LOCUS       NM_005113               2879 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens golgin A5 (GOLGA5), mRNA.
ACCESSION   NM_005113
VERSION     NM_005113.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Christian,J.G., Heymann,J., Paschen,S.A., Vier,J., Schauenburg,L.,
            Rupp,J., Meyer,T.F., Hacker,G. and Heuer,D.
  TITLE     Targeting of a chlamydial protease impedes intracellular bacterial
            growth
  JOURNAL   PLoS Pathog 7 (9), e1002283 (2011)
   PUBMED   21990969
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Sohda,M., Misumi,Y., Yamamoto,A., Nakamura,N., Ogata,S.,
            Sakisaka,S., Hirose,S., Ikehara,Y. and Oda,K.
  TITLE     Interaction of Golgin-84 with the COG complex mediates the
            intra-Golgi retrograde transport
  JOURNAL   Traffic 11 (12), 1552-1566 (2010)
   PUBMED   20874812
  REMARK    GeneRIF: Golgin-84 on coat protein I vesicles interacts with the
            conserved oligomeric Golgi complex before SNARE assembly.
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2879)
  AUTHORS   Heuer,D., Rejman Lipinski,A., Machuy,N., Karlas,A., Wehrens,A.,
            Siedler,F., Brinkmann,V. and Meyer,T.F.
  TITLE     Chlamydia causes fragmentation of the Golgi compartment to ensure
            reproduction
  JOURNAL   Nature 457 (7230), 731-735 (2009)
   PUBMED   19060882
REFERENCE   5  (bases 1 to 2879)
  AUTHORS   Malsam,J., Satoh,A., Pelletier,L. and Warren,G.
  TITLE     Golgin tethers define subpopulations of COPI vesicles
  JOURNAL   Science 307 (5712), 1095-1098 (2005)
   PUBMED   15718469
REFERENCE   6  (bases 1 to 2879)
  AUTHORS   Satoh,A., Wang,Y., Malsam,J., Beard,M.B. and Warren,G.
  TITLE     Golgin-84 is a rab1 binding partner involved in Golgi structure
  JOURNAL   Traffic 4 (3), 153-161 (2003)
   PUBMED   12656988
  REMARK    GeneRIF: involved in generating and maintaining the architecture of
            the Golgi apparatus
REFERENCE   7  (bases 1 to 2879)
  AUTHORS   Diao,A., Rahman,D., Pappin,D.J., Lucocq,J. and Lowe,M.
  TITLE     The coiled-coil membrane protein golgin-84 is a novel rab effector
            required for Golgi ribbon formation
  JOURNAL   J Cell Biol 160 (2), 201-212 (2003)
   PUBMED   12538640
REFERENCE   8  (bases 1 to 2879)
  AUTHORS   Bascom,R.A., Srinivasan,S. and Nussbaum,R.L.
  TITLE     Identification and characterization of golgin-84, a novel Golgi
            integral membrane protein with a cytoplasmic coiled-coil domain
  JOURNAL   J Biol Chem 274 (5), 2953-2962 (1999)
   PUBMED   9915833
  REMARK    Erratum:[J Biol Chem 1999 Apr 30;274(18):12950]
REFERENCE   9  (bases 1 to 2879)
  AUTHORS   Klugbauer,S., Demidchik,E.P., Lengfelder,E. and Rabes,H.M.
  TITLE     Detection of a novel type of RET rearrangement (PTC5) in thyroid
            carcinomas after Chernobyl and analysis of the involved RET-fused
            gene RFG5
  JOURNAL   Cancer Res 58 (2), 198-203 (1998)
   PUBMED   9443391
REFERENCE   10 (bases 1 to 2879)
  AUTHORS   Ishizaka,Y., Ochiai,M., Tahira,T., Sugimura,T. and Nagao,M.
