LOCUS       NM_001184819            8684 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens G protein nucleolar 3 like (GNL3L), transcript variant
            1, mRNA.
ACCESSION   NM_001184819
VERSION     NM_001184819.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8684)
  AUTHORS   He,W., Sun,F., Li,W., Du,R., Yan,S. and Liu,C.
  TITLE     GNL3L promotes autophagy via regulating AMPK signaling in
            esophageal cancer cells
  JOURNAL   Med Oncol 41 (1), 29 (2023)
   PUBMED   38148364
  REMARK    GeneRIF: GNL3L promotes autophagy via regulating AMPK signaling in
            esophageal cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8684)
  AUTHORS   Cai,Q., Chen,S., Zhu,Y. and Li,Z.
  TITLE     Knockdown of GNL3L Alleviates the Progression of COPD Through
            Inhibiting the ATM/p53 Pathway
  JOURNAL   Int J Chron Obstruct Pulmon Dis 18, 2645-2659 (2023)
   PUBMED   38022822
  REMARK    GeneRIF: Knockdown of GNL3L Alleviates the Progression of COPD
            Through Inhibiting the ATM/p53 Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8684)
  AUTHORS   Dai,G., Guo,Z., Chen,H., Jiang,M., Zhou,H., Bao,J., Yu,H. and
            Huang,J.
  TITLE     High expression of guanine nucleotide-binding protein-like-3-like
            is associated with poor prognosis in esophageal cancer
  JOURNAL   Medicine (Baltimore) 100 (21), e25993 (2021)
   PUBMED   34032716
  REMARK    GeneRIF: High expression of guanine nucleotide-binding
            protein-like-3-like is associated with poor prognosis in esophageal
            cancer.
REFERENCE   4  (bases 1 to 8684)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 8684)
  AUTHORS   Oktar,P.A., Yildirim,S., Balci,D. and Can,A.
  TITLE     Continual expression throughout the cell cycle and downregulation
            upon adipogenic differentiation makes nucleostemin a vital human
            MSC proliferation marker
  JOURNAL   Stem Cell Rev Rep 7 (2), 413-424 (2011)
   PUBMED   21063916
  REMARK    GeneRIF: differences in the relative nucleostemin protein and mRNA
            levels may reflect the degree of proliferation of mesnchymal stem
            cells and can be used to characterize in vitro expansion
            capabilities
REFERENCE   6  (bases 1 to 8684)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 8684)
  AUTHORS   Zhu,Q., Meng,L., Hsu,J.K., Lin,T., Teishima,J. and Tsai,R.Y.
  TITLE     GNL3L stabilizes the TRF1 complex and promotes mitotic transition
  JOURNAL   J Cell Biol 185 (5), 827-839 (2009)
   PUBMED   19487455
REFERENCE   8  (bases 1 to 8684)
  AUTHORS   Fu,D. and Collins,K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
REFERENCE   9  (bases 1 to 8684)
  AUTHORS   Rao,M.R., Kumari,G., Balasundaram,D., Sankaranarayanan,R. and
            Mahalingam,S.
  TITLE     A novel lysine-rich domain and GTP binding motifs regulate the
            nucleolar retention of human guanine nucleotide binding protein,
            GNL3L
  JOURNAL   J Mol Biol 364 (4), 637-654 (2006)
   PUBMED   17034816
  REMARK    GeneRIF: GNL3L is composed of distinct modules, each of which plays
            a specific role in molecular interactions for its nucleolar
            retention and subsequent function(s) within the nucleolus
REFERENCE   10 (bases 1 to 8684)
  AUTHORS   Du,X., Rao,M.R., Chen,X.Q., Wu,W., Mahalingam,S. and
            Balasundaram,D.
