LOCUS       NM_001002296            2099 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens golgin A7 (GOLGA7), transcript variant 2, mRNA.
ACCESSION   NM_001002296
VERSION     NM_001002296.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Zeng,X.T., Yu,X.X. and Cheng,W.
  TITLE     Correction to: The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2
            spike (S) protein and their effects on S protein's subcellular
            localization, palmitoylation and pseudovirus entry
  JOURNAL   Virol J 19 (1), 25 (2022)
   PUBMED   35115020
  REMARK    Correction to:[Virol J. 2021 Dec 27;18(1):257. doi:
            10.1186/s12985-021-01722-w.. PMID: 34961524]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2099)
  AUTHORS   Zeng,X.T., Yu,X.X. and Cheng,W.
  TITLE     The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein
            and their effects on S protein's subcellular localization,
            palmitoylation and pseudovirus entry
  JOURNAL   Virol J 18 (1), 257 (2021)
   PUBMED   34961524
  REMARK    GeneRIF: The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike
            (S) protein and their effects on S protein's subcellular
            localization, palmitoylation and pseudovirus entry.
            Erratum:[Virol J. 2022 Feb 3;19(1):25. doi:
            10.1186/s12985-022-01750-0.. PMID: 35115020]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2099)
  AUTHORS   Wu,Z., Zhang,Z., Wang,X., Zhang,J., Ren,C., Li,Y., Gao,L.,
            Liang,X., Wang,P. and Ma,C.
  TITLE     Palmitoylation of SARS-CoV-2 S protein is essential for viral
            infectivity
  JOURNAL   Signal Transduct Target Ther 6 (1), 231 (2021)
   PUBMED   34117209
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2099)
  AUTHORS   Stukalov,A., Girault,V., Grass,V., Karayel,O., Bergant,V.,
            Urban,C., Haas,D.A., Huang,Y., Oubraham,L., Wang,A., Hamad,M.S.,
            Piras,A., Hansen,F.M., Tanzer,M.C., Paron,I., Zinzula,L.,
            Engleitner,T., Reinecke,M., Lavacca,T.M., Ehmann,R., Wolfel,R.,
            Jores,J., Kuster,B., Protzer,U., Rad,R., Ziebuhr,J., Thiel,V.,
            Scaturro,P., Mann,M. and Pichlmair,A.
  TITLE     Multilevel proteomics reveals host perturbations by SARS-CoV-2 and
            SARS-CoV
  JOURNAL   Nature 594 (7862), 246-252 (2021)
   PUBMED   33845483
REFERENCE   5  (bases 1 to 2099)
  AUTHORS   Gordon,D.E., Hiatt,J., Bouhaddou,M., Rezelj,V.V., Ulferts,S.,
            Braberg,H., Jureka,A.S., Obernier,K., Guo,J.Z., Batra,J.,
            Kaake,R.M., Weckstein,A.R., Owens,T.W., Gupta,M., Pourmal,S.,
            Titus,E.W., Cakir,M., Soucheray,M., McGregor,M., Cakir,Z., Jang,G.,
            O'Meara,M.J., Tummino,T.A., Zhang,Z., Foussard,H., Rojc,A.,
            Zhou,Y., Kuchenov,D., Huttenhain,R., Xu,J., Eckhardt,M.,
            Swaney,D.L., Fabius,J.M., Ummadi,M., Tutuncuoglu,B., Rathore,U.,
            Modak,M., Haas,P., Haas,K.M., Naing,Z.Z.C., Pulido,E.H., Shi,Y.,
            Barrio-Hernandez,I., Memon,D., Petsalaki,E., Dunham,A.,
            Marrero,M.C., Burke,D., Koh,C., Vallet,T., Silvas,J.A.,
            Azumaya,C.M., Billesbolle,C., Brilot,A.F., Campbell,M.G.,
            Diallo,A., Dickinson,M.S., Diwanji,D., Herrera,N., Hoppe,N.,
            Kratochvil,H.T., Liu,Y., Merz,G.E., Moritz,M., Nguyen,H.C.,
            Nowotny,C., Puchades,C., Rizo,A.N., Schulze-Gahmen,U., Smith,A.M.,
            Sun,M., Young,I.D., Zhao,J., Asarnow,D., Biel,J., Bowen,A.,
            Braxton,J.R., Chen,J., Chio,C.M., Chio,U.S., Deshpande,I., Doan,L.,
            Faust,B., Flores,S., Jin,M., Kim,K., Lam,V.L., Li,F., Li,J.,
            Li,Y.L., Li,Y., Liu,X., Lo,M., Lopez,K.E., Melo,A.A., Moss,F.R.
            3rd, Nguyen,P., Paulino,J., Pawar,K.I., Peters,J.K., Pospiech,T.H.
