LOCUS       NM_001389704            3906 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens golgin A2 (GOLGA2), transcript variant 13, mRNA.
ACCESSION   NM_001389704
VERSION     NM_001389704.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3906)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3906)
  AUTHORS   Gao,Q., Liu,G., Huang,L., Zhang,Y., Zhang,X., Song,X. and Xing,X.
  TITLE     WDR38, a novel equatorial segment protein, interacts with the
            GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1561-1570 (2023)
   PUBMED   37635409
  REMARK    GeneRIF: WDR38, a novel equatorial segment protein, interacts with
            the GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis.
REFERENCE   3  (bases 1 to 3906)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   4  (bases 1 to 3906)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   5  (bases 1 to 3906)
  AUTHORS   Li,L., Chen,Y., Liao,W., Yu,Q., Lin,H., Shi,Y., Zhang,L., Fu,G.,
            Wang,Z., Li,X., Kong,X., Zhou,T. and Qin,L.
  TITLE     Associations of IFT20 and GM130 protein expressions with
            clinicopathological features and survival of patients with lung
            adenocarcinoma
  JOURNAL   BMC Cancer 22 (1), 809 (2022)
   PUBMED   35869490
  REMARK    GeneRIF: Associations of IFT20 and GM130 protein expressions with
            clinicopathological features and survival of patients with lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3906)
  AUTHORS   Sohda,M., Misumi,Y., Yano,A., Takami,N. and Ikehara,Y.
  TITLE     Phosphorylation of the vesicle docking protein p115 regulates its
            association with the Golgi membrane
  JOURNAL   J Biol Chem 273 (9), 5385-5388 (1998)
   PUBMED   9478999
REFERENCE   7  (bases 1 to 3906)
  AUTHORS   Barr,F.A., Puype,M., Vandekerckhove,J. and Warren,G.
  TITLE     GRASP65, a protein involved in the stacking of Golgi cisternae
  JOURNAL   Cell 91 (2), 253-262 (1997)
   PUBMED   9346242
REFERENCE   8  (bases 1 to 3906)
  AUTHORS   Nakamura,N., Lowe,M., Levine,T.P., Rabouille,C. and Warren,G.
  TITLE     The vesicle docking protein p115 binds GM130, a cis-Golgi matrix
            protein, in a mitotically regulated manner
  JOURNAL   Cell 89 (3), 445-455 (1997)
   PUBMED   9150144
REFERENCE   9  (bases 1 to 3906)
  AUTHORS   Nakamura,N., Rabouille,C., Watson,R., Nilsson,T., Hui,N.,
            Slusarewicz,P., Kreis,T.E. and Warren,G.
  TITLE     Characterization of a cis-Golgi matrix protein, GM130
  JOURNAL   J Cell Biol 131 (6 Pt 2), 1715-1726 (1995)
   PUBMED   8557739
REFERENCE   10 (bases 1 to 3906)
  AUTHORS   Fritzler,M.J., Hamel,J.C., Ochs,R.L. and Chan,E.K.
  TITLE     Molecular characterization of two human autoantigens: unique cDNAs
            encoding 95- and 160-kD proteins of a putative family in the Golgi
            complex
  JOURNAL   J Exp Med 178 (1), 49-62 (1993)
   PUBMED   8315394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590708.18.
            
            On Jan 13, 2021 this sequence version replaced NM_001389704.1.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked cisternae (flattened membrane
            sacs). Interactions between the Golgi and microtubules are thought
            to be important for the reorganization of the Golgi after it
            fragments during mitosis. This gene encodes one of the golgins, a
            family of proteins localized to the Golgi. This encoded protein has
            been postulated to play roles in the stacking of Golgi cisternae
            and in vesicular transport. Several alternatively spliced
            transcript variants of this gene have been described, but the
            full-length nature of these variants has not been determined.
