LOCUS       NM_001368071            5774 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens golgin A8 family member A (GOLGA8A), transcript
            variant 3, mRNA.
ACCESSION   NM_001368071 XM_006720440
VERSION     NM_001368071.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5774)
  AUTHORS   Merino-Zamorano,C., Delgado,P., Fernandez de Retana,S.,
            Fernandez-Cadenas,I., Rodriguez-Luna,D., Montaner,J. and
            Hernandez-Guillamon,M.
  TITLE     Identification of Plasma Biomarkers of Human Intracerebral
            Hemorrhage Subtypes through Microarray Technology
  JOURNAL   J Stroke Cerebrovasc Dis 25 (3), 665-671 (2016)
   PUBMED   26738811
  REMARK    GeneRIF: The microarray analysis and the validation study revealed
            an increase in Golgin A8 Family, Member A (GOLGA8A) mRNA and
            protein levels in Intracerebral hemorrhage.
REFERENCE   2  (bases 1 to 5774)
  AUTHORS   Eystathioy,T., Jakymiw,A., Fujita,D.J., Fritzler,M.J. and Chan,E.K.
  TITLE     Human autoantibodies to a novel Golgi protein golgin-67: high
            similarity with golgin-95/gm 130 autoantigen
  JOURNAL   J Autoimmun 14 (2), 179-187 (2000)
   PUBMED   10677249
REFERENCE   3  (bases 1 to 5774)
  AUTHORS   Jakymiw,A., Raharjo,E., Rattner,J.B., Eystathioy,T., Chan,E.K. and
            Fujita,D.J.
  TITLE     Identification and characterization of a novel Golgi protein,
            golgin-67
  JOURNAL   J Biol Chem 275 (6), 4137-4144 (2000)
   PUBMED   10660574
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025678.7.
            
            On Aug 27, 2019 this sequence version replaced NM_001368071.1.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked, flattened membrane sacs referred
            to as cisternae. Interactions between the Golgi and microtubules
            are thought to be important for the reorganization of the Golgi
            after it fragments during mitosis. The golgins constitute a family
            of proteins which are localized to the Golgi. This gene encodes a
            golgin which structurally resembles its family member GOLGA2,
            suggesting that they may share a similar function. There are many
            similar copies of this gene on chromosome 15. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2009].
            
            Transcript Variant: This variant (3), as well as variant 4, encodes
            isoform 2.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038192.3645049.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               AC025678.7         169016-169426       c
            412-500             AC025678.7         167001-167089       c
            501-712             AC025678.7         139142-139353       c
            713-909             AC025678.7         138292-138488       c
            910-1048            AC025678.7         136535-136673       c
            1049-1096           AC025678.7         132330-132377       c
            1097-1145           AC025678.7         130773-130821       c
            1146-1241           AC025678.7         130252-130347       c
            1242-1545           AC025678.7         122741-123044       c
            1546-1670           AC025678.7         121262-121386       c
            1671-1790           AC025678.7         119451-119570       c
            1791-1907           AC025678.7         118243-118359       c
            1908-1946           AC025678.7         117358-117396       c
            1947-1994           AC025678.7         117045-117092       c
            1995-2079           AC025678.7         116872-116956       c
            2080-2189           AC025678.7         116666-116775       c
            2190-2276           AC025678.7         115579-115665       c
