LOCUS       NM_001038640            3176 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens golgin A6 family member A (GOLGA6A), mRNA.
ACCESSION   NM_001038640 XM_292357
VERSION     NM_001038640.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3176)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3176)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3176)
  AUTHORS   Ventura,M., Mudge,J.M., Palumbo,V., Burn,S., Blennow,E.,
            Pierluigi,M., Giorda,R., Zuffardi,O., Archidiacono,N., Jackson,M.S.
            and Rocchi,M.
  TITLE     Neocentromeres in 15q24-26 map to duplicons which flanked an
            ancestral centromere in 15q25
  JOURNAL   Genome Res 13 (9), 2059-2068 (2003)
   PUBMED   12915487
REFERENCE   4  (bases 1 to 3176)
  AUTHORS   Pujana,M.A., Nadal,M., Guitart,M., Armengol,L., Gratacos,M. and
            Estivill,X.
  TITLE     Human chromosome 15q11-q14 regions of rearrangements contain
            clusters of LCR15 duplicons
  JOURNAL   Eur J Hum Genet 10 (1), 26-35 (2002)
   PUBMED   11896453
REFERENCE   5  (bases 1 to 3176)
  AUTHORS   Gratacos,M., Nadal,M., Martin-Santos,R., Pujana,M.A., Gago,J.,
            Peral,B., Armengol,L., Ponsa,I., Miro,R., Bulbena,A. and
            Estivill,X.
  TITLE     A polymorphic genomic duplication on human chromosome 15 is a
            susceptibility factor for panic and phobic disorders
  JOURNAL   Cell 106 (3), 367-379 (2001)
   PUBMED   11509185
REFERENCE   6  (bases 1 to 3176)
  AUTHORS   Pujana,M.A., Nadal,M., Gratacos,M., Peral,B., Csiszar,K.,
            Gonzalez-Sarmiento,R., Sumoy,L. and Estivill,X.
  TITLE     Additional complexity on human chromosome 15q: identification of a
            set of newly recognized duplicons (LCR15) on 15q11-q13, 15q24, and
            15q26
  JOURNAL   Genome Res 11 (1), 98-111 (2001)
   PUBMED   11156619
REFERENCE   7  (bases 1 to 3176)
  AUTHORS   Gilles,F., Goy,A., Remache,Y., Manova,K. and Zelenetz,A.D.
  TITLE     Cloning and characterization of a Golgin-related gene from the
            large-scale polymorphism linked to the PML gene
  JOURNAL   Genomics 70 (3), 364-374 (2000)
   PUBMED   11161787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF263742.1, BC131515.1 and AC013486.12.
            
            On Apr 27, 2007 this sequence version replaced NM_001038640.1.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked cisternae (flattened membrane
            sacs). Interactions between the Golgi and microtubules are thought
            to be important for the reorganization of the Golgi after it
            fragments during mitosis. The protein encoded by this gene is a
            member of the golgin family of proteins, whose members localize to
            the Golgi. This gene is found in a large, low copy repeat sequence
            or duplicon that is found in multiple copies, that are greather
            than 90% similar, on chromosome 15. Duplicons are associated with
            deletions, inversions and other chromosome rearrangements that
            underlie genomic disease. The protein encoded by this gene is
            thought to be a functional golgin protein while the majority of the
            related copies of this gene are thought to be transcribed
            pseudogenes. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292574.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290438.3/ ENSP00000290438.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               AF263742.1         1-297
            298-907             BC131515.1         278-887
            908-908             AC013486.12        9851-9851
            909-3134            AF263742.1         909-3134