  TITLE     The homologous putative GTPases Grn1p from fission yeast and the
            human GNL3L are required for growth and play a role in processing
            of nucleolar pre-rRNA
  JOURNAL   Mol Biol Cell 17 (1), 460-474 (2006)
   PUBMED   16251348
  REMARK    GeneRIF: analysis uncovers an important role for Grn1p/GNL3L within
            this unique group of nucleolar GTPases
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK001475.1, BC003603.1,
            BQ674906.1 and AL391139.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001184819.1.
            
            Summary: The protein encoded by this gene appears to be a nucleolar
            GTPase that is essential for ribosomal pre-rRNA processing and cell
            proliferation. Two transcript variants encoding the same protein
            have been found for this gene. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.153172.1,
                                           SRR1163657.539830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360845.3/ ENSP00000354091.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AK001475.1         9-92
            85-1888             BC003603.1         1-1804
            1889-2171           BQ674906.1         417-699
            2172-8684           AL391139.19        53342-59854
FEATURES             Location/Qualifiers
     source          1..8684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..8684
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /note="G protein nucleolar 3 like"
                     /db_xref="GeneID:54552"
                     /db_xref="HGNC:HGNC:25553"
                     /db_xref="MIM:300873"
     exon            1..201
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            202..267
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1997
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /note="novel GTPase; guanine nucleotide binding
                     protein-like 3 (nucleolar)-like; G protein nucleolar 3B"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein-like 3-like
                     protein"
                     /protein_id="NP_001171748.1"
                     /db_xref="CCDS:CCDS14360.1"
                     /db_xref="GeneID:54552"
                     /db_xref="HGNC:HGNC:25553"
                     /db_xref="MIM:300873"
                     /translation="MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAP
                     HFVHPNDHANREAELKKKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHK
                     EEVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVL
                     RAQGNKKLVLVLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVD
                     QASESLLKSKACFGAENLMRVLGNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSR
                     ACSVGAVPGITKFMQEVYLDKFIRLLDAPGIVPGPNSEVGTILRNCVHVQKLADPVTP
                     VETILQRCNLEEISNYYGVSGFQTTEHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADW
                     VSGKISFYIPPPATHTLPTHLSAEIVKEMTEVFDIEDTEQANEDTMECLATGESDELL
                     GDTDPLEMEIKLLHSPMTKIADAIENKTTVYKIGDLTGYCTNPNRHQMGWAKRNVDHR
                     PKSNSMVDVCSVDRRSVLQRIMETDPLQQGQALASALKNKKKMQKRADKIASKLSDSM
