LOCUS       NM_001389705            3885 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens golgin A2 (GOLGA2), transcript variant 14, mRNA.
ACCESSION   NM_001389705
VERSION     NM_001389705.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3885)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3885)
  AUTHORS   Gao,Q., Liu,G., Huang,L., Zhang,Y., Zhang,X., Song,X. and Xing,X.
  TITLE     WDR38, a novel equatorial segment protein, interacts with the
            GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1561-1570 (2023)
   PUBMED   37635409
  REMARK    GeneRIF: WDR38, a novel equatorial segment protein, interacts with
            the GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis.
REFERENCE   3  (bases 1 to 3885)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   4  (bases 1 to 3885)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   5  (bases 1 to 3885)
  AUTHORS   Li,L., Chen,Y., Liao,W., Yu,Q., Lin,H., Shi,Y., Zhang,L., Fu,G.,
            Wang,Z., Li,X., Kong,X., Zhou,T. and Qin,L.
  TITLE     Associations of IFT20 and GM130 protein expressions with
            clinicopathological features and survival of patients with lung
            adenocarcinoma
  JOURNAL   BMC Cancer 22 (1), 809 (2022)
   PUBMED   35869490
  REMARK    GeneRIF: Associations of IFT20 and GM130 protein expressions with
            clinicopathological features and survival of patients with lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3885)
  AUTHORS   Sohda,M., Misumi,Y., Yano,A., Takami,N. and Ikehara,Y.
  TITLE     Phosphorylation of the vesicle docking protein p115 regulates its
            association with the Golgi membrane
  JOURNAL   J Biol Chem 273 (9), 5385-5388 (1998)
   PUBMED   9478999
REFERENCE   7  (bases 1 to 3885)
  AUTHORS   Barr,F.A., Puype,M., Vandekerckhove,J. and Warren,G.
  TITLE     GRASP65, a protein involved in the stacking of Golgi cisternae
  JOURNAL   Cell 91 (2), 253-262 (1997)
   PUBMED   9346242
REFERENCE   8  (bases 1 to 3885)
  AUTHORS   Nakamura,N., Lowe,M., Levine,T.P., Rabouille,C. and Warren,G.
  TITLE     The vesicle docking protein p115 binds GM130, a cis-Golgi matrix
            protein, in a mitotically regulated manner
  JOURNAL   Cell 89 (3), 445-455 (1997)
   PUBMED   9150144
REFERENCE   9  (bases 1 to 3885)
  AUTHORS   Nakamura,N., Rabouille,C., Watson,R., Nilsson,T., Hui,N.,
            Slusarewicz,P., Kreis,T.E. and Warren,G.
  TITLE     Characterization of a cis-Golgi matrix protein, GM130
  JOURNAL   J Cell Biol 131 (6 Pt 2), 1715-1726 (1995)
   PUBMED   8557739
REFERENCE   10 (bases 1 to 3885)
  AUTHORS   Fritzler,M.J., Hamel,J.C., Ochs,R.L. and Chan,E.K.
  TITLE     Molecular characterization of two human autoantigens: unique cDNAs
            encoding 95- and 160-kD proteins of a putative family in the Golgi
            complex
  JOURNAL   J Exp Med 178 (1), 49-62 (1993)
   PUBMED   8315394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590708.18.
            
            On Jan 13, 2021 this sequence version replaced NM_001389705.1.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked cisternae (flattened membrane
            sacs). Interactions between the Golgi and microtubules are thought
            to be important for the reorganization of the Golgi after it
            fragments during mitosis. This gene encodes one of the golgins, a
            family of proteins localized to the Golgi. This encoded protein has
            been postulated to play roles in the stacking of Golgi cisternae
            and in vesicular transport. Several alternatively spliced
            transcript variants of this gene have been described, but the
            full-length nature of these variants has not been determined.
