LOCUS       NM_001389688            9016 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens golgin A3 (GOLGA3), transcript variant 8, mRNA.
ACCESSION   NM_001389688
VERSION     NM_001389688.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9016)
  AUTHORS   Shamseldin,H.E., Al Mogarri,I., Alqwaiee,M.M., Alharbi,A.S.,
            Baqais,K., AlSaadi,M., AlAnzi,T., Alhashem,A., Saghier,A.,
            Ameen,W., Ibrahim,N., Yang,J., Abdulwahab,F., Hashem,M.,
            Chivukula,R.R. and Alkuraya,F.S.
  TITLE     An exome-first approach to aid in the diagnosis of primary ciliary
            dyskinesia
  JOURNAL   Hum Genet 139 (10), 1273-1283 (2020)
   PUBMED   32367404
  REMARK    GeneRIF: An exome-first approach to aid in the diagnosis of primary
            ciliary dyskinesia.
REFERENCE   2  (bases 1 to 9016)
  AUTHORS   Gilbert,C.E., Sztul,E. and Machamer,C.E.
  TITLE     Commonly used trafficking blocks disrupt ARF1 activation and the
            localization and function of specific Golgi proteins
  JOURNAL   Mol Biol Cell 29 (8), 937-947 (2018)
   PUBMED   29467256
  REMARK    GeneRIF: Golgin-160 disperses from Golgi membranes in cells
            subjected to cold temperature. Activated ARF1 can prevent
            cold-induced dispersal of golgin-160.
REFERENCE   3  (bases 1 to 9016)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9016)
  AUTHORS   Ohta,E., Misumi,Y., Sohda,M., Fujiwara,T., Yano,A. and Ikehara,Y.
  TITLE     Identification and characterization of GCP16, a novel acylated
            Golgi protein that interacts with GCP170
  JOURNAL   J Biol Chem 278 (51), 51957-51967 (2003)
   PUBMED   14522980
  REMARK    GeneRIF: results indicate that GCP16 is the acylated membrane
            protein, associated with GCP170, and possibly involved in vesicular
            transport from the Golgi to the cell surface
REFERENCE   5  (bases 1 to 9016)
  AUTHORS   Hicks,S.W. and Machamer,C.E.
  TITLE     The NH2-terminal domain of Golgin-160 contains both Golgi and
            nuclear targeting information
  JOURNAL   J Biol Chem 277 (39), 35833-35839 (2002)
   PUBMED   12130652
  REMARK    GeneRIF: NH2 terminal domain of Golgin 160 has a role in nuclear
            transport and Golgi apparatus localization
REFERENCE   6  (bases 1 to 9016)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
REFERENCE   7  (bases 1 to 9016)
  AUTHORS   Mancini,M., Machamer,C.E., Roy,S., Nicholson,D.W., Thornberry,N.A.,
            Casciola-Rosen,L.A. and Rosen,A.
  TITLE     Caspase-2 is localized at the Golgi complex and cleaves golgin-160
            during apoptosis
  JOURNAL   J Cell Biol 149 (3), 603-612 (2000)
   PUBMED   10791974
REFERENCE   8  (bases 1 to 9016)
  AUTHORS   Barr,F.A.
  TITLE     A novel Rab6-interacting domain defines a family of Golgi-targeted
            coiled-coil proteins
  JOURNAL   Curr Biol 9 (7), 381-384 (1999)
   PUBMED   10209123
REFERENCE   9  (bases 1 to 9016)
  AUTHORS   Misumi,Y., Sohda,M., Yano,A., Fujiwara,T. and Ikehara,Y.
  TITLE     Molecular characterization of GCP170, a 170-kDa protein associated
            with the cytoplasmic face of the Golgi membrane
  JOURNAL   J Biol Chem 272 (38), 23851-23858 (1997)
   PUBMED   9295333
REFERENCE   10 (bases 1 to 9016)
  AUTHORS   Fritzler,M.J., Hamel,J.C., Ochs,R.L. and Chan,E.K.
