LOCUS       NM_001389685            9140 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens golgin A3 (GOLGA3), transcript variant 5, mRNA.
ACCESSION   NM_001389685 XM_024448939
VERSION     NM_001389685.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9140)
  AUTHORS   Shamseldin,H.E., Al Mogarri,I., Alqwaiee,M.M., Alharbi,A.S.,
            Baqais,K., AlSaadi,M., AlAnzi,T., Alhashem,A., Saghier,A.,
            Ameen,W., Ibrahim,N., Yang,J., Abdulwahab,F., Hashem,M.,
            Chivukula,R.R. and Alkuraya,F.S.
  TITLE     An exome-first approach to aid in the diagnosis of primary ciliary
            dyskinesia
  JOURNAL   Hum Genet 139 (10), 1273-1283 (2020)
   PUBMED   32367404
  REMARK    GeneRIF: An exome-first approach to aid in the diagnosis of primary
            ciliary dyskinesia.
REFERENCE   2  (bases 1 to 9140)
  AUTHORS   Gilbert,C.E., Sztul,E. and Machamer,C.E.
  TITLE     Commonly used trafficking blocks disrupt ARF1 activation and the
            localization and function of specific Golgi proteins
  JOURNAL   Mol Biol Cell 29 (8), 937-947 (2018)
   PUBMED   29467256
  REMARK    GeneRIF: Golgin-160 disperses from Golgi membranes in cells
            subjected to cold temperature. Activated ARF1 can prevent
            cold-induced dispersal of golgin-160.
REFERENCE   3  (bases 1 to 9140)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9140)
  AUTHORS   Ohta,E., Misumi,Y., Sohda,M., Fujiwara,T., Yano,A. and Ikehara,Y.
  TITLE     Identification and characterization of GCP16, a novel acylated
            Golgi protein that interacts with GCP170
  JOURNAL   J Biol Chem 278 (51), 51957-51967 (2003)
   PUBMED   14522980
  REMARK    GeneRIF: results indicate that GCP16 is the acylated membrane
            protein, associated with GCP170, and possibly involved in vesicular
            transport from the Golgi to the cell surface
REFERENCE   5  (bases 1 to 9140)
  AUTHORS   Hicks,S.W. and Machamer,C.E.
  TITLE     The NH2-terminal domain of Golgin-160 contains both Golgi and
            nuclear targeting information
  JOURNAL   J Biol Chem 277 (39), 35833-35839 (2002)
   PUBMED   12130652
  REMARK    GeneRIF: NH2 terminal domain of Golgin 160 has a role in nuclear
            transport and Golgi apparatus localization
REFERENCE   6  (bases 1 to 9140)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
REFERENCE   7  (bases 1 to 9140)
  AUTHORS   Mancini,M., Machamer,C.E., Roy,S., Nicholson,D.W., Thornberry,N.A.,
            Casciola-Rosen,L.A. and Rosen,A.
  TITLE     Caspase-2 is localized at the Golgi complex and cleaves golgin-160
            during apoptosis
  JOURNAL   J Cell Biol 149 (3), 603-612 (2000)
   PUBMED   10791974
REFERENCE   8  (bases 1 to 9140)
  AUTHORS   Barr,F.A.
  TITLE     A novel Rab6-interacting domain defines a family of Golgi-targeted
            coiled-coil proteins
  JOURNAL   Curr Biol 9 (7), 381-384 (1999)
   PUBMED   10209123
REFERENCE   9  (bases 1 to 9140)
  AUTHORS   Misumi,Y., Sohda,M., Yano,A., Fujiwara,T. and Ikehara,Y.
  TITLE     Molecular characterization of GCP170, a 170-kDa protein associated
            with the cytoplasmic face of the Golgi membrane
  JOURNAL   J Biol Chem 272 (38), 23851-23858 (1997)
   PUBMED   9295333
REFERENCE   10 (bases 1 to 9140)
  AUTHORS   Fritzler,M.J., Hamel,J.C., Ochs,R.L. and Chan,E.K.
  TITLE     Molecular characterization of two human autoantigens: unique cDNAs
            encoding 95- and 160-kD proteins of a putative family in the Golgi
            complex
  JOURNAL   J Exp Med 178 (1), 49-62 (1993)
   PUBMED   8315394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127070.10 and AC136467.11.