                     MSALDLSGNADDGVGD"
     exon            268..329
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            330..437
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            438..554
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            555..638
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            639..774
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            775..878
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1023
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1111
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1286
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1429
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1566
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1694
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1914
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..8684
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4319..4324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /note="hexamer: AACAAA"
     polyA_site      4345
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /note="major polyA site"
     regulatory      6651..6656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /note="hexamer: AGTAAA"
     regulatory      6662..6667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /note="hexamer: TATAAA"
     polyA_site      6671
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
     polyA_site      6680
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
     regulatory      8654..8659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
                     /note="hexamer: AATAAA"
     polyA_site      8684
                     /gene="GNL3L"
                     /gene_synonym="GNL3B"
ORIGIN      
        1 agtcggagcc tagctgcgcg agagtttctg ctcgctcaac cgagttgtcg tgttgccctc
       61 gcttctcaga tccccgccgg aagtgtaagt aagaaacttc tctcctcttt tctcacaatg
      121 tgcgctcacc tagacggccg ggcagttagg atcgtctatt ggatgtgaaa ccagagatgc
      181 ccgccaacct ggaatagaga ggaagagagc aagcagattt gaacctatct gctttcaagc
      241 tggtcatcat gatgaaactt agacacaaaa ataaaaagcc aggtgaaggt tccaagggcc
      301 acaagaagat aagttggccc taccctcagc ctgcaaagca aaatgggaag aaagcaacct
      361 ccaaagtgcc ctctgcacct cattttgttc accccaatga tcatgccaat cgagaggctg
      421 aattaaagaa gaagtgggtt gaggagatga gggagaagca gcaagccgcc cgggagcaag
      481 aaagacaaaa acgcaggacc attgagagct actgtcagga tgtcctaaga cgccaggagg
      541 agtttgagca taaggaggaa gttttgcagg aattaaatat gtttcctcag ctggatgacg
      601 aggccacgag gaaggcttat tacaaggagt tccgtaaggt ggtggaatac tctgatgtga
      661 ttctggaagt cctggatgcc agagacccat taggctgccg ctgcttccaa atggaggagg
      721 ctgtcctgcg agcacaaggc aacaagaagc tggtcctggt cttgaacaag attgacctgg
      781 tccccaagga ggttgtggag aaatggctgg attaccttcg gaatgagttg ccaaccgtgg
      841 ctttcaaggc cagtacccag catcaggtca aaaacctgaa tcgttgcagt gtgccagtag
      901 atcaggcctc tgagtcactg ctgaaaagca aagcctgctt tggagctgaa aacctcatga
      961 gggttctggg gaactattgc cgccttggtg aagtgcgcac ccacattcgt gtgggtgttg
     1021 tgggtcttcc caatgttggg aagagcagcc tgatcaatag cctgaagcgc agccgcgcat