  TITLE     Molecular characterization of two human autoantigens: unique cDNAs
            encoding 95- and 160-kD proteins of a putative family in the Golgi
            complex
  JOURNAL   J Exp Med 178 (1), 49-62 (1993)
   PUBMED   8315394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127070.10 and AC136467.11.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked cisternae (flattened membrane
            sacs). Interactions between the Golgi and microtubules are thought
            to be important for the reorganization of the Golgi after it
            fragments during mitosis. This gene encodes a member of the golgin
            family of proteins which are localized to the Golgi. Its encoded
            protein has been postulated to play a role in nuclear transport and
            Golgi apparatus localization. Several alternatively spliced
            transcript variants that encode different protein isoforms have
            been described for this gene. [provided by RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1205466.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC127070.10        121429-121491
            64-158              AC127070.10        121916-122010
            159-265             AC127070.10        122105-122211
            266-581             AC127070.10        127507-127822
            582-734             AC127070.10        133006-133158
            735-847             AC127070.10        136399-136511
            848-1506            AC127070.10        141269-141927
            1507-1618           AC127070.10        142530-142641
            1619-1925           AC127070.10        144796-145102
            1926-2128           AC127070.10        147849-148051
            2129-2266           AC127070.10        151341-151478
            2267-2428           AC127070.10        153118-153279
            2429-2797           AC127070.10        153598-153966
            2798-2875           AC127070.10        158525-158602
            2876-3139           AC127070.10        160528-160791
            3140-3234           AC127070.10        163031-163125
            3235-3451           AC127070.10        163263-163479
            3452-3595           AC127070.10        165511-165654
            3596-3793           AC127070.10        167325-167522
            3794-3910           AC127070.10        168904-169020
            3911-4050           AC127070.10        172013-172152
            4051-4183           AC127070.10        172728-172860
            4184-4306           AC127070.10        173062-173184
            4307-4471           AC127070.10        174513-174677
            4472-4635           AC127070.10        175498-175661
            4636-7125           AC127070.10        176524-179013
            7126-9016           AC136467.11        21967-23857         c
FEATURES             Location/Qualifiers
     source          1..9016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..9016
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="golgin A3"
                     /db_xref="GeneID:2802"
                     /db_xref="HGNC:HGNC:4426"
                     /db_xref="MIM:602581"
     exon            1..63
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            64..158
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            159..265
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..581
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..4825
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="isoform 3 is encoded by transcript variant 8; golgi
                     autoantigen, golgin subfamily a, 3; SY2/SY10 protein;
                     Golgi peripheral membrane protein; Golgi membrane
                     associated protein; golgin subfamily A member 3;
                     golgin-165; golgin-160; male enhanced antigen-2; golgi
