LOCUS       NM_001389683            8938 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens golgin A3 (GOLGA3), transcript variant 3, mRNA.
ACCESSION   NM_001389683 XM_006719736
VERSION     NM_001389683.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8938)
  AUTHORS   Shamseldin,H.E., Al Mogarri,I., Alqwaiee,M.M., Alharbi,A.S.,
            Baqais,K., AlSaadi,M., AlAnzi,T., Alhashem,A., Saghier,A.,
            Ameen,W., Ibrahim,N., Yang,J., Abdulwahab,F., Hashem,M.,
            Chivukula,R.R. and Alkuraya,F.S.
  TITLE     An exome-first approach to aid in the diagnosis of primary ciliary
            dyskinesia
  JOURNAL   Hum Genet 139 (10), 1273-1283 (2020)
   PUBMED   32367404
  REMARK    GeneRIF: An exome-first approach to aid in the diagnosis of primary
            ciliary dyskinesia.
REFERENCE   2  (bases 1 to 8938)
  AUTHORS   Gilbert,C.E., Sztul,E. and Machamer,C.E.
  TITLE     Commonly used trafficking blocks disrupt ARF1 activation and the
            localization and function of specific Golgi proteins
  JOURNAL   Mol Biol Cell 29 (8), 937-947 (2018)
   PUBMED   29467256
  REMARK    GeneRIF: Golgin-160 disperses from Golgi membranes in cells
            subjected to cold temperature. Activated ARF1 can prevent
            cold-induced dispersal of golgin-160.
REFERENCE   3  (bases 1 to 8938)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8938)
  AUTHORS   Ohta,E., Misumi,Y., Sohda,M., Fujiwara,T., Yano,A. and Ikehara,Y.
  TITLE     Identification and characterization of GCP16, a novel acylated
            Golgi protein that interacts with GCP170
  JOURNAL   J Biol Chem 278 (51), 51957-51967 (2003)
   PUBMED   14522980
  REMARK    GeneRIF: results indicate that GCP16 is the acylated membrane
            protein, associated with GCP170, and possibly involved in vesicular
            transport from the Golgi to the cell surface
REFERENCE   5  (bases 1 to 8938)
  AUTHORS   Hicks,S.W. and Machamer,C.E.
  TITLE     The NH2-terminal domain of Golgin-160 contains both Golgi and
            nuclear targeting information
  JOURNAL   J Biol Chem 277 (39), 35833-35839 (2002)
   PUBMED   12130652
  REMARK    GeneRIF: NH2 terminal domain of Golgin 160 has a role in nuclear
            transport and Golgi apparatus localization
REFERENCE   6  (bases 1 to 8938)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
REFERENCE   7  (bases 1 to 8938)
  AUTHORS   Mancini,M., Machamer,C.E., Roy,S., Nicholson,D.W., Thornberry,N.A.,
            Casciola-Rosen,L.A. and Rosen,A.
  TITLE     Caspase-2 is localized at the Golgi complex and cleaves golgin-160
            during apoptosis
  JOURNAL   J Cell Biol 149 (3), 603-612 (2000)
   PUBMED   10791974
REFERENCE   8  (bases 1 to 8938)
  AUTHORS   Barr,F.A.
  TITLE     A novel Rab6-interacting domain defines a family of Golgi-targeted
            coiled-coil proteins
  JOURNAL   Curr Biol 9 (7), 381-384 (1999)
   PUBMED   10209123
REFERENCE   9  (bases 1 to 8938)
  AUTHORS   Misumi,Y., Sohda,M., Yano,A., Fujiwara,T. and Ikehara,Y.
  TITLE     Molecular characterization of GCP170, a 170-kDa protein associated
            with the cytoplasmic face of the Golgi membrane
  JOURNAL   J Biol Chem 272 (38), 23851-23858 (1997)
   PUBMED   9295333
REFERENCE   10 (bases 1 to 8938)
  AUTHORS   Fritzler,M.J., Hamel,J.C., Ochs,R.L. and Chan,E.K.
