LOCUS       NM_013285               2350 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein nucleolar 2 (GNL2), transcript variant 1,
            mRNA.
ACCESSION   NM_013285
VERSION     NM_013285.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2350)
  AUTHORS   Nakamura,K., Reid,B.M., Chen,A., Chen,Z., Goode,E.L., Permuth,J.B.,
            Teer,J.K., Tyrer,J., Yu,X., Kanetsky,P.A., Pharoah,P.D.,
            Gayther,S.A., Sellers,T.A., Lawrenson,K. and Karreth,F.A.
  TITLE     Functional analysis of the 1p34.3 risk locus implicates GNL2 in
            high-grade serous ovarian cancer
  JOURNAL   Am J Hum Genet 109 (1), 116-135 (2022)
   PUBMED   34965383
  REMARK    GeneRIF: Functional analysis of the 1p34.3 risk locus implicates
            GNL2 in high-grade serous ovarian cancer.
REFERENCE   2  (bases 1 to 2350)
  AUTHORS   Dong,Y., Cai,Q., Fu,L., Liu,H., Ma,M. and Wu,X.
  TITLE     Study of the G Protein Nucleolar 2 Value in Liver Hepatocellular
            Carcinoma Treatment and Prognosis
  JOURNAL   Biomed Res Int 2021, 4873678 (2021)
   PUBMED   34337013
  REMARK    GeneRIF: Study of the G Protein Nucleolar 2 Value in Liver
            Hepatocellular Carcinoma Treatment and Prognosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2350)
  AUTHORS   Datta,D., Anbarasu,K., Rajabather,S., Priya,R.S., Desai,P. and
            Mahalingam,S.
  TITLE     Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase
            Transition by Activating Cyclin-dependent Kinase Inhibitor p21
            Cip1/Waf1
  JOURNAL   J Biol Chem 290 (35), 21536-21552 (2015)
   PUBMED   26203195
  REMARK    GeneRIF: NGP-1 promotes cell cycle progression through the
            activation of the p53/p21(Cip-1/Waf1) pathway.
REFERENCE   4  (bases 1 to 2350)
  AUTHORS   Casadio,A., Longman,D., Hug,N., Delavaine,L., Vallejos Baier,R.,
            Alonso,C.R. and Caceres,J.F.
  TITLE     Identification and characterization of novel factors that act in
            the nonsense-mediated mRNA decay pathway in nematodes, flies and
            mammals
  JOURNAL   EMBO Rep 16 (1), 71-78 (2015)
   PUBMED   25452588
  REMARK    GeneRIF: GNL2 and SEC13 are required for nonsense-mediated mRNA
            decay pathway in human cells.
REFERENCE   5  (bases 1 to 2350)
  AUTHORS   Matsuo,Y., Granneman,S., Thoms,M., Manikas,R.G., Tollervey,D. and
            Hurt,E.
  TITLE     Coupled GTPase and remodelling ATPase activities form a checkpoint
            for ribosome export
  JOURNAL   Nature 505 (7481), 112-116 (2014)
   PUBMED   24240281
REFERENCE   6  (bases 1 to 2350)
  AUTHORS   Cheng,C.Y., Schache,M., Ikram,M.K., Young,T.L., Guggenheim,J.A.,
            Vitart,V., MacGregor,S., Verhoeven,V.J., Barathi,V.A., Liao,J.,
            Hysi,P.G., Bailey-Wilson,J.E., St Pourcain,B., Kemp,J.P.,
            McMahon,G., Timpson,N.J., Evans,D.M., Montgomery,G.W., Mishra,A.,
            Wang,Y.X., Wang,J.J., Rochtchina,E., Polasek,O., Wright,A.F.,
            Amin,N., van Leeuwen,E.M., Wilson,J.F., Pennell,C.E., van
            Duijn,C.M., de Jong,P.T., Vingerling,J.R., Zhou,X., Chen,P., Li,R.,
            Tay,W.T., Zheng,Y., Chew,M., Burdon,K.P., Craig,J.E., Iyengar,S.K.,
            Igo,R.P. Jr., Lass,J.H. Jr., Chew,E.Y., Haller,T., Mihailov,E.,
            Metspalu,A., Wedenoja,J., Simpson,C.L., Wojciechowski,R., Hohn,R.,
            Mirshahi,A., Zeller,T., Pfeiffer,N., Lackner,K.J., Bettecken,T.,
            Meitinger,T., Oexle,K., Pirastu,M., Portas,L., Nag,A.,
            Williams,K.M., Yonova-Doing,E., Klein,R., Klein,B.E.,
            Hosseini,S.M., Paterson,A.D., Makela,K.M., Lehtimaki,T.,
            Kahonen,M., Raitakari,O., Yoshimura,N., Matsuda,F., Chen,L.J.,
            Pang,C.P., Yip,S.P., Yap,M.K., Meguro,A., Mizuki,N., Inoko,H.,
            Foster,P.J., Zhao,J.H., Vithana,E., Tai,E.S., Fan,Q., Xu,L.,
            Campbell,H., Fleck,B., Rudan,I., Aung,T., Hofman,A.,
            Uitterlinden,A.G., Bencic,G., Khor,C.C., Forward,H., Parssinen,O.,
            Mitchell,P., Rivadeneira,F., Hewitt,A.W., Williams,C., Oostra,B.A.,
            Teo,Y.Y., Hammond,C.J., Stambolian,D., Mackey,D.A., Klaver,C.C.,
            Wong,T.Y., Saw,S.M. and Baird,P.N.