            [provided by RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AL590708.18        177198-177312       c
            116-238             AL590708.18        175155-175277       c
            239-277             AL590708.18        167592-167630       c
            278-328             AL590708.18        167275-167325       c
            329-422             AL590708.18        167093-167186       c
            423-529             AL590708.18        166890-166996       c
            530-588             AL590708.18        164339-164397       c
            589-730             AL590708.18        163868-164009       c
            731-820             AL590708.18        162973-163062       c
            821-928             AL590708.18        162759-162866       c
            929-1016            AL590708.18        162477-162564       c
            1017-1336           AL590708.18        161770-162089       c
            1337-1450           AL590708.18        161381-161494       c
            1451-1675           AL590708.18        160472-160696       c
            1676-1751           AL590708.18        160312-160387       c
            1752-1867           AL590708.18        159760-159875       c
            1868-2086           AL590708.18        159285-159503       c
            2087-2189           AL590708.18        159095-159197       c
            2190-2296           AL590708.18        158906-159012       c
            2297-2453           AL590708.18        158674-158830       c
            2454-3906           AL590708.18        157134-158586       c
FEATURES             Location/Qualifiers
     source          1..3906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..3906
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /note="golgin A2"
                     /db_xref="GeneID:2801"
                     /db_xref="HGNC:HGNC:4425"
                     /db_xref="MIM:602580"
     exon            1..115
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2668
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /note="isoform 12 is encoded by transcript variant 13;
                     golgi autoantigen, golgin subfamily a, 2; Golgi matrix
                     protein GM130; SY11 protein; golgin subfamily A member 2;
                     golgin-95; GM130 autoantigen; 130 kDa cis-Golgi matrix
                     protein"
                     /codon_start=1
                     /product="golgin subfamily A member 2 isoform 12"
                     /protein_id="NP_001376633.2"
                     /db_xref="GeneID:2801"
                     /db_xref="HGNC:HGNC:4425"
                     /db_xref="MIM:602580"
                     /translation="MWPQPRLPPRPAMSEETRQSKLAAAKKKLREYQQRNSPGVPTGA
                     KKKKKIKNGSNPETTTSGGCHSPEDKQQNQEITDQLEEEKKECHQKQGALREQLQVHI
                     QTIGILVSEKAELQTALAHTQHAARQKEGESEDLASRLQYSRRRVGELERALSAVSTQ
                     QKKADRYNKELTKERDALRLELYKNTQSNEDLKQEKSELEEKLRVLVTEKAGMQLNLE
                     ELQKKLEMTELLLQQFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVRQLQMERD
                     KYAENLKGESAMWRQRMQQMSEQVHTLREEKECSMSRVQELETSLAELRNQMEPPAGP
                     SEVEQQLQAEAEHLRKELEGLAGQLQAQVQDNEGLSRLNREQEERLLELERAAELWGE
                     QAEARRQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNENMEITSALQSEQ
                     HVKRELGKKLGELQEKLSELKETVELKSQEAQSLQQQRDQYLGHLQQYVAAYQQLTSE
                     KEVLHNQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQLS
                     LMAHPGEGDGLDREEEEDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAE
                     EEQARLRGQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAME
                     KLQSRFMELMQEKADLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKERHREK
                     EEYISRLAQDKEEMKVKLLELQELVLRLVGDRNEWHGRFLAAAQNPADEPTSGAPAPQ
                     ELGAANQQGDLCEVSLAGSVEPAQGEAREGSPRDNPTAQQIMQLLREMQNPRERPGLG
                     SNPCIPFFYRADENDEVKITVI"
     exon            116..238
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            239..277
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            278..328
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            329..422
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            423..529
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            530..588
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            589..730
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            731..820
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            821..928
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1016
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1336
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1450
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1675
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1751
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1867
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2086
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2189
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2296
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2453
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..3906