  TITLE     Molecular characterization of two human autoantigens: unique cDNAs
            encoding 95- and 160-kD proteins of a putative family in the Golgi
            complex
  JOURNAL   J Exp Med 178 (1), 49-62 (1993)
   PUBMED   8315394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127070.10 and AC136467.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 12, 2021 this sequence version replaced XM_006719736.3.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked cisternae (flattened membrane
            sacs). Interactions between the Golgi and microtubules are thought
            to be important for the reorganization of the Golgi after it
            fragments during mitosis. This gene encodes a member of the golgin
            family of proteins which are localized to the Golgi. Its encoded
            protein has been postulated to play a role in nuclear transport and
            Golgi apparatus localization. Several alternatively spliced
            transcript variants that encode different protein isoforms have
            been described for this gene. [provided by RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.9013.1,
                                           SRR11853567.8244.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450791.8/ ENSP00000410378.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC127070.10        120949-121015
            68-383              AC127070.10        127507-127822
            384-656             AC127070.10        133006-133278
            657-769             AC127070.10        136399-136511
            770-1428            AC127070.10        141269-141927
            1429-1540           AC127070.10        142530-142641
            1541-1847           AC127070.10        144796-145102
            1848-2050           AC127070.10        147849-148051
            2051-2188           AC127070.10        151341-151478
            2189-2350           AC127070.10        153118-153279
            2351-2719           AC127070.10        153598-153966
            2720-2797           AC127070.10        158525-158602
            2798-3061           AC127070.10        160528-160791
            3062-3156           AC127070.10        163031-163125
            3157-3373           AC127070.10        163263-163479
            3374-3517           AC127070.10        165511-165654
            3518-3715           AC127070.10        167325-167522
            3716-3832           AC127070.10        168904-169020
            3833-3972           AC127070.10        172013-172152
            3973-4105           AC127070.10        172728-172860
            4106-4228           AC127070.10        173062-173184
            4229-4393           AC127070.10        174513-174677
            4394-4557           AC127070.10        175498-175661
            4558-7047           AC127070.10        176524-179013
            7048-8938           AC136467.11        21967-23857         c
FEATURES             Location/Qualifiers
     source          1..8938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..8938
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="golgin A3"
                     /db_xref="GeneID:2802"
                     /db_xref="HGNC:HGNC:4426"
                     /db_xref="MIM:602581"
     exon            1..67
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            68..383
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..4747
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="isoform 1 is encoded by transcript variant 3; golgi
                     autoantigen, golgin subfamily a, 3; SY2/SY10 protein;
                     Golgi peripheral membrane protein; Golgi membrane
                     associated protein; golgin subfamily A member 3;
                     golgin-165; golgin-160; male enhanced antigen-2; golgi