            
            On Jan 12, 2021 this sequence version replaced XM_024448939.1.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked cisternae (flattened membrane
            sacs). Interactions between the Golgi and microtubules are thought
            to be important for the reorganization of the Golgi after it
            fragments during mitosis. This gene encodes a member of the golgin
            family of proteins which are localized to the Golgi. Its encoded
            protein has been postulated to play a role in nuclear transport and
            Golgi apparatus localization. Several alternatively spliced
            transcript variants that encode different protein isoforms have
            been described for this gene. [provided by RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2844350.1,
                                           SRR14038195.1596821.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC127070.10        120949-121015
            68-162              AC127070.10        121916-122010
            163-269             AC127070.10        122105-122211
            270-585             AC127070.10        127507-127822
            586-858             AC127070.10        133006-133278
            859-971             AC127070.10        136399-136511
            972-1630            AC127070.10        141269-141927
            1631-1742           AC127070.10        142530-142641
            1743-2049           AC127070.10        144796-145102
            2050-2252           AC127070.10        147849-148051
            2253-2390           AC127070.10        151341-151478
            2391-2552           AC127070.10        153118-153279
            2553-2921           AC127070.10        153598-153966
            2922-2999           AC127070.10        158525-158602
            3000-3263           AC127070.10        160528-160791
            3264-3358           AC127070.10        163031-163125
            3359-3575           AC127070.10        163263-163479
            3576-3719           AC127070.10        165511-165654
            3720-3917           AC127070.10        167325-167522
            3918-4034           AC127070.10        168904-169020
            4035-4174           AC127070.10        172013-172152
            4175-4307           AC127070.10        172728-172860
            4308-4430           AC127070.10        173062-173184
            4431-4595           AC127070.10        174513-174677
            4596-4759           AC127070.10        175498-175661
            4760-7249           AC127070.10        176524-179013
            7250-9140           AC136467.11        21967-23857         c
FEATURES             Location/Qualifiers
     source          1..9140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..9140
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="golgin A3"
                     /db_xref="GeneID:2802"
                     /db_xref="HGNC:HGNC:4426"
                     /db_xref="MIM:602581"
     exon            1..67
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            68..162
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            163..269
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            270..585
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..4949
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="isoform 1 is encoded by transcript variant 5; golgi
                     autoantigen, golgin subfamily a, 3; SY2/SY10 protein;
                     Golgi peripheral membrane protein; Golgi membrane
                     associated protein; golgin subfamily A member 3;
                     golgin-165; golgin-160; male enhanced antigen-2; golgi
                     complex-associated protein of 170 kDa"
                     /codon_start=1
                     /product="golgin subfamily A member 3 isoform 1"
