LOCUS       NM_001386895            5690 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens golgin A8 family member A (GOLGA8A), transcript
            variant 7, mRNA.
ACCESSION   NM_001386895
VERSION     NM_001386895.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5690)
  AUTHORS   Merino-Zamorano,C., Delgado,P., Fernandez de Retana,S.,
            Fernandez-Cadenas,I., Rodriguez-Luna,D., Montaner,J. and
            Hernandez-Guillamon,M.
  TITLE     Identification of Plasma Biomarkers of Human Intracerebral
            Hemorrhage Subtypes through Microarray Technology
  JOURNAL   J Stroke Cerebrovasc Dis 25 (3), 665-671 (2016)
   PUBMED   26738811
  REMARK    GeneRIF: The microarray analysis and the validation study revealed
            an increase in Golgin A8 Family, Member A (GOLGA8A) mRNA and
            protein levels in Intracerebral hemorrhage.
REFERENCE   2  (bases 1 to 5690)
  AUTHORS   Eystathioy,T., Jakymiw,A., Fujita,D.J., Fritzler,M.J. and Chan,E.K.
  TITLE     Human autoantibodies to a novel Golgi protein golgin-67: high
            similarity with golgin-95/gm 130 autoantigen
  JOURNAL   J Autoimmun 14 (2), 179-187 (2000)
   PUBMED   10677249
REFERENCE   3  (bases 1 to 5690)
  AUTHORS   Jakymiw,A., Raharjo,E., Rattner,J.B., Eystathioy,T., Chan,E.K. and
            Fujita,D.J.
  TITLE     Identification and characterization of a novel Golgi protein,
            golgin-67
  JOURNAL   J Biol Chem 275 (6), 4137-4144 (2000)
   PUBMED   10660574
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025678.7.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked, flattened membrane sacs referred
            to as cisternae. Interactions between the Golgi and microtubules
            are thought to be important for the reorganization of the Golgi
            after it fragments during mitosis. The golgins constitute a family
            of proteins which are localized to the Golgi. This gene encodes a
            golgin which structurally resembles its family member GOLGA2,
            suggesting that they may share a similar function. There are many
            similar copies of this gene on chromosome 15. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2009].
            
            Transcript Variant: This variant (7), as well as variants 1 and 6,
            encodes isoform 1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038191.1769202.1, SRR14038193.191329.1
                                    [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               AC025678.7         169016-169426       c
            412-500             AC025678.7         167001-167089       c
            501-712             AC025678.7         139142-139353       c
            713-909             AC025678.7         138292-138488       c
            910-1048            AC025678.7         136535-136673       c
            1049-1096           AC025678.7         132330-132377       c
            1097-1145           AC025678.7         130773-130821       c
            1146-1241           AC025678.7         130252-130347       c
            1242-1315           AC025678.7         122971-123044       c
            1316-1458           AC025678.7         122741-122883       c
            1459-1583           AC025678.7         121262-121386       c
            1584-1703           AC025678.7         119451-119570       c
            1704-1820           AC025678.7         118243-118359       c
            1821-1859           AC025678.7         117358-117396       c
            1860-1907           AC025678.7         117045-117092       c
            1908-1992           AC025678.7         116872-116956       c
            1993-2102           AC025678.7         116666-116775       c
            2103-2189           AC025678.7         115579-115665       c