                     complex-associated protein of 170 kDa"
                     /codon_start=1
                     /product="golgin subfamily A member 3 isoform 1"
                     /protein_id="NP_001376612.1"
                     /db_xref="CCDS:CCDS9281.1"
                     /db_xref="GeneID:2802"
                     /db_xref="HGNC:HGNC:4426"
                     /db_xref="MIM:602581"
                     /translation="MDGASAEQDGLQEDRSHSGPSSLPEAPLKPPGPLVPPDQQDKVQ
                     CAEVNRASTEGESPDGPGQGGLCQNGPTPPFPDPPSSLDPTTSPVGPDASPGVAGFHD
                     NLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEE
                     QLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPRASTLAMTKEYSFLRTSVP
                     RGPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQN
                     RSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSK
                     TVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICS
                     SVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQ
                     AQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVA
                     EEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQA
                     EISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQL
                     TETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERE
                     RLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSL
                     DALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARR
                     LEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYR
                     RDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQH
                     MADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAIT
                     EQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQ
                     GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELED
                     ELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE
                     ADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGH
                     NRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEAR
                     AQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG
                     LQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGA
                     AKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLK
                     QEMDSLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGHAGPRGDPQRHSQSRASKE
                     GPGE"
     exon            384..656
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..769
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1428
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1540
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1847
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2050
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2188
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2350
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2719
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2797
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..3061
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3156
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3373
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3517
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3715
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3832
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3972
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3973..4105
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4106..4228
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4393
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..4557
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..8938
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8916..8921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="hexamer: AATAAA"
