LOCUS       NM_198066               3867 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glucosamine-phosphate N-acetyltransferase 1 (GNPNAT1),
            mRNA.
ACCESSION   NM_198066
VERSION     NM_198066.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3867)
  AUTHORS   Hu,H., Wang,Z.W., Hu,S., Xiang,Y., Deng,Y., Wan,F.J., Zhang,T.C.,
            Yang,Z.Y. and Liao,X.H.
  TITLE     GNPNAT1 promotes the stemness of breast cancer and serves as a
            potential prognostic biomarker
  JOURNAL   Oncol Rep 50 (2) (2023)
   PUBMED   37387422
  REMARK    GeneRIF: GNPNAT1 promotes the stemness of breast cancer and serves
            as a potential prognostic biomarker.
REFERENCE   2  (bases 1 to 3867)
  AUTHORS   Yuan,R., Zhang,Y., Wang,Y., Chen,H., Zhang,R., Hu,Z., Chai,C. and
            Chen,T.
  TITLE     GNPNAT1 is a potential biomarker correlated with immune
            infiltration and immunotherapy outcome in breast cancer
  JOURNAL   Front Immunol 14, 1152678 (2023)
   PUBMED   37215111
  REMARK    GeneRIF: GNPNAT1 is a potential biomarker correlated with immune
            infiltration and immunotherapy outcome in breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3867)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3867)
  AUTHORS   Zhang,S., Zhang,H., Li,H., Guo,J., Wang,J. and Zhang,L.
  TITLE     Potential role of glucosamine-phosphate N-acetyltransferase 1 in
            the development of lung adenocarcinoma
  JOURNAL   Aging (Albany NY) 13 (5), 7430-7453 (2021)
   PUBMED   33686019
  REMARK    GeneRIF: Potential role of glucosamine-phosphate
            N-acetyltransferase 1 in the development of lung adenocarcinoma.
REFERENCE   5  (bases 1 to 3867)
  AUTHORS   Zheng,X., Li,Y., Ma,C., Zhang,J., Zhang,Y., Fu,Z. and Luo,H.
  TITLE     Independent Prognostic Potential of GNPNAT1 in Lung Adenocarcinoma
  JOURNAL   Biomed Res Int 2020, 8851437 (2020)
   PUBMED   33178836
  REMARK    GeneRIF: Independent Prognostic Potential of GNPNAT1 in Lung
            Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3867)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 3867)
  AUTHORS   Brockhausen,I., Nair,D.G., Chen,M., Yang,X., Allingham,J.S.,
            Szarek,W.A. and Anastassiades,T.
  TITLE     Human acetyl-CoA:glucosamine-6-phosphate N-acetyltransferase 1 has
            a relaxed donor specificity and transfers acyl groups up to four
            carbons in length
  JOURNAL   Biochem Cell Biol 94 (2), 197-204 (2016)
   PUBMED   26935656
  REMARK    GeneRIF: The Glucosamine-6-phosphate N-acetyltransferase1 (GNA1)
            catalyses the transfer of an acetyl group from acetyl coenzyme A to
            glucosamine-6-phosphate to form N-acetylglucosamine-6-phosphate
            which is an essential intermediate in UDP-GlcNAc biosynthesis.
REFERENCE   8  (bases 1 to 3867)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   9  (bases 1 to 3867)
  AUTHORS   Wang,J., Liu,X., Liang,Y.H., Li,L.F. and Su,X.D.
  TITLE     Acceptor substrate binding revealed by crystal structure of human
            glucosamine-6-phosphate N-acetyltransferase 1
  JOURNAL   FEBS Lett 582 (20), 2973-2978 (2008)
   PUBMED   18675810
  REMARK    GeneRIF: Crystal structures of human GNA1, including apo GNA1, the
            GNA1-GlcN6P complex and an E156A mutant were reported.
REFERENCE   10 (bases 1 to 3867)
  AUTHORS   Vessal,M. and Jaberi-Pour,M.