  CONSRTM   Consortium for Refractive Error and Myopia; Fuchs' Genetics
            Multi-Center Study Group; Wellcome Trust Case Control Consortium 2;
            Diabetes Control and Complications Trial/Epidemiology of Diabetes
            Interventions, and Complications Research Group
  TITLE     Nine loci for ocular axial length identified through genome-wide
            association studies, including shared loci with refractive error
  JOURNAL   Am J Hum Genet 93 (2), 264-277 (2013)
   PUBMED   24144296
REFERENCE   7  (bases 1 to 2350)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 2350)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 2350)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (bases 1 to 2350)
  AUTHORS   Racevskis,J., Dill,A., Stockert,R. and Fineberg,S.A.
  TITLE     Cloning of a novel nucleolar guanosine 5'-triphosphate binding
            protein autoantigen from a breast tumor
  JOURNAL   Cell Growth Differ 7 (2), 271-280 (1996)
   PUBMED   8822211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB452094.1, BC009250.2 and AA766044.1.
            
            On Nov 22, 2018 this sequence version replaced NM_013285.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.126743.1,
                                           SRR3476690.1153684.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373062.8/ ENSP00000362153.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB452094.1         49-64
            17-2346             BC009250.2         1-2330
            2347-2350           AA766044.1         22-25               c
FEATURES             Location/Qualifiers
     source          1..2350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..2350
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /note="G protein nucleolar 2"
                     /db_xref="GeneID:29889"
                     /db_xref="HGNC:HGNC:29925"
                     /db_xref="MIM:609365"
     exon            1..179
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2311
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleolar GTPase; guanine nucleotide binding protein-like
                     2 (nucleolar); nucleolar G-protein gene 1; nucleolar
                     GTP-binding protein 2; novel nucleolar guanosine
                     5'-triphosphate binding protein autoantigen; autoantigen
                     NGP-1; nucleostemin-2"
                     /codon_start=1
                     /product="nucleolar GTP-binding protein 2 isoform 1"
                     /protein_id="NP_037417.1"
                     /db_xref="CCDS:CCDS421.1"
                     /db_xref="GeneID:29889"
                     /db_xref="HGNC:HGNC:29925"
                     /db_xref="MIM:609365"
                     /translation="MVKPKYKGRSTINPSKASTNPDRVQGAGGQNMRDRATIRRLNMY
                     RQKERRNSRGKIIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTV
                     MKDPYKVVMKQSKLPMSLLHDRIRPHNLKVHILDTESFETTFGPKSQRKRPNLFASDM
                     QSLIENAEMSTESYDQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSD
                     VVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDY
                     PTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKK
                     VCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKSPED
                     HIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLQTVGKMVLND
                     WQRGRIPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEEVTETAGEGSESIIKE
                     ETEENSHCDANTEMQQILTRVRQNFGKINVVPQFSGDDLVPVEVSDLEEELESFSDEE
                     EEEQEQQRDDAEESSSEPEEENVGNDTKAVIKALDEKIAKYQKFLDKAKAKKFSAVRI
                     SKGLSEKIFAKPEEQRKTLEEDVDDRAPSKKGKKRKAQREEEQEHSNKAPRALTSKER
                     RRAVRQQRPKKVGVRYYETHNVKNRNRNKKKTNDSEGQKHKRKKFRQKQ"
     exon            180..264
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            265..359
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..499
