LOCUS       NM_014366               1933 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens G protein nucleolar 3 (GNL3), transcript variant 1,
            mRNA.
ACCESSION   NM_014366
VERSION     NM_014366.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1933)
  AUTHORS   Dai,G. and Sun,Y.
  TITLE     Knockdown of GNL3 inhibits LUAD cell growth by regulating
            Wnt-beta-catenin pathway
  JOURNAL   Allergol Immunopathol (Madr) 52 (4), 46-52 (2024)
   PUBMED   38970264
  REMARK    GeneRIF: Knockdown of GNL3 inhibits LUAD cell growth by regulating
            Wnt-beta-catenin pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1933)
  AUTHORS   Lebdy,R., Canut,M., Patouillard,J., Cadoret,J.C., Letessier,A.,
            Ammar,J., Basbous,J., Urbach,S., Miotto,B., Constantinou,A., Abou
            Merhi,R. and Ribeyre,C.
  TITLE     The nucleolar protein GNL3 prevents resection of stalled
            replication forks
  JOURNAL   EMBO Rep 24 (12), e57585 (2023)
   PUBMED   37965896
  REMARK    GeneRIF: The nucleolar protein GNL3 prevents resection of stalled
            replication forks.
REFERENCE   3  (bases 1 to 1933)
  AUTHORS   Wang,X., Xiao,L., Wang,Z., Zhi,L. and Li,Q.
  TITLE     Common variants in GNL3 gene contributed the susceptibility of hand
            osteoarthritis in Han Chinese population
  JOURNAL   Sci Rep 12 (1), 16110 (2022)
   PUBMED   36167888
  REMARK    GeneRIF: Common variants in GNL3 gene contributed the
            susceptibility of hand osteoarthritis in Han Chinese population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1933)
  AUTHORS   Cela,I., Cufaro,M.C., Fucito,M., Pieragostino,D., Lanuti,P.,
            Sallese,M., Del Boccio,P., Di Matteo,A., Allocati,N., De
            Laurenzi,V. and Federici,L.
  TITLE     Proteomic Investigation of the Role of Nucleostemin in
            Nucleophosmin-Mutated OCI-AML 3 Cell Line
  JOURNAL   Int J Mol Sci 23 (14), 7655 (2022)
   PUBMED   35886999
  REMARK    GeneRIF: Proteomic Investigation of the Role of Nucleostemin in
            Nucleophosmin-Mutated OCI-AML 3 Cell Line.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1933)
  AUTHORS   Li,J., Xu,J., Wang,Y., Li,Q., Sun,X., Fu,W. and Zhang,B.
  TITLE     Association of Nucleostemin Polymorphisms with Chronic Hepatitis B
            Virus Infection in Chinese Han Population
  JOURNAL   Genet Test Mol Biomarkers 26 (5), 255-262 (2022)
   PUBMED   35638911
  REMARK    GeneRIF: Association of Nucleostemin Polymorphisms with Chronic
            Hepatitis B Virus Infection in Chinese Han Population.
REFERENCE   6  (bases 1 to 1933)
  AUTHORS   Schwartz,P.H., Bryant,P.J., Fuja,T.J., Su,H., O'Dowd,D.K. and
            Klassen,H.
  TITLE     Isolation and characterization of neural progenitor cells from
            post-mortem human cortex
  JOURNAL   J Neurosci Res 74 (6), 838-851 (2003)
   PUBMED   14648588
REFERENCE   7  (bases 1 to 1933)
  AUTHORS   Tsai,R.Y. and McKay,R.D.
  TITLE     A nucleolar mechanism controlling cell proliferation in stem cells
            and cancer cells
  JOURNAL   Genes Dev 16 (23), 2991-3003 (2002)
   PUBMED   12464630
REFERENCE   8  (bases 1 to 1933)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 1933)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   10 (bases 1 to 1933)
  AUTHORS   Charpentier,A.H., Bednarek,A.K., Daniel,R.L., Hawkins,K.A.,
            Laflin,K.J., Gaddis,S., MacLeod,M.C. and Aldaz,C.M.
  TITLE     Effects of estrogen on global gene expression: identification of
            novel targets of estrogen action
  JOURNAL   Cancer Res 60 (21), 5977-5983 (2000)
   PUBMED   11085516
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI028402.1, CF272475.1,
            AK027514.1 and BC001024.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_014366.4.
            
            Summary: The protein encoded by this gene may interact with p53 and
            may be involved in tumorigenesis. The encoded protein also appears
            to be important for stem cell proliferation. This protein is found
            in both the nucleus and nucleolus. Three transcript variants
            encoding two different isoforms have been found for this gene.