            2190-2297           AC025678.7         115364-115471       c
            2298-2385           AC025678.7         115059-115146       c
            2386-2642           AC025678.7         114415-114671       c
            2643-2786           AC025678.7         114004-114147       c
            2787-2887           AC025678.7         113769-113869       c
            2888-2988           AC025678.7         113586-113686       c
            2989-3144           AC025678.7         113319-113474       c
            3145-5690           AC025678.7         110686-113231       c
FEATURES             Location/Qualifiers
     source          1..5690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..5690
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="golgin A8 family member A"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
     exon            1..411
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            412..500
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            501..712
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            713..909
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1048
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1096
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1145
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1241
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1315
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1458
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1583
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     CDS             1536..3347
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="isoform 1 is encoded by transcript variant 7; golgi
                     autoantigen, golgin subfamily a, 8A; golgin subfamily A
                     member 8A; GM88 autoantigen; 88-kDa golgi protein;
                     golgin-67; 88 kDa Golgi matrix protein; Golgin subfamily A
                     member 8B"
                     /codon_start=1
                     /product="golgin subfamily A member 8A isoform 1"
                     /protein_id="NP_001373824.1"
                     /db_xref="CCDS:CCDS10038.1"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
                     /translation="MAEETGQSKLAAAKKKFKEYWQRNRPGVPAAAKRNTKANGSSPE
                     TAASGGCHSSEASSSASSSLHARQSPCQEQAAVLNSRSIKISRLNDTIKSLKQQKKQV
                     EHQLEEEKKANNEKQKAERELEGQIQRLNTEKKKLNTDLYHMKHSLRYFEEESKDLAG
                     RLQRSSQRIGELEWSLCAVAATQKKKPDGFSSRSKALLKRQLEQSIREQILLKGHVTQ
                     LKESLKEVQLERDQYAEQIKGERAQWQQRMRKMSQEVCTLKEEKKHDTHRVEELERSL
                     SRLKNQMAEPLPPDAPAVSSEVELQDLRKELERVAGELQAQVENNQCISLLNRGQKER
                     LREQEERLQEQQERLREREKRLQQLAEPQSDLEELKHENKSALQLEQQVKELQEKLGQ
                     VMETLTSAEKEPEAAVPASGTGGESSGLMDLLEEKADLREHVEKLELGFIQYRRERCH
                     QKVHRLLTEPGDSAKDASPGGGHHQAGPGQGGEEGEAAGAAGDGVAACGSYSEGHGKF
                     LAAARNPAAEPSPGAPAPQELGAADKHGDLCEASLTNSVEPAQGEAREGSSQDNPTAQ
                     PVVQLLGEMQDHQEHPGLGSNCCVPCFCWAWLPRRRR"
     exon            1584..1703
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1820
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1859
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1907
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1992
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2102
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2189
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2297
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2385
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2642
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2786
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2887
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..2988
