LOCUS       NM_001389684            8934 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens golgin A3 (GOLGA3), transcript variant 4, mRNA.
ACCESSION   NM_001389684 XM_006719737
VERSION     NM_001389684.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8934)
  AUTHORS   Shamseldin,H.E., Al Mogarri,I., Alqwaiee,M.M., Alharbi,A.S.,
            Baqais,K., AlSaadi,M., AlAnzi,T., Alhashem,A., Saghier,A.,
            Ameen,W., Ibrahim,N., Yang,J., Abdulwahab,F., Hashem,M.,
            Chivukula,R.R. and Alkuraya,F.S.
  TITLE     An exome-first approach to aid in the diagnosis of primary ciliary
            dyskinesia
  JOURNAL   Hum Genet 139 (10), 1273-1283 (2020)
   PUBMED   32367404
  REMARK    GeneRIF: An exome-first approach to aid in the diagnosis of primary
            ciliary dyskinesia.
REFERENCE   2  (bases 1 to 8934)
  AUTHORS   Gilbert,C.E., Sztul,E. and Machamer,C.E.
  TITLE     Commonly used trafficking blocks disrupt ARF1 activation and the
            localization and function of specific Golgi proteins
  JOURNAL   Mol Biol Cell 29 (8), 937-947 (2018)
   PUBMED   29467256
  REMARK    GeneRIF: Golgin-160 disperses from Golgi membranes in cells
            subjected to cold temperature. Activated ARF1 can prevent
            cold-induced dispersal of golgin-160.
REFERENCE   3  (bases 1 to 8934)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8934)
  AUTHORS   Ohta,E., Misumi,Y., Sohda,M., Fujiwara,T., Yano,A. and Ikehara,Y.
  TITLE     Identification and characterization of GCP16, a novel acylated
            Golgi protein that interacts with GCP170
  JOURNAL   J Biol Chem 278 (51), 51957-51967 (2003)
   PUBMED   14522980
  REMARK    GeneRIF: results indicate that GCP16 is the acylated membrane
            protein, associated with GCP170, and possibly involved in vesicular
            transport from the Golgi to the cell surface
REFERENCE   5  (bases 1 to 8934)
  AUTHORS   Hicks,S.W. and Machamer,C.E.
  TITLE     The NH2-terminal domain of Golgin-160 contains both Golgi and
            nuclear targeting information
  JOURNAL   J Biol Chem 277 (39), 35833-35839 (2002)
   PUBMED   12130652
  REMARK    GeneRIF: NH2 terminal domain of Golgin 160 has a role in nuclear
            transport and Golgi apparatus localization
REFERENCE   6  (bases 1 to 8934)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
REFERENCE   7  (bases 1 to 8934)
  AUTHORS   Mancini,M., Machamer,C.E., Roy,S., Nicholson,D.W., Thornberry,N.A.,
            Casciola-Rosen,L.A. and Rosen,A.
  TITLE     Caspase-2 is localized at the Golgi complex and cleaves golgin-160
            during apoptosis
  JOURNAL   J Cell Biol 149 (3), 603-612 (2000)
   PUBMED   10791974
REFERENCE   8  (bases 1 to 8934)
  AUTHORS   Barr,F.A.
  TITLE     A novel Rab6-interacting domain defines a family of Golgi-targeted
            coiled-coil proteins
  JOURNAL   Curr Biol 9 (7), 381-384 (1999)
   PUBMED   10209123
REFERENCE   9  (bases 1 to 8934)
  AUTHORS   Misumi,Y., Sohda,M., Yano,A., Fujiwara,T. and Ikehara,Y.
  TITLE     Molecular characterization of GCP170, a 170-kDa protein associated
            with the cytoplasmic face of the Golgi membrane
  JOURNAL   J Biol Chem 272 (38), 23851-23858 (1997)
   PUBMED   9295333
REFERENCE   10 (bases 1 to 8934)
  AUTHORS   Fritzler,M.J., Hamel,J.C., Ochs,R.L. and Chan,E.K.
  TITLE     Molecular characterization of two human autoantigens: unique cDNAs
            encoding 95- and 160-kD proteins of a putative family in the Golgi
            complex
  JOURNAL   J Exp Med 178 (1), 49-62 (1993)
   PUBMED   8315394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127070.10 and AC136467.11.