                     /protein_id="NP_001376614.1"
                     /db_xref="CCDS:CCDS9281.1"
                     /db_xref="GeneID:2802"
                     /db_xref="HGNC:HGNC:4426"
                     /db_xref="MIM:602581"
                     /translation="MDGASAEQDGLQEDRSHSGPSSLPEAPLKPPGPLVPPDQQDKVQ
                     CAEVNRASTEGESPDGPGQGGLCQNGPTPPFPDPPSSLDPTTSPVGPDASPGVAGFHD
                     NLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEE
                     QLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPRASTLAMTKEYSFLRTSVP
                     RGPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQN
                     RSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSK
                     TVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICS
                     SVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQ
                     AQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVA
                     EEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQA
                     EISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQL
                     TETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERE
                     RLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSL
                     DALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARR
                     LEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYR
                     RDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQH
                     MADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAIT
                     EQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQ
                     GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELED
                     ELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE
                     ADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGH
                     NRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEAR
                     AQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG
                     LQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGA
                     AKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLK
                     QEMDSLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGHAGPRGDPQRHSQSRASKE
                     GPGE"
     exon            586..858
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..971
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1630
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1742
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..2049
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2252
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2390
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2552
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2921
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..2999
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3263
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3358
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3575
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3719
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..3917
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..4034
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4174
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4307
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4430
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4431..4595
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4596..4759
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4760..9140
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9118..9123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="hexamer: AATAAA"
     polyA_site      9140
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="major polyA site"