            Jr., Safari,M., Sangwan,S., Schaefer,K., Thomas,P.V., Thwin,A.C.,
            Trenker,R., Tse,E., Tsui,T.K.M., Wang,F., Whitis,N., Yu,Z.,
            Zhang,K., Zhang,Y., Zhou,F., Saltzberg,D., Hodder,A.J.,
            Shun-Shion,A.S., Williams,D.M., White,K.M., Rosales,R., Kehrer,T.,
            Miorin,L., Moreno,E., Patel,A.H., Rihn,S., Khalid,M.M.,
            Vallejo-Gracia,A., Fozouni,P., Simoneau,C.R., Roth,T.L., Wu,D.,
            Karim,M.A., Ghoussaini,M., Dunham,I., Berardi,F., Weigang,S.,
            Chazal,M., Park,J., Logue,J., McGrath,M., Weston,S., Haupt,R.,
            Hastie,C.J., Elliott,M., Brown,F., Burness,K.A., Reid,E.,
            Dorward,M., Johnson,C., Wilkinson,S.G., Geyer,A., Giesel,D.M.,
            Baillie,C., Raggett,S., Leech,H., Toth,R., Goodman,N., Keough,K.C.,
            Lind,A.L., Klesh,R.J., Hemphill,K.R., Carlson-Stevermer,J., Oki,J.,
            Holden,K., Maures,T., Pollard,K.S., Sali,A., Agard,D.A., Cheng,Y.,
            Fraser,J.S., Frost,A., Jura,N., Kortemme,T., Manglik,A.,
            Southworth,D.R., Stroud,R.M., Alessi,D.R., Davies,P., Frieman,M.B.,
            Ideker,T., Abate,C., Jouvenet,N., Kochs,G., Shoichet,B., Ott,M.,
            Palmarini,M., Shokat,K.M., Garcia-Sastre,A., Rassen,J.A.,
            Grosse,R., Rosenberg,O.S., Verba,K.A., Basler,C.F., Vignuzzi,M.,
            Peden,A.A., Beltrao,P. and Krogan,N.J.
  CONSRTM   QCRG Structural Biology Consortium; Zoonomia Consortium
  TITLE     Comparative host-coronavirus protein interaction networks reveal
            pan-viral disease mechanisms
  JOURNAL   Science 370 (6521) (2020)
   PUBMED   33060197
REFERENCE   6  (bases 1 to 2099)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2099)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 2099)
  AUTHORS   Swarthout,J.T., Lobo,S., Farh,L., Croke,M.R., Greentree,W.K.,
            Deschenes,R.J. and Linder,M.E.
  TITLE     DHHC9 and GCP16 constitute a human protein fatty acyltransferase
            with specificity for H- and N-Ras
  JOURNAL   J Biol Chem 280 (35), 31141-31148 (2005)
   PUBMED   16000296
  REMARK    GeneRIF: Data show that H- and N-Ras are palmitoylated by a human
            protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes.
REFERENCE   9  (bases 1 to 2099)
  AUTHORS   Ohta,E., Misumi,Y., Sohda,M., Fujiwara,T., Yano,A. and Ikehara,Y.
  TITLE     Identification and characterization of GCP16, a novel acylated
            Golgi protein that interacts with GCP170
  JOURNAL   J Biol Chem 278 (51), 51957-51967 (2003)
   PUBMED   14522980
  REMARK    GeneRIF: results indicate that GCP16 is the acylated membrane
            protein, associated with GCP170, and possibly involved in vesicular
            transport from the Golgi to the cell surface
REFERENCE   10 (bases 1 to 2099)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009630.14, BC012032.1, BC001227.2, AF068291.1, AV650886.1,
            AF125102.1 and BG939345.1.