            
            On Jan 12, 2021 this sequence version replaced XM_006719737.3.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked cisternae (flattened membrane
            sacs). Interactions between the Golgi and microtubules are thought
            to be important for the reorganization of the Golgi after it
            fragments during mitosis. This gene encodes a member of the golgin
            family of proteins which are localized to the Golgi. Its encoded
            protein has been postulated to play a role in nuclear transport and
            Golgi apparatus localization. Several alternatively spliced
            transcript variants that encode different protein isoforms have
            been described for this gene. [provided by RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.3775044.1,
                                           SRR14038197.2444881.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC127070.10        120737-120799
            64-379              AC127070.10        127507-127822
            380-652             AC127070.10        133006-133278
            653-765             AC127070.10        136399-136511
            766-1424            AC127070.10        141269-141927
            1425-1536           AC127070.10        142530-142641
            1537-1843           AC127070.10        144796-145102
            1844-2046           AC127070.10        147849-148051
            2047-2184           AC127070.10        151341-151478
            2185-2346           AC127070.10        153118-153279
            2347-2715           AC127070.10        153598-153966
            2716-2793           AC127070.10        158525-158602
            2794-3057           AC127070.10        160528-160791
            3058-3152           AC127070.10        163031-163125
            3153-3369           AC127070.10        163263-163479
            3370-3513           AC127070.10        165511-165654
            3514-3711           AC127070.10        167325-167522
            3712-3828           AC127070.10        168904-169020
            3829-3968           AC127070.10        172013-172152
            3969-4101           AC127070.10        172728-172860
            4102-4224           AC127070.10        173062-173184
            4225-4389           AC127070.10        174513-174677
            4390-4553           AC127070.10        175498-175661
            4554-7043           AC127070.10        176524-179013
            7044-8934           AC136467.11        21967-23857         c
FEATURES             Location/Qualifiers
     source          1..8934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..8934
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="golgin A3"
                     /db_xref="GeneID:2802"
                     /db_xref="HGNC:HGNC:4426"
                     /db_xref="MIM:602581"
     exon            1..63
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            64..379
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..4743
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="isoform 1 is encoded by transcript variant 4; golgi
                     autoantigen, golgin subfamily a, 3; SY2/SY10 protein;
                     Golgi peripheral membrane protein; Golgi membrane
                     associated protein; golgin subfamily A member 3;
                     golgin-165; golgin-160; male enhanced antigen-2; golgi
                     complex-associated protein of 170 kDa"
                     /codon_start=1
                     /product="golgin subfamily A member 3 isoform 1"
                     /protein_id="NP_001376613.1"
                     /db_xref="CCDS:CCDS9281.1"
                     /db_xref="GeneID:2802"