     polyA_site      8938
                     /gene="GOLGA3"
                     /gene_synonym="GCP170; MEA-2"
                     /note="major polyA site"
ORIGIN      
        1 ctctcacggc cacgtctccg ccggagcatc cgggccgggc ggcctccggg gctgccagag
       61 cagcagggta tcatgatatt agctggtttg acatcaagtc atttgtgagt catcagatct
      121 tctcctgaaa atgggagaca cagtagggcc cctcccagga gctcttggct gttgctgatg
      181 gcagaagcca agcttgtcca aggttcactt gtagcccctc agcgtcagct cagctggtgt
      241 cgtcctgacc atggacggcg cgtcggccga gcaagatggc ctccaggagg acagatccca
      301 cagtggcccc tcgtctctcc ccgaggcccc actgaagccc ccgggcccac tggtgccacc
      361 tgaccagcag gacaaagtcc agtgtgccga ggtaaacaga gcatccacgg aaggggaaag
      421 cccggatgga cctggccagg gaggcctctg tcagaacggg ccaacgccac ccttcccaga
      481 ccctccgtcg tctctcgatc ccaccacaag cccagtgggc cctgatgcct ctccaggtgt
      541 ggctggtttc catgacaacc taaggaagtc tcagggaact agtgctgagg gcagtgttag
      601 aaaagaagct ttgcagtctc tcagactcag tcttcctatg caagaaacgc aactgtgctc
      661 tacagattct cccctgcccc tggagaagga ggagcaggtc cgacttcagg ctcggaagtg
      721 gctggaagag cagctcaaac agtacagggt gaagcgccag caggagaggt ccagtcaacc
      781 tgcaaccaaa acgagacttt ttagcacgct tgatcctgag ctcatgttaa acccagaaaa
      841 cttaccaagg gccagtaccc tggctatgac aaaagaatat tccttcctgc gcaccagtgt
      901 ccctcggggg cctaaggtgg gcagcctggg gcttccggca catcctaggg agaaaaaaac
      961 ttccaaatca agcaaaatcc ggtctctggc cgattacaga actgaagatt caaatgcggg
     1021 gaattctggg ggaaatgtcc cggctcccga ttctaccaag ggttccctga agcagaacag
     1081 aagcagtgcg gcgtccgttg tgtctgagat cagcctgtcc cccgacactg acgaccgtct
     1141 ggagaacacc tccctggctg gagacagcgt gtctgaggtg gatggaaatg acagcgacag
     1201 ctcatcgtac agcagcgcct ccacccgagg gacctatggc attctgtcga agacagtggg
     1261 cacgcaggac accccctata tggtcaacgg ccaggagatt cctgcggata ccctgggcca
     1321 gttcccctcc attaaggacg tcctccaggc cgcagccgct gagcaccaag accaggggca
     1381 ggaggtcaac ggggaggtgc ggagtcggag agacagcatc tgcagcagcg tgtccttgga
     1441 gagctctgca gcagaaacac aggaggagat gctgcaggtg ctcaaagaga aaatgcgact
     1501 cgaaggacag ctggaagcct tgtcactgga ggcgagtcag gcacttaaag agaaggctga
     1561 gctgcaggcc cagctggccg ccctcagcac gaagctgcag gcgcaggtgg agtgcagcca
     1621 cagcagccag cagcggcagg attcgctgag ctcggaggtg gacaccctga agcagtcgtg
     1681 ctgggacctg gagcgagcca tgactgacct gcagaacatg ctggaggcaa aaaatgccag
     1741 cctggcgtcg tccaacaacg acttgcaggt ggccgaggag cagtaccaga ggcttatggc
     1801 caaggtagag gacatgcaga ggagcatgct cagcaaggac aacacagtgc acgacctgcg
     1861 acagcagatg acagccttgc agagccagct tcagcaggtg cagctggagc ggacgacgct
     1921 gaccagcaag ctgaaggcgt cgcaggcgga gatctcgtcc ctgcagagtg tccggcagtg
     1981 gtaccagcag cagctcgccc tggcacagga ggcccgcgtc aggctgcagg gtgagatggc
     2041 ccacatccag gttggacaga tgacccaggc aggtctcctg gagcacctga aactcgagaa
     2101 tgtgtccctg tcccagcagc tgacggaaac tcagcacagg tccatgaagg agaaggggcg
     2161 catcgcggca cagctgcagg gcattgaggc tgacatgttg gatcaggaag cagccttcat
     2221 gcagattcag gaggcaaaga cgatggtgga ggaggacctt cagaggaggc tggaagagtt
     2281 tgaaggtgag agggagcggc tgcagaggat ggcggactcg gcggcatccc tggagcagca
     2341 gctggagcag gtgaagttga ctttactcca gcgagaccag cagcttgagg ctttgcagca
     2401 ggagcacctg gacctgatga aacagctcac cttgactcag gaggctctgc agagcaggga
     2461 gcagtccctc gatgccctgc agacacacta cgatgagctg caggccaggc tgggggagct
     2521 gcagggcgag gccgcctcca gggaggacac gatctgcctc ctgcagaacg agaagatcat
     2581 cttggaggcg gctttgcagg cggccaagag tggcaaggag gagcttgaca gaggagcaag
     2641 acgcttggaa gaaggtaccg aggaaacgtc ggaaacttta gagaagttaa gagaagaatt
     2701 agctatcaaa tccggccagg tggaacacct gcagcaggag actgctgctc tgaaaaagca
     2761 aatgcaaaaa ataaaggaac agtttctcca acaaaaggtg atggtggagg cctaccggcg
     2821 cgacgccacc tccaaagacc agctcatcag tgagctgaaa gccaccagga agaggctgga