     1081 gcagcgtggg agctgttcct ggaattacca aattcatgca ggaggtctac ctggacaagt
     1141 tcatccggct cttggatgct ccaggcattg tcccagggcc caactcagag gtgggcacca
     1201 tcctgcgtaa ctgcgtccac gtgcagaagc tggcagaccc tgtgacccca gtggagacca
     1261 tcctgcagcg ctgcaacctg gaggagattt ccaactatta tggcgtctct gggttccaga
     1321 ccactgagca ctttctgacg gcagtggccc accgtttggg gaagaagaag aagggaggct
     1381 tatatagtca ggaacaggcg gccaaagctg tcctagctga ctgggtgagc gggaagatca
     1441 gcttctatat accaccacca gccactcaca ctctgcccac ccatctcagt gctgagatcg
     1501 ttaaggaaat gaccgaggtc tttgacatcg aggatactga gcaggccaat gaagacacca
     1561 tggaatgctt ggccaccgga gaatctgatg agctgttggg tgacacggac ccacttgaaa
     1621 tggagatcaa gttgctccat tctccgatga cgaaaatagc agatgccatt gaaaataaaa
     1681 ccaccgtgta taagattgga gatctcactg ggtattgcac caatccgaac cgtcatcaga
     1741 tggggtgggc taaacgcaat gtggaccacc gccctaagag caacagtatg gtggatgtct
     1801 gctcagtgga ccgccgctca gtgctgcaga ggatcatgga gacggacccc ctgcaacagg
     1861 gccaggctct ggcatctgcc ctgaaaaata agaagaagat gcagaaacgt gcagataaaa
     1921 tcgccagcaa gctgtctgat tccatgatgt ctgctctcga cctctctggc aatgctgatg
     1981 atggtgttgg tgactaatcg actgatctca cttcccttcc gctccaagca ccagttccgg
     2041 tggtacgggg gaataccagt gaaatagttt ggttctccct gaagcatctg catattgaaa
     2101 gaacgctttc cccactgtgt gtcttctccc cctcctccag taaaaacagt cccggctagg
     2161 tgctgtggct cacgtctgta atcccagcac tttgggaggc cgaggtgggc agatcacctg
     2221 aggtcaggag ttcgagacca gcctggccaa catggtgaaa ccccgtctct actaaaaata
     2281 caaaaaaatt tagccgtgct tagtggcacc tataatccca gctacttggg aggctgaggc
     2341 aggagaatcg cctgaacctg ggagactaag gcaggagaat cgcctgaacc tgggaggcag
     2401 aggttgcagt gagcccagac ggcaccattg cactctagcc tgggcaacaa cacgaaactc
     2461 cgtcccaaaa aaaaaaaaaa aaaaaaaatc ccaaggggct gcagctgcca aacccaatac
     2521 cctctattta acccctactc tgttttacaa gagaaataaa agaagtatca gcagagctca
     2581 ggtgctaaca cctgttgagg gctgacctac aaaactctgc ctacaaaact ctcttagaca
     2641 ggtgaatatg ccactagaag ttaggttgct ggtagacctg ggggtccctg cgggagggtg
     2701 atggtttctt taccacccca caggagattt cagtggcaag gcatgcctgc agtgggcttt
     2761 gggccatgca tcttccaagt ccataggtct tcacctgggt ggcagtgaga aaaagtagaa
     2821 agtaatgagc ctcctgtgtc tctggaaggt tctagggata gggtagaggg aagaagagaa
     2881 caaacaagcc tggcttgtgc tgaagtgtgg taggcactac cctgtttgcg tgaagagaaa
     2941 acaaagcacc tgttagtagg gaggctttag ggggaagccc cgtcttgggg gcatttctgg
     3001 gcagattgtg aattggagga atctctttaa ctgaagtact ctggctggac cctgcccttg
     3061 tgtgaccatg tctcctattg caccagcatt tgaattccat ggctcaagag ggttctggta
     3121 ccatttattc acagactgta tcctcgagag agctgctata tatgggagtg taccagccaa
     3181 ctccttttcc agtgtctgta agtcacctca ttaaagtata attagctgtc tcctctggga
     3241 gatcctaccc catcagacaa gggcagtgag cccaagcagt gccagaggcc ctcagaaagg
     3301 gattagggta gatgattgca actgaaacac aatcttcttt ctttgccagg gtattttggg
     3361 ggttttgccc caaaatatac cctgggcata gcattactgc agtcttggat gtctacccca
     3421 aacttccaca ccatccttcg acccacagct gcacctttat ttatttattt tgctctgttg
     3481 cccaggctgg agtgcaatgg cgtgatctcg gctcactgca acctctgcct cccgggttca
     3541 agtgatcctc ctgccttagc ctcccaagta gctgggatta caggcacctg ccaccacgcc
     3601 tggctagttt ttgtattttt agtagagacg atgtttcacc atgttgacca ggctggtctc