            [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.150617.1,
                                           SRR3476690.1094464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418458.6/ ENSP00000395772.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AI028402.1         113-144
            33-769              CF272475.1         14-750
            770-1928            AK027514.1         883-2041
            1929-1933           BC001024.2         1890-1894
FEATURES             Location/Qualifiers
     source          1..1933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..1933
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /note="G protein nucleolar 3"
                     /db_xref="GeneID:26354"
                     /db_xref="HGNC:HGNC:29931"
                     /db_xref="MIM:608011"
     exon            1..74
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1711
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleostemin; guanine nucleotide-binding protein-like 3;
                     estradiol-induced nucleotide binding protein; E2-induced
                     gene 3 protein; novel nucleolar protein 47; nucleolar
                     GTP-binding protein 3; guanine nucleotide binding
                     protein-like 3 (nucleolar)"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein-like 3
                     isoform 1"
                     /protein_id="NP_055181.3"
                     /db_xref="CCDS:CCDS2861.1"
                     /db_xref="GeneID:26354"
                     /db_xref="HGNC:HGNC:29931"
                     /db_xref="MIM:608011"
                     /translation="MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKP
                     RKDPGVPNSAPFKEALLREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSN
                     VEPMEKEFGLCKTENKAKSGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQ
                     VEEAIVQSGQKKLVLILNKSDLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITK
                     RVKAKKNAAPFRSEVCFGKEGLWKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQ
                     EQMCNVGVSMGLTRSMQVVPLDKQITIIDSPSFIVSPLNSSSALALRSPASIEVVKPM
                     EAASAILSQADARQVVLKYTVPGYRNSLEFFTVLAQRRGMHQKGGIPNVEGAAKLLWS
                     EWTGASLAYYCHPPTSWTPPPYFNESIVVDMKSGFNLEELEKNNAQSIRAIKGPHLAN
                     SILFQSSGLTNGIIEEKDIHEELPKRKERKQEEREDDKDSDQETVDEEVDENSSGMFA
                     AEETGEALSEETTAGEQSTRSFILDKIIEEDDAYDFSTDYV"
     exon            75..133
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..271
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..385
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..469
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..602
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..715
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..842
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..930
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1105
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1248
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1385
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1561
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1628
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1933
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1905..1910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /note="hexamer: AATAAA"
     polyA_site      1933
                     /gene="GNL3"
                     /gene_synonym="C77032; E2IG3; NNP47; NS; Nug1"
                     /note="major polyA site"
ORIGIN      
        1 agttcacacg tggcgccagc ggaggcaggt tgatgtgttt gtgcttcctt ctacagccaa
       61 tatgaaaagg cctaagttaa agaaagcaag taaacgcatg acctgccata agcggtataa
      121 aatccaaaaa aaggttcgag aacatcatcg aaaattaaga aaggaggcta aaaagcgggg
      181 tcacaagaag cctaggaaag acccaggagt tccaaacagt gctcccttta aggaggctct
      241 tcttagggaa gctgagctaa ggaaacagag gcttgaagaa ctaaaacagc agcagaaact
      301 tgacaggcag aaggaactag aaaagaaaag aaaacttgaa actaatcctg atattaagcc
      361 atcaaatgtg gaacctatgg aaaaggagtt tgggctttgc aaaactgaga acaaagccaa
      421 gtcgggcaaa cagaattcaa agaagctgta ctgccaagaa cttaaaaagg tgattgaagc
      481 ctccgatgtt gtcctagagg tgttggatgc cagagatcct cttggttgca gatgtcctca
      541 ggtagaagag gccattgtcc agagtggaca gaaaaagctg gtacttatat taaataaatc
      601 agatctggta ccaaaggaga atttggagag ctggctaaat tatttgaaga aagaattgcc
      661 aacagtggtg ttcagagcct caacaaaacc aaaggataaa gggaagataa ccaagcgtgt
      721 gaaggcaaag aagaatgctg ctccattcag aagtgaagtc tgctttggga aagagggcct
      781 ttggaaactt cttggaggtt ttcaggaaac ttgcagcaaa gccattcggg ttggagtaat
      841 tggtttccca aatgtgggga aaagcagcat tatcaatagc ttaaaacaag aacagatgtg
      901 taatgttggt gtatccatgg ggcttacaag gagcatgcaa gttgtcccct tggacaaaca
      961 gatcacaatc atagatagtc cgagcttcat cgtatctcca cttaattcct cctctgcgct
     1021 tgctctgcga agtccagcaa gtattgaagt agtaaaaccg atggaggctg ccagtgccat
     1081 cctttcccag gctgatgctc gacaggtagt actgaaatat actgtcccag gctacaggaa
     1141 ttctctggaa ttttttactg tgcttgctca gagaagaggt atgcaccaaa aaggtggaat
     1201 cccaaatgtt gaaggtgctg ccaaactgct gtggtctgag tggacaggtg cctcattagc
     1261 ttactattgc catcccccta catcttggac tcctcctcca tattttaatg agagtattgt
     1321 ggtagacatg aaaagcggct tcaatctgga agaactggaa aagaacaatg cacagagcat
     1381 aagagccatc aagggccctc atttggccaa tagcatcctt ttccagtctt ccggtctgac
     1441 aaatggaata atagaagaaa aggacataca tgaagaattg ccaaaacgga aagaaaggaa
     1501 gcaggaggag agggaggatg acaaagacag tgaccaggaa actgttgatg aagaagttga
     1561 tgaaaacagc tcaggcatgt ttgctgcaga agagacaggg gaggcactgt ctgaggagac
     1621 tacagcaggt gaacagtcta caaggtcttt tatcttggat aaaatcattg aagaggatga
     1681 tgcttatgac ttcagtacag attatgtgta acagaacaat ggctttttat gatttttttt
     1741 ttaacatttt aagcagactg ctaaactgtt ctctgtataa gttatggtat gcatgagctg
     1801 tgtaaatttt gtgaatatgt attatattaa aaccaggcaa cttggaatcc ctaaattctg
     1861 taaaaagaca attcatctca ttgtgagtgg aagtagttat ctggaataaa aaaagaagat
     1921 acctattgaa aaa
//