ORIGIN      
        1 ctctcacggc cacgtctccg ccggagcatc cgggccgggc ggcctccggg gctgccagag
       61 cagcaggaga ctgggtgtgt tgctgtattg cccaggctgg tgtggaactc ctggcctcaa
      121 gcgatcctcc caccccagcc tcccaaagtg ctggtgttac aggcagtata ccttaaatgg
      181 caagaaggaa ataaatcatc tgacatcact cagattgaag aggagctttt tttcccccga
      241 ttgccttaag aagtagcata ctttcccaag tatcatgata ttagctggtt tgacatcaag
      301 tcatttgtga gtcatcagat cttctcctga aaatgggaga cacagtaggg cccctcccag
      361 gagctcttgg ctgttgctga tggcagaagc caagcttgtc caaggttcac ttgtagcccc
      421 tcagcgtcag ctcagctggt gtcgtcctga ccatggacgg cgcgtcggcc gagcaagatg
      481 gcctccagga ggacagatcc cacagtggcc cctcgtctct ccccgaggcc ccactgaagc
      541 ccccgggccc actggtgcca cctgaccagc aggacaaagt ccagtgtgcc gaggtaaaca
      601 gagcatccac ggaaggggaa agcccggatg gacctggcca gggaggcctc tgtcagaacg
      661 ggccaacgcc acccttccca gaccctccgt cgtctctcga tcccaccaca agcccagtgg
      721 gccctgatgc ctctccaggt gtggctggtt tccatgacaa cctaaggaag tctcagggaa
      781 ctagtgctga gggcagtgtt agaaaagaag ctttgcagtc tctcagactc agtcttccta
      841 tgcaagaaac gcaactgtgc tctacagatt ctcccctgcc cctggagaag gaggagcagg
      901 tccgacttca ggctcggaag tggctggaag agcagctcaa acagtacagg gtgaagcgcc
      961 agcaggagag gtccagtcaa cctgcaacca aaacgagact ttttagcacg cttgatcctg
     1021 agctcatgtt aaacccagaa aacttaccaa gggccagtac cctggctatg acaaaagaat
     1081 attccttcct gcgcaccagt gtccctcggg ggcctaaggt gggcagcctg gggcttccgg
     1141 cacatcctag ggagaaaaaa acttccaaat caagcaaaat ccggtctctg gccgattaca
     1201 gaactgaaga ttcaaatgcg gggaattctg ggggaaatgt cccggctccc gattctacca
     1261 agggttccct gaagcagaac agaagcagtg cggcgtccgt tgtgtctgag atcagcctgt
     1321 cccccgacac tgacgaccgt ctggagaaca cctccctggc tggagacagc gtgtctgagg
     1381 tggatggaaa tgacagcgac agctcatcgt acagcagcgc ctccacccga gggacctatg
     1441 gcattctgtc gaagacagtg ggcacgcagg acacccccta tatggtcaac ggccaggaga
     1501 ttcctgcgga taccctgggc cagttcccct ccattaagga cgtcctccag gccgcagccg
     1561 ctgagcacca agaccagggg caggaggtca acggggaggt gcggagtcgg agagacagca
     1621 tctgcagcag cgtgtccttg gagagctctg cagcagaaac acaggaggag atgctgcagg
     1681 tgctcaaaga gaaaatgcga ctcgaaggac agctggaagc cttgtcactg gaggcgagtc
     1741 aggcacttaa agagaaggct gagctgcagg cccagctggc cgccctcagc acgaagctgc
     1801 aggcgcaggt ggagtgcagc cacagcagcc agcagcggca ggattcgctg agctcggagg
     1861 tggacaccct gaagcagtcg tgctgggacc tggagcgagc catgactgac ctgcagaaca
     1921 tgctggaggc aaaaaatgcc agcctggcgt cgtccaacaa cgacttgcag gtggccgagg
     1981 agcagtacca gaggcttatg gccaaggtag aggacatgca gaggagcatg ctcagcaagg
     2041 acaacacagt gcacgacctg cgacagcaga tgacagcctt gcagagccag cttcagcagg
     2101 tgcagctgga gcggacgacg ctgaccagca agctgaaggc gtcgcaggcg gagatctcgt
     2161 ccctgcagag tgtccggcag tggtaccagc agcagctcgc cctggcacag gaggcccgcg
     2221 tcaggctgca gggtgagatg gcccacatcc aggttggaca gatgacccag gcaggtctcc
     2281 tggagcacct gaaactcgag aatgtgtccc tgtcccagca gctgacggaa actcagcaca
     2341 ggtccatgaa ggagaagggg cgcatcgcgg cacagctgca gggcattgag gctgacatgt
     2401 tggatcagga agcagccttc atgcagattc aggaggcaaa gacgatggtg gaggaggacc
     2461 ttcagaggag gctggaagag tttgaaggtg agagggagcg gctgcagagg atggcggact
     2521 cggcggcatc cctggagcag cagctggagc aggtgaagtt gactttactc cagcgagacc
     2581 agcagcttga ggctttgcag caggagcacc tggacctgat gaaacagctc accttgactc
     2641 aggaggctct gcagagcagg gagcagtccc tcgatgccct gcagacacac tacgatgagc
     2701 tgcaggccag gctgggggag ctgcagggcg aggccgcctc cagggaggac acgatctgcc
     2761 tcctgcagaa cgagaagatc atcttggagg cggctttgca ggcggccaag agtggcaagg
     2821 aggagcttga cagaggagca agacgcttgg aagaaggtac cgaggaaacg tcggaaactt
     2881 tagagaagtt aagagaagaa ttagctatca aatccggcca ggtggaacac ctgcagcagg
     2941 agactgctgc tctgaaaaag caaatgcaaa aaataaagga acagtttctc caacaaaagg
     3001 tgatggtgga ggcctaccgg cgcgacgcca cctccaaaga ccagctcatc agtgagctga