                     complex-associated protein of 170 kDa"
                     /codon_start=1
                     /product="golgin subfamily A member 3 isoform 3"
                     /protein_id="NP_001376617.1"
                     /db_xref="CCDS:CCDS91785.1"
                     /db_xref="GeneID:2802"
                     /db_xref="HGNC:HGNC:4426"
                     /db_xref="MIM:602581"
                     /translation="MDGASAEQDGLQEDRSHSGPSSLPEAPLKPPGPLVPPDQQDKVQ
                     CAEVNRASTEGESPDGPGQGGLCQNGPTPPFPDPPSSLDPTTSPVGPDASPGSTDSPL
                     PLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPR
                     ASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGN
                     SGGNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSD
                     SSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQD
                     QGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQAL
                     KEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNM
                     LEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQ
                     QVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQ
                     AGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKT
                     MVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDL
                     MKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEA
                     ALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQM
                     QKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRT
                     AEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANE
                     ALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQE
                     ALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIA
                     LTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSN
                     AALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKE
                     KVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIRE
                     GKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS
                     LKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNM
                     KTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPP
                     AVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGH
                     AGPRGDPQRHSQSRASKEGPGE"
     exon            582..734
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..847
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1506
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1618
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1925
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2128
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2266
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2428
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2797
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2875
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3139
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3234
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3451
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3595
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3793
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3910
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4050
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4051..4183
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4306
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4471
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4635
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4636..9016
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8994..8999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="hexamer: AATAAA"