  TITLE     Partial purification and kinetic properties of three different
            D-glucosamine 6-P:N-acetyltransferase forms from human placenta
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 121 (4), 379-384 (1998)
   PUBMED   9972309
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG717628.1, AK090577.1, AL139317.5 and CA435370.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198066.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.455389.1,
                                           SRR1803613.44163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216410.8/ ENSP00000216410.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BG717628.1         65-70
            7-1467              AK090577.1         1-1461
            1468-3808           AL139317.5         33136-35476         c
            3809-3867           CA435370.1         18-76               c
FEATURES             Location/Qualifiers
     source          1..3867
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..3867
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /note="glucosamine-phosphate N-acetyltransferase 1"
                     /db_xref="GeneID:64841"
                     /db_xref="HGNC:HGNC:19980"
                     /db_xref="MIM:616510"
     exon            1..180
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            181..348
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..749
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /EC_number="2.3.1.4"
                     /note="phosphoglucosamine acetylase; phosphoglucosamine
                     transacetylase"
                     /codon_start=1
                     /product="glucosamine 6-phosphate N-acetyltransferase"
                     /protein_id="NP_932332.1"
                     /db_xref="CCDS:CCDS9712.1"
                     /db_xref="GeneID:64841"
                     /db_xref="HGNC:HGNC:19980"
                     /db_xref="MIM:616510"
                     /translation="MKPDETPMFDPSLLKEVDWSQNTATFSPAISPTHPGEGLVLRPL
                     CTADLNRGFFKVLGQLTETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATAT
                     LIIEHKFIHSCAKRGRVEDVVVSDECRGKQLGKLLLSTLTLLSKKLNCYKITLECLPQ
                     NVGFYKKFGYTVSEENYMCRRFLK"
     exon            349..411
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            412..539
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            540..601
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            602..3867
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3845..3850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /note="hexamer: AATAAA"
     polyA_site      3867
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgagg tggaggcgtt ggcgctgcca cgtctgggcc gcggttccca actgtggcgc
       61 gggcggtgga ggaggaggtg gggctggcgc tgaagccgga tccggatccg gtgctgtgca
      121 cactggtggg ggagagtccg acgcgcctgg ctaggagcgc cgaccgcagg gcctctacgg
      181 accttactag aaaaatgaaa cctgatgaaa ctcctatgtt tgacccaagt ctactcaaag
      241 aagtggactg gagtcagaat acagctacat tttctccagc catttcccca acacatcctg
      301 gagaaggctt ggttttgagg cctctttgta ctgctgactt aaatagaggt ttttttaagg
      361 tattgggtca gctaacagag actggagttg tcagccctga acaatttatg aaatcttttg
      421 agcatatgaa gaaatctggg gattattatg ttacagttgt agaagatgtg actctaggac
      481 agattgttgc tacggcaact ctgattatag aacataaatt catccattcc tgtgctaaga
      541 gaggaagagt agaagatgtt gttgttagtg atgaatgcag aggaaagcag cttggcaaat
      601 tgttattatc aacccttact ttgctaagca agaaactgaa ctgttacaag attacccttg
      661 aatgtctacc acaaaatgtt ggtttctata aaaagtttgg atatactgta tctgaagaaa
      721 actacatgtg tcggaggttt ctaaagtaaa aatcttgtaa gaaaattgtc aaaggggcta
      781 atgctacaag gctacactct tcctagagtt gaaatatttt gttgctgcag ccgagtgacc
