LOCUS       NM_024312               5720 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens N-acetylglucosamine-1-phosphate transferase subunits
            alpha and beta (GNPTAB), mRNA.
ACCESSION   NM_024312
VERSION     NM_024312.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5720)
  AUTHORS   Richards,C.M., Jabs,S., Qiao,W., Varanese,L.D., Schweizer,M.,
            Mosen,P.R., Riley,N.M., Klussendorf,M., Zengel,J.R., Flynn,R.A.,
            Rustagi,A., Widen,J.C., Peters,C.E., Ooi,Y.S., Xie,X., Shi,P.Y.,
            Bartenschlager,R., Puschnik,A.S., Bogyo,M., Bertozzi,C.R.,
            Blish,C.A., Winter,D., Nagamine,C.M., Braulke,T. and Carette,J.E.
  TITLE     The human disease gene LYSET is essential for lysosomal enzyme
            transport and viral infection
  JOURNAL   Science 378 (6615), eabn5648 (2022)
   PUBMED   36074821
REFERENCE   2  (bases 1 to 5720)
  AUTHORS   Di Lorenzo,G., Westermann,L.M., Yorgan,T.A., Sturznickel,J.,
            Ludwig,N.F., Ammer,L.S., Baranowsky,A., Ahmadi,S.,
            Pourbarkhordariesfandabadi,E., Breyer,S.R., Board,T.N., Foster,A.,
            Mercer,J., Tylee,K., Velho,R.V., Schweizer,M., Renne,T.,
            Braulke,T., Randon,D.N., Sperb-Ludwig,F., de Camargo Pinto,L.L.,
            Moreno,C.A., Cavalcanti,D.P., Amling,M., Kutsche,K., Winter,D.,
            Muschol,N.M., Schwartz,I.V.D., Rolvien,T., Danyukova,T., Schinke,T.
            and Pohl,S.
  TITLE     Pathogenic variants in GNPTAB and GNPTG encoding distinct subunits
            of GlcNAc-1-phosphotransferase differentially impact bone
            resorption in patients with mucolipidosis type II and III
  JOURNAL   Genet Med 23 (12), 2369-2377 (2021)
   PUBMED   34341521
  REMARK    GeneRIF: Pathogenic variants in GNPTAB and GNPTG encoding distinct
            subunits of GlcNAc-1-phosphotransferase differentially impact bone
            resorption in patients with mucolipidosis type II and III.
REFERENCE   3  (bases 1 to 5720)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5720)
  AUTHORS   Pasumarthi,D., Gupta,N., Sheth,J., Jain,S.J.M.N., Rungsung,I.,
            Kabra,M., Ranganath,P., Aggarwal,S., Phadke,S.R., Girisha,K.M.,
            Shukla,A., Datar,C., Verma,I.C., Puri,R.D., Bhavsar,R., Mistry,M.,
            Sankar,V.H., Gowrishankar,K., Agrawal,D., Nair,M., Danda,S.,
            Soni,J.P. and Dalal,A.
  TITLE     Identification and characterization of 30 novel pathogenic
            variations in 69 unrelated Indian patients with Mucolipidosis Type
            II and Type III
  JOURNAL   J Hum Genet 65 (11), 971-984 (2020)
   PUBMED   32651481
  REMARK    GeneRIF: Identification and characterization of 30 novel pathogenic
            variations in 69 unrelated Indian patients with Mucolipidosis Type
            II and Type III.
REFERENCE   5  (bases 1 to 5720)
  AUTHORS   Kudo,M., Bao,M., D'Souza,A., Ying,F., Pan,H., Roe,B.A. and
            Canfield,W.M.
  TITLE     The alpha- and beta-subunits of the human
            UDP-N-acetylglucosamine:lysosomal enzyme
            N-acetylglucosamine-1-phosphotransferase [corrected] are encoded by
            a single cDNA
  JOURNAL   J Biol Chem 280 (43), 36141-36149 (2005)
   PUBMED   16120602
  REMARK    GeneRIF: GNPTAB alpha and beta subunits are encoded by a single
            cDNA
            Erratum:[J Biol Chem. 2005 Dec 23;280(51):42476]
REFERENCE   6  (bases 1 to 5720)
  AUTHORS   Tiede,S., Storch,S., Lubke,T., Henrissat,B., Bargal,R.,
            Raas-Rothschild,A. and Braulke,T.
  TITLE     Mucolipidosis II is caused by mutations in GNPTA encoding the
            alpha/beta GlcNAc-1-phosphotransferase
  JOURNAL   Nat Med 11 (10), 1109-1112 (2005)
   PUBMED   16200072
  REMARK    GeneRIF: results provide evidence that GNPTA encodes a subunit of
            GlcNAc-1-phosphotransferase defective in individuals with
            mucolipidosis II
REFERENCE   7  (bases 1 to 5720)
  AUTHORS   Paik,K.H., Song,S.M., Ki,C.S., Yu,H.W., Kim,J.S., Min,K.H.,
            Chang,S.H., Yoo,E.J., Lee,I.J., Kwan,E.K., Han,S.J. and Jin,D.K.