                     /db_xref="HGNC:HGNC:4426"
                     /db_xref="MIM:602581"
                     /translation="MDGASAEQDGLQEDRSHSGPSSLPEAPLKPPGPLVPPDQQDKVQ
                     CAEVNRASTEGESPDGPGQGGLCQNGPTPPFPDPPSSLDPTTSPVGPDASPGVAGFHD
                     NLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEE
                     QLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPRASTLAMTKEYSFLRTSVP
                     RGPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQN
                     RSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSK
                     TVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICS
                     SVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQ
                     AQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVA
                     EEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQA
                     EISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQL
                     TETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERE
                     RLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSL
                     DALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARR
                     LEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYR
                     RDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQH
                     MADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAIT
                     EQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQ
                     GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELED
                     ELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE
                     ADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGH
                     NRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEAR
                     AQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG
                     LQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGA
                     AKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLK
                     QEMDSLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGHAGPRGDPQRHSQSRASKE
                     GPGE"
     exon            380..652
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..765
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..1424
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1536
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1843
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2046
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2184
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2346
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2715
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2793
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..3057
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3152
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3369
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3513
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3711
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3828
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..3968
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4101
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4224
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4389
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4390..4553
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4554..8934
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8912..8917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="hexamer: AATAAA"
     polyA_site      8934
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="major polyA site"
ORIGIN      
        1 actagggaaa ggtccgcaaa ctcttaaggt cactttctga aggcggcctc atcacagtcg