     3661 gaactcttga cctcaagtga tccactcgct tcggcctccc aaagtgctgg gattataggc
     3721 gtgagccact gtgcccagcc tcacagctgc atcttaacct tacctttgcc tctgcctctc
     3781 aagctggtac ctcctaattt acatcctaag agtggaacca tgtgacaagg actggagtgc
     3841 cattggctgt ggactgttca ggcagggaag tacaagacca ctcttgtatt caggggcaac
     3901 caaaggagag aattacgtac ttgttgagta caaactgcac caagccctgg agacccatta
     3961 ccaccgttaa ccctcaatac agctctgcta gtaagggatt cgtctcccca aatgaaaaaa
     4021 aaaagtaatc tcagaatgtt ggccgagcat ggtggctcac acctgtaatc ccagttatgc
     4081 aggaggctga ggcaggagaa tcacttgatc tcaggaggcg gaggttgcag tgagtcgaca
     4141 tcacaccact gcactccagc ctgggggaca gagtgagact tcgtctcgga aaaaaaaaaa
     4201 aaaagttgac aggatggcca gacccaagtg ggcgtattaa gtggtggtgc taggattgga
     4261 acccaagcgt gattaaaacc ctatgcaggc cctttcctct atattgtact gcctccttaa
     4321 caaaggaaga ttgattaagc ccctactttg tgccagtctc tgttatcaag tccgttaaat
     4381 gcatttaacg ttaaattttt tcttttttgg tttaaaaaac tctagtttct taaactacta
     4441 gtttttagtg tcttgctaaa actatgtgct cttgaatagg ctacaactta tttcacacta
     4501 tctcattgaa ctctcctggt atgtgatagt gttataatga aaaattgcat accaggacag
     4561 ctaagtctat tttgcaacca tacagcgttt cataatttag catttaaaat acagacagtc
     4621 cccgactttt ggtggtttga tgtgggattt ttggtggaaa agcagtatac attcagaatg
     4681 cacctctact tatgatgggg ctacttcctg gtaaacccat tgtaatgtgc aaattacggg
     4741 tttatcagga ggtgacccca tcggtaatgg agaagtgctg ggaggtaaat attagaaatg
     4801 gaagtatcta aatgagtaag aaacagcatg ggagcataat ttggccaaaa tcaaacagaa
     4861 ctaaagtagt catgtcggta agaatttggg actgcaggcc agttacgata gctctcacct
     4921 gtaatcccag cattttggga ggccgaggca ggcggatcac ttgaggtcag gagttcaaga
     4981 ccagcctaaa caatatggcg aaacctcatc tctaccaaaa aaatacaaag attagctggg
     5041 catggtgtct catgcctgta gtcccagcta cctatggggc tgaggcagga ggatctcttg
     5101 agcccaggag gtcgatgctg cattgagccg agattgtgcc actgctctcc agcgtgggca
     5161 acagagtgag actgtctcag ggggaaaaaa aaagaggaaa acaaaaaaga cgttgggagt
     5221 gcagtttctc tacctacagc atatctcaaa ggtttttttt aaaaaagtat tttcttaact
     5281 ttttaccttc atttttcaaa acaattaggg tacaatttac atatagtaaa gttcactctt
     5341 tatagtttta gttatgtgag tttgtacaaa catatacagg agtgaaccac taccacaatc
     5401 gaaatatagt tgcatcaccc ccctaaaact ctccaggccc ttttgtagtc aactcctacc
     5461 cccgaccctc agattctgct aaccactgat ttgttttctg cccctatagt tttgctttag
     5521 tatgactgtc atatcaatag aatcatacaa tgagtaggct tattttatgc cttcaggttt
     5581 taaaaattat aaacatttac attacagtaa aattcactct ggtatacagt tctataaagc
     5641 tctgataaat gtgtagagtt gtgtaaccac caatgcaacc aaggtacaga acagtcctct
     5701 tagcctctcc ctaccaaatt tattcctgct actttgtagt caaaaccagt cccctacacc
     5761 caaaccctgg cagtcactgg tttttttctt cgttctcttt tttttttttt tttttttgag
     5821 acagagtcta gctctgttgt ccaggctgga gtggtgcagt ggcgtgatct cggttcactg
     5881 caacctccgc ctccagggtt caagcggttc tcctgcctca gcctcccgag tagctgggat
     5941 tatgggcgcc cgccaccacg cccagctaat ttttgtattt ttagtagaga tggggtttca
     6001 ctgttttggc caggctggtc tcgaactcct gacctcatga tcctcctgcc tcagcctccc
     6061 aaagtgctgg gattacaaga gtgagccact gcgcctggcc tttttctttg ttcttatatt
     6121 tttgtctttt tttttttttt ttttttgaaa cagagtctca ctctttcact gaggctggag