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..684
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..751
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..910
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1024
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1153
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1258
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1417
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1531
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1983
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2066
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2158
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2350
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2328..2333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /note="hexamer: ATTAAA"
     polyA_site      2350
                     /gene="GNL2"
                     /gene_synonym="HUMAUANTIG; Ngp-1; NGP1; Nog2; Nug2"
                     /note="major polyA site"
ORIGIN      
        1 gcacacgtgg tccggcgtgg ttcaggcggg tgtcttcggc cgggcttggg aacataaaag
       61 tttgtttcac cacgtaagcc ggacctcgca ctccggtccc ggtctcgtcg ccaagatggt
      121 gaagcccaag tacaaaggac ggagcaccat caacccgtcc aaggccagca caaacccaga
      181 tcgagtgcag ggagcaggag gccaaaacat gagggaccgg gccaccatcc ggcgcctgaa
      241 tatgtatagg caaaaggagc gcaggaacag tcgtggtaaa ataattaaac ccctgcaata
      301 tcaatcaacg gtggcttctg gcacagtggc aagagtagag ccaaatatta aatggtttgg
      361 aaacacacgt gtgattaagc agtcatcatt acaaaaattt caagaggaaa tggatacagt
      421 tatgaaggat ccatacaaag ttgtcatgaa gcaaagcaag ttaccaatgt ctcttctcca
      481 tgatcgaatc cggcctcata acttgaaggt gcacattctt gatactgaaa gttttgaaac
      541 tacatttggc cctaagtcac agaggaaacg accaaactta tttgcaagtg atatgcagtc
      601 tcttatcgaa aatgctgaaa tgtccactga gagctatgac cagggcaagg atcgtgattt
      661 ggtaactgaa gacactggtg tgagaaatga agctcaagaa gagatctata aaaagggaca
      721 gtccaaaaga atatggggtg agctctacaa ggtgatagat tcatcagatg ttgtagttca
      781 agttcttgat gctagagatc caatgggtac tcgttcccct cacattgaaa cttacctgaa
      841 gaaggaaaaa ccttggaaac acctcatttt tgtacttaac aaatgtgacc ttgttccaac
      901 ctgggcaaca aaacggtggg ttgctgtcct ctcccaggat tatccaacac ttgctttcca
      961 tgcaagcctt actaacccgt ttggcaaggg agcattcatt cagcttctgc ggcagtttgg
     1021 aaagttgcac actgacaaga aacagatcag tgttgggttc attggctatc caaatgttgg
     1081 caagagctct gtgataaata cattgcgttc taagaaagtt tgcaacgtgg ctcccattgc
     1141 aggtgaaaca aaggtctggc agtatattac tttgatgcgt cggatattcc tgattgactg
     1201 tccaggtgtg gtttacccct ctgaggactc cgagacagac attgtgctaa aaggagttgt
     1261 tcaagtagaa aaaattaaga gtcctgaaga ccacattggt gctgtacttg aacgagcaaa
     1321 gccagaatat atcagcaaaa catacaagat tgattcttgg gagaatgctg aggactttct
     1381 tgagaagctc gctttccgga ctgggaagtt actaaagggt ggagagcccg acttgcagac
     1441 tgtgggtaag atggtcctca atgactggca gaggggccgg attcctttct ttgtcaagcc
     1501 acccaatgca gagccacttg tggcccccca gcttctaccc tcctcatctt tggaagttgt
     1561 cccagaagca gcccagaaca atccagggga ggaagtcaca gaaactgcag gtgaagggtc
     1621 agaatccatc attaaggaag aaacagaaga gaacagtcac tgtgatgcta acacagagat
     1681 gcagcagatt ctcacacgag ttcggcagaa ctttggtaaa atcaacgtgg tgcctcagtt
     1741 ttctggggat gacctggttc ctgtggaggt gtcagatctt gaggaagagc ttgagagctt
     1801 ttctgatgaa gaggaggagg aacaggagca acaaagagat gatgcggaag agtcttcctc
     1861 ggagcctgag gaggaaaatg tgggaaacga caccaaagcc gttattaaag cactggatga
     1921 gaagattgcc aaatatcaga agtttctaga caaagccaaa gccaaaaagt tttcagcagt
     1981 cagaatatcc aagggactga gtgaaaagat atttgcaaaa cctgaagaac aaagaaaaac
     2041 actggaagaa gatgtagatg acagagcacc ttccaaaaag ggaaagaagc ggaaggcaca
     2101 aagggaagag gaacaggaac attcaaataa agctcccagg gcgcttacat caaaagaacg
     2161 gaggcgagca gtacgacagc aacggccgaa aaaagttggt gtgcgctact atgaaacaca
     2221 caacgtgaaa aataggaaca ggaacaaaaa gaagaccaat gactcagagg gacagaaaca
     2281 caaacgcaaa aaattcagac aaaagcagta atgtttaaaa ggtttttatt aaattataca
     2341 aaaacaggca
//