  TITLE     Activation of the ret-II oncogene without a sequence encoding a
            transmembrane domain and transforming activity of two ret-II
            oncogene products differing in carboxy-termini due to alternative
            splicing
  JOURNAL   Oncogene 4 (6), 789-794 (1989)
   PUBMED   2734021
  REMARK    Erratum:[Oncogene 1989 Nov;4(11):1415]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132987.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005113.3.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked cisternae (flattened membrane
            sacs). Interactions between the Golgi and microtubules are thought
            to be important for the reorganization of the Golgi after it
            fragments during mitosis. This gene encodes one of the golgins, a
            family of proteins localized to the Golgi. This protein is a
            coiled-coil membrane protein that has been postulated to play a
            role in vesicle tethering and docking. Translocations involving
            this gene and the ret proto-oncogene have been found in tumor
            tissues; the chimeric sequences have been designated RET-II and
            PTC5. A pseudogene of this gene is located on the short arm of
            chromosome 5. [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.122087.1,
                                           SRR1803611.169184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000163416.7/ ENSP00000163416.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AL132987.4         90983-91134         c
            153-726             AL132987.4         87458-88031         c
            727-954             AL132987.4         78476-78703         c
            955-1174            AL132987.4         75920-76139         c
            1175-1298           AL132987.4         75062-75185         c
            1299-1502           AL132987.4         73685-73888         c
            1503-1673           AL132987.4         69018-69188         c
            1674-1802           AL132987.4         65603-65731         c
            1803-1901           AL132987.4         60795-60893         c
            1902-2127           AL132987.4         52092-52317         c
            2128-2233           AL132987.4         49775-49880         c
            2234-2297           AL132987.4         47990-48053         c
            2298-2879           AL132987.4         45492-46073         c
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..2879
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /note="golgin A5"
                     /db_xref="GeneID:9950"
                     /db_xref="HGNC:HGNC:4428"
                     /db_xref="MIM:606918"
     exon            1..152
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            153..726
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..2378
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /note="golgi integral membrane protein 5; golgi
                     autoantigen, golgin subfamily a, 5; golgin-84; RET-fused
                     gene 5 protein; cell proliferation-inducing gene 31
                     protein"
                     /codon_start=1
                     /product="golgin subfamily A member 5"
                     /protein_id="NP_005104.4"
                     /db_xref="CCDS:CCDS9905.1"
                     /db_xref="GeneID:9950"
                     /db_xref="HGNC:HGNC:4428"
                     /db_xref="MIM:606918"
                     /translation="MSWFVDLAGKAEDLLNRVDQGAATALSRKDNASNIYSKNTDYTE
                     LHQQNTDLIYQTGPKSTYISSAADNIRNQKATILAGTANVKVGSRTPVEASHPVENAS
                     VPRPSSHFVRRKKSEPDDELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSS
                     VNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDD
                     GKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKS
                     DRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQ
                     DQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEA
                     ITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLK
                     EGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAE
                     SAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEE
                     IQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQ
                     QMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQ
                     FSIRLGIFLRRYPIARVFVIIYMALLHLWVMIVLLTYTPEMHHDQPYGK"
     exon            727..954
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1174