  TITLE     Identification of mutations in the GNPTA (MGC4170) gene coding for
            GlcNAc-phosphotransferase alpha/beta subunits in Korean patients
            with mucolipidosis type II or type IIIA
  JOURNAL   Hum Mutat 26 (4), 308-314 (2005)
   PUBMED   16116615
REFERENCE   8  (bases 1 to 5720)
  AUTHORS   Tiede,S., Muschol,N., Reutter,G., Cantz,M., Ullrich,K. and
            Braulke,T.
  TITLE     Missense mutations in N-acetylglucosamine-1-phosphotransferase
            alpha/beta subunit gene in a patient with mucolipidosis III and a
            mild clinical phenotype
  JOURNAL   Am J Med Genet A 137A (3), 235-240 (2005)
   PUBMED   16094673
REFERENCE   9  (bases 1 to 5720)
  AUTHORS   Leroy,J.G., Cathey,S.S. and Friez,M.J.
  TITLE     Mucolipidosis III Alpha/Beta - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301730
REFERENCE   10 (bases 1 to 5720)
  AUTHORS   Leroy,J.G., Cathey,S.S. and Friez,M.J.
  TITLE     GNPTAB-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301728
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC063950.37, BP276948.1 and
            AM085438.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024312.4.
            
            Summary: This gene encodes two of three subunit types of the
            membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a
            heterohexameric complex composed of two alpha, two beta, and two
            gamma subunits. The encoded protein is proteolytically cleaved at
            the Lys928-Asp929 bond to yield mature alpha and beta polypeptides
            while the gamma subunits are the product of a distinct gene (GeneID
            84572). In the Golgi apparatus, the heterohexameric complex
            catalyzes the first step in the synthesis of mannose 6-phosphate
            recognition markers on certain oligosaccharides of newly
            synthesized lysosomal enzymes. These recognition markers are
            essential for appropriate trafficking of lysosomal enzymes.
            Mutations in this gene have been associated with both mucolipidosis
            II and mucolipidosis IIIA.[provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM085438.1, AY687932.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299314.12/ ENSP00000299314.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC063950.37        110494-110585       c
            93-105              BP276948.1         1-13
            106-5720            AM085438.1         1-5615
FEATURES             Location/Qualifiers
     source          1..5720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..5720
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /note="N-acetylglucosamine-1-phosphate transferase
                     subunits alpha and beta"
                     /db_xref="GeneID:79158"
                     /db_xref="HGNC:HGNC:29670"
                     /db_xref="MIM:607840"
     exon            1..401
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            402..487
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            488..607
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            608..649
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            650..855
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            856..920
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1055
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1217
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1397
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1568
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1692
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1896
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2999
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3199
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3419
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3533
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3619
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3718