            3135-3176           AF263742.1         3137-3178
FEATURES             Location/Qualifiers
     source          1..3176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..3176
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /note="golgin A6 family member A"
                     /db_xref="GeneID:342096"
                     /db_xref="HGNC:HGNC:13567"
                     /db_xref="MIM:610288"
     exon            1..125
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2123
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /note="golgi autoantigen, golgin subfamily a, 6A; Golgin
                     linked to PML; golgi autoantigen, golgin subfamily a,
                     member 6; golgin-like protein"
                     /codon_start=1
                     /product="golgin subfamily A member 6A"
                     /protein_id="NP_001033729.2"
                     /db_xref="CCDS:CCDS32290.1"
                     /db_xref="GeneID:342096"
                     /db_xref="HGNC:HGNC:13567"
                     /db_xref="MIM:610288"
                     /translation="MWPQPYLPPHPMMLEESRQNKLAAAKKKLKEYQQRKSPGIPAGA
                     KTKKKKTDSSPETTTSGGCHSPGDSQYQELAVALESSSVTISQLNENIESLKQQKKQV
                     EHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAG
                     RLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLQRWLQQTIKERALLNAHVTQV
                     TESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLS
                     ELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKE
                     QKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQE
                     ERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFE
                     DLNNEKKSALQLEQQVKELQEKLDEEHLEAASHQNQQLETQLSLVALPGEGDGGQHLD
                     SEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQPSGVTDGMR
                     ESFTVYESQGAVPNTRHQEMEDVIRLAQKEEEMKVKLLELQELVLPLVGNHEGHGKFL
                     IAAQNPADEPTPGAPAPQELGAAGEQDVFYEVSLDNNVEPAPGAAREGSPHDNPTVQQ
                     IVQLSPVMQDT"
     exon            126..245
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            246..326
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            327..365
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            366..416
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            417..498
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            499..605
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            606..692
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            693..800
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            801..888
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1397
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1466
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1542
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1634
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1737
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1841
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1995
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..3176
                     /gene="GOLGA6A"
                     /gene_synonym="GLP; GOLGA6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcacacag cagccttgta ggtgactgga ggtgttcgct gatgtggccc caaccctacc
       61 tccctcccca ccccatgatg ttagaagaat ctcgacagaa taaattggca gcagccaaga
      121 aaaagctaaa agaatatcag caaaggaaga gccctggtat tccagcagga gcaaagacaa
      181 aaaagaaaaa aactgacagt agccctgaga caaccacttc cggtggttgc cactcacctg
      241 gggatagcca gtaccaagaa ctagcagtag ccctggagtc aagctcagtg acaatcagtc
