LOCUS       NP_001353173            1029 aa            linear   PRI 30-APR-2025
DEFINITION  golgin subfamily A member 2 isoform 1 [Homo sapiens].
ACCESSION   NP_001353173 XP_005251987
VERSION     NP_001353173.2
DBSOURCE    REFSEQ: accession NM_001366244.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1029)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1029)
  AUTHORS   Gao,Q., Liu,G., Huang,L., Zhang,Y., Zhang,X., Song,X. and Xing,X.
  TITLE     WDR38, a novel equatorial segment protein, interacts with the
            GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1561-1570 (2023)
   PUBMED   37635409
  REMARK    GeneRIF: WDR38, a novel equatorial segment protein, interacts with
            the GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis.
REFERENCE   3  (residues 1 to 1029)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   4  (residues 1 to 1029)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   5  (residues 1 to 1029)
  AUTHORS   Li,L., Chen,Y., Liao,W., Yu,Q., Lin,H., Shi,Y., Zhang,L., Fu,G.,
            Wang,Z., Li,X., Kong,X., Zhou,T. and Qin,L.
  TITLE     Associations of IFT20 and GM130 protein expressions with
            clinicopathological features and survival of patients with lung
            adenocarcinoma
  JOURNAL   BMC Cancer 22 (1), 809 (2022)
   PUBMED   35869490
  REMARK    GeneRIF: Associations of IFT20 and GM130 protein expressions with
            clinicopathological features and survival of patients with lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1029)
  AUTHORS   Sohda,M., Misumi,Y., Yano,A., Takami,N. and Ikehara,Y.
  TITLE     Phosphorylation of the vesicle docking protein p115 regulates its
            association with the Golgi membrane
  JOURNAL   J Biol Chem 273 (9), 5385-5388 (1998)
   PUBMED   9478999
REFERENCE   7  (residues 1 to 1029)
  AUTHORS   Barr,F.A., Puype,M., Vandekerckhove,J. and Warren,G.
  TITLE     GRASP65, a protein involved in the stacking of Golgi cisternae
  JOURNAL   Cell 91 (2), 253-262 (1997)
   PUBMED   9346242
REFERENCE   8  (residues 1 to 1029)
  AUTHORS   Nakamura,N., Lowe,M., Levine,T.P., Rabouille,C. and Warren,G.
  TITLE     The vesicle docking protein p115 binds GM130, a cis-Golgi matrix
            protein, in a mitotically regulated manner
  JOURNAL   Cell 89 (3), 445-455 (1997)
   PUBMED   9150144
REFERENCE   9  (residues 1 to 1029)
  AUTHORS   Nakamura,N., Rabouille,C., Watson,R., Nilsson,T., Hui,N.,
            Slusarewicz,P., Kreis,T.E. and Warren,G.
  TITLE     Characterization of a cis-Golgi matrix protein, GM130
  JOURNAL   J Cell Biol 131 (6 Pt 2), 1715-1726 (1995)
   PUBMED   8557739
REFERENCE   10 (residues 1 to 1029)
  AUTHORS   Fritzler,M.J., Hamel,J.C., Ochs,R.L. and Chan,E.K.
  TITLE     Molecular characterization of two human autoantigens: unique cDNAs
            encoding 95- and 160-kD proteins of a putative family in the Golgi
            complex
  JOURNAL   J Exp Med 178 (1), 49-62 (1993)
   PUBMED   8315394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590708.18.
            
            On Jan 13, 2021 this sequence version replaced NP_001353173.1.
            
            Summary: The Golgi apparatus, which participates in glycosylation
            and transport of proteins and lipids in the secretory pathway,
            consists of a series of stacked cisternae (flattened membrane
            sacs). Interactions between the Golgi and microtubules are thought
            to be important for the reorganization of the Golgi after it
            fragments during mitosis. This gene encodes one of the golgins, a
            family of proteins localized to the Golgi. This encoded protein has
            been postulated to play roles in the stacking of Golgi cisternae
            and in vesicular transport. Several alternatively spliced
            transcript variants of this gene have been described, but the
            full-length nature of these variants has not been determined.
            [provided by RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2912032.1,
                                           SRR14038193.120215.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611957.5/ ENSP00000478799.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     Protein         1..1029
                     /product="golgin subfamily A member 2 isoform 1"
                     /note="golgi autoantigen, golgin subfamily a, 2; Golgi
                     matrix protein GM130; SY11 protein; golgin subfamily A
                     member 2; golgin-95; GM130 autoantigen; 130 kDa cis-Golgi
                     matrix protein"
                     /calculated_mol_wt=115970
     Region          <180..472
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          408..935
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          980..1025
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..1029
                     /gene="GOLGA2"
                     /gene_synonym="DEDHMB; GM130"
                     /coded_by="NM_001366244.2:32..3121"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS94495.1"
                     /db_xref="GeneID:2801"
                     /db_xref="HGNC:HGNC:4425"
                     /db_xref="MIM:602580"
ORIGIN      
        1 mwpqprlppr pamseetrqs klaaakkklr eyqqrnspgv ptgakkkkki kngsnpettt
       61 sggchspedi qdilkvlvsd lnrsngvalp pldkwktpkd naatlqpsdd tvlpggvpsp
      121 gasltsmaas qnhdadnvpn lmdetktfss teslrqlsqq lnglvcesat cvngegpass
      181 anlkdlesry qqlavaldss yvtnkqlnit ieklkqqnqe itdqleeekk echqkqgalr
      241 eqlqvhiqti gilvsekael qtalahtqha arqkegesed lasrlqysrr rvgelerals
      301 avstqqkkad rynkeltker dalrlelykn tqsnedlkqe kseleeklrv lvtekagmql
      361 nleelqkkle mtelllqqfs srceapdanq qlqqameera qleahlgqvm esvrqlqmer
      421 dkyaenlkge samwrqrmqq mseqvhtlre ekecsmsrvq eletslaelr nqmaeppppe
      481 ppagpseveq qlqaeaehlr keleglagql qaqvqdnegl srlnreqeer lleleraael
      541 wgeqaearrq iletmqndrt tisralsqnr elkeqlaelq sgfvkltnen meitsalqse
      601 qhvkrelgkk lgelqeklse lketvelksq eaqslqqqrd qylghlqqyv aayqqltsek
      661 evlhnqlllq tqlvdqlqqq eaqgkavaem arqelqetqe rleaatqqnq qlraqlslma
      721 hpgegdgldr eeeedeeeee eeavavpqpm psipedlesr eamvaffnsa vasaeeeqar
      781 lrgqlkeqrv rcrrlahlla saqkepeaaa papgtggdsv cgethralqg ameklqsrfm
      841 elmqekadlk erveelehrc iqlsgetdti geyialyqsq ravlkerhre keeyisrlaq
      901 dkeemkvkll elqelvlrlv gdrnewhgrf laaaqnpade ptsgapapqe lgaanqqgdl
      961 cevslagsve paqgearegs prdnptaqqi mqllremqnp rerpglgsnp cipffyrade
     1021 ndevkitvi
//