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3144
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..5690
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5667..5672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="hexamer: AATAAA"
     polyA_site      5690
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="major polyA site"
ORIGIN      
        1 gctattcagc tgtcgggcta atcagcagtc gaggtgtgcg gctaggcgcg agctctgcgg
       61 gagctcagcc cccgggagag acccggcagc ggcgcggcga ggacggcggc gcggcgagga
      121 cggcggcgcg gcgaggacgg cggcgcggcg aggacggcgg cgcggcgagg acggcggcgc
      181 ggcgaggacg gcggcgcggc gaggacggcg gcgcggcgag gacggcggcg cggcgaggac
      241 ggcggcgcgg cgaggacggc ggcgcggcga ggacggcggc gcggcgagga cggcggcgcg
      301 gcgaggacgg cggcgcggcg aggacggcgg cgcggcgagg acggcggcgc ggcgaggacg
      361 gcggcgcggc gaggacggcg gcggaccggg gcagccccgc gccctggcca ggaataatcg
      421 gtggagatgg attgtgaaat ggaggtgcat aaatatccag tttgccaacc gagctaagaa
      481 atgctggata aaagtaaaag ctctactgag atgaagaaag aaaaagaata cctgctcagc
      541 tccagagaca cgtaaaggga cagagattgg gggacagaag gaagtgcatt aattccttcc
      601 acgacccctg aagagcagcg gtgggtctga gcatcctatc tccaggaagc aggccagcag
      661 gcaagccagc tgccacctcg tcctgtgcaa agcacaggca ccgtccccaa aagatttcca
      721 aagatgatgt taaacccagc cacggttctg atctccagga aagcaattgc tgtggtacaa
      781 aaggacaagg gttaaaagag aacagtggga gctctctttc ccagctaact cacgcagtgt
      841 gacgcagagg ctttcagcac agcccagggt gcccgggact gaaaactcct tcaccagccc
      901 cctccacagg atatagaaga cttagatcac tacgagatga aagcagagcc cattagtggg
      961 aaaaagttgg aggatgaagg aattgaaaaa gaaaatttgg caatattaga gaaattagga
     1021 agactgaaag acaagagcat ttaactgcaa actgttgtcg ttgtcaactg ggttgtcttc
     1081 ctgaagtatg aatccggtat gtattgtgtg gaggagcatt acgtattgaa cttctcacaa
     1141 aacagggctg aagcagtgcc tactcgacag aaccggtcat cgtacaaaga aatgccacgt
     1201 gactcaaagg caaagccaga gtgcagcttg gagcaaagaa gatgatgtct cactctgtca
     1261 cccaagatgg agtgcaatgg cacgatctca gctcactgca acctctgcct cccagtagag
     1321 acggggtttc accatgttgg gcaggctagt cttggaacta ctgacctcag gtgatccgcc
     1381 cactttggcc tcccgaaagt gctgggatta cagtcatgag ccaccatgcc cagcctattt
     1441 atttctgatt ctttaagggt gactggatgt gttgatcagc gctcgctggg atttggctga
     1501 cgtggcccca gccccgcctc cctccccacc ccacaatggc agaagaaact ggacagagta
     1561 aattagctgc agccaagaaa aagttcaaag aatattggca gagaaaccgc cctggtgttc
     1621 cagcagcagc gaagaggaac acgaaagcaa atggcagtag ccctgagacg gccgcttctg
     1681 gtggttgcca ctcatctgag gcttcctcct ccgcctcctc ctctctgcat gcgcgtcaga
     1741 gcccgtgcca agaacaagca gcagtcctga actcgaggtc cataaaaatc agtcgactga
     1801 atgacaccat caaatctttg aaacaacaga agaaacaagt ggaacatcag ctggaagaag
     1861 aaaagaaagc aaacaatgag aaacagaaag ctgaaaggga gctagagggt caaatccaga
     1921 gattgaacac agagaaaaag aaactaaata cggacctgta tcacatgaaa cattctctca
     1981 gatactttga agaagagtcc aaggatctgg ccggccgcct gcaacgttca tcgcagcgta
     2041 taggagagtt agagtggtct ctctgtgctg tcgccgccac acagaagaag aagccggatg
     2101 ggttctcgag ccgcagtaaa gcacttctca agcggcagtt agagcagtcc atacgggagc
     2161 agatactgct gaaaggacac gtgacacagt tgaaggagtc gcttaaagaa gtccagctgg
     2221 agagagatca atatgctgaa caaataaaag gagagagggc ccagtggcag cagaggatga
     2281 ggaaaatgtc gcaggaggtt tgcacattga aggaggagaa gaagcatgat acgcatcggg
     2341 tagaggagct ggagaggagc ttgtccagac tcaaaaacca gatggctgag ccactgcccc
     2401 cggatgcccc agcagtgtcc tctgaggtgg agctgcaaga cctgaggaag gagctggaga
     2461 gagtggcagg agagctccag gctcaggtgg aaaacaatca gtgcatcagt ctcctgaacc
     2521 gtgggcaaaa ggagaggctt cgcgagcagg aggagaggct tcaggagcag caggagaggc
     2581 ttcgggaacg ggagaagagg cttcagcagc tggccgagcc acagagcgac ttggaggagc
     2641 tgaagcacga gaacaagagc gcactgcagt tggagcagca agtaaaggag ctgcaggaga