            [provided by RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AL590708.18        177198-177312       c
            116-238             AL590708.18        175155-175277       c
            239-289             AL590708.18        167275-167325       c
            290-383             AL590708.18        167093-167186       c
            384-490             AL590708.18        166890-166996       c
            491-549             AL590708.18        164339-164397       c
            550-691             AL590708.18        163868-164009       c
            692-781             AL590708.18        162973-163062       c
            782-889             AL590708.18        162759-162866       c
            890-977             AL590708.18        162477-162564       c
            978-1315            AL590708.18        161770-162107       c
            1316-1429           AL590708.18        161381-161494       c
            1430-1654           AL590708.18        160472-160696       c
            1655-1730           AL590708.18        160312-160387       c
            1731-1846           AL590708.18        159760-159875       c
            1847-2065           AL590708.18        159285-159503       c
            2066-2168           AL590708.18        159095-159197       c
            2169-2275           AL590708.18        158906-159012       c
            2276-2432           AL590708.18        158674-158830       c
            2433-3885           AL590708.18        157134-158586       c
FEATURES             Location/Qualifiers
     source          1..3885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..3885
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /note="golgin A2"
                     /db_xref="GeneID:2801"
                     /db_xref="HGNC:HGNC:4425"
                     /db_xref="MIM:602580"
     exon            1..115
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2647
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /note="isoform 13 is encoded by transcript variant 14;
                     golgi autoantigen, golgin subfamily a, 2; Golgi matrix
                     protein GM130; SY11 protein; golgin subfamily A member 2;
                     golgin-95; GM130 autoantigen; 130 kDa cis-Golgi matrix
                     protein"
                     /codon_start=1
                     /product="golgin subfamily A member 2 isoform 13"
                     /protein_id="NP_001376634.2"
                     /db_xref="GeneID:2801"
                     /db_xref="HGNC:HGNC:4425"
                     /db_xref="MIM:602580"
                     /translation="MWPQPRLPPRPAMSEETRQSKLAAAKKKLREYQQRNSPGVPTGA
                     KKKKKIKNGSNPETTTSGGCHSPEDEKKECHQKQGALREQLQVHIQTIGILVSEKAEL
                     QTALAHTQHAARQKEGESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTK
                     ERDALRLELYKNTQSNEDLKQEKSELEEKLRVLVTEKAGMQLNLEELQKKLEMTELLL
                     QQFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVRQLQMERDKYAENLKGESAMW
                     RQRMQQMSEQVHTLREEKECSMSRVQELETSLAELRNQMAEPPPPEPPAGPSEVEQQL
                     QAEAEHLRKELEGLAGQLQAQVQDNEGLSRLNREQEERLLELERAAELWGEQAEARRQ
                     ILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNENMEITSALQSEQHVKRELG
                     KKLGELQEKLSELKETVELKSQEAQSLQQQRDQYLGHLQQYVAAYQQLTSEKEVLHNQ
                     LLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQLSLMAHPGE
                     GDGLDREEEEDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAEEEQARLR
                     GQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAMEKLQSRFM
                     ELMQEKADLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKERHREKEEYISRL
                     AQDKEEMKVKLLELQELVLRLVGDRNEWHGRFLAAAQNPADEPTSGAPAPQELGAANQ
                     QGDLCEVSLAGSVEPAQGEAREGSPRDNPTAQQIMQLLREMQNPRERPGLGSNPCIPF
                     FYRADENDEVKITVI"
     exon            116..238
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            239..289
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            290..383
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            384..490
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            491..549
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            550..691
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            692..781
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            782..889
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            890..977
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1315
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1429
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1654
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1730
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1846
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2065
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2168
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2275
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2432
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..3885
