LOCUS       NM_001174124            1889 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens golgin A7 (GOLGA7), transcript variant 3, mRNA.
ACCESSION   NM_001174124
VERSION     NM_001174124.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1889)
  AUTHORS   Zeng,X.T., Yu,X.X. and Cheng,W.
  TITLE     Correction to: The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2
            spike (S) protein and their effects on S protein's subcellular
            localization, palmitoylation and pseudovirus entry
  JOURNAL   Virol J 19 (1), 25 (2022)
   PUBMED   35115020
  REMARK    Correction to:[Virol J. 2021 Dec 27;18(1):257. doi:
            10.1186/s12985-021-01722-w.. PMID: 34961524]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1889)
  AUTHORS   Zeng,X.T., Yu,X.X. and Cheng,W.
  TITLE     The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein
            and their effects on S protein's subcellular localization,
            palmitoylation and pseudovirus entry
  JOURNAL   Virol J 18 (1), 257 (2021)
   PUBMED   34961524
  REMARK    GeneRIF: The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike
            (S) protein and their effects on S protein's subcellular
            localization, palmitoylation and pseudovirus entry.
            Erratum:[Virol J. 2022 Feb 3;19(1):25. doi:
            10.1186/s12985-022-01750-0.. PMID: 35115020]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1889)
  AUTHORS   Wu,Z., Zhang,Z., Wang,X., Zhang,J., Ren,C., Li,Y., Gao,L.,
            Liang,X., Wang,P. and Ma,C.
  TITLE     Palmitoylation of SARS-CoV-2 S protein is essential for viral
            infectivity
  JOURNAL   Signal Transduct Target Ther 6 (1), 231 (2021)
   PUBMED   34117209
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1889)
  AUTHORS   Stukalov,A., Girault,V., Grass,V., Karayel,O., Bergant,V.,
            Urban,C., Haas,D.A., Huang,Y., Oubraham,L., Wang,A., Hamad,M.S.,
            Piras,A., Hansen,F.M., Tanzer,M.C., Paron,I., Zinzula,L.,
            Engleitner,T., Reinecke,M., Lavacca,T.M., Ehmann,R., Wolfel,R.,
            Jores,J., Kuster,B., Protzer,U., Rad,R., Ziebuhr,J., Thiel,V.,
            Scaturro,P., Mann,M. and Pichlmair,A.
  TITLE     Multilevel proteomics reveals host perturbations by SARS-CoV-2 and
            SARS-CoV
  JOURNAL   Nature 594 (7862), 246-252 (2021)
   PUBMED   33845483
REFERENCE   5  (bases 1 to 1889)
  AUTHORS   Gordon,D.E., Hiatt,J., Bouhaddou,M., Rezelj,V.V., Ulferts,S.,
            Braberg,H., Jureka,A.S., Obernier,K., Guo,J.Z., Batra,J.,
            Kaake,R.M., Weckstein,A.R., Owens,T.W., Gupta,M., Pourmal,S.,
            Titus,E.W., Cakir,M., Soucheray,M., McGregor,M., Cakir,Z., Jang,G.,
            O'Meara,M.J., Tummino,T.A., Zhang,Z., Foussard,H., Rojc,A.,
            Zhou,Y., Kuchenov,D., Huttenhain,R., Xu,J., Eckhardt,M.,
            Swaney,D.L., Fabius,J.M., Ummadi,M., Tutuncuoglu,B., Rathore,U.,
            Modak,M., Haas,P., Haas,K.M., Naing,Z.Z.C., Pulido,E.H., Shi,Y.,
            Barrio-Hernandez,I., Memon,D., Petsalaki,E., Dunham,A.,
            Marrero,M.C., Burke,D., Koh,C., Vallet,T., Silvas,J.A.,
            Azumaya,C.M., Billesbolle,C., Brilot,A.F., Campbell,M.G.,
            Diallo,A., Dickinson,M.S., Diwanji,D., Herrera,N., Hoppe,N.,
            Kratochvil,H.T., Liu,Y., Merz,G.E., Moritz,M., Nguyen,H.C.,
            Nowotny,C., Puchades,C., Rizo,A.N., Schulze-Gahmen,U., Smith,A.M.,
            Sun,M., Young,I.D., Zhao,J., Asarnow,D., Biel,J., Bowen,A.,
            Braxton,J.R., Chen,J., Chio,C.M., Chio,U.S., Deshpande,I., Doan,L.,
            Faust,B., Flores,S., Jin,M., Kim,K., Lam,V.L., Li,F., Li,J.,
            Li,Y.L., Li,Y., Liu,X., Lo,M., Lopez,K.E., Melo,A.A., Moss,F.R.