       61 gaggtatcat gatattagct ggtttgacat caagtcattt gtgagtcatc agatcttctc
      121 ctgaaaatgg gagacacagt agggcccctc ccaggagctc ttggctgttg ctgatggcag
      181 aagccaagct tgtccaaggt tcacttgtag cccctcagcg tcagctcagc tggtgtcgtc
      241 ctgaccatgg acggcgcgtc ggccgagcaa gatggcctcc aggaggacag atcccacagt
      301 ggcccctcgt ctctccccga ggccccactg aagcccccgg gcccactggt gccacctgac
      361 cagcaggaca aagtccagtg tgccgaggta aacagagcat ccacggaagg ggaaagcccg
      421 gatggacctg gccagggagg cctctgtcag aacgggccaa cgccaccctt cccagaccct
      481 ccgtcgtctc tcgatcccac cacaagccca gtgggccctg atgcctctcc aggtgtggct
      541 ggtttccatg acaacctaag gaagtctcag ggaactagtg ctgagggcag tgttagaaaa
      601 gaagctttgc agtctctcag actcagtctt cctatgcaag aaacgcaact gtgctctaca
      661 gattctcccc tgcccctgga gaaggaggag caggtccgac ttcaggctcg gaagtggctg
      721 gaagagcagc tcaaacagta cagggtgaag cgccagcagg agaggtccag tcaacctgca
      781 accaaaacga gactttttag cacgcttgat cctgagctca tgttaaaccc agaaaactta
      841 ccaagggcca gtaccctggc tatgacaaaa gaatattcct tcctgcgcac cagtgtccct
      901 cgggggccta aggtgggcag cctggggctt ccggcacatc ctagggagaa aaaaacttcc
      961 aaatcaagca aaatccggtc tctggccgat tacagaactg aagattcaaa tgcggggaat
     1021 tctgggggaa atgtcccggc tcccgattct accaagggtt ccctgaagca gaacagaagc
     1081 agtgcggcgt ccgttgtgtc tgagatcagc ctgtcccccg acactgacga ccgtctggag
     1141 aacacctccc tggctggaga cagcgtgtct gaggtggatg gaaatgacag cgacagctca
     1201 tcgtacagca gcgcctccac ccgagggacc tatggcattc tgtcgaagac agtgggcacg
     1261 caggacaccc cctatatggt caacggccag gagattcctg cggataccct gggccagttc
     1321 ccctccatta aggacgtcct ccaggccgca gccgctgagc accaagacca ggggcaggag
     1381 gtcaacgggg aggtgcggag tcggagagac agcatctgca gcagcgtgtc cttggagagc
     1441 tctgcagcag aaacacagga ggagatgctg caggtgctca aagagaaaat gcgactcgaa
     1501 ggacagctgg aagccttgtc actggaggcg agtcaggcac ttaaagagaa ggctgagctg
     1561 caggcccagc tggccgccct cagcacgaag ctgcaggcgc aggtggagtg cagccacagc
     1621 agccagcagc ggcaggattc gctgagctcg gaggtggaca ccctgaagca gtcgtgctgg
     1681 gacctggagc gagccatgac tgacctgcag aacatgctgg aggcaaaaaa tgccagcctg
     1741 gcgtcgtcca acaacgactt gcaggtggcc gaggagcagt accagaggct tatggccaag
     1801 gtagaggaca tgcagaggag catgctcagc aaggacaaca cagtgcacga cctgcgacag
     1861 cagatgacag ccttgcagag ccagcttcag caggtgcagc tggagcggac gacgctgacc
     1921 agcaagctga aggcgtcgca ggcggagatc tcgtccctgc agagtgtccg gcagtggtac
     1981 cagcagcagc tcgccctggc acaggaggcc cgcgtcaggc tgcagggtga gatggcccac
     2041 atccaggttg gacagatgac ccaggcaggt ctcctggagc acctgaaact cgagaatgtg
     2101 tccctgtccc agcagctgac ggaaactcag cacaggtcca tgaaggagaa ggggcgcatc
     2161 gcggcacagc tgcagggcat tgaggctgac atgttggatc aggaagcagc cttcatgcag
     2221 attcaggagg caaagacgat ggtggaggag gaccttcaga ggaggctgga agagtttgaa
     2281 ggtgagaggg agcggctgca gaggatggcg gactcggcgg catccctgga gcagcagctg
     2341 gagcaggtga agttgacttt actccagcga gaccagcagc ttgaggcttt gcagcaggag
     2401 cacctggacc tgatgaaaca gctcaccttg actcaggagg ctctgcagag cagggagcag
     2461 tccctcgatg ccctgcagac acactacgat gagctgcagg ccaggctggg ggagctgcag
     2521 ggcgaggccg cctccaggga ggacacgatc tgcctcctgc agaacgagaa gatcatcttg
     2581 gaggcggctt tgcaggcggc caagagtggc aaggaggagc ttgacagagg agcaagacgc
     2641 ttggaagaag gtaccgagga aacgtcggaa actttagaga agttaagaga agaattagct
     2701 atcaaatccg gccaggtgga acacctgcag caggagactg ctgctctgaa aaagcaaatg
     2761 caaaaaataa aggaacagtt tctccaacaa aaggtgatgg tggaggccta ccggcgcgac
     2821 gccacctcca aagaccagct catcagtgag ctgaaagcca ccaggaagag gctggactcg
     2881 gagctgaagg agctgcggca ggagctgatg caagtgcacg gggagaagcg gactgccgag
     2941 gcggagctct cgcgcctgca cagagaggtg gcccaggtcc gtcagcacat ggcggacctt