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3866..3871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /note="hexamer: AATAAA"
     polyA_site      3885
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /note="major polyA site"
ORIGIN      
        1 gacttccgca gtggttgccg ggatcgcgct gatgtggccc caaccccgcc tccctccccg
       61 ccccgcgatg tcggaagaaa cccgacagag caaattggcc gcagcgaaga aaaagttgag
      121 agaatatcag cagaggaata gccctggtgt tcctacagga gcgaaaaaga agaagaaaat
      181 aaaaaatggc agtaaccctg agacaaccac ttctggtggt tgccactcac ctgaggatga
      241 aaagaaagaa tgccaccaaa agcagggagc cctaagggag cagttacagg ttcacattca
      301 gaccataggg atcctcgtat cagagaaagc tgagttacag acagccctgg ctcacactca
      361 gcatgctgcc aggcagaaag aaggagagtc tgaagatctg gccagccgcc tgcagtattc
      421 ccggcggcgt gtgggagagt tggagcgggc tctctctgct gtctccacgc agcagaagaa
      481 ggcagacagg tacaacaagg agttaaccaa agagagagac gccctcaggc tggagttata
      541 caagaacacc caaagcaatg aggacctgaa gcaagagaaa tcagaattgg aagagaagct
      601 tcgggtccta gtgactgaga aggctggcat gcagcttaac ttggaagaat tgcaaaagaa
      661 gttagagatg acggaactcc tgcttcaaca gttttcaagc cggtgtgaag cccctgatgc
      721 taaccagcag ttacagcagg ccatggagga gcgggcacag ctggaagcac acctggggca
      781 ggtaatggag tcggttagac aactacaaat ggagagagat aaatatgcgg agaatctcaa
      841 aggagagagc gccatgtggc ggcagaggat gcagcagatg tcagagcagg tgcacacatt
      901 gagagaggag aaggaatgta gcatgagtcg ggtacaggag ctggagacga gcttggctga
      961 actgaggaac cagatggctg aacccccgcc cccagagccc ccagcagggc cctccgaggt
     1021 ggagcagcag ctacaagcgg aggctgagca cctgcggaag gagctggagg gtctggcagg
     1081 acagcttcaa gcccaggtgc aagacaatga gggcttgagt cgcctgaacc gggagcagga
     1141 ggagaggctg ctggagctgg agcgggcggc cgagctctgg ggggagcagg cggaggcgcg
     1201 caggcaaatc ctggagacca tgcagaacga ccgcactacc atcagccgcg cactctccca
     1261 gaaccgggag ctcaaggagc agctggctga gctgcagagc ggatttgtaa agctgactaa
     1321 tgagaacatg gagatcacca gcgcactgca gtcggagcag cacgtcaaga gggagctggg
     1381 aaagaagctg ggcgagctgc aggagaagct gagcgagctg aaggaaacgg tggagctgaa
     1441 gagccaagag gctcaaagtc tgcagcagca gcgagaccag tacctgggac acctgcagca
     1501 gtatgtggcc gcctatcagc agctgacctc tgagaaggag gtgctgcata atcagctact
     1561 gctgcagacc cagctcgtgg accagctgca gcagcaggaa gctcagggca aagcggtggc
     1621 cgagatggcc cgccaagagt tgcaggaaac ccaggagcgc ctggaagctg ccacccagca
     1681 gaatcagcag ctacgggccc agttgagcct catggctcac cctggggaag gagatggact
     1741 ggaccgggag gaggaggagg atgaggagga ggaggaggag gaggcggtgg cagtacctca
     1801 gcccatgcca agcatcccgg aggacctgga gagccgggaa gccatggtgg catttttcaa
     1861 ctcagctgta gccagtgccg aggaggagca ggcaaggcta cgtgggcagc tgaaggagca
     1921 aagggtgcgc tgccggcgcc tggctcacct gctggcctcg gcccagaagg agcctgaggc
     1981 agcagcccca gccccaggga ccgggggtga ttctgtgtgt ggggagaccc accgggccct
     2041 gcagggggcc atggagaagc tgcagagccg ctttatggag ctcatgcagg agaaggcaga
     2101 cctgaaggag agggtagagg aactggaaca tcgctgcatc cagctttctg gagagacaga
     2161 caccattgga gagtacattg cactgtacca gagccagagg gcagtgctga aggagcggca
     2221 ccgggagaag gaggagtaca tcagcaggct ggcccaagac aaggaggaga tgaaggtgaa
     2281 gctgctggag ctgcaggagc tggtcttacg gcttgtgggc gaccgcaacg agtggcatgg
     2341 cagattcctg gcagctgccc agaaccctgc tgatgagccc acttcagggg ccccagcccc
     2401 ccaggaactt ggggctgcca accagcaggg tgatctttgc gaggtgagcc tcgccggcag
     2461 tgtggagcct gcccaaggag aggccaggga gggttctccc cgtgacaacc ccactgcaca
     2521 gcagatcatg cagctgcttc gtgagatgca gaacccccgg gagcgcccag gcttgggcag
     2581 caacccctgc attccttttt tttaccgggc tgacgagaat gatgaggtga agatcactgt
     2641 catctaaaag ccggctactg tcagcaaagc ctgaagaagt ggggctggat accctgcccc
     2701 caccatatcc ctaccatccc ttctcagtca accctttacc cttacagtag caagcataga
     2761 cccctgtcta acgggggtag acaggtgcag atgaggtgaa gatcactgtc atctaaaagc
     2821 tggccactaa attaaaaaaa aattaaaagt tatgggatta aaaaaagtta tgggataaaa
     2881 aaggttatgg gtaacttatg gtataaaagt tatgaaaaaa ggccaggtgc agtggctcac
     2941 gcctgtaatc ccagcacttt tgggaggctg aggttgggag ttcaagacca gcctggtcaa
     3001 catggtgaaa ctgtgtctct actaaaaata caaaaattag ccaggcatgg tggcacgtgc
     3061 ctgtaatccc agctactcgg gaggctgagg caggagaatc gcttgaacct gggaggtgga
     3121 ggttgcagtg ggctgagatc acgccattgc actccagcct gggcgacaga gtgagactct
     3181 gtctcaaaaa aaaaaaaaat tatgaaaaaa gttatgggat taaagaaagt caggataaaa
     3241 attttaaaaa gcaggccact gtcagcaaag cctggagaag tggggccgga ggctccgccc
     3301 ccatcatgtg cctgccaccc cttcccagtc atccctttac tcttacagta gcaaataaga
     3361 cccctgtcta atggggggag acaaatgtgt agacccttag ccaccttggc cagggctgac
     3421 tccttaaatt tctggatgat gatgattgtt atttaatagc cagaggctca tataattggc
     3481 ctctttggaa gaggcctcat ggcctcctta ctctcaccaa agcaattttt ccctcagggg
     3541 ggctcccatc ttcttacaca gagaggcagc tgaggcagga cagtggggct aactgtagac
     3601 caggcgaggg cacgggctgc tggggtggcc ctgcttcccc agtgtacata ttgtatctgt
     3661 gtaacatttt gtatattcca ggggtagggc cgccccctgt atcataccta gcagaggttg
     3721 gagctggcac atggggagga ggttctaata attatttggg gctgggaaac ttatttattg
     3781 atagcatagg acagaggaag gaggcgggga tggggtcgtg gcgccctggt gatgcgactc
     3841 ctgtttattt tgctttttat ttcggaataa atggatttag ccata
//
