatttgaat gttagagcta
     3541 ctcatgatta tttgtgtttc taatttatag tttaagttta tttgtaaaaa gttaaaagag
     3601 agtgggtctc tgtggctctc actgatgttc actctggcat ccttcagcat ttttcttttt
     3661 tcatttcata attgtaggtc attagcatgc atatcgagtt tgcccttacg tggtgggagt
     3721 tcaaacacac aaagacccac tctttgcaca aaactgttct cgctggtttg gaataggctc
     3781 ccgtgctttt ctaatgttat tgcagcatgg atgtccatta cagaattcag ataaaatttg
     3841 ctaatgttct gctatgatgt ttgatctcat cttaatcaca gtgagctctt ctatagctca
     3901 atatgcggtt tgccctcaag tgtgcactgt ttattacttt gtaatatgcc actgtgagta
     3961 ctgacattta gagctgttta aaggccgaga actggaaaca gcctttcctc cattttctgt
     4021 gtattggtga tgggagtgat aaccttttgg gggagctttc taaatctcac agaagaggaa
     4081 agtggcctgc tctggcaggt atgtgcagga tacagtgtgt ttcatctgtt ccggtgccaa
     4141 gaatgagcag tgtactgtgg cagttccctt tggatttgta tgtgctctgg gctcatgaag
     4201 atattgcatc gtgagctgca gcagttgcac tctttttcag tgacctaaaa agggcttatt
     4261 tccgaggaat gaaaggctgc catcattggc tgtgggtgtg aaaaaccttt cctagcttag
     4321 agcatttgta tctacaatac attttaaagt cagagttcgt gttccctgtt ttaatcacat
     4381 gactacctgt cccagtacac gaaagggcgc tggttggcat tcttcttaat gtatttagtg
     4441 aagatcataa gaaatccttt aagagtttaa atgtctctga aacaggcata caggctctag
     4501 tcaagaatga attagagtga aggaaagctg tgtgacacct ggcattcctc tctgttcatg
     4561 gagcttcttt gaggcttgaa gtttgatttt actatctaga cctctctggc taatacctat
     4621 tcttcaacca cctcggttac tctgacatag gaatttactt cttttccttg agtggaaaac
     4681 actttagaaa gtaataacaa acattattat aaactaatat atgtgagagt acttagttga
     4741 aacaaaaagg aattttagta gacagtatta tattatcttt gaaaatcaag gagaagttta
     4801 tgcaacttaa aatgtttaca cactgtggtg caatctactg tttgtgaatg tctgtattat
     4861 caggaaacat gtctatacga tcgcagagtt gtatttcctc acaaacttct ttacgaagag
     4921 tgaaatacgt ttttgtacct ctcattttca gtcagggaca tactttgtgc aatatttctg
     4981 tgattgtgcc tatgcatgat gaatgaatgc atttcaatca tacattgcct aaatcataac
     5041 ttgatgatgc ttgggaaaga atcaacagtt aaaacttcat gaagttctaa tgtctgtgtt
     5101 ccaaaacaca tcacattatt aggttgtagg gagatatgta ggtgtgctcc ctggggtggg
     5161 gagttttcta gttactagac catctccatt tttagcactt ggcagcctca tgatcctttt
     5221 ataaatgtga gattaacagg agagcagcaa tacgattttg ccaatggaat aacagatttg
     5281 ccggcattca ctgaaagagg gcagatattg ggtccttgta acttcaactg actcttccaa
     5341 attgtatgaa tttatcaatg tattacacaa atccagtttc agaatgataa aaaatgttag
     5401 accaaataat gcggctaatt aacagtcgta tgatttctag cccatgggtt taaaactgta
     5461 tcttaaagag tcattttaaa ataatataaa tattaaaaaa tgtaactgct atcttaatgt
     5521 tctgaaataa aacattttaa aatataaatc ctgtagttta aaaggaagaa atggtgggaa
     5581 ggaaaagtag agaaagaaat gccaattcca ggccaaagcg ttatttgcca agttttctta
     5641 gaatgaattt taccaatgta tgagttcttg ttaacagaat gtgtaacgga aatactgaaa
     5701 gacttttgct taaagtggca ttattgactg ctgatgtgat gctactgtaa tgcaataaat
     5761 ttttaaattg ttgcaaa
//
