LOCUS       NM_000406               4402 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens gonadotropin releasing hormone receptor (GNRHR),
            transcript variant 1, mRNA.
ACCESSION   NM_000406
VERSION     NM_000406.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4402)
  AUTHORS   Mohammadzadeh,P., Roueinfar,M. and Amberg,G.C.
  TITLE     AXL receptor tyrosine kinase modulates gonadotropin-releasing
            hormone receptor signaling
  JOURNAL   Cell Commun Signal 21 (1), 284 (2023)
   PUBMED   37828510
  REMARK    GeneRIF: AXL receptor tyrosine kinase modulates
            gonadotropin-releasing hormone receptor signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4402)
  AUTHORS   Li,X., Zhang,X., Shen,Z., Chen,Z., Wang,H. and Zhang,X.
  TITLE     GnRH receptor mediates lipid storage in female adipocytes via AMPK
            pathway
  JOURNAL   Int J Med Sci 19 (9), 1442-1450 (2022)
   PUBMED   36035370
  REMARK    GeneRIF: GnRH receptor mediates lipid storage in female adipocytes
            via AMPK pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4402)
  AUTHORS   Barczynski,B., Fraszczak,K., Wertel,I., Zakrzewska,E., Zdunek,M.,
            Szumilo,J. and Kotarski,J.
  TITLE     Immunohistochemical Expression of LHRH Receptor in Different
            Compartments of Female Genital Tract in Patients With Endometrial
            Cancer
  JOURNAL   Appl Immunohistochem Mol Morphol 30 (7), 509-516 (2022)
   PUBMED   35777983
  REMARK    GeneRIF: Immunohistochemical Expression of LHRH Receptor in
            Different Compartments of Female Genital Tract in Patients With
            Endometrial Cancer.
REFERENCE   4  (bases 1 to 4402)
  AUTHORS   Chen,C.P. and Lu,X.
  TITLE     Gonadotropin-releasing hormone receptor inhibits triple-negative
            breast cancer proliferation and metastasis
  JOURNAL   J Int Med Res 50 (3), 3000605221082895 (2022)
   PUBMED   35264044
  REMARK    GeneRIF: Gonadotropin-releasing hormone receptor inhibits
            triple-negative breast cancer proliferation and metastasis.
REFERENCE   5  (bases 1 to 4402)
  AUTHORS   Makretskaya,N.A., Gerasimova,M.V., Vasilyev,E.V., Zubkova,N.A.,
            Kalinchenko,N.Y., Kolodkina,A.A., Petrov,V.M., Pogoda,T.V.,
            Panova,A.V., Frolova,E.B., Poliakov,A.V. and Tiulpakov,A.N.
  TITLE     [Clinical and molecular genetic features of cases of isolated
            hypogonadotropic hypogonadism, associated with defects in GNRHR
            genes]
  JOURNAL   Probl Endokrinol (Mosk) 67 (3), 62-67 (2021)
   PUBMED   34297503
  REMARK    GeneRIF: [Clinical and molecular genetic features of cases of
            isolated hypogonadotropic hypogonadism, associated with defects in
            GNRHR genes].
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4402)
  AUTHORS   Leung,P.C., Squire,J., Peng,C., Fan,N., Hayden,M.R. and
            Olofsson,J.I.
  TITLE     Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene
            to human chromosome 4q21.2 by fluorescence in situ hybridization
  JOURNAL   Mamm Genome 6 (4), 309-310 (1995)
   PUBMED   7613048
REFERENCE   7  (bases 1 to 4402)
  AUTHORS   Fan,N.C., Peng,C., Krisinger,J. and Leung,P.C.
  TITLE     The human gonadotropin-releasing hormone receptor gene: complete
            structure including multiple promoters, transcription initiation
            sites, and polyadenylation signals
  JOURNAL   Mol Cell Endocrinol 107 (2), R1-R8 (1995)
   PUBMED   7768323
  REMARK    GeneRIF: Reports complete structure of human gonadotropin-releasing
            hormone receptor gene with figure 2 showing multiple promoters,
            transcription sites, and polyadenylation signals.