     2701 agctgggcca ggtgatggag acgctcacct cggccgagaa ggagccagag gcagcagtcc
     2761 cagcctcagg gactgggggc gagtctagcg gccttatgga cctcctggag gagaaggcgg
     2821 acctgaggga gcatgtggag aaactggaac ttggattcat ccagtaccgg agagagagat
     2881 gccatcagaa agtacatcgc cttctaacag agccagggga cagtgccaaa gatgcgtcac
     2941 cgggaggagg ccatcatcag gctggcccag gacaaggagg agaggaaggt gaagctgctg
     3001 gagctgcagg agatggtgtt gcggcttgtg gcagctacag cgaggggcac ggcaaattcc
     3061 tggccgctgc ccggaaccct gctgctgaac ccagtccagg agccccagcc ccccaggagc
     3121 tcggggctgc cgacaagcat ggtgatcttt gtgaggcgag cctcaccaac agcgtggagc
     3181 ctgcacaagg agaagccagg gagggttctt cccaggacaa ccctactgca cagccagtcg
     3241 tgcagctcct tggtgagatg caggaccacc aggagcaccc aggcttgggc agcaactgct
     3301 gtgtgccatg cttttgctgg gcttggctgc cgagaagaag gagataaaca ccaccatcat
     3361 caaagagctg ctcaagaaat ttttaaaaac gaaacaaagt tatggggtta atctcctaca
     3421 caattcattt acttcatttg aatgttagag ctactcatga ttatttgtgt ttctaattta
     3481 tagtttaagt ttatttgtaa aaagttaaaa gagagtgggt ctctgtggct ctcactgatg
     3541 ttcactctgg catccttcag catttttctt ttttcatttc ataattgtag gtcattagca
     3601 tgcatatcga gtttgccctt acgtggtggg agttcaaaca cacaaagacc cactctttgc
     3661 acaaaactgt tctcgctggt ttggaatagg ctcccgtgct tttctaatgt tattgcagca
     3721 tggatgtcca ttacagaatt cagataaaat ttgctaatgt tctgctatga tgtttgatct
     3781 catcttaatc acagtgagct cttctatagc tcaatatgcg gtttgccctc aagtgtgcac
     3841 tgtttattac tttgtaatat gccactgtga gtactgacat ttagagctgt ttaaaggccg
     3901 agaactggaa acagcctttc ctccattttc tgtgtattgg tgatgggagt gataaccttt
     3961 tgggggagct ttctaaatct cacagaagag gaaagtggcc tgctctggca ggtatgtgca
     4021 ggatacagtg tgtttcatct gttccggtgc caagaatgag cagtgtactg tggcagttcc
     4081 ctttggattt gtatgtgctc tgggctcatg aagatattgc atcgtgagct gcagcagttg
     4141 cactcttttt cagtgaccta aaaagggctt atttccgagg aatgaaaggc tgccatcatt
     4201 ggctgtgggt gtgaaaaacc tttcctagct tagagcattt gtatctacaa tacattttaa
     4261 agtcagagtt cgtgttccct gttttaatca catgactacc tgtcccagta cacgaaaggg
     4321 cgctggttgg cattcttctt aatgtattta gtgaagatca taagaaatcc tttaagagtt
     4381 taaatgtctc tgaaacaggc atacaggctc tagtcaagaa tgaattagag tgaaggaaag
     4441 ctgtgtgaca cctggcattc ctctctgttc atggagcttc tttgaggctt gaagtttgat
     4501 tttactatct agacctctct ggctaatacc tattcttcaa ccacctcggt tactctgaca
     4561 taggaattta cttcttttcc ttgagtggaa aacactttag aaagtaataa caaacattat
     4621 tataaactaa tatatgtgag agtacttagt tgaaacaaaa aggaatttta gtagacagta
     4681 ttatattatc tttgaaaatc aaggagaagt ttatgcaact taaaatgttt acacactgtg
     4741 gtgcaatcta ctgtttgtga atgtctgtat tatcaggaaa catgtctata cgatcgcaga
     4801 gttgtatttc ctcacaaact tctttacgaa gagtgaaata cgtttttgta cctctcattt
     4861 tcagtcaggg acatactttg tgcaatattt ctgtgattgt gcctatgcat gatgaatgaa
     4921 tgcatttcaa tcatacattg cctaaatcat aacttgatga tgcttgggaa agaatcaaca
     4981 gttaaaactt catgaagttc taatgtctgt gttccaaaac acatcacatt attaggttgt
     5041 agggagatat gtaggtgtgc tccctggggt ggggagtttt ctagttacta gaccatctcc
     5101 atttttagca cttggcagcc tcatgatcct tttataaatg tgagattaac aggagagcag
     5161 caatacgatt ttgccaatgg aataacagat ttgccggcat tcactgaaag agggcagata
     5221 ttgggtcctt gtaacttcaa ctgactcttc caaattgtat gaatttatca atgtattaca
     5281 caaatccagt ttcagaatga taaaaaatgt tagaccaaat aatgcggcta attaacagtc
     5341 gtatgatttc tagcccatgg gtttaaaact gtatcttaaa gagtcatttt aaaataatat
     5401 aaatattaaa aaatgtaact gctatcttaa tgttctgaaa taaaacattt taaaatataa
     5461 atcctgtagt ttaaaaggaa gaaatggtgg gaaggaaaag tagagaaaga aatgccaatt
     5521 ccaggccaaa gcgttatttg ccaagttttc ttagaatgaa ttttaccaat gtatgagttc
     5581 ttgttaacag aatgtgtaac ggaaatactg aaagactttt gcttaaagtg gcattattga
     5641 ctgctgatgt gatgctactg taatgcaata aatttttaaa ttgttgcaaa
//