     3001 gaagggcatc tccagtcggc gcagaaggag cgagacgaga tggaaacaca cttgcagtcg
     3061 ttgcagttcg ataaggagca gatggtcgcg gtcacagagg ccaatgaggc gctgaagaaa
     3121 caaatcgaag agttgcagca agaggcccgg aaggccatca cggaacagaa gcagaagatg
     3181 aggcggctgg gctcagactt gaccagcgcc cagaaggaga tgaagaccaa acataaggcc
     3241 tacgagaacg ccgtgggcat cctcagccgc cgcctgcagg aggccctcgc ggccaaggag
     3301 gctgcggacg cggagctggg ccagctccga gcccagggtg gcagcagtga cagcagcctg
     3361 gctctacatg aaaggatcca ggccctggag gcggagctgc aggctgtcag tcatagcaag
     3421 acgctgctgg aaaaggaact gcaggaggtc atagcgctga ccagccagga gctggaggag
     3481 tcccgggaga aggtgctgga gctggaggac gagcttcaag aatccagagg ctttaggaag
     3541 aagataaaac gccttgagga gtcaaacaag aagttggctc ttgaattaga gcacgagaaa
     3601 gggaagctta cgggcctcgg tcagtccaac gcagctctgc gggaacacaa cagcatccta
     3661 gaaacagctt tggccaagag ggaggcagac ctagtccagt tgaaccttca ggtgcaggca
     3721 gttttgcagc gcaaagaaga ggaggatcgc cagatgaagc atcttgtcca ggccctgcag
     3781 gcctcactag agaaggagaa ggagaaggtg aacagcctca aggagcaggt ggctgctgcc
     3841 aaggtggaag ccgggcataa ccgccgccac ttcaaggcgg cctccttgga gctgagtgag
     3901 gtgaagaagg agctgcaggc caaggaacac ctggtgcaga agctgcaggc cgaggccgac
     3961 gaccttcaga ttcgggaggg gaaacattcc caggagatag cacagttcca agcagagctg
     4021 gccgaggccc gggcacagct ccagctcctg cagaagcagc tggacgagca gctcagcaaa
     4081 cagcccgtgg gaaaccaaga gatggaaaat ctcaaatggg aggtggatca gaaagaaaga
     4141 gaaatccagt ccttgaagca gcagctggac ttgacggagc agcagggcag gaaggaactg
     4201 gaagggctac agcagctgct gcagaacgtc aagtctgagt tggagatggc ccaggaagac
     4261 ctgtccatga cccagaagga taaatttatg ctccaggcaa aagtgtcgga gctgaagaac
     4321 aacatgaaga ccctgctcca gcagaaccag cagctcaagc tggacctacg ccgcggcgcg
     4381 gccaagacga gaaaggagcc gaaaggcgag gccagctctt ccaaccctgc cacgcccatc
     4441 aagatcccgg actgcccagt tcccgcctcg ctgctggagg agctgctgag accaccgccc
     4501 gccgtgagca aggagcccct caagaacctg aacagctgcc tccagcagct caagcaggag
     4561 atggacagcc tgcagcgcca gatggaggag cacgccctga cggtgcacga gtctctgtcc
     4621 tcgtggacgc cgctggagcc agccactgcc agccctgtgc ccccgggggg tcacgccggc
     4681 ccacgcggcg acccacagag acacagtcag agcagggctt ccaaagaagg gccgggagag
     4741 tgactgctgt ggactcgcct ccgtgcgccg ctgccccaga aggctcttat caatgttatt
     4801 tatttgattg tgtggtcgat gtttttctaa gacatgaaat ttaagttttg ttttgccttt
     4861 aacaagaagt aaaatatata gcagaatgag agccaaggac tagaaaaaca ttcgaagatc
     4921 acaattagct tttcacatgg aatgaccaac tcttaaaagc ctgataggct ctcggcgagg
     4981 agctttgaac gtgtctgaag ggttacttgt aggtcgtggc ttctgagcgg ccaccgatgc
     5041 tgctctctgc gggtgacagg gagaggctgc gtaactggga gcagctgtgt gacagggtct
     5101 gcggcaccgc gcctggccag gccggctgca gtttctcact tccctgttcc attcagtaag
     5161 agctttactt ttccgcagaa atgaaatttt atctgtacct ttggcttttt acttgttttt
     5221 ttggatagcc atcccaccat aggatgtgta catagatact gaatatcata atccaatctt
     5281 tgtttttttt tttttttttt ttttgagaca gagtctcgct ttgttgccca ggctggagtg
     5341 cagtggcaca ctctccgctc actgcaagct ccgcctccca ggttcatgcg attctcctgc
     5401 ctcagcctct cgagtagctg ggattacagg cgtgcgccac tatgccaggc taatgtttgt
     5461 atttttagta gcaatggggt ttcaccatgt tggccaggat ggtctcgatc tcctgacctc
     5521 aagtgatctg cccatctcag cctcccaaag tgctgggatt acaggcgtga gcccctgcgc
     5581 ccggcctgtc acccagtctt taagaagcat atgctcatgt tattgaagaa gaacctactt
     5641 attattgatt gccttttgaa aatttgttgg gaataattta cctgcaggat ttagggatag
     5701 tcagaaaatt ctaagaaata taattatttt atttaccttc taaagccaaa tattcttaca
     5761 cagaaaggtc ctctgttgtt ctggttttac tttgttgctg aggatctttc cttcctgctg
     5821 gtctcttcct ctcaggccac tggccctgtg tgattccacc gtggctggcc actgggaagg
     5881 ggcagcttgg acccttggtc aggcctgacg gccatcagga ggcacaagga cactgaggcc
