LOCUS       NM_002078               7806 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens golgin A4 (GOLGA4), transcript variant 2, mRNA.
ACCESSION   NM_002078
VERSION     NM_002078.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7806)
  AUTHORS   Downes,C.E.J., Rehn,J., Heatley,S.L., Yeung,D., McClure,B.J. and
            White,D.L.
  TITLE     Identification of a novel GOLGA4-JAK2 fusion gene in B-cell acute
            lymphoblastic leukaemia
  JOURNAL   Br J Haematol 196 (3), 700-705 (2022)
   PUBMED   34697799
  REMARK    GeneRIF: Identification of a novel GOLGA4-JAK2 fusion gene in
            B-cell acute lymphoblastic leukaemia.
REFERENCE   2  (bases 1 to 7806)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7806)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7806)
  AUTHORS   Cao,Y., Lei,Y., Luo,Y., Tan,T., Du,B., Zheng,Y., Sun,L. and
            Liang,Q.
  TITLE     The actomyosin network is influenced by NMHC IIA and regulated by
            CrpF46, which is involved in controlling cell migration
  JOURNAL   Exp Cell Res 373 (1-2), 119-131 (2018)
   PUBMED   30336116
  REMARK    GeneRIF: CrpF46 regulates cell migration by centrosomal
            reorientation and altering the function of the actomyosin network
            by controlling specific phosphorylation of myosin.
REFERENCE   5  (bases 1 to 7806)
  AUTHORS   Kork,F., Jankowski,J., Goswami,A., Weis,J., Brook,G., Yamoah,A.,
            Anink,J., Aronica,E., Fritz,S., Huck,C., Schipke,C., Peters,O.,
            Tepel,M., Noels,H. and Jankowski,V.
  TITLE     Golgin A4 in CSF and granulovacuolar degenerations of patients with
            Alzheimer disease
  JOURNAL   Neurology 91 (19), e1799-e1808 (2018)
   PUBMED   30305446
  REMARK    GeneRIF: This study provides Class III evidence that elevated
            cerebrospinal fluid golgin A4 levels identify patients with
            Alzheimer disease.
REFERENCE   6  (bases 1 to 7806)
  AUTHORS   Barr,F.A.
  TITLE     A novel Rab6-interacting domain defines a family of Golgi-targeted
            coiled-coil proteins
  JOURNAL   Curr Biol 9 (7), 381-384 (1999)
   PUBMED   10209123
REFERENCE   7  (bases 1 to 7806)
  AUTHORS   Gleeson,P.A., Anderson,T.J., Stow,J.L., Griffiths,G., Toh,B.H. and
            Matheson,F.
  TITLE     p230 is associated with vesicles budding from the trans-Golgi
            network
  JOURNAL   J Cell Sci 109 (Pt 12), 2811-2821 (1996)
   PUBMED   9013329
REFERENCE   8  (bases 1 to 7806)
  AUTHORS   Erlich,R., Gleeson,P.A., Campbell,P., Dietzsch,E. and Toh,B.H.
  TITLE     Molecular characterization of trans-Golgi p230. A human peripheral
            membrane protein encoded by a gene on chromosome 6p12-22 contains
            extensive coiled-coil alpha-helical domains and a granin motif
  JOURNAL   J Biol Chem 271 (14), 8328-8337 (1996)
   PUBMED   8626529
REFERENCE   9  (bases 1 to 7806)
  AUTHORS   Fritzler,M.J., Lung,C.C., Hamel,J.C., Griffith,K.J. and Chan,E.K.
  TITLE     Molecular characterization of Golgin-245, a novel Golgi complex
            protein containing a granin signature
  JOURNAL   J Biol Chem 270 (52), 31262-31268 (1995)
   PUBMED   8537393
REFERENCE   10 (bases 1 to 7806)
  AUTHORS   Kooy,J., Toh,B.H., Pettitt,J.M., Erlich,R. and Gleeson,P.A.
  TITLE     Human autoantibodies as reagents to conserved Golgi components.