            2277-2384           AC025678.7         115364-115471       c
            2385-2472           AC025678.7         115059-115146       c
            2473-2729           AC025678.7         114415-114671       c
            2730-2870           AC025678.7         114004-114144       c
            2871-2971           AC025678.7         113769-113869       c
            2972-3072           AC025678.7         113586-113686       c
            3073-3228           AC025678.7         113319-113474       c
            3229-5774           AC025678.7         110686-113231       c
FEATURES             Location/Qualifiers
     source          1..5774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..5774
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="golgin A8 family member A"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
     exon            1..411
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            412..500
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            501..712
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            713..909
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1048
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1096
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1145
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1241
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1545
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1670
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     CDS             1623..3431
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="isoform 2 is encoded by transcript variant 3; golgi
                     autoantigen, golgin subfamily a, 8A; golgin subfamily A
                     member 8A; GM88 autoantigen; 88-kDa golgi protein;
                     golgin-67; 88 kDa Golgi matrix protein; Golgin subfamily A
                     member 8B"
                     /codon_start=1
                     /product="golgin subfamily A member 8A isoform 2"
                     /protein_id="NP_001355000.1"
                     /db_xref="CCDS:CCDS91979.1"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
                     /translation="MAEETGQSKLAAAKKKFKEYWQRNRPGVPAAAKRNTKANGSSPE
                     TAASGGCHSSEASSSASSSLHARQSPCQEQAAVLNSRSIKISRLNDTIKSLKQQKKQV
                     EHQLEEEKKANNEKQKAERELEGQIQRLNTEKKKLNTDLYHMKHSLRYFEEESKDLAG
                     RLQRSSQRIGELEWSLCAVAATQKKKPDGFSSRSKALLKRQLEQSIREQILLKGHVTQ
                     LKESLKEVQLERDQYAEQIKGERAQWQQRMRKMSQEVCTLKEEKKHDTHRVEELERSL
                     SRLKNQMAEPLPPDAPAVSSEVELQDLRKELERVAGELQAQVENNQCISLLNRGQKER
                     LREQEERLQEQQERLREREKRLQQLAEPQSDLEELHENKSALQLEQQVKELQEKLGQV
                     METLTSAEKEPEAAVPASGTGGESSGLMDLLEEKADLREHVEKLELGFIQYRRERCHQ
                     KVHRLLTEPGDSAKDASPGGGHHQAGPGQGGEEGEAAGAAGDGVAACGSYSEGHGKFL
                     AAARNPAAEPSPGAPAPQELGAADKHGDLCEASLTNSVEPAQGEAREGSSQDNPTAQP
                     VVQLLGEMQDHQEHPGLGSNCCVPCFCWAWLPRRRR"
     exon            1671..1790
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1907
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1946
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..1994
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2079
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2189
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2276
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2384
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2472
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2729
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2870
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2971
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3072
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3228