     6181 tgcagtggcg tgatcttggc tcactgcaac ctccacctcc tgggttcaag cgattctcct
     6241 gccttagcct cccgagtaac agggactaca ggtgcccacc accatgctgg gctaattttt
     6301 gtatttttag tagaggcggg ggtttctcca cactggccag gctggtcttg aacttctgac
     6361 ctcaaaagat ccacccacct cggcctccca aagtgctggg attataggca tgaaccaccg
     6421 tgtccggcca tatattttcg tcttttgaag actgttatat acatgaaatt atatggtatg
     6481 tagcattttg agagcgactt cttttgctat gagtaataca tttgagattc atccatattt
     6541 ctcagtatat taatagttct tatttctgag tcactccatt gtgtggattt actactgttt
     6601 gttccccagt tgaaggatgt ttaggatctt tgcagttttg gacaattaca agtaaagctg
     6661 ctataaacat ttgtatgcaa cattttgtgt tttcatttat ctatagtaaa tacctagagt
     6721 tggattgctg ggatatatgg taagcatatg tttgacattt taagaaactt ctaaactgtt
     6781 tttcaaagtg gctctaccat ttcacattcc catcagtatg aaagtttcat ttccacatcc
     6841 tctctagtac ttgggggtgt cagtttagtt ttttaatttt taaatttttt aattttttta
     6901 atacatttaa atagagatgg ggtctcactg tgttgaccag gatggtcttg aactgctggc
     6961 ctcaagtaat cctcccatct cggtctccca aagtgctagg attacaggtg tgagccacca
     7021 tgcccagcca ggttttttga cattaagtat gtggtggtat ctcatcgttt ttatttgcat
     7081 cctctaatga tttgagcata ttttatatgc ttatttgcta tctacatatc ttctttggca
     7141 aggtgttcac atctcttgca tattttggat tgttttatta tttttgaatt ttgaggatta
     7201 tatgctggat acaggggtgt tttttttttt tttttttttt gaaacagagt cctcacccag
     7261 gttggagtgt agtggtgcaa tctcggctca ctgcaacctc tgcctcctgg gttcaagtaa
     7321 ttctcatgcc tcagcctcct gagtagctgg aattacaggc gcaggccacc atgcttggct
     7381 aacttttata tttttaccag agacaaggtt tcaccatgtt ggcaaggctg gtcttgaact
     7441 ctggacctca agtgatacac ccgtcttagc ctcccaaagt tctgggatta caggcatgag
     7501 ccattgtgcc tggccagtat cttgtcttct cattctgtaa acggtgtctt tttttcatta
     7561 tgggaaagct ttattgacac atttgttttt atttttaaaa attatggtaa aatacacaga
     7621 acataaacgt taccatctga tatggtttgg ctgtgtccac acctaaatct cgaattgtag
     7681 ttcccataat ccccacacat atgtaccaca ttttctttat ccagtctttc gttgatagac
     7741 atttaggtcg attccatgtc tttggtattg tgaatagtgc tgcagtgaac atatgtgtgc
     7801 atgtgtcttt atggcagaat gatttatatt atgcataacc aaaactgtac ttattaaaca
     7861 ataacctccc aaccccttct gcccacaacc tctggcgact gccatgctac tttctgtctc
     7921 tgaatttgaa taccctgata gtcatataat atttatcttt ttgtgactgg cttatttcac
     7981 tttgcataat gtattcaagc ttaatctgtg ttgtagcctg cgtcagaatt tcttttcttt
     8041 ttaatgctga gtattattct attgtgtgta tataccacat tttatttatc cattcatcca
     8101 ctgatggaca tgtgcattgt tcccaccttt tggctattgt gaaaaatgct gttatgaata
     8161 tgggtatgga gatctctccc cttattttga gacaggatct cactgtcacc caggctgggg
     8221 tgcagtggtg tgctcatagg tcactgtagc ttcgacctcc tgggctcaag cgaacctccc
     8281 acctccgcct cttgagtagc tgggaccaca ggcatgtgcc accatggctg ttaaatttat
     8341 taatttgttt ttctatggat catgcttttt gtgttacatc agaggagtct ttgcttaaca
     8401 tgagatgaca aaggttttct cccatgtttc ctcctaaaag ttttatagtt ttaggtttta
     8461 catttaggtc tatgatccat tttgagtcaa tttttgtata tggtacaagg tatgaatcta
     8521 tgctttttaa aaaaatatgg ttacccaatt tttctagcag tatgtgctaa aactttgcta
     8581 aagtcactta gttctagtag ctttttttgc agatttaacc agactttcta catagacaat
     8641 catatcttct gtgaataaac atggttttat ttcttcatgt ctaa
//