            Characterization of a peripheral, 230-kDa compartment-specific
            Golgi protein
  JOURNAL   J Biol Chem 267 (28), 20255-20263 (1992)
   PUBMED   1400343
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC045543.1, U41740.1 and
            AW881112.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002078.4.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked cisternae (flattened membrane
            sacs). Interactions between the Golgi and microtubules are thought
            to be important for the reorganization of the Golgi after it
            fragments during mitosis. This gene encodes one of the golgins, a
            family of proteins localized to the Golgi. This protein has been
            postulated to play a role in Rab6-regulated membrane-tethering
            events in the Golgi apparatus. Alternatively spliced transcript
            variants encoding different isoforms have been identified in this
            gene. [provided by RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U41740.1, X82834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361924.7/ ENSP00000354486.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BC045543.1         81-92
            13-7233             U41740.1           18-7238
            7234-7673           U41740.1           7240-7679
            7674-7806           AW881112.1         286-418
FEATURES             Location/Qualifiers
     source          1..7806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..7806
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /note="golgin A4"
                     /db_xref="GeneID:2803"
                     /db_xref="HGNC:HGNC:4427"
                     /db_xref="MIM:602509"
     exon            1..352
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..6973
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /note="isoform 2 is encoded by transcript variant 2; golgi
                     autoantigen, golgin subfamily a, 4; 256 kDa golgin; 72.1
                     protein; golgin-245; trans-Golgi p230; golgin subfamily A
                     member 4; golgin-240; protein 72.1; centrosome-related
                     protein F46"
                     /codon_start=1
                     /product="golgin subfamily A member 4 isoform 2"
                     /protein_id="NP_002069.2"
                     /db_xref="CCDS:CCDS2666.1"
                     /db_xref="GeneID:2803"
                     /db_xref="HGNC:HGNC:4427"
                     /db_xref="MIM:602509"
                     /translation="MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTE
                     QLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESL
                     NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSEL
                     VTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKD
                     QYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGT
                     SVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK
                     DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK
                     QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE
                     ERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQ
                     EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYR
                     TRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQD
                     ALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVK
                     QTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII
                     KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA
                     KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL
                     DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMIL
                     QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK
                     KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE
                     SLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKE
                     EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKS
                     LKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL
                     EFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE
                     ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEK
