LOCUS       NM_138335               2235 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens glucosamine-6-phosphate deaminase 2 (GNPDA2),
            transcript variant 1, mRNA.
ACCESSION   NM_138335
VERSION     NM_138335.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2235)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 2235)
  AUTHORS   Oikari,S., Makkonen,K., Deen,A.J., Tyni,I., Karna,R., Tammi,R.H.
            and Tammi,M.I.
  TITLE     Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA
            enzymes in the maintenance of UDP-GlcNAc content and hyaluronan
            synthesis
  JOURNAL   Glycobiology 26 (7), 710-722 (2016)
   PUBMED   26887390
  REMARK    GeneRIF: GNPDA1 siRNA induced GFAT2 which was hardly measurable in
            these cells under standard culture conditions, GNPDA2 siRNA
            increased GFAT1, and GFAT1 siRNA increased the expression of
            hyaluronan synthase 2 (HAS2). Silencing of GFAT1 stimulated GNPDA1
            and GDPDA2, and inhibited cell migration.
REFERENCE   5  (bases 1 to 2235)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   6  (bases 1 to 2235)
  AUTHORS   Brandys,M.K., van Elburg,A.A., Loos,R.J.F., Bauer,F., Hendriks,J.,
            van der Schouw,Y.T. and Adan,R.A.H.
  TITLE     Are recently identified genetic variants regulating BMI in the
            general population associated with anorexia nervosa?
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (2), 695-699 (2010)
   PUBMED   19746409
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2235)
  AUTHORS   Renstrom,F., Payne,F., Nordstrom,A., Brito,E.C., Rolandsson,O.,
            Hallmans,G., Barroso,I., Nordstrom,P. and Franks,P.W.
  CONSRTM   GIANT Consortium
  TITLE     Replication and extension of genome-wide association study results
            for obesity in 4923 adults from northern Sweden
  JOURNAL   Hum Mol Genet 18 (8), 1489-1496 (2009)
   PUBMED   19164386
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2235)
  AUTHORS   Willer,C.J., Speliotes,E.K., Loos,R.J., Li,S., Lindgren,C.M.,
            Heid,I.M., Berndt,S.I., Elliott,A.L., Jackson,A.U., Lamina,C.,
            Lettre,G., Lim,N., Lyon,H.N., McCarroll,S.A., Papadakis,K., Qi,L.,
            Randall,J.C., Roccasecca,R.M., Sanna,S., Scheet,P., Weedon,M.N.,
            Wheeler,E., Zhao,J.H., Jacobs,L.C., Prokopenko,I., Soranzo,N.,
            Tanaka,T., Timpson,N.J., Almgren,P., Bennett,A., Bergman,R.N.,
            Bingham,S.A., Bonnycastle,L.L., Brown,M., Burtt,N.P., Chines,P.,
            Coin,L., Collins,F.S., Connell,J.M., Cooper,C., Smith,G.D.,
            Dennison,E.M., Deodhar,P., Elliott,P., Erdos,M.R., Estrada,K.,
            Evans,D.M., Gianniny,L., Gieger,C., Gillson,C.J., Guiducci,C.,
            Hackett,R., Hadley,D., Hall,A.S., Havulinna,A.S., Hebebrand,J.,
            Hofman,A., Isomaa,B., Jacobs,K.B., Johnson,T., Jousilahti,P.,
            Jovanovic,Z., Khaw,K.T., Kraft,P., Kuokkanen,M., Kuusisto,J.,
            Laitinen,J., Lakatta,E.G., Luan,J., Luben,R.N., Mangino,M.,
            McArdle,W.L., Meitinger,T., Mulas,A., Munroe,P.B., Narisu,N.,
            Ness,A.R., Northstone,K., O'Rahilly,S., Purmann,C., Rees,M.G.,
            Ridderstrale,M., Ring,S.M., Rivadeneira,F., Ruokonen,A.,
            Sandhu,M.S., Saramies,J., Scott,L.J., Scuteri,A., Silander,K.,
            Sims,M.A., Song,K., Stephens,J., Stevens,S., Stringham,H.M.,
            Tung,Y.C., Valle,T.T., Van Duijn,C.M., Vimaleswaran,K.S.,
            Vollenweider,P., Waeber,G., Wallace,C., Watanabe,R.M.,
            Waterworth,D.M., Watkins,N., Witteman,J.C., Zeggini,E., Zhai,G.,
            Zillikens,M.C., Altshuler,D., Caulfield,M.J., Chanock,S.J.,
            Farooqi,I.S., Ferrucci,L., Guralnik,J.M., Hattersley,A.T., Hu,F.B.,
            Jarvelin,M.R., Laakso,M., Mooser,V., Ong,K.K., Ouwehand,W.H.,
            Salomaa,V., Samani,N.J., Spector,T.D., Tuomi,T., Tuomilehto,J.,
            Uda,M., Uitterlinden,A.G., Wareham,N.J., Deloukas,P.,
            Frayling,T.M., Groop,L.C., Hayes,R.B., Hunter,D.J., Mohlke,K.L.,
            Peltonen,L., Schlessinger,D., Strachan,D.P., Wichmann,H.E.,
            McCarthy,M.I., Boehnke,M., Barroso,I., Abecasis,G.R. and
            Hirschhorn,J.N.