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1298
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1502
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1673
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1802
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1901
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2127
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2233
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2297
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2879
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2739..2744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /note="hexamer: AATAAA"
     polyA_site      2760
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /note="major polyA site"
     regulatory      2861..2866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /note="hexamer: AATAAA"
     polyA_site      2879
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
ORIGIN      
        1 gcttcccttc cacgtctccc ggaagcggta gcagggcccc ggcgggtcgg ggaggaggtt
       61 tactcagctt gggccccctc cgggccagcc gccgaggggg cgcggcccag gacggcggct
      121 aggccgtagt gcagcctctc cggagtcctc aggtttgcca ataggattat cctgctgcca
      181 tcatgtcttg gtttgttgat cttgctggaa aggcagaaga tcttttaaac cgagttgatc
      241 aaggggctgc aacagctctc agtaggaaag acaatgccag caacatatat agcaaaaata
      301 ctgactatac tgaacttcac cagcaaaata cagatttgat atatcagact ggacctaaat
      361 ctacgtatat ttcatcagca gctgataaca ttcgaaatca aaaagccacc atcttagctg
      421 gcactgcaaa tgtgaaagta ggatctcgga caccagtaga ggcctctcat cctgttgaaa
      481 atgcatctgt tcctaggcct tcatcccatt ttgtgcgaag aaaaaagtca gaacctgatg
      541 atgagctgct gtttgatttt cttaatagtt cacagaagga gcctaccggg agggtggaaa
      601 tcagaaagga aaaaggcaag acacctgtct ttcagagctc tcagacatca agtgtcagtt
      661 ctgtgaaccc cagtgtaacc accatcaaaa ccattgaaga aaattctttt gggagccaaa
      721 cccacgaagc tgccagtaac tcagattcta gccatgaagg tcaagaggaa tcttcaaagg
      781 aaaatgtgtc atcaaatgct gcctgccctg accacacccc aacacctaat gatgatggca
      841 aatcacatga actgtctaac cttcgactgg agaatcagct gctgaggaat gaagttcagt
      901 ctttaaatca agaaatggcc tcgttactcc aaagatccaa agagactcaa gaagaattaa
      961 acaaagcaag agcaagagtt gaaaagtgga atgctgacca ttcaaagagt gatcgaatga
     1021 ctcgaggact ccgagcccaa gtagatgacc tgactgaagc tgtggctgca aaggattccc
     1081 agctggctgt actgaaagtg agactccagg aagctgacca gctactgagt actcgcacag
     1141 aagcattaga agccttacag agtgaaaaat cacgaataat gcaggatcaa agtgaaggta
     1201 acagcctgca gaatcaagct ctgcagactt ttcaggagag actgcatgaa gcggatgcca
     1261 ctctgaagag agagcaggag agctataaac agatgcagag cgagtttgct gcacgcctta
     1321 ataaagtgga aatggaacgt cagaatttag cagaagcaat tacactggcc gaaagaaaat
     1381 actcagatga gaagaagagg gttgatgaac tgcagcagca agtcaagctg tataagttga
     1441 acttggagtc ctctaagcag gaattaattg actacaagca aaaagctact agaatactgc
     1501 aatctaagga aaaattgatt aacagcttga aagaaggctc tggttttgaa ggcctagata
     1561 gcagcactgc cagtagcatg gagctggaag aacttcggca tgagaaagag atgcagaggg
     1621 aggaaataca gaagctgatg ggccagatac atcagctcag atccgaatta caggatatgg
     1681 aggcacagca agttaatgaa gcagaatcag caagagaaca gttacaggat ctgcatgacc
     1741 aaatagctgg gcagaaagca tccaaacaag aactagagac agaactggag cgactgaagc
     1801 aggagttcca ctatatagaa gaagatcttt atcgaacaaa gaacacattg caaagcagaa
     1861 ttaaagatcg agacgaagaa attcaaaaac tcaggaatca gcttaccaat aaaactttaa
     1921 gcaatagcag tcagtctgag ttagaaaatc gactccatca gctaacagag actctcatcc
     1981 agaaacagac catgctggag agtctcagca cagaaaagaa ctccctggtc tttcaactgg
     2041 agcgcctcga acagcagatg aactccgcct ctggaagtag tagtaatggg tcttcgatta
     2101 atatgtctgg aattgacaat ggtgaaggca ctcgtctgcg aaatgttcct gttcttttta
     2161 atgacacaga aactaatctg gcaggaatgt acggaaaagt tcgcaaagct gctagttcaa
     2221 ttgatcagtt tagtattcgc ctgggaattt ttctccgaag ataccccata gcgcgagttt
     2281 ttgtaattat atatatggct ttgcttcacc tctgggtcat gattgttctg ttgacttaca
     2341 caccagaaat gcaccacgac caaccatatg gcaaatgaac caagcccagt tgttgcagtg
     2401 attggttgtc tttttctaga cttgggatct gcaagaaggc caattgccta aaatttctga
     2461 gaacagtgca caagattatt ttatcactac aagcttttaa ctttttaagt tattgtacaa
     2521 gtattctacc taaatcttcc aatttccttt aaatggtaag agtttctaaa acagacaata
     2581 atttaacaag ctcagctctg ctttatctga gtttagtggt cctaatatat atgtagagaa
     2641 agatggtggg gttgttcacc tctgtacaga ccatctgtat gttaggtgac attgattatg
     2701 ggttataatc agggaaacta attgtattta gtgacaaaaa taaaaagttt ttttttataa
     2761 ttcagtctgc ttttggattt tcatatattt aactttgcaa aaagatttac tttgtacatg
     2821 ttacaggctt gattggtgta aatcttttta taaatacata aataaaagaa aaatatgca
//