      301 aactcaatga aaacatagaa tcattgaaac agcagaagaa acaagtggaa catcagctgg
      361 aagaagcaaa gaaaacaaac aatgaaatac acaaagcaca aatggagcgg ttagagacaa
      421 tcaacatcct cacattggaa aaggcagact tgaagaccac cctttaccat actaaacgtg
      481 ctgcccgaca cttcgaagaa gagtccaagg atctggctgg ccgcctgcaa tactccttac
      541 agcgtattca agaattggag cgggctctct gtgctgtgtc tacacagcag caggaagagg
      601 acaggtcctc gagctgcaga gaagcggtcc tccagcggtg gttacagcag accataaagg
      661 agcgggcgct gctgaacgca cacgtgacac aggtgacaga gtcactaaaa caagtccagc
      721 tagagcgaga cgaatatgct aaacacataa aaggagagag ggcccggtgg caggagagga
      781 tgtggaaaat gtcggtggag gctcgaacat tgaaggaaga gaagaagcgt gacatacatc
      841 ggatacagga gctggagagg agcttgtccg aactcaaaaa ccagatggct gagcccccat
      901 ccctggcgcc cccagcagtg acctctgtgg tggaacagct acaagatgag gccaaacacc
      961 tgaggcagga ggtggaaggt ctggagggaa agctccagtc ccaggtggaa aacaatcagg
     1021 ccttgagtct ccttagcaag gaacaaaagc agagactcca ggagcaggag gagatgctcc
     1081 gagagcagga ggcgcagaga gtgcgggagc aggagagact gtgtgaacaa aacgagaggc
     1141 ttcgggagca gcagaagacg ctacaggagc agggtgagag gctgcgaaag caggagcaga
     1201 ggctacgcaa acaggaggag aggctgcgaa aggaggagga gaggctgcaa aagcaggaaa
     1261 agaggctgtg ggaccaggag gagaggctgt ggaagaagga ggagaggcta caaaagcagg
     1321 aggagaggct cgcgctctcc cagaaccaca agctcgacaa gcagctggcc gagccacagt
     1381 gcagcttcga ggatctgaac aacgagaaaa agagcgcact gcagttggag cagcaagtaa
     1441 aggagctgca ggagaagcta gacgaggagc acctagaagc tgccagccac cagaaccaac
     1501 agctagagac ccagctaagc ctcgtggctc tccctggaga aggagatgga ggacaacatc
     1561 tggacagtga ggaggaggag gcgcctcggc ccacgccaaa catcccagag gacctggaga
     1621 gccgggaggc cacgagcagc tttatggacc tcccgaagga gaaggcggac gggacggagc
     1681 aggtggagag acgagagctt ggattcgtcc agccttctgg agtgacagac ggcatgagag
     1741 agtccttcac cgtatatgaa agccaggggg cagtgccaaa cacgcggcac caggagatgg
     1801 aggatgtcat caggctggcc cagaaggagg aggagatgaa ggtgaagctg ctggagctgc
     1861 aagagttggt gttgcccctt gtgggcaacc atgaggggca tggcaaattc ctcatcgctg
     1921 cccagaaccc tgctgatgag cccactccag gggccccagc cccccaggaa cttggggctg
     1981 ccggtgagca ggatgttttt tatgaagtga gcctggacaa caacgtggag cctgcaccag
     2041 gagcggccag ggagggttct ccccatgaca accccactgt acagcagatc gtgcagctgt
     2101 ctcctgtcat gcaggacacc taggagcacc caggcttgcc cagcaaaccc tgcgtgccat
     2161 tcttctacca ggcagccgag aacagggaga taaacatcat catcttctaa gagctggtca
     2221 agaaatttaa aacaacaaca acaacaaaaa gttacggggt tcatctccta cacaattcat
     2281 ttactccatt tgaatgctag agccactcac atttatttgt gtttctaatt taccgtttaa
     2341 atttatttgt aaaaagttaa gggagagttg gtctttccct gatgttcttt ctggcatcct
     2401 ttagcatttt tatttttaat ttgataattg taggtcatta gtatgcatat cgagtttgcc
     2461 cttaggtggt gggaattcaa acacacaaag acccactaat ttgcacaaaa ctattctggc
     2521 tggtttggaa caggctgcca tgctttttta atgttattgc agcatgtata ttcattccag
     2581 aattcagata aaatgtgctt atgttctgct attacgtttg atcgaatcct aaccacagtg
     2641 agctcttcat tagctcaata tgtggtttgc cctcaattga gcactgttta ttactttgta
     2701 atatgccact gtgagtactg acatttagag ttgtttaaag gccaagaact ggaaacagcc
     2761 ttttccctat tttctgtgta ttggggatgg gagtaataac attttgggga gctttttaaa
     2821 tctcacagaa gaggaaagtg gcctgctctg gcaggtgtgt gcaggataga gtgtgtttca
     2881 tttgttctgg tgccaagaat gagcgctgta ctatggtagt tcccttagga tttgtatgtg
     2941 ctctgggctc atgaagatat tgcatcatga gctgcagcag ttgtaccctt tcttgatgac
     3001 ctaaaaaggg attatttctg aggaatgaaa ggctcccatc attgactgtg gatgtggaaa
     3061 accttttcta gcttagagca tttatatcta caatacattt taaagtcaga gttcatgtta
     3121 cctgttttaa tcacgagtat atgtcccagt acacaaaagg gcactggttg gcattc
//