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3887..3892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /note="hexamer: AATAAA"
     polyA_site      3906
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /note="major polyA site"
ORIGIN      
        1 gacttccgca gtggttgccg ggatcgcgct gatgtggccc caaccccgcc tccctccccg
       61 ccccgcgatg tcggaagaaa cccgacagag caaattggcc gcagcgaaga aaaagttgag
      121 agaatatcag cagaggaata gccctggtgt tcctacagga gcgaaaaaga agaagaaaat
      181 aaaaaatggc agtaaccctg agacaaccac ttctggtggt tgccactcac ctgaggataa
      241 acaacagaac caagaaatta cggatcagtt ggaagaagaa aagaaagaat gccaccaaaa
      301 gcagggagcc ctaagggagc agttacaggt tcacattcag accataggga tcctcgtatc
      361 agagaaagct gagttacaga cagccctggc tcacactcag catgctgcca ggcagaaaga
      421 aggagagtct gaagatctgg ccagccgcct gcagtattcc cggcggcgtg tgggagagtt
      481 ggagcgggct ctctctgctg tctccacgca gcagaagaag gcagacaggt acaacaagga
      541 gttaaccaaa gagagagacg ccctcaggct ggagttatac aagaacaccc aaagcaatga
      601 ggacctgaag caagagaaat cagaattgga agagaagctt cgggtcctag tgactgagaa
      661 ggctggcatg cagcttaact tggaagaatt gcaaaagaag ttagagatga cggaactcct
      721 gcttcaacag ttttcaagcc ggtgtgaagc ccctgatgct aaccagcagt tacagcaggc
      781 catggaggag cgggcacagc tggaagcaca cctggggcag gtaatggagt cggttagaca
      841 actacaaatg gagagagata aatatgcgga gaatctcaaa ggagagagcg ccatgtggcg
      901 gcagaggatg cagcagatgt cagagcaggt gcacacattg agagaggaga aggaatgtag
      961 catgagtcgg gtacaggagc tggagacgag cttggctgaa ctgaggaacc agatggagcc
     1021 cccagcaggg ccctccgagg tggagcagca gctacaagcg gaggctgagc acctgcggaa
     1081 ggagctggag ggtctggcag gacagcttca agcccaggtg caagacaatg agggcttgag
     1141 tcgcctgaac cgggagcagg aggagaggct gctggagctg gagcgggcgg ccgagctctg
     1201 gggggagcag gcggaggcgc gcaggcaaat cctggagacc atgcagaacg accgcactac
     1261 catcagccgc gcactctccc agaaccggga gctcaaggag cagctggctg agctgcagag
     1321 cggatttgta aagctgacta atgagaacat ggagatcacc agcgcactgc agtcggagca
     1381 gcacgtcaag agggagctgg gaaagaagct gggcgagctg caggagaagc tgagcgagct
     1441 gaaggaaacg gtggagctga agagccaaga ggctcaaagt ctgcagcagc agcgagacca
     1501 gtacctggga cacctgcagc agtatgtggc cgcctatcag cagctgacct ctgagaagga
     1561 ggtgctgcat aatcagctac tgctgcagac ccagctcgtg gaccagctgc agcagcagga
     1621 agctcagggc aaagcggtgg ccgagatggc ccgccaagag ttgcaggaaa cccaggagcg
     1681 cctggaagct gccacccagc agaatcagca gctacgggcc cagttgagcc tcatggctca
     1741 ccctggggaa ggagatggac tggaccggga ggaggaggag gatgaggagg aggaggagga
     1801 ggaggcggtg gcagtacctc agcccatgcc aagcatcccg gaggacctgg agagccggga
     1861 agccatggtg gcatttttca actcagctgt agccagtgcc gaggaggagc aggcaaggct
     1921 acgtgggcag ctgaaggagc aaagggtgcg ctgccggcgc ctggctcacc tgctggcctc
     1981 ggcccagaag gagcctgagg cagcagcccc agccccaggg accgggggtg attctgtgtg
     2041 tggggagacc caccgggccc tgcagggggc catggagaag ctgcagagcc gctttatgga
     2101 gctcatgcag gagaaggcag acctgaagga gagggtagag gaactggaac atcgctgcat
     2161 ccagctttct ggagagacag acaccattgg agagtacatt gcactgtacc agagccagag
     2221 ggcagtgctg aaggagcggc accgggagaa ggaggagtac atcagcaggc tggcccaaga
     2281 caaggaggag atgaaggtga agctgctgga gctgcaggag ctggtcttac ggcttgtggg
     2341 cgaccgcaac gagtggcatg gcagattcct ggcagctgcc cagaaccctg ctgatgagcc
     2401 cacttcaggg gccccagccc cccaggaact tggggctgcc aaccagcagg gtgatctttg
     2461 cgaggtgagc ctcgccggca gtgtggagcc tgcccaagga gaggccaggg agggttctcc
     2521 ccgtgacaac cccactgcac agcagatcat gcagctgctt cgtgagatgc agaacccccg
     2581 ggagcgccca ggcttgggca gcaacccctg cattcctttt ttttaccggg ctgacgagaa
     2641 tgatgaggtg aagatcactg tcatctaaaa gccggctact gtcagcaaag cctgaagaag
     2701 tggggctgga taccctgccc ccaccatatc cctaccatcc cttctcagtc aaccctttac
     2761 ccttacagta gcaagcatag acccctgtct aacgggggta gacaggtgca gatgaggtga
     2821 agatcactgt catctaaaag ctggccacta aattaaaaaa aaattaaaag ttatgggatt
     2881 aaaaaaagtt atgggataaa aaaggttatg ggtaacttat ggtataaaag ttatgaaaaa
     2941 aggccaggtg cagtggctca cgcctgtaat cccagcactt ttgggaggct gaggttggga
     3001 gttcaagacc agcctggtca acatggtgaa actgtgtctc tactaaaaat acaaaaatta
     3061 gccaggcatg gtggcacgtg cctgtaatcc cagctactcg ggaggctgag gcaggagaat
     3121 cgcttgaacc tgggaggtgg aggttgcagt gggctgagat cacgccattg cactccagcc
     3181 tgggcgacag agtgagactc tgtctcaaaa aaaaaaaaaa ttatgaaaaa agttatggga
     3241 ttaaagaaag tcaggataaa aattttaaaa agcaggccac tgtcagcaaa gcctggagaa
     3301 gtggggccgg aggctccgcc cccatcatgt gcctgccacc ccttcccagt catcccttta
     3361 ctcttacagt agcaaataag acccctgtct aatgggggga gacaaatgtg tagaccctta
     3421 gccaccttgg ccagggctga ctccttaaat ttctggatga tgatgattgt tatttaatag
     3481 ccagaggctc atataattgg cctctttgga agaggcctca tggcctcctt actctcacca
     3541 aagcaatttt tccctcaggg gggctcccat cttcttacac agagaggcag ctgaggcagg
     3601 acagtggggc taactgtaga ccaggcgagg gcacgggctg ctggggtggc cctgcttccc
     3661 cagtgtacat attgtatctg tgtaacattt tgtatattcc aggggtaggg ccgccccctg
     3721 tatcatacct agcagaggtt ggagctggca catggggagg aggttctaat aattatttgg
     3781 ggctgggaaa cttatttatt gatagcatag gacagaggaa ggaggcgggg atggggtcgt
     3841 ggcgccctgg tgatgcgact cctgtttatt ttgcttttta tttcggaata aatggattta
     3901 gccata
//