REFERENCE   8  (bases 1 to 4402)
  AUTHORS   Kakar,S.S., Grizzle,W.E. and Neill,J.D.
  TITLE     The nucleotide sequences of human GnRH receptors in breast and
            ovarian tumors are identical with that found in pituitary
  JOURNAL   Mol Cell Endocrinol 106 (1-2), 145-149 (1994)
   PUBMED   7534732
REFERENCE   9  (bases 1 to 4402)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
REFERENCE   10 (bases 1 to 4402)
  AUTHORS   Kakar,S.S., Musgrove,L.C., Devor,D.C., Sellers,J.C. and Neill,J.D.
  TITLE     Cloning, sequencing, and expression of human gonadotropin releasing
            hormone (GnRH) receptor
  JOURNAL   Biochem Biophys Res Commun 189 (1), 289-295 (1992)
   PUBMED   1333190
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079880.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 5, 2019 this sequence version replaced NM_000406.2.
            
            Summary: This gene encodes the receptor for type 1
            gonadotropin-releasing hormone. This receptor is a member of the
            seven-transmembrane, G-protein coupled receptor (GPCR) family. It
            is expressed on the surface of pituitary gonadotrope cells as well
            as lymphocytes, breast, ovary, and prostate. Following binding of
            gonadotropin-releasing hormone, the receptor associates with
            G-proteins that activate a phosphatidylinositol-calcium second
            messenger system. Activation of the receptor ultimately causes the
            release of gonadotropic luteinizing hormone (LH) and follicle
            stimulating hormone (FSH). Defects in this gene are a cause of
            hypogonadotropic hypogonadism (HH). Alternative splicing results in
            multiple transcript variants encoding different isoforms. More than
            18 transcription initiation sites in the 5' region and multiple
            polyA signals in the 3' region have been identified for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S60587.1, L07949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267753, SAMN03267755
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226413.5/ ENSP00000226413.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-575               AC079880.6         88142-88716         c
            576-795             AC079880.6         78896-79115         c
            796-4402            AC079880.6         71446-75052         c
FEATURES             Location/Qualifiers
     source          1..4402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..4402
                     /gene="GNRHR"
                     /gene_synonym="GNRHR1; GRHR; HH7; LHRHR; LRHR"
                     /note="gonadotropin releasing hormone receptor"
                     /db_xref="GeneID:2798"
                     /db_xref="HGNC:HGNC:4421"
                     /db_xref="MIM:138850"
     exon            1..575
                     /gene="GNRHR"
                     /gene_synonym="GNRHR1; GRHR; HH7; LHRHR; LRHR"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1040
                     /gene="GNRHR"
                     /gene_synonym="GNRHR1; GRHR; HH7; LHRHR; LRHR"
                     /note="isoform 1 is encoded by transcript variant 1; type
                     I GnRH receptor; gonadotropin-releasing hormone (type 1)
                     receptor 1; leutinizing hormone releasing horomone
                     receptor; luliberin receptor; leutinizing-releasing
                     hormone receptor; gnRH-R; gnRH receptor"
                     /codon_start=1