      841 tccataaata ctggactgaa aaaacattgt aatactacaa gtataatgac atttagaaga
      901 ttactttggg ctggtgggac atgctgtgaa tttagattac aaatgaatat tataaagggg
      961 atgattttta accaaaggaa tatattttta acttgaatct tttcttgcat tgtatttttc
     1021 taaaagtttg gcttcctttc ttggtagtca agagtatggg taataaggag ttatatgtct
     1081 gctatctgtg ttgctcattt aaaaaaagta tacattgaat aaggctgttt atcacatgca
     1141 taaaattaaa tatttttgtt tcaaagaaac atctcaatac acttaggggt gtattgtttc
     1201 ccacatatta agtcagggtg gataaattag ttattataac taaacatagt atagtccaac
     1261 attcgttgat cccaatacag gcaaacaacc tggtcaacct tttgaagtag aagaaatgaa
     1321 aattacttga caagattaaa agtaaaacaa tttaaatgtt ttactgaaag tttatatagt
     1381 atagtctatg tagataaaaa gtaccacttg tcttttctgt gaattatgac tattcatttg
     1441 ttaaaaatac ctaagagcaa ttatagtggg acatctaagg tcctctgtaa acagtgaatt
     1501 agcaaacctc agcctatgtg tttctaccct gatttttttc ttttcatggg tatctgaagc
     1561 ctctaagttt tttcaaaaat ggagtatcac aaaattgagt gaaacacaat acttaatgta
     1621 ttgtactaga ttgccaaatt cataaaatgt taatggaagc tttttgatgt gattataatg
     1681 gcactattct ggtcattatc ctattttgat tttatttaat tttttaaagt tgaagaatta
     1741 aatattttaa tggttctaat cttttgcatt ccatgttgca ttaaacctgt ttatatgagt
     1801 agtcttctgt tagaatcaca tctgtgcttt tcttgagtct gctgttgaac tattagatta
     1861 agtcataatt cataaaattt tagtttaatg tgctctttgt aaaatgaaat tgtaaagaaa
     1921 ataccagtgt ttctcatccc attgactcac accacgtcat ctggattttg gatttccctc
     1981 catgcagcca gctatagttg gctttccaaa acaacagaaa tccttcacca atagagtgca
     2041 ctacttacct gcttatagcc tatacagacg aactgatctg tccttcgtga aacgcaacaa
     2101 agctagttct gtcttttcag aagtcctaca accttgacaa agagtagttt tatcaggtaa
     2161 atcctggtaa ttaaaaacgc atgtttttaa aaattagcct ggtaaggccg ggtgcagtgg
     2221 ctcacgcctg taatcccagc actttgggag gctgaggtgg gcagatcaca aggtcaggag
     2281 tttgagacca gcctgaccaa aatggtgaaa ccctgtctct actaaaaaaa agaaaaatta
     2341 gccagacgtg gtggcatgcg cctgtaatcc cagctactca ggaagctgag gcgagagaat
     2401 cgcttgaacc cgggaggcaa aggttgcagt gagctgagat cacaccactg cactccagcc
     2461 tggcgacaga gagagactcc atctcaaaac aaaacaaaaa aaattagcct acttaaaggc
     2521 acaactaaat gctttattac ctttcttacc actgaacaat ttgaggtaaa atcattcaca
     2581 aggttggcac ttcagtaaat ccctttaaat agtgttccta agatatctct taaatcctcc
     2641 cataggaaat agaattacag gtaaggtaca ccatacaaaa attgtgtcat tgaggacaat
     2701 ggtgatctgt aattttagtt gagtatgttt atgatttttg aagccatatg gtgagtaaat
     2761 gtaaatatga aaaaagtgct acataaaaca cttcttaaac tttttttttt taaaaactgc
     2821 tccttgtgga gcaggactac cccataggca gtgtacccac aatagatagc cttttgttgt
     2881 tgttgttgtt gagacaaggt ctcgctgttg cccaggctag agcgcagggg cacaatcacc
     2941 acacactgcc gcttcaatct cctgggctca aatgatcctt ccacctcagc ctcccatgtg
     3001 gctgggacta taggtgcatg ccaccacacc cagctaatta aaaaaatttt ttgtgtggag
     3061 tctatgttgc ccaggctggt ctcttaactc ctaggctcaa gtgatcctcc cacctcagcc
     3121 tcccaaagtg cttggatgac aggtgcgagc cactgcacct ggcccacatt ttttaaagag
     3181 acactgtccc actccatcac ccaggctgga gtccagtggt gtgatcatag ctcactgcat
     3241 cctccagttc ctgggttcaa gccatccctc ctgcctcagc ctccccagta gctggaacta
     3301 caggtgtgtg ccatcacacc tggctttaca tttttctgtg gggtcttact atattgccca
     3361 agccggtctc aaactcctga gctcaagtga tcctctgcct cagcctccag agtatctggg
     3421 attacatatg tcggctaccg tgtctggccg ttcacatctt tggccactat ttgcttgtga
     3481 aaaggtataa tgaggtggta cttatcattt ttactgtgtc tcatgttttg tatatttttg
     3541 tttcatcaac taagatgcac tgtaacatct ctgaaatctg gatatattat caatggttta
     3601 tcatagtttt gttagcaata cactgtcttt tagtggtgcc taaaataatg gtatagttgt
     3661 gaggtgatct tagatttgat gaagcacagt atgcaggtag gcctaatggg ggaagatggt
     3721 aatataaaag caagaagtat tttttttttg taatgactga aagctgttct gtggatgacc
     3781 taccctttcc tttaaacacg attctctcac ttccaactcc aaacttgctc aactaatcct
     3841 taaaaataaa cttgagctgg aatttga
//