            3rd, Nguyen,P., Paulino,J., Pawar,K.I., Peters,J.K., Pospiech,T.H.
            Jr., Safari,M., Sangwan,S., Schaefer,K., Thomas,P.V., Thwin,A.C.,
            Trenker,R., Tse,E., Tsui,T.K.M., Wang,F., Whitis,N., Yu,Z.,
            Zhang,K., Zhang,Y., Zhou,F., Saltzberg,D., Hodder,A.J.,
            Shun-Shion,A.S., Williams,D.M., White,K.M., Rosales,R., Kehrer,T.,
            Miorin,L., Moreno,E., Patel,A.H., Rihn,S., Khalid,M.M.,
            Vallejo-Gracia,A., Fozouni,P., Simoneau,C.R., Roth,T.L., Wu,D.,
            Karim,M.A., Ghoussaini,M., Dunham,I., Berardi,F., Weigang,S.,
            Chazal,M., Park,J., Logue,J., McGrath,M., Weston,S., Haupt,R.,
            Hastie,C.J., Elliott,M., Brown,F., Burness,K.A., Reid,E.,
            Dorward,M., Johnson,C., Wilkinson,S.G., Geyer,A., Giesel,D.M.,
            Baillie,C., Raggett,S., Leech,H., Toth,R., Goodman,N., Keough,K.C.,
            Lind,A.L., Klesh,R.J., Hemphill,K.R., Carlson-Stevermer,J., Oki,J.,
            Holden,K., Maures,T., Pollard,K.S., Sali,A., Agard,D.A., Cheng,Y.,
            Fraser,J.S., Frost,A., Jura,N., Kortemme,T., Manglik,A.,
            Southworth,D.R., Stroud,R.M., Alessi,D.R., Davies,P., Frieman,M.B.,
            Ideker,T., Abate,C., Jouvenet,N., Kochs,G., Shoichet,B., Ott,M.,
            Palmarini,M., Shokat,K.M., Garcia-Sastre,A., Rassen,J.A.,
            Grosse,R., Rosenberg,O.S., Verba,K.A., Basler,C.F., Vignuzzi,M.,
            Peden,A.A., Beltrao,P. and Krogan,N.J.
  CONSRTM   QCRG Structural Biology Consortium; Zoonomia Consortium
  TITLE     Comparative host-coronavirus protein interaction networks reveal
            pan-viral disease mechanisms
  JOURNAL   Science 370 (6521) (2020)
   PUBMED   33060197
REFERENCE   6  (bases 1 to 1889)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1889)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1889)
  AUTHORS   Swarthout,J.T., Lobo,S., Farh,L., Croke,M.R., Greentree,W.K.,
            Deschenes,R.J. and Linder,M.E.
  TITLE     DHHC9 and GCP16 constitute a human protein fatty acyltransferase
            with specificity for H- and N-Ras
  JOURNAL   J Biol Chem 280 (35), 31141-31148 (2005)
   PUBMED   16000296
  REMARK    GeneRIF: Data show that H- and N-Ras are palmitoylated by a human
            protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes.
REFERENCE   9  (bases 1 to 1889)
  AUTHORS   Ohta,E., Misumi,Y., Sohda,M., Fujiwara,T., Yano,A. and Ikehara,Y.