            
            On May 17, 2019 this sequence version replaced NM_001002296.1.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longer isoform (a). Variants 1, 2, 4 and
            5 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1134319.1,
                                           SRR3476690.394859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357743.9/ ENSP00000350378.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC009630.14        157972-158043       c
            73-452              BC012032.1         1-380
            453-639             BC001227.2         238-424
            640-1207            BC001227.2         430-997
            1208-1272           AF068291.1         968-1032
            1273-1318           BC001227.2         1063-1108
            1319-1370           AV650886.1         436-487
            1371-1481           BC001227.2         1161-1271
            1482-1885           AF125102.1         1251-1654
            1886-2097           BG939345.1         20-231              c
            2098-2099           BC001227.2         1888-1889
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..2099
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /note="golgin A7"
                     /db_xref="GeneID:51125"
                     /db_xref="HGNC:HGNC:24876"
                     /db_xref="MIM:609453"
     exon            1..384
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..687
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /note="isoform a is encoded by transcript variant 2; Golgi
                     complex-associated protein of 16kDa; golgi autoantigen,
                     golgin subfamily a, 7; golgin subfamily A member 7; golgi
                     complex-associated protein of 16 kDa"
                     /codon_start=1
                     /product="golgin subfamily A member 7 isoform a"
                     /protein_id="NP_001002296.1"
                     /db_xref="CCDS:CCDS34887.1"
                     /db_xref="GeneID:51125"
                     /db_xref="HGNC:HGNC:24876"
                     /db_xref="MIM:609453"
                     /translation="MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFE
                     ETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNE
                     KIYAPQGLLLTDPIERGLRVIEITIYEDRGMSSGR"
     exon            385..537
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     exon            538..639
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     exon            640..702
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     exon            703..2099
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2079..2084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /note="hexamer: AATAAA"
     polyA_site      2099
                     /gene="GOLGA7"
                     /gene_synonym="GCP16; GOLGA3AP1; GOLGA7A; HSPC041"
                     /note="major polyA site"
ORIGIN      
        1 ggcggtgcga cagcagctgg agggcagagg aggcgggttt gtgtttcccg ggccgaaccg
       61 ggttgtgggg ggcgcggggc ctgggccagg cggcagctaa ggcccgcggt gacagcatgg
      121 gtgaagggga gcggggcaga ggaggccttg ggctgttttc ggcggcgggt gggggcgagg
      181 ggctggcggg tcagagtccc gggtccaggc cggggctctg actcgcggtt ggtgttcccc
      241 cgaccccgca gcgcggggtg tcctgtcctc gccatgaggc cgcagcaggc gccggtgtcc
      301 ggaaaggtgt tcattcagcg agactacagc agtggcacac gctgccagtt ccagaccaag
      361 ttccctgcgg agctggagaa ccggattgat aggcagcagt ttgaagaaac agttcgaact
      421 ctaaataacc tttatgcaga agcagagaag ctcggcggcc agtcatatct cgaaggttgt
      481 ttggcttgtt taacagcata taccatcttc ctatgcatgg aaactcatta tgagaaggtt
      541 ctgaagaaag tctccaaata cattcaagag cagaatgaga agatctatgc tccacaaggc
      601 ctcctcctga cagaccctat tgagcgagga ctgcgagtta ttgaaattac catttatgaa
      661 gacagaggca tgagcagtgg aagataaacc gaagaattaa agatcccact tccagccggg
      721 cccctcatgt atccactggc cgaccgcaga gtgtccctac ctcctctcca gagcatcatt
      781 cctttctatc tgctgccaga gccacggtgc catttactcc aaggactcac tttctaaaat
      841 tccacacctg gagtgacctc tagtcgctca gcatccactt tgtgtctcca aattgtgtag
      901 gactctgtaa tcttttgatt agtttctgag aaaacacaat gaagcacttc actttttttt
      961 attcaaagcc atttaataaa acacagttgg tcagcccagt gcaaagcttg ttatctgcca
     1021 ccagtacata ccattggttc tcttcattcc ttgggccagc ttctcaggtg gctttagacc
     1081 tcaacaagcc gtatcttcac cagtgttcta tcttgttccc ctaaattaat aaaatgtttt
     1141 tctccaggat tttggtgagg gttggctgtg gctgtcgttt tgcacctccc agatttcaaa
     1201 gaattactgg ttttaccatg actcaaatct taagatctgt ttctactatt cagttcctca
     1261 aactgaagct tattgaaaaa aaaatgtata atgttatttg ttttattata gcaattatgc
     1321 ctaattaaag cagtatttaa tgcaatttcc agttatttct ttggagaatt ttatgtcatt
     1381 gttccattac cttgaatgtt ggaaagatat gatacgtgct gcttgttcat cacaaaaatc
     1441 agtaagcaca ataaagtgga tgccaaacca tcagacacat aaatgttccc gctgtgtccc
     1501 tggatatgga ataagcaggt ataaaaaata ttttaattat agttttgtta taaatataac
     1561 ttatgagaaa aaaatttgat aggaataata ctgtatatta ctaattttta actatcccta
     1621 aggcaaacct tatgacccac agaattttct catatacagt attcagtgca cagaaatctt
     1681 atgattggct caagtacagt aagttacttc tcagtaaaac tctcaagtct gagtccatat
     1741 ttgtagctct gcttttggct gtacgttcct aggatcgggg ctgcttatgc ctttcgttta
     1801 tccttggggt ttgagagcgc tgtatttggg agagagttta aaaatacatt aggagagaga
     1861 aaccattaaa agtttcactg tcagatatat tgtaggtgct aatactggat ttcgtctcag
     1921 atttaatttc ttttatgggt ctgttagtca ttcaacaaat cccataagta tgtgttaata
     1981 ttttaattgt gtaaaactca tttgttactt tacagcctgt aatagtgtgt ctgcattttc
     2041 aacctgttgc aataactttg ctgaaatatt aacacattaa taaaactttt cttaaacaa
//