  CONSRTM   Wellcome Trust Case Control Consortium; Genetic Investigation of
            ANthropometric Traits Consortium
  TITLE     Six new loci associated with body mass index highlight a neuronal
            influence on body weight regulation
  JOURNAL   Nat Genet 41 (1), 25-34 (2009)
   PUBMED   19079261
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 2235)
  AUTHORS   Arreola,R., Valderrama,B., Morante,M.L. and Horjales,E.
  TITLE     Two mammalian glucosamine-6-phosphate deaminases: a structural and
            genetic study
  JOURNAL   FEBS Lett 551 (1-3), 63-70 (2003)
   PUBMED   12965206
REFERENCE   10 (bases 1 to 2235)
  AUTHORS   Zhang,J., Zhang,W., Zou,D., Chen,G., Wan,T., Li,N. and Cao,X.
  TITLE     Cloning and functional characterization of GNPI2, a novel human
            homolog of glucosamine-6-phosphate isomerase/oscillin
  JOURNAL   J Cell Biochem 88 (5), 932-940 (2003)
   PUBMED   12616532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096586.3.
            
            On May 17, 2019 this sequence version replaced NM_138335.2.
            
            Summary: The protein encoded by this gene is an allosteric enzyme
            that catalyzes the reversible reaction converting
            D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium.
            Variations of this gene have been reported to be associated with
            influencing body mass index and susceptibility to obesity. A
            pseudogene of this gene is located on chromosome 9. Alternative
            splicing results in multiple transcript variants that encode
            different protein isoforms. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.48875.1,
                                           SRR1660803.116381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295448.8/ ENSP00000295448.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC096586.3         88577-88659
            84-242              AC096586.3         92891-93049
            243-344             AC096586.3         96723-96824
            345-527             AC096586.3         97838-98020
            528-712             AC096586.3         103996-104180
            713-887             AC096586.3         107207-107381
            888-2235            AC096586.3         111991-113338
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p12"
     gene            1..2235
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /note="glucosamine-6-phosphate deaminase 2"
                     /db_xref="GeneID:132789"
                     /db_xref="HGNC:HGNC:21526"
                     /db_xref="MIM:613222"
     exon            1..83
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /inference="alignment:Splign:2.1.0"
     exon            84..242
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..949
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /EC_number="3.5.99.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glucosamine-6-phosphate isomerase 2; glcN6P deaminase 2;
                     glucosamine-6-phosphate isomerase SB52"
                     /codon_start=1
                     /product="glucosamine-6-phosphate deaminase 2 isoform 1"
                     /protein_id="NP_612208.1"
                     /db_xref="CCDS:CCDS3469.1"
                     /db_xref="GeneID:132789"
                     /db_xref="HGNC:HGNC:21526"
                     /db_xref="MIM:613222"
                     /translation="MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTGST
                     PLGCYKKLIEYHKNGHLSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPN
                     NAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK
                     TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEE
                     GVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKGLMHVHNKLVDPLFSMKDGN
                     "
     exon            243..344
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /inference="alignment:Splign:2.1.0"
     exon            345..527
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /inference="alignment:Splign:2.1.0"
     exon            528..712
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /inference="alignment:Splign:2.1.0"