                     EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTD
                     LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVD
                     DWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKR
                     FDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN
                     QQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEH
                     VNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK
                     GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS
                     QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAE
                     AKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL
                     QEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELL
                     EENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK
                     EHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTI
                     KETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKV
                     RDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQ
                     IHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMMGRE
                     TKTMAKVITTVLKFPDDQTQKILEREDARLMFTSPRSGIF"
     exon            353..442
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            443..757
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            758..805
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            806..862
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            863..961
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1094
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1282
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1366
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1514
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1693
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1825
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1981
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..6219
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            6220..6341
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            6342..6472
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            6473..6586
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            6587..6607
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            6608..6676
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            6677..6752
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            6753..6856
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            6857..6943
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            6944..7006
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     exon            7007..7806
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7654..7659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /note="hexamer: AATAAA"
     polyA_site      7678
                     /gene="GOLGA4"
                     /gene_synonym="CRPF46; GCP2; GOLG; MU-RMS-40.18; p230"
                     /note="major polyA site"
ORIGIN      
        1 agttcacctg ctgccgttgt cgtcgccgcc gcggctcccg gggctggatg gggggccgag
       61 gccagccagt ggcacccgga agaaagagac gcggcggcgg cgacgccgac accctcagga
      121 cgagtgtccg gacttgccca cagcctcaag gaggagacgg cgaggcccgg cccccgctgt
      181 ccctggtgta aagaagtcgc cgtagccgtc gcggccggga ctccccgggc tctcgccctt
      241 caggtttcgt tgacactcag gaccgtacgt acgctgcgcc atgttcaaga aactgaagca
      301 aaagatcagc gaggagcagc agcagctcca gcaggcgctg gctcctgctc aggcgtcctc
      361 caattcttca acaccaacaa gaatgaggag caggacatct tcatttacag agcaacttga
      421 tgaaggtaca cccaatagag agtcaggtga cacacagtct tttgcacaga agctccagct
      481 ccgggtgccc tccgtggagt ctttgtttcg aagtccgata aaggaatctc tattccggtc
      541 ttcttctaaa gagtctttgg tacgaacatc ttccagagaa tccctgaatc gacttgacct
      601 ggacagttct actgccagtt ttgatccacc ctctgatatg gatagcgagg ctgaagactt
      661 ggtagggaat tcagacagtc tcaacaaaga acagttgatt cagcggttgc gaagaatgga
      721 acgaagctta agtagctaca ggggaaaata ttctgagctt gttacagctt atcagatgct
      781 tcagagagag aagaaaaagc tacaaggtat attaagtcag agtcaggata aatcacttcg
      841 gagaatagca gaattaagag aggagctcca aatggaccag caggcaaaga aacatctgca
      901 agaggagttt gatgcatctt tagaggagaa agatcagtat atcagtgttc tccaaactca