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..5774
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5751..5756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="hexamer: AATAAA"
     polyA_site      5774
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /note="major polyA site"
ORIGIN      
        1 gctattcagc tgtcgggcta atcagcagtc gaggtgtgcg gctaggcgcg agctctgcgg
       61 gagctcagcc cccgggagag acccggcagc ggcgcggcga ggacggcggc gcggcgagga
      121 cggcggcgcg gcgaggacgg cggcgcggcg aggacggcgg cgcggcgagg acggcggcgc
      181 ggcgaggacg gcggcgcggc gaggacggcg gcgcggcgag gacggcggcg cggcgaggac
      241 ggcggcgcgg cgaggacggc ggcgcggcga ggacggcggc gcggcgagga cggcggcgcg
      301 gcgaggacgg cggcgcggcg aggacggcgg cgcggcgagg acggcggcgc ggcgaggacg
      361 gcggcgcggc gaggacggcg gcggaccggg gcagccccgc gccctggcca ggaataatcg
      421 gtggagatgg attgtgaaat ggaggtgcat aaatatccag tttgccaacc gagctaagaa
      481 atgctggata aaagtaaaag ctctactgag atgaagaaag aaaaagaata cctgctcagc
      541 tccagagaca cgtaaaggga cagagattgg gggacagaag gaagtgcatt aattccttcc
      601 acgacccctg aagagcagcg gtgggtctga gcatcctatc tccaggaagc aggccagcag
      661 gcaagccagc tgccacctcg tcctgtgcaa agcacaggca ccgtccccaa aagatttcca
      721 aagatgatgt taaacccagc cacggttctg atctccagga aagcaattgc tgtggtacaa
      781 aaggacaagg gttaaaagag aacagtggga gctctctttc ccagctaact cacgcagtgt
      841 gacgcagagg ctttcagcac agcccagggt gcccgggact gaaaactcct tcaccagccc
      901 cctccacagg atatagaaga cttagatcac tacgagatga aagcagagcc cattagtggg
      961 aaaaagttgg aggatgaagg aattgaaaaa gaaaatttgg caatattaga gaaattagga
     1021 agactgaaag acaagagcat ttaactgcaa actgttgtcg ttgtcaactg ggttgtcttc
     1081 ctgaagtatg aatccggtat gtattgtgtg gaggagcatt acgtattgaa cttctcacaa
     1141 aacagggctg aagcagtgcc tactcgacag aaccggtcat cgtacaaaga aatgccacgt
     1201 gactcaaagg caaagccaga gtgcagcttg gagcaaagaa gatgatgtct cactctgtca
     1261 cccaagatgg agtgcaatgg cacgatctca gctcactgca acctctgcct cccaggttca
     1321 agcaattatc ctgcctcagc cacccgagta gctgagatta caggcctctg ccaccatgct
     1381 cagctatttt ttgtattttt agtagagacg gggtttcacc atgttgggca ggctagtctt
     1441 ggaactactg acctcaggtg atccgcccac tttggcctcc cgaaagtgct gggattacag
     1501 tcatgagcca ccatgcccag cctatttatt tctgattctt taagggtgac tggatgtgtt
     1561 gatcagcgct cgctgggatt tggctgacgt ggccccagcc ccgcctccct ccccacccca
     1621 caatggcaga agaaactgga cagagtaaat tagctgcagc caagaaaaag ttcaaagaat
     1681 attggcagag aaaccgccct ggtgttccag cagcagcgaa gaggaacacg aaagcaaatg
     1741 gcagtagccc tgagacggcc gcttctggtg gttgccactc atctgaggct tcctcctccg
     1801 cctcctcctc tctgcatgcg cgtcagagcc cgtgccaaga acaagcagca gtcctgaact
     1861 cgaggtccat aaaaatcagt cgactgaatg acaccatcaa atctttgaaa caacagaaga
     1921 aacaagtgga acatcagctg gaagaagaaa agaaagcaaa caatgagaaa cagaaagctg
     1981 aaagggagct agagggtcaa atccagagat tgaacacaga gaaaaagaaa ctaaatacgg
     2041 acctgtatca catgaaacat tctctcagat actttgaaga agagtccaag gatctggccg
     2101 gccgcctgca acgttcatcg cagcgtatag gagagttaga gtggtctctc tgtgctgtcg
     2161 ccgccacaca gaagaagaag ccggatgggt tctcgagccg cagtaaagca cttctcaagc
     2221 ggcagttaga gcagtccata cgggagcaga tactgctgaa aggacacgtg acacagttga
     2281 aggagtcgct taaagaagtc cagctggaga gagatcaata tgctgaacaa ataaaaggag
     2341 agagggccca gtggcagcag aggatgagga aaatgtcgca ggaggtttgc acattgaagg
     2401 aggagaagaa gcatgatacg catcgggtag aggagctgga gaggagcttg tccagactca
     2461 aaaaccagat ggctgagcca ctgcccccgg atgccccagc agtgtcctct gaggtggagc
     2521 tgcaagacct gaggaaggag ctggagagag tggcaggaga gctccaggct caggtggaaa
     2581 acaatcagtg catcagtctc ctgaaccgtg ggcaaaagga gaggcttcgc gagcaggagg
     2641 agaggcttca ggagcagcag gagaggcttc gggaacggga gaagaggctt cagcagctgg
     2701 ccgagccaca gagcgacttg gaggagctgc acgagaacaa gagcgcactg cagttggagc