     exon            713..887
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /inference="alignment:Splign:2.1.0"
     exon            888..2235
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1855..1860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /note="hexamer: AATAAA"
     regulatory      1867..1872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /note="hexamer: AATAAA"
     polyA_site      1879
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /note="major polyA site"
     polyA_site      1885
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /note="major polyA site"
     regulatory      2107..2112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /note="hexamer: ATTAAA"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /note="hexamer: AATAAA"
     polyA_site      2143
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
     regulatory      2150..2155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /note="hexamer: AATGAA"
     regulatory      2155..2160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
                     /note="hexamer: AATAAA"
     polyA_site      2161
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
     polyA_site      2168
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
     polyA_site      2187
                     /gene="GNPDA2"
                     /gene_synonym="GNP2; SB52"
ORIGIN      
        1 actggtcagc tggggtcgct ctcgggtggt tgggtgttgc ttgttcccgc tgttccagca
       61 tcgaagaacc attgggtctg ccggtttgaa cttgttctgg aagctgtgcg tcaccgtaat
      121 gaggcttgta attcttgata actatgactt ggctagtgaa tgggcagcca aatacatctg
      181 taatcgcatc attcagttca aacctggaca ggacagatat tttacactgg gtttaccaac
      241 agggagtaca cctttaggat gctataaaaa actaatagaa tatcataaga atggacacct
      301 ttcttttaaa tatgtgaaga cctttaatat ggatgaatat gtaggacttc caagaaatca
      361 tcctgaaagc taccattctt atatgtggaa taattttttt aagcatatcg atatagatcc
      421 taataatgca catatccttg acgggaatgc tgcagattta caagcagaat gtgatgcttt
      481 tgaaaacaaa ataaaagaag ctggaggaat agatcttttt gttggaggaa ttggtccaga
      541 tggtcatatc gctttcaatg agcctggatc cagtttagtg tcaaggacaa gattaaagac
      601 tctagcaatg gataccatct tggcaaatgc caaatatttt gatggagatt tatcaaaagt
      661 gccaactatg gctctaactg ttggtgtggg gacagtgatg gatgctagag aagtaatgat
      721 ccttataaca ggggcacaca aggcatttgc cctgtacaaa gcaatagaag aaggagtcaa
      781 tcacatgtgg actgtttccg ctttccagca gcatccccgg actatttttg tatgcgatga
      841 agatgctact ttagaattaa gagttaaaac tgtgaaatac tttaaaggtc taatgcatgt
      901 gcacaataaa cttgtggatc cactattcag tatgaaagat ggaaactgaa ggagactgga
      961 gcaaaattca gcttgaatga acagagcact ttttactaag tagtagatga attttcagct
     1021 atgcaatatg acaaaacatg gggaattttg aagattgtca ttttttcatt cgagtctcta
     1081 tgttaaacat tccatatttt gaatatttat atcttgtact tgggtttaag agaagtagct
     1141 ggctctcaag attgactggc tatttattat aaagtactga agtcacatag ccacctataa
     1201 aacagcatag aaatgtctgc ctgtttaaaa agtcatttta aaggtagagt gtccacatca
     1261 ggcaccattt gtgatatgac tccagtggcg tatatttcat tttttaatga caagacactc
     1321 caaacctttc agataacaaa ctatcattgc agaccttcac ttttggaatg caatctttat
     1381 attttctgtg catcacacac atgcttttct gcacgtggtt gccttagtca tcttcctaca
     1441 gcaccatcta gacatcaaaa attgtgctat atatcattgg taaaggaaat ttgaagagat
     1501 gacagtgcct aaaagtacag tttacatcct tttggaaagt atgtgtaagt gcatgttttt
     1561 tgtgcacctt cttctatagc acttttttac aaatatctta tttttattta acgacttggg
     1621 ttcatgtccc taatataagt atcttgacaa ttatgagctt tatacctagc aagccacttc
     1681 aggaaattct tttggagaat attttctgat tattgttaaa cttaatatac aattagcttt
     1741 attccttata aaatgtctaa aagaataata cgaagtatat ataaaaggaa ttactgtaaa
     1801 ctacattgcc atagcaattt acataaaagt atattgtttt ttatctttaa ctcaaataaa
     1861 gcgtgtaata aataagttat ctaaatttcc agaagtgaac ctgaagaata catgcattcg
     1921 actcccaaca attatagtac atgtgaacct gcattcattt tgggtttgtt accatcatgc
     1981 attaggagag ttaggttaaa agatgtcttt gcctctgtgg ggagcaaaaa aatgctcctt
     2041 ttgcttattt tgcatttcat aagcccacct ggtagaagaa gccttactta tctgcttgtc
     2101 tatgtgatta aaatgtagtt tcttaaaata ttaaaatagc aaataaatta atgaaataaa
     2161 attggtaata gggttttatg gttaaaagtg ggggatgggg taaattatgc tgctttaatt
     2221 ccagatgatg tttta
//