      961 ggtttctcta ctgaaacaac gattacgaaa tggcccgatg aatgttgatg tactgaaacc
     1021 acttcctcag ctggaaccac aggctgaagt cttcactaaa gaagagaatc cagaaagtga
     1081 tggagagcca gtagtggaag atggaacttc tgtaaaaaca ctggaaacac tccagcaaag
     1141 agtgaagcgt caagagaacc tacttaagcg ttgtaaggaa acaattcagt cacataagga
     1201 acaatgtaca ctattaacta gtgaaaaaga agctctgcaa gaacaactgg atgaaagact
     1261 tcaagaacta gaaaagataa aggaccttca tatggccgag aagactaaac ttatcactca
     1321 gttgcgtgat gcaaagaact taattgaaca gcttgaacaa gataagggaa tggtaatcgc
     1381 agagacaaaa cgtcagatgc atgaaaccct ggaaatgaaa gaagaagaaa ttgctcaact
     1441 ccgtagtcgc atcaaacaga tgactaccca gggagaggaa ttacgggaac agaaagaaaa
     1501 gtccgaaaga gctgcttttg aggaacttga aaaagctttg agtacagccc aaaaaacaga
     1561 ggaagcacgg agaaaactga aggcagaaat ggatgaacaa ataaaaacta tcgaaaaaac
     1621 aagtgaggag gaacgcatca gtcttcaaca ggaattaagt cgggtgaaac aggaggttgt
     1681 tgatgtaatg aaaaaatcct cagaagaaca aattgctaag ctacagaagc ttcatgaaaa
     1741 ggagctggcc agaaaagagc aggaactgac caagaagctt cagacccgag aaagggaatt
     1801 tcaggaacaa atgaaagtag ctcttgaaaa gagtcaatca gaatatttga agatcagcca
     1861 agaaaaagaa cagcaagaat ctttggccct agaagagtta gagttgcaga aaaaagcaat
     1921 cctcacagaa agtgaaaata aacttcggga ccttcagcaa gaagcagaga cttacagaac
     1981 tagaattctt gaattggaaa gttctttgga aaaaagctta caagaaaaca aaaatcagtc
     2041 aaaagatttg gctgttcatc tggaagctga aaaaaataag cacaataagg agattacagt
     2101 catggttgaa aaacacaaga cagaattgga aagccttaag catcagcagg atgccctttg
     2161 gactgaaaaa ctccaagtct taaagcaaca atatcagact gaaatggaaa aacttaggga
     2221 aaagtgtgaa caagaaaaag aaacattgtt gaaagacaaa gagattatct tccaggccca
     2281 catagaagaa atgaatgaaa agactttaga aaagcttgat gtgaagcaaa cagaactaga
     2341 atcattatct tctgaactgt cagaagtatt aaaagcccgt cacaaactag aagaggaact
     2401 ttctgttctg aaagatcaaa cagataaaat gaagcaggaa ttagaggcca agatggatga
     2461 acagaaaaat catcaccagc agcaagttga cagtatcatt aaagaacacg aggtatctat
     2521 ccagaggact gagaaggcat taaaagatca aattaatcaa cttgagcttc tcttgaagga
     2581 aagggacaag catttgaaag agcatcaggc tcatgtagaa aatttagagg cagatattaa
     2641 aaggtctgaa ggggaactcc agcaggcatc tgctaagctg gacgtttttc agtcttacca
     2701 gagtgccaca catgagcaga caaaagcata tgaggaacag ttggcccaat tgcagcagaa
     2761 gttgttggat ttggaaacag aaagaattct tcttaccaaa caggttgctg aagttgaagc
     2821 acaaaagaaa gatgtttgta ctgagttaga tgctcacaaa atccaggtgc aggacttaat
     2881 gcagcaactt gaaaaacaaa atagtgaaat ggagcaaaaa gtaaaatctt taacccaagt
     2941 ctatgagtcc aaacttgaag atggtaacaa agaacaggaa cagacaaagc aaatcttggt
     3001 ggaaaaggaa aatatgattt tacaaatgag agaaggacag aagaaagaaa ttgagatact
     3061 cacacagaaa ttgtcagcca aggaggacag tattcatatt ttgaatgagg aatatgaaac
     3121 caaatttaaa aaccaagaaa aaaagatgga aaaagttaag cagaaagcaa aggagatgca
     3181 agaaacgtta aagaaaaaat tactggatca ggaagccaaa cttaagaaag agcttgaaaa
     3241 tactgctcta gagcttagtc agaaagaaaa acagtttaat gccaaaatgc tggaaatggc
     3301 acaggctaac tcagctggaa tcagtgatgc agtgtcaaga ctggaaacaa accaaaaaga
     3361 acaaatagaa agtcttactg aggttcatcg acgagaactc aatgatgtca tatcaatctg
     3421 ggaaaagaaa cttaatcagc aagctgaaga acttcaggaa atacatgaaa tccaattaca
     3481 ggaaaaagaa caagaggtag cagaactgaa acaaaagatc ctcctatttg ggtgtgaaaa
     3541 agaagagatg aacaaggaaa taacatggct gaaggaagaa ggtgttaagc aggatacaac
     3601 attaaatgaa ttacaggaac agttaaagca gaagtctgcc catgtgaatt ctcttgcaca
     3661 agatgaaact aaactgaaag ctcatcttga aaagctagag gttgacttga ataagtctct
     3721 gaaggaaaat acttttcttc aagagcagct agttgaactg aagatgctgg cagaagaaga
     3781 taagcggaag gtttctgagt tgactagcaa gttgaaaacc acagatgaag aattccagag
     3841 tttgaaatct tcacatgaaa aaagtaacaa aagcctagag gacaagagct tggaatttaa
     3901 aaaactgtct gaggaactag cgattcagct agatatttgc tgtaagaaaa ccgaagcctt
     3961 attagaagct aaaacaaatg agctaatcaa cattagtagt agtaaaacta atgccattct
     4021 ttctaggatt tctcattgtc agcaccgtac aactaaagtt aaggaggcac tgttaattaa
     4081 aacttgcaca gtttctgaat tagaagcaca acttagacag ttgacagagg agcaaaatac
     4141 actaaatatt tcttttcaac aggctactca tcagttagaa gaaaaagaaa atcaaattaa
     4201 gagcatgaag gctgatattg aaagtcttgt aacagaaaaa gaagccttac agaaggaagg
     4261 aggcaatcag caacaggctg cttctgaaaa ggagtcttgt ataacacagt tgaagaaaga
     4321 gttatctgaa aacatcaatg ctgtcacatt gatgaaagaa gagcttaaag aaaaaaaagt