     5941 ccatatctga tctgaccttt gggggggcac agggagaggc cggtggagga ggaggaggag
     6001 agcagaccag gggctccctg cagcgactcc cgcggtttcc cctggagtca gccaggtgta
     6061 ggtcgcaggc ggtaacaaac ctcacactcc tgttccccaa gtgaaaatct ttaccattgt
     6121 ctgtgggagc gcctgtactc gtgtgtagga gcacctgtac ttctgcagtc atcgagaagt
     6181 cctggatctt ttgtggttac accagcatca tgtggcaagc agaggcgact tccggaagag
     6241 acaggcaggc accgtgagga aggtggctgt gctctcccag gtgtctcaga gacagatgcc
     6301 ttatttaaaa tcagcacgac atgtgtgaga tcttctgttt cctaccccaa atcctgaaac
     6361 cctgcagaca ctggctgact gggagaggtg gggtctgtaa gttgtcccct agtttgctaa
     6421 gaaaatctaa aataatattt attatatgag ttaggagaga gagaatgggt ccgcgtggcc
     6481 tcctctgcag atgtactggt ctgaaatgag gttctgagtc actggccagg ccagatgtgc
     6541 tcatgtcggt gtctggtgtc tgttttgtgg agaaaacagt atggtgtgtt ttaagctatt
     6601 tgtgttctgt tgtaatatac ttttagaagg ttaattggta aggttaaggt agcattaacc
     6661 acaaagatgt ttggtattta aaaaatattc tctagcaaat attggaattt ccaaaatata
     6721 tcatttgtac agggttaatt ttgaaataat acttgaaaat ttcattataa atatatccta
     6781 ctttttatct taagttgaag atgttattta ctaaattgtt cttgtaccat tagaaaaaaa
     6841 aatacggcaa tttacgttct tatttatttt ggctgtacta cccctttgtt ttaattttaa
     6901 aatcaagaaa tcgggccggg cgcggtggct catgcctgta atcccagcac tttgggaggc
     6961 cgaggcgggt ggatcacctg aggtcaagag gtccagacca tcctggccaa catggcaaaa
     7021 ccccgtcttt actaaacata caaaaattag ccgggtgtcg tagtgcgcac ctataatccc
     7081 agctacttgg gaggctgagg caggagaatc acttgaaccc aggaggcgga gcttgcagtg
     7141 agccgagatc gcgccactgc cctccagcct gggcaacaga gcgagactcc gtctcaaaaa
     7201 taaataaatg attttaaaaa atctaaaatc gagaaatcac acattcagtg gggagcgact
     7261 tctccttgct tatgggaagt cctcaagtga gtgatgttca ccatgtattt ttttttctct
     7321 taggacagac taattctgaa aataccgaag gaaaagtagc tctatgttct caccccggtt
     7381 ttcctgcgtg tgtgcccttg ggtgcgatgc ctcccccagc gctctgtggt cgccggtgcc
     7441 agggccccct ctggtttggc agggcctggc tgcctttgct ccctgcagtg agtcttttgg
     7501 tgttttcatg cacggcttgt gcttctggat ctgaggcctc tcgtgttcac gcggacactt
     7561 ccttccttaa gaagacgcct aaaagaggaa gttggaattt tttttttttt tttttgagac
     7621 agagtctcgc tctgtcgccc aggctggagt gcagtggcgt gatctctgct cactgcaagc
     7681 tccgccatct gggttcaagc gattctcctg cctcattctc cccagtagct gggattacag
     7741 gtgcccgcca ccacaccagc ctaatttttg tatttttaga ggggtggagt tccaccatgt
     7801 tggccaggct ggtcttgaac tcttgacctc aggtgatcct gagcctcagc ctcccaaagt
     7861 gctggaatta taggcgtgaa ccaccgcccc cggctgcagt tggattttta aattgctttt
     7921 ttttattgtt gaggtttttt tatctccaag ggactctccc ggcacttcta ccttccagag
     7981 ttacttcagt gcataaagtt tgaattattt tgttcttgtg ggcagaagtg ggaatgatgg
     8041 aatatcctca cggaaaaggc agtgaagttg ggagtactgc ttacaaaaca gggtcaccag
     8101 tgcattatgt ggcgtgttca tccccacgcc gtgtgtcacg ggctagggcg gcgtgttcat
     8161 ccccacaccg tgtgtcacaa caggctaggg cacttcacga tgtcactact tgtttttctg
     8221 atgttccaaa aacaacgtaa cttggttttc atgtgttttt ccgtggtata tgtgagattg
     8281 atgctacggg tcttacggac tcacacccgt tcccactctc tgcaatatgg atcaggcagt
     8341 gtttctgata ggatgtgaaa tggactctcc tcgggtgggt ccagcagggg ccctgcccac
     8401 cagaacacag tccgtgctgt gctgcgctaa ggagctggcc ctcaactctc cttggtgcag
     8461 ggttcccaca accgagttct agttccctga ggtctttaaa aacaaaaaca gaatgttgta
     8521 cgtgaagatt ctaggagggg agggaccagc aaatctgaga gaaccgtcct ggggcctccc
     8581 ttcgaggagc cctctgatgt gaggagggac ttgagttgag tgacgctgtg gtgtgaggtg
     8641 ttctgagctc actgaccgga aggtccaggt gaatctcgtc ataagtgatc tcaggctctc
     8701 acaggatccg gagggaaatg tgttagaggg tctggaaaat tcagtgcttt tgagttactt
     8761 gtttttatta aaaatttcct cacaaaagag agtcctcaag ttgtggctgt tcttgggaaa
     8821 ggggtcaccg tgtctgacaa agtgtaactt taaaaagcac gttgattttt tacaaatgta
     8881 agtgtgcttg ggaattcctt aaattttgtg caataaacta ttttttggta aaga
//