     2881 ctcggagctg aaggagctgc ggcaggagct gatgcaagtg cacggggaga agcggactgc
     2941 cgaggcggag ctctcgcgcc tgcacagaga ggtggcccag gtccgtcagc acatggcgga
     3001 ccttgaaggg catctccagt cggcgcagaa ggagcgagac gagatggaaa cacacttgca
     3061 gtcgttgcag ttcgataagg agcagatggt cgcggtcaca gaggccaatg aggcgctgaa
     3121 gaaacaaatc gaagagttgc agcaagaggc ccggaaggcc atcacggaac agaagcagaa
     3181 gatgaggcgg ctgggctcag acttgaccag cgcccagaag gagatgaaga ccaaacataa
     3241 ggcctacgag aacgccgtgg gcatcctcag ccgccgcctg caggaggccc tcgcggccaa
     3301 ggaggctgcg gacgcggagc tgggccagct ccgagcccag ggtggcagca gtgacagcag
     3361 cctggctcta catgaaagga tccaggccct ggaggcggag ctgcaggctg tcagtcatag
     3421 caagacgctg ctggaaaagg aactgcagga ggtcatagcg ctgaccagcc aggagctgga
     3481 ggagtcccgg gagaaggtgc tggagctgga ggacgagctt caagaatcca gaggctttag
     3541 gaagaagata aaacgccttg aggagtcaaa caagaagttg gctcttgaat tagagcacga
     3601 gaaagggaag cttacgggcc tcggtcagtc caacgcagct ctgcgggaac acaacagcat
     3661 cctagaaaca gctttggcca agagggaggc agacctagtc cagttgaacc ttcaggtgca
     3721 ggcagttttg cagcgcaaag aagaggagga tcgccagatg aagcatcttg tccaggccct
     3781 gcaggcctca ctagagaagg agaaggagaa ggtgaacagc ctcaaggagc aggtggctgc
     3841 tgccaaggtg gaagccgggc ataaccgccg ccacttcaag gcggcctcct tggagctgag
     3901 tgaggtgaag aaggagctgc aggccaagga acacctggtg cagaagctgc aggccgaggc
     3961 cgacgacctt cagattcggg aggggaaaca ttcccaggag atagcacagt tccaagcaga
     4021 gctggccgag gcccgggcac agctccagct cctgcagaag cagctggacg agcagctcag
     4081 caaacagccc gtgggaaacc aagagatgga aaatctcaaa tgggaggtgg atcagaaaga
     4141 aagagaaatc cagtccttga agcagcagct ggacttgacg gagcagcagg gcaggaagga
     4201 actggaaggg ctacagcagc tgctgcagaa cgtcaagtct gagttggaga tggcccagga
     4261 agacctgtcc atgacccaga aggataaatt tatgctccag gcaaaagtgt cggagctgaa
     4321 gaacaacatg aagaccctgc tccagcagaa ccagcagctc aagctggacc tacgccgcgg
     4381 cgcggccaag acgagaaagg agccgaaagg cgaggccagc tcttccaacc ctgccacgcc
     4441 catcaagatc ccggactgcc cagttcccgc ctcgctgctg gaggagctgc tgagaccacc
     4501 gcccgccgtg agcaaggagc ccctcaagaa cctgaacagc tgcctccagc agctcaagca
     4561 ggagatggac agcctgcagc gccagatgga ggagcacgcc ctgacggtgc acgagtctct
     4621 gtcctcgtgg acgccgctgg agccagccac tgccagccct gtgcccccgg ggggtcacgc
     4681 cggcccacgc ggcgacccac agagacacag tcagagcagg gcttccaaag aagggccggg
     4741 agagtgactg ctgtggactc gcctccgtgc gccgctgccc cagaaggctc ttatcaatgt
     4801 tatttatttg attgtgtggt cgatgttttt ctaagacatg aaatttaagt tttgttttgc
     4861 ctttaacaag aagtaaaata tatagcagaa tgagagccaa ggactagaaa aacattcgaa
     4921 gatcacaatt agcttttcac atggaatgac caactcttaa aagcctgata ggctctcggc
     4981 gaggagcttt gaacgtgtct gaagggttac ttgtaggtcg tggcttctga gcggccaccg
     5041 atgctgctct ctgcgggtga cagggagagg ctgcgtaact gggagcagct gtgtgacagg
     5101 gtctgcggca ccgcgcctgg ccaggccggc tgcagtttct cacttccctg ttccattcag
     5161 taagagcttt acttttccgc agaaatgaaa ttttatctgt acctttggct ttttacttgt
     5221 ttttttggat agccatccca ccataggatg tgtacataga tactgaatat cataatccaa
     5281 tctttgtttt tttttttttt ttttttttga gacagagtct cgctttgttg cccaggctgg
     5341 agtgcagtgg cacactctcc gctcactgca agctccgcct cccaggttca tgcgattctc
     5401 ctgcctcagc ctctcgagta gctgggatta caggcgtgcg ccactatgcc aggctaatgt
     5461 ttgtattttt agtagcaatg gggtttcacc atgttggcca ggatggtctc gatctcctga
     5521 cctcaagtga tctgcccatc tcagcctccc aaagtgctgg gattacaggc gtgagcccct
     5581 gcgcccggcc tgtcacccag tctttaagaa gcatatgctc atgttattga agaagaacct
     5641 acttattatt gattgccttt tgaaaatttg ttgggaataa tttacctgca ggatttaggg
     5701 atagtcagaa aattctaaga aatataatta ttttatttac cttctaaagc caaatattct
     5761 tacacagaaa ggtcctctgt tgttctggtt ttactttgtt gctgaggatc tttccttcct
     5821 gctggtctct tcctctcagg ccactggccc tgtgtgattc caccgtggct ggccactggg