     polyA_site      9016
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctggcc gacttgtctt cattccaggt ggccagagcg agtggggccg ggcgttgtca
       61 cggagactgg gtgtgttgct gtattgccca ggctggtgtg gaactcctgg cctcaagcga
      121 tcctcccacc ccagcctccc aaagtgctgg tgttacaggc agtatacctt aaatggcaag
      181 aaggaaataa atcatctgac atcactcaga ttgaagagga gctttttttc ccccgattgc
      241 cttaagaagt agcatacttt cccaagtatc atgatattag ctggtttgac atcaagtcat
      301 ttgtgagtca tcagatcttc tcctgaaaat gggagacaca gtagggcccc tcccaggagc
      361 tcttggctgt tgctgatggc agaagccaag cttgtccaag gttcacttgt agcccctcag
      421 cgtcagctca gctggtgtcg tcctgaccat ggacggcgcg tcggccgagc aagatggcct
      481 ccaggaggac agatcccaca gtggcccctc gtctctcccc gaggccccac tgaagccccc
      541 gggcccactg gtgccacctg accagcagga caaagtccag tgtgccgagg taaacagagc
      601 atccacggaa ggggaaagcc cggatggacc tggccaggga ggcctctgtc agaacgggcc
      661 aacgccaccc ttcccagacc ctccgtcgtc tctcgatccc accacaagcc cagtgggccc
      721 tgatgcctct ccaggctcta cagattctcc cctgcccctg gagaaggagg agcaggtccg
      781 acttcaggct cggaagtggc tggaagagca gctcaaacag tacagggtga agcgccagca
      841 ggagaggtcc agtcaacctg caaccaaaac gagacttttt agcacgcttg atcctgagct
      901 catgttaaac ccagaaaact taccaagggc cagtaccctg gctatgacaa aagaatattc
      961 cttcctgcgc accagtgtcc ctcgggggcc taaggtgggc agcctggggc ttccggcaca
     1021 tcctagggag aaaaaaactt ccaaatcaag caaaatccgg tctctggccg attacagaac
     1081 tgaagattca aatgcgggga attctggggg aaatgtcccg gctcccgatt ctaccaaggg
     1141 ttccctgaag cagaacagaa gcagtgcggc gtccgttgtg tctgagatca gcctgtcccc
     1201 cgacactgac gaccgtctgg agaacacctc cctggctgga gacagcgtgt ctgaggtgga
     1261 tggaaatgac agcgacagct catcgtacag cagcgcctcc acccgaggga cctatggcat
     1321 tctgtcgaag acagtgggca cgcaggacac cccctatatg gtcaacggcc aggagattcc
     1381 tgcggatacc ctgggccagt tcccctccat taaggacgtc ctccaggccg cagccgctga
     1441 gcaccaagac caggggcagg aggtcaacgg ggaggtgcgg agtcggagag acagcatctg
     1501 cagcagcgtg tccttggaga gctctgcagc agaaacacag gaggagatgc tgcaggtgct
     1561 caaagagaaa atgcgactcg aaggacagct ggaagccttg tcactggagg cgagtcaggc
     1621 acttaaagag aaggctgagc tgcaggccca gctggccgcc ctcagcacga agctgcaggc
     1681 gcaggtggag tgcagccaca gcagccagca gcggcaggat tcgctgagct cggaggtgga
     1741 caccctgaag cagtcgtgct gggacctgga gcgagccatg actgacctgc agaacatgct
     1801 ggaggcaaaa aatgccagcc tggcgtcgtc caacaacgac ttgcaggtgg ccgaggagca
     1861 gtaccagagg cttatggcca aggtagagga catgcagagg agcatgctca gcaaggacaa
     1921 cacagtgcac gacctgcgac agcagatgac agccttgcag agccagcttc agcaggtgca
     1981 gctggagcgg acgacgctga ccagcaagct gaaggcgtcg caggcggaga tctcgtccct
     2041 gcagagtgtc cggcagtggt accagcagca gctcgccctg gcacaggagg cccgcgtcag
     2101 gctgcagggt gagatggccc acatccaggt tggacagatg acccaggcag gtctcctgga
     2161 gcacctgaaa ctcgagaatg tgtccctgtc ccagcagctg acggaaactc agcacaggtc
     2221 catgaaggag aaggggcgca tcgcggcaca gctgcagggc attgaggctg acatgttgga
     2281 tcaggaagca gccttcatgc agattcagga ggcaaagacg atggtggagg aggaccttca
     2341 gaggaggctg gaagagtttg aaggtgagag ggagcggctg cagaggatgg cggactcggc
     2401 ggcatccctg gagcagcagc tggagcaggt gaagttgact ttactccagc gagaccagca
     2461 gcttgaggct ttgcagcagg agcacctgga cctgatgaaa cagctcacct tgactcagga
     2521 ggctctgcag agcagggagc agtccctcga tgccctgcag acacactacg atgagctgca
     2581 ggccaggctg ggggagctgc agggcgaggc cgcctccagg gaggacacga tctgcctcct
     2641 gcagaacgag aagatcatct tggaggcggc tttgcaggcg gccaagagtg gcaaggagga
     2701 gcttgacaga ggagcaagac gcttggaaga aggtaccgag gaaacgtcgg aaactttaga
     2761 gaagttaaga gaagaattag ctatcaaatc cggccaggtg gaacacctgc agcaggagac
     2821 tgctgctctg aaaaagcaaa tgcaaaaaat aaaggaacag tttctccaac aaaaggtgat
     2881 ggtggaggcc taccggcgcg acgccacctc caaagaccag ctcatcagtg agctgaaagc