     2761 agcaagtaaa ggagctgcag gagaagctgg gccaggtgat ggagacgctc acctcggccg
     2821 agaaggagcc agaggcagca gtcccagcct cagggactgg gggcgagtct agcggcctta
     2881 tggacctcct ggaggagaag gcggacctga gggagcatgt ggagaaactg gaacttggat
     2941 tcatccagta ccggagagag agatgccatc agaaagtaca tcgccttcta acagagccag
     3001 gggacagtgc caaagatgcg tcaccgggag gaggccatca tcaggctggc ccaggacaag
     3061 gaggagagga aggtgaagct gctggagctg caggagatgg tgttgcggct tgtggcagct
     3121 acagcgaggg gcacggcaaa ttcctggccg ctgcccggaa ccctgctgct gaacccagtc
     3181 caggagcccc agccccccag gagctcgggg ctgccgacaa gcatggtgat ctttgtgagg
     3241 cgagcctcac caacagcgtg gagcctgcac aaggagaagc cagggagggt tcttcccagg
     3301 acaaccctac tgcacagcca gtcgtgcagc tccttggtga gatgcaggac caccaggagc
     3361 acccaggctt gggcagcaac tgctgtgtgc catgcttttg ctgggcttgg ctgccgagaa
     3421 gaaggagata aacaccacca tcatcaaaga gctgctcaag aaatttttaa aaacgaaaca
     3481 aagttatggg gttaatctcc tacacaattc atttacttca tttgaatgtt agagctactc
     3541 atgattattt gtgtttctaa tttatagttt aagtttattt gtaaaaagtt aaaagagagt
     3601 gggtctctgt ggctctcact gatgttcact ctggcatcct tcagcatttt tcttttttca
     3661 tttcataatt gtaggtcatt agcatgcata tcgagtttgc ccttacgtgg tgggagttca
     3721 aacacacaaa gacccactct ttgcacaaaa ctgttctcgc tggtttggaa taggctcccg
     3781 tgcttttcta atgttattgc agcatggatg tccattacag aattcagata aaatttgcta
     3841 atgttctgct atgatgtttg atctcatctt aatcacagtg agctcttcta tagctcaata
     3901 tgcggtttgc cctcaagtgt gcactgttta ttactttgta atatgccact gtgagtactg
     3961 acatttagag ctgtttaaag gccgagaact ggaaacagcc tttcctccat tttctgtgta
     4021 ttggtgatgg gagtgataac cttttggggg agctttctaa atctcacaga agaggaaagt
     4081 ggcctgctct ggcaggtatg tgcaggatac agtgtgtttc atctgttccg gtgccaagaa
     4141 tgagcagtgt actgtggcag ttccctttgg atttgtatgt gctctgggct catgaagata
     4201 ttgcatcgtg agctgcagca gttgcactct ttttcagtga cctaaaaagg gcttatttcc
     4261 gaggaatgaa aggctgccat cattggctgt gggtgtgaaa aacctttcct agcttagagc
     4321 atttgtatct acaatacatt ttaaagtcag agttcgtgtt ccctgtttta atcacatgac
     4381 tacctgtccc agtacacgaa agggcgctgg ttggcattct tcttaatgta tttagtgaag
     4441 atcataagaa atcctttaag agtttaaatg tctctgaaac aggcatacag gctctagtca
     4501 agaatgaatt agagtgaagg aaagctgtgt gacacctggc attcctctct gttcatggag
     4561 cttctttgag gcttgaagtt tgattttact atctagacct ctctggctaa tacctattct
     4621 tcaaccacct cggttactct gacataggaa tttacttctt ttccttgagt ggaaaacact
     4681 ttagaaagta ataacaaaca ttattataaa ctaatatatg tgagagtact tagttgaaac
     4741 aaaaaggaat tttagtagac agtattatat tatctttgaa aatcaaggag aagtttatgc
     4801 aacttaaaat gtttacacac tgtggtgcaa tctactgttt gtgaatgtct gtattatcag
     4861 gaaacatgtc tatacgatcg cagagttgta tttcctcaca aacttcttta cgaagagtga
     4921 aatacgtttt tgtacctctc attttcagtc agggacatac tttgtgcaat atttctgtga
     4981 ttgtgcctat gcatgatgaa tgaatgcatt tcaatcatac attgcctaaa tcataacttg
     5041 atgatgcttg ggaaagaatc aacagttaaa acttcatgaa gttctaatgt ctgtgttcca
     5101 aaacacatca cattattagg ttgtagggag atatgtaggt gtgctccctg gggtggggag
     5161 ttttctagtt actagaccat ctccattttt agcacttggc agcctcatga tccttttata
     5221 aatgtgagat taacaggaga gcagcaatac gattttgcca atggaataac agatttgccg
     5281 gcattcactg aaagagggca gatattgggt ccttgtaact tcaactgact cttccaaatt
     5341 gtatgaattt atcaatgtat tacacaaatc cagtttcaga atgataaaaa atgttagacc
     5401 aaataatgcg gctaattaac agtcgtatga tttctagccc atgggtttaa aactgtatct
     5461 taaagagtca ttttaaaata atataaatat taaaaaatgt aactgctatc ttaatgttct
     5521 gaaataaaac attttaaaat ataaatcctg tagtttaaaa ggaagaaatg gtgggaagga
     5581 aaagtagaga aagaaatgcc aattccaggc caaagcgtta tttgccaagt tttcttagaa
     5641 tgaattttac caatgtatga gttcttgtta acagaatgtg taacggaaat actgaaagac
     5701 ttttgcttaa agtggcatta ttgactgctg atgtgatgct actgtaatgc aataaatttt
     5761 taaattgttg caaa
//