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3886
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3887..3977
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     exon            3978..5720
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4978..4983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /note="hexamer: AGTAAA"
     polyA_site      4996
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
     regulatory      5696..5701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /note="hexamer: CATAAA"
     polyA_site      5720
                     /gene="GNPTAB"
                     /gene_synonym="GNPTA; ICD"
                     /note="major polyA site"
ORIGIN      
        1 gcagccgcct ctcgcccggc cagacccggg cggcgccggc cgcctcgccg gccgcaggtc
       61 cgcctccgcc gcgccgaggg cgtgggctcc cggctcccgg aagcggcggc cgcggcgcgg
      121 agccgagcgg gcgtccgtcg ccggagctgc aatgagcggc gcccggaggc tgtgacctgc
      181 gcgcggcggc ccgaccgggg cccctgaatg gcggctcgct gaggcggcgg cggcggcggc
      241 ggcggctcag gctcctcggg gcgtggcgtg gcggtgaagg ggtgatgctg ttcaagctcc
      301 tgcagagaca gacctatacc tgcctgtccc acaggtatgg gctctacgtg tgcttcttgg
      361 gcgtcgttgt caccatcgtc tccgccttcc agttcggaga ggtggttctg gaatggagcc
      421 gagatcaata ccatgttttg tttgattcct atagagacaa tattgctgga aagtcctttc
      481 agaatcggct ttgtctgccc atgccgattg acgttgttta cacctgggtg aatggcacag
      541 atcttgaact actgaaggaa ctacagcagg tcagagaaca gatggaggag gagcagaaag
      601 caatgagaga aatccttggg aaaaacacaa cggaacctac taagaagagt gagaagcagt
      661 tagagtgttt gctaacacac tgcattaagg tgccaatgct tgtcctggac ccagccctgc
      721 cagccaacat caccctgaag gacctgccat ctctttatcc ttcttttcat tctgccagtg
      781 acattttcaa tgttgcaaaa ccaaaaaacc cttctaccaa tgtctcagtt gttgtttttg
      841 acagtactaa ggatgttgaa gatgcccact ctggactgct taaaggaaat agcagacaga
      901 cagtatggag gggctacttg acaacagata aagaagtccc tggattagtg ctaatgcaag
      961 atttggcttt cctgagtgga tttccaccaa cattcaagga aacaaatcaa ctaaaaacaa
     1021 aattgccaga aaatctttcc tctaaagtca aactgttgca gttgtattca gaggccagtg
     1081 tagcgcttct aaaactgaat aaccccaagg attttcaaga attgaataag caaactaaga
     1141 agaacatgac cattgatgga aaagaactga ccataagtcc tgcatattta ttatgggatc
     1201 tgagcgccat cagccagtct aagcaggatg aagacatctc tgccagtcgt tttgaagata
     1261 acgaagaact gaggtactca ttgcgatcta tcgagaggca tgcaccatgg gttcggaata
     1321 ttttcattgt caccaacggg cagattccat cctggctgaa ccttgacaat cctcgagtga
     1381 caatagtaac acaccaggat gtttttcgaa atttgagcca cttgcctacc tttagttcac
     1441 ctgctattga aagtcacatt catcgcatcg aagggctgtc ccagaagttt atttacctaa
     1501 atgatgatgt catgtttggg aaggatgtct ggccagatga tttttacagt cactccaaag
     1561 gccagaaggt ttatttgaca tggcctgtgc caaactgtgc cgagggctgc ccaggttcct
     1621 ggattaagga tggctattgt gacaaggctt gtaataattc agcctgcgat tgggatggtg
     1681 gggattgctc tggaaacagt ggagggagtc gctatattgc aggaggtgga ggtactggga
     1741 gtattggagt tggacagccc tggcagtttg gtggaggaat aaacagtgtc tcttactgta
     1801 atcagggatg tgcgaattcc tggctcgctg ataagttctg tgaccaagca tgcaatgtct
     1861 tgtcctgtgg gtttgatgct ggcgactgtg ggcaagatca ttttcatgaa ttgtataaag
     1921 tgatccttct cccaaaccag actcactata ttattccaaa aggtgaatgc ctgccttatt
     1981 tcagctttgc agaagtagcc aaaagaggag ttgaaggtgc ctatagtgac aatccaataa
     2041 ttcgacatgc ttctattgcc aacaagtgga aaaccatcca cctcataatg cacagtggaa
     2101 tgaatgccac cacaatacat tttaatctca cgtttcaaaa tacaaacgat gaagagttca
     2161 aaatgcagat aacagtggag gtggacacaa gggagggacc aaaactgaat tctacagccc
     2221 agaagggtta cgaaaattta gttagtccca taacacttct tccagaggcg gaaatccttt
     2281 ttgaggatat tcccaaagaa aaacgcttcc cgaagtttaa gagacatgat gttaactcaa
     2341 caaggagagc ccaggaagag gtgaaaattc ccctggtaaa tatttcactc cttccaaaag
     2401 acgcccagtt gagtctcaat accttggatt tgcaactgga acatggagac atcactttga
     2461 aaggatacaa tttgtccaag tcagccttgc tgagatcatt tctgatgaac tcacagcatg
     2521 ctaaaataaa aaatcaagct ataataacag atgaaacaaa tgacagtttg gtggctccac