     3061 aagccaccag gaagaggctg gactcggagc tgaaggagct gcggcaggag ctgatgcaag
     3121 tgcacgggga gaagcggact gccgaggcgg agctctcgcg cctgcacaga gaggtggccc
     3181 aggtccgtca gcacatggcg gaccttgaag ggcatctcca gtcggcgcag aaggagcgag
     3241 acgagatgga aacacacttg cagtcgttgc agttcgataa ggagcagatg gtcgcggtca
     3301 cagaggccaa tgaggcgctg aagaaacaaa tcgaagagtt gcagcaagag gcccggaagg
     3361 ccatcacgga acagaagcag aagatgaggc ggctgggctc agacttgacc agcgcccaga
     3421 aggagatgaa gaccaaacat aaggcctacg agaacgccgt gggcatcctc agccgccgcc
     3481 tgcaggaggc cctcgcggcc aaggaggctg cggacgcgga gctgggccag ctccgagccc
     3541 agggtggcag cagtgacagc agcctggctc tacatgaaag gatccaggcc ctggaggcgg
     3601 agctgcaggc tgtcagtcat agcaagacgc tgctggaaaa ggaactgcag gaggtcatag
     3661 cgctgaccag ccaggagctg gaggagtccc gggagaaggt gctggagctg gaggacgagc
     3721 ttcaagaatc cagaggcttt aggaagaaga taaaacgcct tgaggagtca aacaagaagt
     3781 tggctcttga attagagcac gagaaaggga agcttacggg cctcggtcag tccaacgcag
     3841 ctctgcggga acacaacagc atcctagaaa cagctttggc caagagggag gcagacctag
     3901 tccagttgaa ccttcaggtg caggcagttt tgcagcgcaa agaagaggag gatcgccaga
     3961 tgaagcatct tgtccaggcc ctgcaggcct cactagagaa ggagaaggag aaggtgaaca
     4021 gcctcaagga gcaggtggct gctgccaagg tggaagccgg gcataaccgc cgccacttca
     4081 aggcggcctc cttggagctg agtgaggtga agaaggagct gcaggccaag gaacacctgg
     4141 tgcagaagct gcaggccgag gccgacgacc ttcagattcg ggaggggaaa cattcccagg
     4201 agatagcaca gttccaagca gagctggccg aggcccgggc acagctccag ctcctgcaga
     4261 agcagctgga cgagcagctc agcaaacagc ccgtgggaaa ccaagagatg gaaaatctca
     4321 aatgggaggt ggatcagaaa gaaagagaaa tccagtcctt gaagcagcag ctggacttga
     4381 cggagcagca gggcaggaag gaactggaag ggctacagca gctgctgcag aacgtcaagt
     4441 ctgagttgga gatggcccag gaagacctgt ccatgaccca gaaggataaa tttatgctcc
     4501 aggcaaaagt gtcggagctg aagaacaaca tgaagaccct gctccagcag aaccagcagc
     4561 tcaagctgga cctacgccgc ggcgcggcca agacgagaaa ggagccgaaa ggcgaggcca
     4621 gctcttccaa ccctgccacg cccatcaaga tcccggactg cccagttccc gcctcgctgc
     4681 tggaggagct gctgagacca ccgcccgccg tgagcaagga gcccctcaag aacctgaaca
     4741 gctgcctcca gcagctcaag caggagatgg acagcctgca gcgccagatg gaggagcacg
     4801 ccctgacggt gcacgagtct ctgtcctcgt ggacgccgct ggagccagcc actgccagcc
     4861 ctgtgccccc ggggggtcac gccggcccac gcggcgaccc acagagacac agtcagagca
     4921 gggcttccaa agaagggccg ggagagtgac tgctgtggac tcgcctccgt gcgccgctgc
     4981 cccagaaggc tcttatcaat gttatttatt tgattgtgtg gtcgatgttt ttctaagaca
     5041 tgaaatttaa gttttgtttt gcctttaaca agaagtaaaa tatatagcag aatgagagcc
     5101 aaggactaga aaaacattcg aagatcacaa ttagcttttc acatggaatg accaactctt
     5161 aaaagcctga taggctctcg gcgaggagct ttgaacgtgt ctgaagggtt acttgtaggt
     5221 cgtggcttct gagcggccac cgatgctgct ctctgcgggt gacagggaga ggctgcgtaa
     5281 ctgggagcag ctgtgtgaca gggtctgcgg caccgcgcct ggccaggccg gctgcagttt
     5341 ctcacttccc tgttccattc agtaagagct ttacttttcc gcagaaatga aattttatct
     5401 gtacctttgg ctttttactt gtttttttgg atagccatcc caccatagga tgtgtacata
     5461 gatactgaat atcataatcc aatctttgtt tttttttttt tttttttttt gagacagagt
     5521 ctcgctttgt tgcccaggct ggagtgcagt ggcacactct ccgctcactg caagctccgc
     5581 ctcccaggtt catgcgattc tcctgcctca gcctctcgag tagctgggat tacaggcgtg
     5641 cgccactatg ccaggctaat gtttgtattt ttagtagcaa tggggtttca ccatgttggc
     5701 caggatggtc tcgatctcct gacctcaagt gatctgccca tctcagcctc ccaaagtgct
     5761 gggattacag gcgtgagccc ctgcgcccgg cctgtcaccc agtctttaag aagcatatgc
     5821 tcatgttatt gaagaagaac ctacttatta ttgattgcct tttgaaaatt tgttgggaat
     5881 aatttacctg caggatttag ggatagtcag aaaattctaa gaaatataat tattttattt
     5941 accttctaaa gccaaatatt cttacacaga aaggtcctct gttgttctgg ttttactttg
     6001 ttgctgagga tctttccttc ctgctggtct cttcctctca ggccactggc cctgtgtgat
     6061 tccaccgtgg ctggccactg ggaaggggca gcttggaccc ttggtcaggc ctgacggcca