                     /product="gonadotropin-releasing hormone receptor isoform
                     1"
                     /protein_id="NP_000397.1"
                     /db_xref="CCDS:CCDS3517.1"
                     /db_xref="GeneID:2798"
                     /db_xref="HGNC:HGNC:4421"
                     /db_xref="MIM:138850"
                     /translation="MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFF
                     LFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWN
                     ITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMV
                     GLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSC
                     LFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSF
                     TVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL"
     exon            576..795
                     /gene="GNRHR"
                     /gene_synonym="GNRHR1; GRHR; HH7; LHRHR; LRHR"
                     /inference="alignment:Splign:2.1.0"
     exon            796..4402
                     /gene="GNRHR"
                     /gene_synonym="GNRHR1; GRHR; HH7; LHRHR; LRHR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4382..4387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNRHR"
                     /gene_synonym="GNRHR1; GRHR; HH7; LHRHR; LRHR"
                     /note="hexamer: AATAAA"
     polyA_site      4402
                     /gene="GNRHR"
                     /gene_synonym="GNRHR1; GRHR; HH7; LHRHR; LRHR"
                     /note="major polyA site"
ORIGIN      
        1 aaaatatcag atgcaccaga gacacaaggc ttgaagctct gtcctgggaa aatatggcaa
       61 acagtgcctc tcctgaacag aatcaaaatc actgttcagc catcaacaac agcatcccac
      121 tgatgcaggg caacctcccc actctgacct tgtctggaaa gatccgagtg acggttactt
      181 tcttcctttt tctgctctct gcgaccttta atgcttcttt cttgttgaaa cttcagaagt
      241 ggacacagaa gaaagagaaa gggaaaaagc tctcaagaat gaagctgctc ttaaaacatc
      301 tgaccttagc caacctgttg gagactctga ttgtcatgcc actggatggg atgtggaaca
      361 ttacagtcca atggtatgct ggagagttac tctgcaaagt tctcagttat ctaaagcttt
      421 tctccatgta tgccccagcc ttcatgatgg tggtgatcag cctggaccgc tccctggcta
      481 tcacgaggcc cctagctttg aaaagcaaca gcaaagtcgg acagtccatg gttggcctgg
      541 cctggatcct cagtagtgtc tttgcaggac cacagttata catcttcagg atgattcatc
      601 tagcagacag ctctggacag acaaaagttt tctctcaatg tgtaacacac tgcagttttt
      661 cacaatggtg gcatcaagca ttttataact ttttcacctt cagctgcctc ttcatcatcc
      721 ctcttttcat catgctgatc tgcaatgcaa aaatcatctt caccctgaca cgggtccttc
      781 atcaggaccc ccacgaacta caactgaatc agtccaagaa caatatacca agagcacggc
      841 tgaagactct aaaaatgacg gttgcatttg ccacttcatt tactgtctgc tggactccct
      901 actatgtcct aggaatttgg tattggtttg atcctgaaat gttaaacagg ttgtcagacc
      961 cagtaaatca cttcttcttt ctctttgcct ttttaaaccc atgctttgat ccacttatct
     1021 atggatattt ttctctgtga ttgatagact acacaagaag tcatatgaag aagggtaagg
     1081 taatgaatct ctccatctgg gaatgattaa cacaaatgtt ggagcatgtt tacatacaaa
     1141 caaagtagga tttacactta agttatcatt cttttagaaa ctcagtcttc agagcctcaa
     1201 ttattaagga aaagtcttca ggaaaaatac taaaatattt tctcttcctc ataagcttct
     1261 aaattaatct ctgccttttc tgacctcata taacacatta tgtaggtttc ttatcacttt
     1321 ctctttgcat aataatgtac taatatttaa aataccttca gcctaaggca caaggatgcc
     1381 aaaaaaacaa aggtgagaaa ccacaacaca ggtctaaact cagcatgctt tggtgagttt
     1441 ttctccaaaa ggggcatatt agcaattaga gttgtatgct atataataca tagagcacag
     1501 agccctttgc ccataatatc aactttccct cctatagtta aaaagaaaaa aaatgaatct
     1561 atttttctct ttggcttcaa aagcattctg acatttggag gagtcagtaa ccaatcccac