  TITLE     Identification and characterization of GCP16, a novel acylated
            Golgi protein that interacts with GCP170
  JOURNAL   J Biol Chem 278 (51), 51957-51967 (2003)
   PUBMED   14522980
  REMARK    GeneRIF: results indicate that GCP16 is the acylated membrane
            protein, associated with GCP170, and possibly involved in vesicular
            transport from the Golgi to the cell surface
REFERENCE   10 (bases 1 to 1889)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK026613.1, AC009630.14 and BC001227.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001174124.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate splice site in the 3' coding region that results in a
            frameshift, compared to variant 2. The resulting isoform (b) has a
            shorter and distinct C-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026613.1, BC001227.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-817               AK026613.1         1-817
            818-1852            AC009630.14        137682-138716       c
            1853-1889           BC001227.2         1853-1889
FEATURES             Location/Qualifiers
     source          1..1889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..1889
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /note="golgin A7"
                     /db_xref="GeneID:51125"
                     /db_xref="HGNC:HGNC:24876"
                     /db_xref="MIM:609453"
     exon            1..36
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     exon            37..169
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..463
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /note="isoform b is encoded by transcript variant 3; Golgi
                     complex-associated protein of 16kDa; golgi autoantigen,
                     golgin subfamily a, 7; golgin subfamily A member 7; golgi
                     complex-associated protein of 16 kDa"
                     /codon_start=1
                     /product="golgin subfamily A member 7 isoform b"
                     /protein_id="NP_001167595.1"
                     /db_xref="CCDS:CCDS55226.1"
                     /db_xref="GeneID:51125"
                     /db_xref="HGNC:HGNC:24876"
                     /db_xref="MIM:609453"
                     /translation="MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFE
                     ETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNE
                     KIYAPQGLLLTDPIERGLRVFRLKLPFMKTEA"
     exon            170..322
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     exon            323..424
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     exon            425..492
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     exon            493..1889
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /note="hexamer: AATAAA"
     polyA_site      1889
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /note="major polyA site"
ORIGIN      
        1 ggcggtgcga cagcagctgg agggcagagg aggcggcgcg gggtgtcctg tcctcgccat
       61 gaggccgcag caggcgccgg tgtccggaaa ggtgttcatt cagcgagact acagcagtgg
      121 cacacgctgc cagttccaga ccaagttccc tgcggagctg gagaaccgga ttgataggca
      181 gcagtttgaa gaaacagttc gaactctaaa taacctttat gcagaagcag agaagctcgg
      241 cggccagtca tatctcgaag gttgtttggc ttgtttaaca gcatatacca tcttcctatg
      301 catggaaact cattatgaga aggttctgaa gaaagtctcc aaatacattc aagagcagaa
      361 tgagaagatc tatgctccac aaggcctcct cctgacagac cctattgagc gaggactgcg
      421 agtttttaga ttgaaattac catttatgaa gacagaggca tgagcagtgg aagataaacc
      481 gaagaattaa agatcccact tccagccggg cccctcatgt atccactggc cgaccgcaga
      541 gtgtccctac ctcctctcca gagcatcatt cctttctatc tgctgccaga gccacggtgc
      601 catttactcc aaggactcac tttctaaaat tccacacctg gagtgacctc tagtcgctca
      661 gcatccactt tgtgtctcca aattgtgtag gactctgtaa tcttttgatt agtttctgag
      721 aaaacacaat gaagcacttc actttttttt attcaaagcc atttaataaa acacagttgg
      781 tcagcccagt gcaaagcttg ttatctgcca ccagtacata ccattggttc tcttcattcc
      841 ttgggccagc ttctcaggtg gctttagacc tcaacaagcc gtatcttcac cagtgttcta
      901 tcttgttccc ctaaattaat aaaatgtttt tctccaggat tttggtgagg gttggctgtg
      961 gctgtcgttt tgcacctccc agatttcaaa gaattactgg ttttaccatg actcaaatct
     1021 taagatctgt ttctactatt cagttcctca aactgaagct tattgaaaaa aaaatgtata
     1081 atgttatttg ttttattata gcaattatgc ctaattaaag cagtatttaa tgcaatttcc
     1141 agttatttct ttggagaatt ttatgtcatt gttccattac cttgaatgtt ggaaagatat
     1201 gatacgtgct gcttgttcat cacaaaaatc agtaagcaca ataaagtgga tgccaaacca
     1261 tcagacacat aaatgttccc gctgtgtccc tggatatgga ataagcaggt ataaaaaata
     1321 ttttaattat agttttgtta taaatataac ttatgagaaa aaaatttgat aggaataata
     1381 ctgtatatta ctaattttta actatcccta aggcaaacct tatgacccac agaattttct
     1441 catatacagt attcagtgca cagaaatctt atgattggct caagtacagt aagttacttc
     1501 tcagtaaaac tctcaagtct gagtccatat ttgtagctct gcttttggct gtacgttcct
     1561 aggatcgggg ctgcttatgc ctttcgttta tccttggggt ttgagagcgc tgtatttggg
     1621 agagagttta aaaatacatt aggagagaga aaccattaaa agtttcactg tcagatatat
     1681 tgtaggtgct aatactggat ttcgtctcag atttaatttc ttttatgggt ctgttagtca
     1741 ttcaacaaat cccataagta tgtgttaata ttttaattgt gtaaaactca tttgttactt
     1801 tacagcctgt aatagtgtgt ctgcattttc aacctgttgc aataactttg ctgaaatatt
     1861 aacacattaa taaaactttt cttaaacaa
//