     2941 caccaggaag aggctggact cggagctgaa ggagctgcgg caggagctga tgcaagtgca
     3001 cggggagaag cggactgccg aggcggagct ctcgcgcctg cacagagagg tggcccaggt
     3061 ccgtcagcac atggcggacc ttgaagggca tctccagtcg gcgcagaagg agcgagacga
     3121 gatggaaaca cacttgcagt cgttgcagtt cgataaggag cagatggtcg cggtcacaga
     3181 ggccaatgag gcgctgaaga aacaaatcga agagttgcag caagaggccc ggaaggccat
     3241 cacggaacag aagcagaaga tgaggcggct gggctcagac ttgaccagcg cccagaagga
     3301 gatgaagacc aaacataagg cctacgagaa cgccgtgggc atcctcagcc gccgcctgca
     3361 ggaggccctc gcggccaagg aggctgcgga cgcggagctg ggccagctcc gagcccaggg
     3421 tggcagcagt gacagcagcc tggctctaca tgaaaggatc caggccctgg aggcggagct
     3481 gcaggctgtc agtcatagca agacgctgct ggaaaaggaa ctgcaggagg tcatagcgct
     3541 gaccagccag gagctggagg agtcccggga gaaggtgctg gagctggagg acgagcttca
     3601 agaatccaga ggctttagga agaagataaa acgccttgag gagtcaaaca agaagttggc
     3661 tcttgaatta gagcacgaga aagggaagct tacgggcctc ggtcagtcca acgcagctct
     3721 gcgggaacac aacagcatcc tagaaacagc tttggccaag agggaggcag acctagtcca
     3781 gttgaacctt caggtgcagg cagttttgca gcgcaaagaa gaggaggatc gccagatgaa
     3841 gcatcttgtc caggccctgc aggcctcact agagaaggag aaggagaagg tgaacagcct
     3901 caaggagcag gtggctgctg ccaaggtgga agccgggcat aaccgccgcc acttcaaggc
     3961 ggcctccttg gagctgagtg aggtgaagaa ggagctgcag gccaaggaac acctggtgca
     4021 gaagctgcag gccgaggccg acgaccttca gattcgggag gggaaacatt cccaggagat
     4081 agcacagttc caagcagagc tggccgaggc ccgggcacag ctccagctcc tgcagaagca
     4141 gctggacgag cagctcagca aacagcccgt gggaaaccaa gagatggaaa atctcaaatg
     4201 ggaggtggat cagaaagaaa gagaaatcca gtccttgaag cagcagctgg acttgacgga
     4261 gcagcagggc aggaaggaac tggaagggct acagcagctg ctgcagaacg tcaagtctga
     4321 gttggagatg gcccaggaag acctgtccat gacccagaag gataaattta tgctccaggc
     4381 aaaagtgtcg gagctgaaga acaacatgaa gaccctgctc cagcagaacc agcagctcaa
     4441 gctggaccta cgccgcggcg cggccaagac gagaaaggag ccgaaaggcg aggccagctc
     4501 ttccaaccct gccacgccca tcaagatccc ggactgccca gttcccgcct cgctgctgga
     4561 ggagctgctg agaccaccgc ccgccgtgag caaggagccc ctcaagaacc tgaacagctg
     4621 cctccagcag ctcaagcagg agatggacag cctgcagcgc cagatggagg agcacgccct
     4681 gacggtgcac gagtctctgt cctcgtggac gccgctggag ccagccactg ccagccctgt
     4741 gcccccgggg ggtcacgccg gcccacgcgg cgacccacag agacacagtc agagcagggc
     4801 ttccaaagaa gggccgggag agtgactgct gtggactcgc ctccgtgcgc cgctgcccca
     4861 gaaggctctt atcaatgtta tttatttgat tgtgtggtcg atgtttttct aagacatgaa
     4921 atttaagttt tgttttgcct ttaacaagaa gtaaaatata tagcagaatg agagccaagg
     4981 actagaaaaa cattcgaaga tcacaattag cttttcacat ggaatgacca actcttaaaa
     5041 gcctgatagg ctctcggcga ggagctttga acgtgtctga agggttactt gtaggtcgtg
     5101 gcttctgagc ggccaccgat gctgctctct gcgggtgaca gggagaggct gcgtaactgg
     5161 gagcagctgt gtgacagggt ctgcggcacc gcgcctggcc aggccggctg cagtttctca
     5221 cttccctgtt ccattcagta agagctttac ttttccgcag aaatgaaatt ttatctgtac
     5281 ctttggcttt ttacttgttt ttttggatag ccatcccacc ataggatgtg tacatagata
     5341 ctgaatatca taatccaatc tttgtttttt tttttttttt ttttttgaga cagagtctcg
     5401 ctttgttgcc caggctggag tgcagtggca cactctccgc tcactgcaag ctccgcctcc
     5461 caggttcatg cgattctcct gcctcagcct ctcgagtagc tgggattaca ggcgtgcgcc
     5521 actatgccag gctaatgttt gtatttttag tagcaatggg gtttcaccat gttggccagg
     5581 atggtctcga tctcctgacc tcaagtgatc tgcccatctc agcctcccaa agtgctggga
     5641 ttacaggcgt gagcccctgc gcccggcctg tcacccagtc tttaagaagc atatgctcat
     5701 gttattgaag aagaacctac ttattattga ttgccttttg aaaatttgtt gggaataatt
     5761 tacctgcagg atttagggat agtcagaaaa ttctaagaaa tataattatt ttatttacct
     5821 tctaaagcca aatattctta cacagaaagg tcctctgttg ttctggtttt actttgttgc
     5881 tgaggatctt tccttcctgc tggtctcttc ctctcaggcc actggccctg tgtgattcca
     5941 ccgtggctgg ccactgggaa ggggcagctt ggacccttgg tcaggcctga cggccatcag