     1621 caaccactcc agcaacctga caagactatg agtagttctc cttcatccta tttatgtggt
     1681 acaggttgtg aagtatctct atataaaggg aaattttaga ggggttagga tttggacagg
     1741 ggtttagaac attcctctaa gctatctagt ctgtggagtt tgtggcaatt aattgccata
     1801 aaataacaat gtttccaaat gcaactaaga aaatactcat agtgagtacg ctctatgcat
     1861 agtatgactt ctattttaat gtgaagaatt ttttgtctct ctcctgatct tactaaatcc
     1921 atatttcata aataactgag aataattaaa acaaaattaa gcaaatgcac aagcaaaaag
     1981 atgcttgata cacaaaagga actctggaga gaaaactaca gcttcagtct gtacagatca
     2041 aagaagacag aacatgtcag gggaaggagg gaaagatctt gatgcagggt ttcttaacct
     2101 gcagtctatg cacaacacta tatttccatg taatgttttt atttcagccc tatttgtatt
     2161 attttgtgca tttaaaaaac acaatcttaa ggggatagac tagactgcca cagcagccca
     2221 tggcacaact aacacctact gatattcaca ttaaatagta tggtttccaa aatatgtctg
     2281 cacaacaaga cctctttatg taattcaggc ttgtgtctac ctcttccatg aaaaatggaa
     2341 agggatgaaa ataatgggag tataataccc atttaatgtg aaaaacataa gagtcttaaa
     2401 agaaattaag ccatttaaca ttttttaaat aggtaagata ccattatatt tatatgagct
     2461 atgtactgcc acaaaaaaag atgaaatgta atttctaaat actccaggtg tgtggtatta
     2521 tggaaagcaa attgccaact aatggcacgt cctttctttc tttgattttc tcctctcata
     2581 cttcagtttt atagtgttgt gttgttgttt ttttcatatc ctaccttact ttccaattct
     2641 gtctcaattg aactccctct gtctactcac tctttcattc atagcttctt ttccattaaa
     2701 ctcatacctt taattaacca attcatggcc cagttctaca gttgaattgg acaaggctaa
     2761 aattctgtag tgtgctaaaa tgctcaagtt ggcacataaa cccattccaa gattttatag
     2821 ttcttgtaga taacacaggg atgtagataa gttgaaacaa aaccagtgtc ctctaagtct
     2881 ctatcatata cttattccta aactgataat tcttacttct ggatttaaaa tcaaaaataa
     2941 cacacttgta cagatacaat ctaagggctt tatcacacac gtgttaacga atgtatctca
     3001 gcttggttct tcttgtgtgc tcattatgga tctctctgtc ttaggaattg cctcaggcat
     3061 tttttttttt tacacattaa ctaaagggct attcgaaatc ttgactcagg ggttcttaac
     3121 ctacatttca tgcaaaaaat atatatattt caatgtattt tttattttag tcctatttgt
     3181 attattttat gcatttaaaa acacagtcct gagagggatg gaccagactg ccacagcagc
     3241 tcatagcaca aaaaaaggtt aagaagtcct agttgacttt gtatatatat aaagaaatct
     3301 attacaataa aaatataaca taatctattc atctatttat atgcaaacat aaaaatgtaa
     3361 atattgaaac aagattgctt caatatgctt attgttttca aaccaacaaa ctctcttaag
     3421 gttcaatatg taataaaaaa cataacacaa ataattattc tatatgaata ttatggttca
     3481 taaattataa tgtataatct atacattata atgtaatata taaactaaaa tttatggcac
     3541 aaaagataaa tatggctttg aaattaaaga tattccactc aacagacaat atttcatatt
     3601 tgatattaca atcatttatt ttatgtccta ttataataaa aggtgaggac tccttgtaaa
     3661 aaaggaaatg ttccacagag tcaatctaat atatcagata ttggagattc tatcttggtt
     3721 tctcttcctt tacttagcct ataaaactag ttaaaaatgg aatttctttt agcaattcag
     3781 tttagtacag gagtgacatt aactaatgac aataaattaa acaaagccta cattagttca
     3841 atttaagcct attcaacaga aatatagaaa tatagtagct aaaaaaatac tctggggaag
     3901 gtaccacaaa cattatctac cagggaacat agcataaatt agtctgaaat ttcctgagag
     3961 tgactttgtc ttagaactta ggtggtagtc atgaagagat aatgttttta ggcagttaaa
     4021 atacttctag aactccatct attttacctg tggtccactt tcctacattg aaccaatgcc
     4081 ttgggcttct ctaattacta tacattgtgc tcatatgaat aaaagaaatt ttaaaagaaa
     4141 aaaaatcaga ttcaatataa tcttgcttat catttttatg attattagga atcaagttta
     4201 aaacaattag tctaacttta aaagttatat aaaatgtatg catagcagca atagataaac
     4261 atatatgaaa actgttaata tagttatctg catgatttct taaaaatttc ttccttgtga
     4321 attcctgtaa ttccaaattc ccaaaatgaa ctcatattgc atgtgtatta agagaaaaca
     4381 taataaatgt tatatgtgtg tg
//