     5881 aaggggcagc ttggaccctt ggtcaggcct gacggccatc aggaggcaca aggacactga
     5941 ggccccatat ctgatctgac ctttgggggg gcacagggag aggccggtgg aggaggagga
     6001 ggagagcaga ccaggggctc cctgcagcga ctcccgcggt ttcccctgga gtcagccagg
     6061 tgtaggtcgc aggcggtaac aaacctcaca ctcctgttcc ccaagtgaaa atctttacca
     6121 ttgtctgtgg gagcgcctgt actcgtgtgt aggagcacct gtacttctgc agtcatcgag
     6181 aagtcctgga tcttttgtgg ttacaccagc atcatgtggc aagcagaggc gacttccgga
     6241 agagacaggc aggcaccgtg aggaaggtgg ctgtgctctc ccaggtgtct cagagacaga
     6301 tgccttattt aaaatcagca cgacatgtgt gagatcttct gtttcctacc ccaaatcctg
     6361 aaaccctgca gacactggct gactgggaga ggtggggtct gtaagttgtc ccctagtttg
     6421 ctaagaaaat ctaaaataat atttattata tgagttagga gagagagaat gggtccgcgt
     6481 ggcctcctct gcagatgtac tggtctgaaa tgaggttctg agtcactggc caggccagat
     6541 gtgctcatgt cggtgtctgg tgtctgtttt gtggagaaaa cagtatggtg tgttttaagc
     6601 tatttgtgtt ctgttgtaat atacttttag aaggttaatt ggtaaggtta aggtagcatt
     6661 aaccacaaag atgtttggta tttaaaaaat attctctagc aaatattgga atttccaaaa
     6721 tatatcattt gtacagggtt aattttgaaa taatacttga aaatttcatt ataaatatat
     6781 cctacttttt atcttaagtt gaagatgtta tttactaaat tgttcttgta ccattagaaa
     6841 aaaaaatacg gcaatttacg ttcttattta ttttggctgt actacccctt tgttttaatt
     6901 ttaaaatcaa gaaatcgggc cgggcgcggt ggctcatgcc tgtaatccca gcactttggg
     6961 aggccgaggc gggtggatca cctgaggtca agaggtccag accatcctgg ccaacatggc
     7021 aaaaccccgt ctttactaaa catacaaaaa ttagccgggt gtcgtagtgc gcacctataa
     7081 tcccagctac ttgggaggct gaggcaggag aatcacttga acccaggagg cggagcttgc
     7141 agtgagccga gatcgcgcca ctgccctcca gcctgggcaa cagagcgaga ctccgtctca
     7201 aaaataaata aatgatttta aaaaatctaa aatcgagaaa tcacacattc agtggggagc
     7261 gacttctcct tgcttatggg aagtcctcaa gtgagtgatg ttcaccatgt attttttttt
     7321 ctcttaggac agactaattc tgaaaatacc gaaggaaaag tagctctatg ttctcacccc
     7381 ggttttcctg cgtgtgtgcc cttgggtgcg atgcctcccc cagcgctctg tggtcgccgg
     7441 tgccagggcc ccctctggtt tggcagggcc tggctgcctt tgctccctgc agtgagtctt
     7501 ttggtgtttt catgcacggc ttgtgcttct ggatctgagg cctctcgtgt tcacgcggac
     7561 acttccttcc ttaagaagac gcctaaaaga ggaagttgga attttttttt tttttttttg
     7621 agacagagtc tcgctctgtc gcccaggctg gagtgcagtg gcgtgatctc tgctcactgc
     7681 aagctccgcc atctgggttc aagcgattct cctgcctcat tctccccagt agctgggatt
     7741 acaggtgccc gccaccacac cagcctaatt tttgtatttt tagaggggtg gagttccacc
     7801 atgttggcca ggctggtctt gaactcttga cctcaggtga tcctgagcct cagcctccca
     7861 aagtgctgga attataggcg tgaaccaccg cccccggctg cagttggatt tttaaattgc
     7921 ttttttttat tgttgaggtt tttttatctc caagggactc tcccggcact tctaccttcc
     7981 agagttactt cagtgcataa agtttgaatt attttgttct tgtgggcaga agtgggaatg
     8041 atggaatatc ctcacggaaa aggcagtgaa gttgggagta ctgcttacaa aacagggtca
     8101 ccagtgcatt atgtggcgtg ttcatcccca cgccgtgtgt cacgggctag ggcggcgtgt
     8161 tcatccccac accgtgtgtc acaacaggct agggcacttc acgatgtcac tacttgtttt
     8221 tctgatgttc caaaaacaac gtaacttggt tttcatgtgt ttttccgtgg tatatgtgag
     8281 attgatgcta cgggtcttac ggactcacac ccgttcccac tctctgcaat atggatcagg
     8341 cagtgtttct gataggatgt gaaatggact ctcctcgggt gggtccagca ggggccctgc
     8401 ccaccagaac acagtccgtg ctgtgctgcg ctaaggagct ggccctcaac tctccttggt
     8461 gcagggttcc cacaaccgag ttctagttcc ctgaggtctt taaaaacaaa aacagaatgt
     8521 tgtacgtgaa gattctagga ggggagggac cagcaaatct gagagaaccg tcctggggcc
     8581 tcccttcgag gagccctctg atgtgaggag ggacttgagt tgagtgacgc tgtggtgtga
     8641 ggtgttctga gctcactgac cggaaggtcc aggtgaatct cgtcataagt gatctcaggc
     8701 tctcacagga tccggaggga aatgtgttag agggtctgga aaattcagtg cttttgagtt
     8761 acttgttttt attaaaaatt tcctcacaaa agagagtcct caagttgtgg ctgttcttgg
     8821 gaaaggggtc accgtgtctg acaaagtgta actttaaaaa gcacgttgat tttttacaaa
     8881 tgtaagtgtg cttgggaatt ccttaaattt tgtgcaataa actatttttt ggtaaaga
//