     6001 gaggcacaag gacactgagg ccccatatct gatctgacct ttgggggggc acagggagag
     6061 gccggtggag gaggaggagg agagcagacc aggggctccc tgcagcgact cccgcggttt
     6121 cccctggagt cagccaggtg taggtcgcag gcggtaacaa acctcacact cctgttcccc
     6181 aagtgaaaat ctttaccatt gtctgtggga gcgcctgtac tcgtgtgtag gagcacctgt
     6241 acttctgcag tcatcgagaa gtcctggatc ttttgtggtt acaccagcat catgtggcaa
     6301 gcagaggcga cttccggaag agacaggcag gcaccgtgag gaaggtggct gtgctctccc
     6361 aggtgtctca gagacagatg ccttatttaa aatcagcacg acatgtgtga gatcttctgt
     6421 ttcctacccc aaatcctgaa accctgcaga cactggctga ctgggagagg tggggtctgt
     6481 aagttgtccc ctagtttgct aagaaaatct aaaataatat ttattatatg agttaggaga
     6541 gagagaatgg gtccgcgtgg cctcctctgc agatgtactg gtctgaaatg aggttctgag
     6601 tcactggcca ggccagatgt gctcatgtcg gtgtctggtg tctgttttgt ggagaaaaca
     6661 gtatggtgtg ttttaagcta tttgtgttct gttgtaatat acttttagaa ggttaattgg
     6721 taaggttaag gtagcattaa ccacaaagat gtttggtatt taaaaaatat tctctagcaa
     6781 atattggaat ttccaaaata tatcatttgt acagggttaa ttttgaaata atacttgaaa
     6841 atttcattat aaatatatcc tactttttat cttaagttga agatgttatt tactaaattg
     6901 ttcttgtacc attagaaaaa aaaatacggc aatttacgtt cttatttatt ttggctgtac
     6961 tacccctttg ttttaatttt aaaatcaaga aatcgggccg ggcgcggtgg ctcatgcctg
     7021 taatcccagc actttgggag gccgaggcgg gtggatcacc tgaggtcaag aggtccagac
     7081 catcctggcc aacatggcaa aaccccgtct ttactaaaca tacaaaaatt agccgggtgt
     7141 cgtagtgcgc acctataatc ccagctactt gggaggctga ggcaggagaa tcacttgaac
     7201 ccaggaggcg gagcttgcag tgagccgaga tcgcgccact gccctccagc ctgggcaaca
     7261 gagcgagact ccgtctcaaa aataaataaa tgattttaaa aaatctaaaa tcgagaaatc
     7321 acacattcag tggggagcga cttctccttg cttatgggaa gtcctcaagt gagtgatgtt
     7381 caccatgtat ttttttttct cttaggacag actaattctg aaaataccga aggaaaagta
     7441 gctctatgtt ctcaccccgg ttttcctgcg tgtgtgccct tgggtgcgat gcctccccca
     7501 gcgctctgtg gtcgccggtg ccagggcccc ctctggtttg gcagggcctg gctgcctttg
     7561 ctccctgcag tgagtctttt ggtgttttca tgcacggctt gtgcttctgg atctgaggcc
     7621 tctcgtgttc acgcggacac ttccttcctt aagaagacgc ctaaaagagg aagttggaat
     7681 tttttttttt tttttttgag acagagtctc gctctgtcgc ccaggctgga gtgcagtggc
     7741 gtgatctctg ctcactgcaa gctccgccat ctgggttcaa gcgattctcc tgcctcattc
     7801 tccccagtag ctgggattac aggtgcccgc caccacacca gcctaatttt tgtattttta
     7861 gaggggtgga gttccaccat gttggccagg ctggtcttga actcttgacc tcaggtgatc
     7921 ctgagcctca gcctcccaaa gtgctggaat tataggcgtg aaccaccgcc cccggctgca
     7981 gttggatttt taaattgctt ttttttattg ttgaggtttt tttatctcca agggactctc
     8041 ccggcacttc taccttccag agttacttca gtgcataaag tttgaattat tttgttcttg
     8101 tgggcagaag tgggaatgat ggaatatcct cacggaaaag gcagtgaagt tgggagtact
     8161 gcttacaaaa cagggtcacc agtgcattat gtggcgtgtt catccccacg ccgtgtgtca
     8221 cgggctaggg cggcgtgttc atccccacac cgtgtgtcac aacaggctag ggcacttcac
     8281 gatgtcacta cttgtttttc tgatgttcca aaaacaacgt aacttggttt tcatgtgttt
     8341 ttccgtggta tatgtgagat tgatgctacg ggtcttacgg actcacaccc gttcccactc
     8401 tctgcaatat ggatcaggca gtgtttctga taggatgtga aatggactct cctcgggtgg
     8461 gtccagcagg ggccctgccc accagaacac agtccgtgct gtgctgcgct aaggagctgg
     8521 ccctcaactc tccttggtgc agggttccca caaccgagtt ctagttccct gaggtcttta
     8581 aaaacaaaaa cagaatgttg tacgtgaaga ttctaggagg ggagggacca gcaaatctga
     8641 gagaaccgtc ctggggcctc ccttcgagga gccctctgat gtgaggaggg acttgagttg
     8701 agtgacgctg tggtgtgagg tgttctgagc tcactgaccg gaaggtccag gtgaatctcg
     8761 tcataagtga tctcaggctc tcacaggatc cggagggaaa tgtgttagag ggtctggaaa
     8821 attcagtgct tttgagttac ttgtttttat taaaaatttc ctcacaaaag agagtcctca
     8881 agttgtggct gttcttggga aaggggtcac cgtgtctgac aaagtgtaac tttaaaaagc
     8941 acgttgattt tttacaaatg taagtgtgct tgggaattcc ttaaattttg tgcaataaac
     9001 tattttttgg taaaga
//