     4381 tgagattagc agtcttagta aacaactaac tgatttgaat gttcagcttc aaaatagcat
     4441 cagcctatcc gaaaaagaag cagccatttc atcactaaga aagcagtatg atgaagaaaa
     4501 atgtgaattg ctggatcagg tgcaagattt atcttttaaa gttgacactc tgagtaaaga
     4561 gaaaatttct gctcttgagc aggtagatga ctggtccaat aaattctcag aatggaagaa
     4621 gaaagcacag tcaagattta cacagcatca aaacactgtt aaagaattgc agatccagct
     4681 tgagttaaaa tcaaaggaag cttatgaaaa ggatgagcag ataaatttat tgaaggaaga
     4741 gcttgatcag caaaataaaa gatttgattg tttaaagggt gaaatggaag acgacaagag
     4801 caagatggag aaaaaggagt ctaatttaga aacagagtta aagtctcaaa cagcaagaat
     4861 tatggaatta gaggaccata ttacccagaa aactattgaa atagagtcct taaatgaagt
     4921 tcttaaaaat tacaatcaac aaaaggatat tgaacacaaa gaattggttc agaaacttca
     4981 acattttcaa gagttaggag aagaaaagga caacagggtt aaagaagctg aagaaaaaat
     5041 cttaacactt gaaaaccaag tttattccat gaaagctgaa cttgaaacta agaagaaaga
     5101 attagaacat gtgaatttaa gtgtgaaaag caaagaggag gagttaaagg cattggaaga
     5161 taggcttgag tcagaaagtg ctgcaaaatt agcagagttg aagagaaaag ctgaacaaaa
     5221 aattgctgcc attaagaagc agttgttatc tcaaatggaa gagaaagaag aacagtataa
     5281 aaaaggtaca gaaagccatt tgagtgagct aaatacaaaa ttgcaggaaa gagaaaggga
     5341 agttcacatc ttggaagaaa aacttaagtc agtggaaagt tcacagtcag aaacattaat
     5401 tgtacccaga tcagcaaaaa atgtggcagc atatactgaa caagaagaag cagattccca
     5461 aggctgtgtg cagaagacat atgaagaaaa aatcagtgtt ttacaaagaa acttaactga
     5521 aaaagaaaag ctattgcaga gggtagggca ggaaaaagaa gagacagttt cttctcattt
     5581 tgaaatgcga tgccaatacc aggagcgctt aataaagcta gaacatgctg aggcaaagca
     5641 acatgaagat caaagtatga taggtcatct tcaagaggag cttgaagaaa aaaacaagaa
     5701 atattccttg atagtagccc agcatgtgga aaaagaagga ggtaaaaata acatacaggc
     5761 aaagcaaaac ttggaaaatg tgtttgacga cgtccagaaa accctccagg agaaggaact
     5821 aacctgtcag attttggagc aaaagataaa agagctggat tcctgcttag taagacagaa
     5881 agaagtacat agagttgaaa tggaagagtt gacctcaaaa tatgaaaaat tacaggcttt
     5941 acaacagatg gatggaagaa ataaacccac agaacttttg gaagaaaaca ctgaagaaaa
     6001 gtccaaatca catttggtcc aacccaaatt gcttagtaac atggaagccc agcacaatga
     6061 tctggagttt aaattagccg gggcagaacg ggagaaacag aaactgggca aggagattgt
     6121 tagattgcag aaagaccttc gaatgttgag aaaggagcat cagcaagaat tggaaatact
     6181 aaagaaagaa tatgatcaag aaagggaaga gaaaatcaaa caggagcagg aagatcttga
     6241 actgaagcac aattccacat taaaacagct gatgagggag tttaatacac agctggcaca
     6301 aaaggaacaa gagctggaaa tgaccataaa agaaactatc aataaggccc aggaggtgga
     6361 ggctgaactt ttagaaagcc atcaagaaga gacaaatcag ttacttaaaa aaattgctga
     6421 gaaagatgat gatctaaaac gaacagccaa aagatatgaa gaaatccttg atgctcgtga
     6481 agaagaaatg actgcaaaag taagggacct gcagactcaa cttgaggagc tgcagaagaa
     6541 ataccagcaa aagctagagc aggaggagaa ccctggcaat gataatgtaa caattatgga
     6601 gctacagaca cagctagcac agaagacgac tttaatcagt gattcgaaat tgaaagagca
     6661 agagttcaga gaacagattc acaatttaga agaccgtttg aagaaatatg aaaagaatgt
     6721 atatgcaaca actgtgggga caccttacaa aggtggcaat ttgtaccata cggatgtctc
     6781 actctttgga gaacctaccg aatttgagta tttgcgaaaa gtgctttttg agtatatgat
     6841 gggtcgtgag actaagacca tggcaaaagt tataaccacc gtactgaagt tccctgatga
     6901 tcagactcag aaaattttgg aaagagaaga tgctcggctg atgtttactt cacctcgcag
     6961 tggtatcttc tgagtaaacc atcagtctgt gcttagttaa catgtgtcat ggctccgatc
     7021 ttcatcttga agaagagtga cattgggtga ctgctgcttg gaaaactgtc cacacttgct
     7081 actctttgag aatgaagttg tcattcaggg cccctcatgt agccaaaaga ccaagaaaaa
     7141 tctggcccac agataagttg cagactgcct ttaaaataga ttttatcagt ggagaaatgg
     7201 tgatagtttt ttcttcagtt ttctcttggg aagagtttta tgttgtttaa aagatatttt
     7261 gataacttaa cctgctttat gggcttacat aatattcctt tcatccattc tttttaaaga
     7321 acggcttacc tttcctattt atttttaggg tgatttttta aaaagacttg tgcaatacat
     7381 tttgaggtga aacttagtgg attttttctg ataaattaga gcatttaatt gactatttta
     7441 ttcaggttga tctgttgaat atttgctaaa gaccagttct ttaagctaag acatgtaaaa
     7501 aatcccaaat ggcagtacct cattgtttac ttagcttttg tacttatatt tttcagagga
     7561 aaaaacacta ctgtaaattg tgaatagcca atacataact gtattgtatg caaatctgtg
     7621 attgttggca gtgtcatctc tgagaaacag ataaataaag tttatttact atataacatt
     7681 tgtttattgt acttgttcct cagttgaaat ctattttaaa atgtttaaga atgcatattc
     7741 tatttggatg aatttagtga ggaattattt gtcaatataa ctaaatgctg agcatttgaa
     7801 aagaat
//