     6121 tcaggaggca caaggacact gaggccccat atctgatctg acctttgggg gggcacaggg
     6181 agaggccggt ggaggaggag gaggagagca gaccaggggc tccctgcagc gactcccgcg
     6241 gtttcccctg gagtcagcca ggtgtaggtc gcaggcggta acaaacctca cactcctgtt
     6301 ccccaagtga aaatctttac cattgtctgt gggagcgcct gtactcgtgt gtaggagcac
     6361 ctgtacttct gcagtcatcg agaagtcctg gatcttttgt ggttacacca gcatcatgtg
     6421 gcaagcagag gcgacttccg gaagagacag gcaggcaccg tgaggaaggt ggctgtgctc
     6481 tcccaggtgt ctcagagaca gatgccttat ttaaaatcag cacgacatgt gtgagatctt
     6541 ctgtttccta ccccaaatcc tgaaaccctg cagacactgg ctgactggga gaggtggggt
     6601 ctgtaagttg tcccctagtt tgctaagaaa atctaaaata atatttatta tatgagttag
     6661 gagagagaga atgggtccgc gtggcctcct ctgcagatgt actggtctga aatgaggttc
     6721 tgagtcactg gccaggccag atgtgctcat gtcggtgtct ggtgtctgtt ttgtggagaa
     6781 aacagtatgg tgtgttttaa gctatttgtg ttctgttgta atatactttt agaaggttaa
     6841 ttggtaaggt taaggtagca ttaaccacaa agatgtttgg tatttaaaaa atattctcta
     6901 gcaaatattg gaatttccaa aatatatcat ttgtacaggg ttaattttga aataatactt
     6961 gaaaatttca ttataaatat atcctacttt ttatcttaag ttgaagatgt tatttactaa
     7021 attgttcttg taccattaga aaaaaaaata cggcaattta cgttcttatt tattttggct
     7081 gtactacccc tttgttttaa ttttaaaatc aagaaatcgg gccgggcgcg gtggctcatg
     7141 cctgtaatcc cagcactttg ggaggccgag gcgggtggat cacctgaggt caagaggtcc
     7201 agaccatcct ggccaacatg gcaaaacccc gtctttacta aacatacaaa aattagccgg
     7261 gtgtcgtagt gcgcacctat aatcccagct acttgggagg ctgaggcagg agaatcactt
     7321 gaacccagga ggcggagctt gcagtgagcc gagatcgcgc cactgccctc cagcctgggc
     7381 aacagagcga gactccgtct caaaaataaa taaatgattt taaaaaatct aaaatcgaga
     7441 aatcacacat tcagtgggga gcgacttctc cttgcttatg ggaagtcctc aagtgagtga
     7501 tgttcaccat gtattttttt ttctcttagg acagactaat tctgaaaata ccgaaggaaa
     7561 agtagctcta tgttctcacc ccggttttcc tgcgtgtgtg cccttgggtg cgatgcctcc
     7621 cccagcgctc tgtggtcgcc ggtgccaggg ccccctctgg tttggcaggg cctggctgcc
     7681 tttgctccct gcagtgagtc ttttggtgtt ttcatgcacg gcttgtgctt ctggatctga
     7741 ggcctctcgt gttcacgcgg acacttcctt ccttaagaag acgcctaaaa gaggaagttg
     7801 gaattttttt tttttttttt tgagacagag tctcgctctg tcgcccaggc tggagtgcag
     7861 tggcgtgatc tctgctcact gcaagctccg ccatctgggt tcaagcgatt ctcctgcctc
     7921 attctcccca gtagctggga ttacaggtgc ccgccaccac accagcctaa tttttgtatt
     7981 tttagagggg tggagttcca ccatgttggc caggctggtc ttgaactctt gacctcaggt
     8041 gatcctgagc ctcagcctcc caaagtgctg gaattatagg cgtgaaccac cgcccccggc
     8101 tgcagttgga tttttaaatt gctttttttt attgttgagg tttttttatc tccaagggac
     8161 tctcccggca cttctacctt ccagagttac ttcagtgcat aaagtttgaa ttattttgtt
     8221 cttgtgggca gaagtgggaa tgatggaata tcctcacgga aaaggcagtg aagttgggag
     8281 tactgcttac aaaacagggt caccagtgca ttatgtggcg tgttcatccc cacgccgtgt
     8341 gtcacgggct agggcggcgt gttcatcccc acaccgtgtg tcacaacagg ctagggcact
     8401 tcacgatgtc actacttgtt tttctgatgt tccaaaaaca acgtaacttg gttttcatgt
     8461 gtttttccgt ggtatatgtg agattgatgc tacgggtctt acggactcac acccgttccc
     8521 actctctgca atatggatca ggcagtgttt ctgataggat gtgaaatgga ctctcctcgg
     8581 gtgggtccag caggggccct gcccaccaga acacagtccg tgctgtgctg cgctaaggag
     8641 ctggccctca actctccttg gtgcagggtt cccacaaccg agttctagtt ccctgaggtc
     8701 tttaaaaaca aaaacagaat gttgtacgtg aagattctag gaggggaggg accagcaaat
     8761 ctgagagaac cgtcctgggg cctcccttcg aggagccctc tgatgtgagg agggacttga
     8821 gttgagtgac gctgtggtgt gaggtgttct gagctcactg accggaaggt ccaggtgaat
     8881 ctcgtcataa gtgatctcag gctctcacag gatccggagg gaaatgtgtt agagggtctg
     8941 gaaaattcag tgcttttgag ttacttgttt ttattaaaaa tttcctcaca aaagagagtc
     9001 ctcaagttgt ggctgttctt gggaaagggg tcaccgtgtc tgacaaagtg taactttaaa
     9061 aagcacgttg attttttaca aatgtaagtg tgcttgggaa ttccttaaat tttgtgcaat
     9121 aaactatttt ttggtaaaga
//