     2581 aggaaaaaca ggttcataaa agcatcttgc caaacagctt aggagtgtct gaaagattgc
     2641 agaggttgac ttttcctgca gtgagtgtaa aagtgaatgg tcatgaccag ggtcagaatc
     2701 cacccctgga cttggagacc acagcaagat ttagagtgga aactcacacc caaaaaacca
     2761 taggcggaaa tgtgacaaaa gaaaagcccc catctctgat tgttccactg gaaagccaga
     2821 tgacaaaaga aaagaaaatc acagggaaag aaaaagagaa cagtagaatg gaggaaaatg
     2881 ctgaaaatca cataggcgtt actgaagtgt tacttggaag aaagctgcag cattacacag
     2941 atagttactt gggctttttg ccatgggaga aaaaaaagta tttccaagat cttctcgacg
     3001 aagaagagtc attgaagaca caattggcat acttcactga tagcaaaaat actgggaggc
     3061 aactaaaaga tacatttgca gattccctca gatatgtaaa taaaattcta aatagcaagt
     3121 ttggattcac atcgcggaaa gtccctgctc acatgcctca catgattgac cggattgtta
     3181 tgcaagaact gcaagatatg ttccctgaag aatttgacaa gacgtcattt cacaaagtgc
     3241 gccattctga ggatatgcag tttgccttct cttattttta ttatctcatg agtgcagtgc
     3301 agccactgaa tatatctcaa gtctttgatg aagttgatac agatcaatct ggtgtcttgt
     3361 ctgacagaga aatccgaaca ctggctacca gaattcacga actgccgtta agtttgcagg
     3421 atttgacagg tctggaacac atgctaataa attgctcaaa aatgcttcct gctgatatca
     3481 cgcagctaaa taatattcca ccaactcagg aatcctacta tgatcccaac ctgccaccgg
     3541 tcactaaaag tctagtaaca aactgtaaac cagtaactga caaaatccac aaagcatata
     3601 aggacaaaaa caaatatagg tttgaaatca tgggagaaga agaaatcgct tttaaaatga
     3661 ttcgtaccaa cgtttctcat gtggttggcc agttggatga cataagaaaa aaccctagga
     3721 agtttgtttg cctgaatgac aacattgacc acaatcataa agatgctcag acagtgaagg
     3781 ctgttctcag ggacttctat gaatccatgt tccccatacc ttcccaattt gaactgccaa
     3841 gagagtatcg aaaccgtttc cttcatatgc atgagctgca ggaatggagg gcttatcgag
     3901 acaaattgaa gttttggacc cattgtgtac tagcaacatt gattatgttt actatattct
     3961 cattttttgc tgagcagtta attgcactta agcggaagat atttcccaga aggaggatac
     4021 acaaagaagc tagtcccaat cgaatcagag tatagaagat cttcatttga aaaccatcta
     4081 cctcagcatt tactgagcat tttaaaactc agcttcacag agatgtcttt gtgatgtgat
     4141 gcttagcagt ttggcccgaa gaaggaaaat atccagtacc atgctgtttt gtggcatgaa
     4201 tatagcccac tgaccaggaa ttatttaacc aacccactga aaacttgtgt gttgagcagc
     4261 tctgaactga ttttactttt aaagaatttg ctcatggacc tgtcatcctt tttataaaaa
     4321 ggctcactga caagagacag ctgttaattt cccacagcaa tcattgcaga ctaactttat
     4381 taggagaagc ctatgccagc tgggagtgat tgctaagagg ctccagtctt tgcattccaa
     4441 agccttttgc taaagttttg cacttttttt ttttcatttc ccatttttaa gtagttacta
     4501 agttaactag ttattcttgc ttctgagtat aacgaattgg gatgtctaaa cctattttta
     4561 tagatgttat ttaaataatg cagcaatatc acctcttatt gacaatacct aaattatgag
     4621 ttttattaat atttaagact gtaaatggtc ttaaaccact aactactgaa gagctcaatg
     4681 attgacatct gaaatgcttt gtaattattg acttcagccc ctaagaatgc tatgatttca
     4741 cgtgcaggtc taatttcaaa gggctagagt tagtactact taccagatgt aattatgttt
     4801 tggaaatgta catattcaaa cagaagtgcc tcattttaga aatgagtagt gctgatggca
     4861 ctggcacatt acagtggtgt cttgtttaat actcattggt atattccagt agctatctct
     4921 ctcagttggt ttttgataga acagaggcca gcaaactttc tttgtaaaag gctggttagt
     4981 aaattattgc aggccacctg tgtctttgtc atacattctt cttgctgttg tttagtttgt
     5041 tttttttcaa acaaccctct aaaaatgtaa aaaccatgtt tagcttgcag ctgtacaaaa
     5101 actgcccacc agccagatgt gaccctcagg ccatcatttg ccaatcactg agaattagtt
     5161 tttgttgttg ttgttgttgt tgtttttgag acagagtctc tctctgttgc ccaggctgga
     5221 gtgcagtggc gcaatctcag ctcactgcaa cctccgcctc ccgggttcaa gcagttctgt
     5281 ctcagccttc tgagtagctg ggactacagg tgcatgccac cacaccctgc taatttttgt
     5341 atttttagta gagacggggg ttccaccata ttggtcaggc ttatcttgaa ctcctgacct
     5401 caggtgatcc acctgcctct gcctcccaaa gtgctgagat tacaggcata agccagtgca
     5461 cccagccgag aattagtatt tttatgtatg gttaaacctt ggcgtctagc catattttat
     5521 gtcataatac aatggatttg tgaagagcag attccatgag taactctgac aggtatttta
     5581 gatcatgatc tcaacaatat tcttccaaaa tggcatacat cttttgtaca aagaacttga
     5641 aatgtaaata ctgtgtttgt gctgtaagag ttgtgtattt caaaaactga aatctcataa
     5701 aaagttaaat ttttgtctga
//
