LOCUS       NM_005275               6801 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens G protein nucleolar 1 (putative) (GNL1), mRNA.
ACCESSION   NM_005275
VERSION     NM_005275.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6801)
  AUTHORS   Krishnan,R., Murugiah,M., Lakshmi,N.P. and Mahalingam,S.
  TITLE     Guanine nucleotide binding protein like-1 (GNL1) promotes cancer
            cell proliferation and survival through AKT/p21 CIP1 signaling
            cascade
  JOURNAL   Mol Biol Cell 31 (26), 2904-2919 (2020)
   PUBMED   33147101
  REMARK    GeneRIF: Guanine nucleotide binding protein like-1 (GNL1) promotes
            cancer cell proliferation and survival through AKT/p21 (CIP1)
            signaling cascade.
REFERENCE   2  (bases 1 to 6801)
  AUTHORS   Krishnan,R., Boddapati,N. and Mahalingam,S.
  TITLE     Interplay between human nucleolar GNL1 and RPS20 is critical to
            modulate cell proliferation
  JOURNAL   Sci Rep 8 (1), 11421 (2018)
   PUBMED   30061673
  REMARK    GeneRIF: cross-talk between GNL1 and RPS20 is critical to promote
            cell proliferation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6801)
  AUTHORS   Liu,Y.H., Chen,Y.J., Wu,H.H., Wang,T.Y. and Tsai,F.J.
  TITLE     Single nucleotide polymorphisms at the PRR3, ABCF1, and GNL1 genes
            in the HLA class I region are associated with Graves'
            ophthalmopathy in a gender-dependent manner
  JOURNAL   Ophthalmology 121 (10), 2033-2039 (2014)
   PUBMED   24908204
  REMARK    GeneRIF: The results suggested that SNPs at PRR3 and ABCF1 genes
            and the haplotype composed by SNPs at GNL1 and PRR3 between the
            HLA-A and HLA-C genes tended to predict Graves ophthalmology in a
            gender-dependent manner in patients with Graves Disease in Taiwan.
REFERENCE   4  (bases 1 to 6801)
  AUTHORS   Boddapati,N., Anbarasu,K., Suryaraja,R., Tendulkar,A.V. and
            Mahalingam,S.
  TITLE     Subcellular distribution of the human putative nucleolar GTPase
            GNL1 is regulated by a novel arginine/lysine-rich domain and a GTP
            binding domain in a cell cycle-dependent manner
  JOURNAL   J Mol Biol 416 (3), 346-366 (2012)
   PUBMED   22244851
  REMARK    GeneRIF: The results demonstrated that multiple mechanisms are
            involved in the translocation of GNL1 to the nucleolus in a cell
            cycle-dependent manner to regulate cell growth and proliferation.
REFERENCE   5  (bases 1 to 6801)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 6801)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6801)
  AUTHORS   Matsuoka,S., Ballif,B.A., Smogorzewska,A., McDonald,E.R. 3rd,
            Hurov,K.E., Luo,J., Bakalarski,C.E., Zhao,Z., Solimini,N.,
            Lerenthal,Y., Shiloh,Y., Gygi,S.P. and Elledge,S.J.
  TITLE     ATM and ATR substrate analysis reveals extensive protein networks
            responsive to DNA damage
  JOURNAL   Science 316 (5828), 1160-1166 (2007)
   PUBMED   17525332
REFERENCE   8  (bases 1 to 6801)
  AUTHORS   Shiina,T., Ota,M., Shimizu,S., Katsuyama,Y., Hashimoto,N.,
            Takasu,M., Anzai,T., Kulski,J.K., Kikkawa,E., Naruse,T., Kimura,N.,
            Yanagiya,K., Watanabe,A., Hosomichi,K., Kohara,S., Iwamoto,C.,
            Umehara,Y., Meyer,A., Wanner,V., Sano,K., Macquin,C., Ikeo,K.,
            Tokunaga,K., Gojobori,T., Inoko,H. and Bahram,S.
  TITLE     Rapid evolution of major histocompatibility complex class I genes
            in primates generates new disease alleles in humans via hitchhiking
            diversity
  JOURNAL   Genetics 173 (3), 1555-1570 (2006)
   PUBMED   16702430
REFERENCE   9  (bases 1 to 6801)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 6801)
  AUTHORS   Vernet,C., Ribouchon,M.T., Chimini,G. and Pontarotti,P.
  TITLE     Structure and evolution of a member of a new subfamily of
            GTP-binding proteins mapping to the human MHC class I region
  JOURNAL   Mamm Genome 5 (2), 100-105 (1994)
   PUBMED   8180467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662800.4.
            
            On Nov 19, 2020 this sequence version replaced NM_005275.4.
            
            Summary: The GNL1 gene, identified in the human major
            histocompatibility complex class I region, shows a high degree of
            similarity with its mouse counterpart. The GNL1 gene is located
            less than 2 kb centromeric to HLA-E, in the same transcriptional
            orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.665787.1, BC018366.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376621.8/ ENSP00000365806.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AL662800.4         56306-56664         c
            360-525             AL662800.4         55730-55895         c
            526-662             AL662800.4         55230-55366         c
            663-814             AL662800.4         54939-55090         c
            815-886             AL662800.4         54750-54821         c
            887-1094            AL662800.4         53525-53732         c
            1095-1190           AL662800.4         53259-53354         c
            1191-1385           AL662800.4         52642-52836         c
            1386-1564           AL662800.4         47527-47705         c
            1565-1727           AL662800.4         47287-47449         c
            1728-1868           AL662800.4         46871-47011         c
            1869-6801           AL662800.4         41556-46488         c
FEATURES             Location/Qualifiers
     source          1..6801
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..6801
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /note="G protein nucleolar 1 (putative)"
                     /db_xref="GeneID:2794"
                     /db_xref="HGNC:HGNC:4413"
                     /db_xref="MIM:143024"
     exon            1..359
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..2110
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /note="HSR1 GTP-binding protein; GTP-binding protein HSR1"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein-like 1"
                     /protein_id="NP_005266.2"
                     /db_xref="CCDS:CCDS4680.1"
                     /db_xref="GeneID:2794"
                     /db_xref="HGNC:HGNC:4413"
                     /db_xref="MIM:143024"
                     /translation="MPRKKPFSVKQKKKQLQDKRERKRGLQDGLRSSSNSRSGSRERR
                     EEQTDTSDGESVTHHIRRLNQQPSQGLGPRGYDPNRYRLHFERDSREEVERRKRAARE
                     QVLQPVSAELLELDIREVYQPGSVLDFPRRPPWSYEMSKEQLMSQEERSFQDYLGKIH
                     GAYSSEKLSYFEHNLETWRQLWRVLEMSDIVLLITDIRHPVVNFPPALYEYVTGELGL
                     ALVLVLNKVDLAPPALVVAWKHYFHQHYPQLHVVLFTSFPRDPRTPQDPSSVLKKSRR
                     RGRGWTRALGPEQLLRACEAITVGKVDLSSWREKIARDVAGATWGNGSGEEEEEEDGP
                     AVLVEQQTDSAMEPTGPTQERYKDGVVTIGCVGFPNVGKSSLINGLVGRKVVSVSRTP
                     GHTRYFQTYFLTPSVKLCDCPGLIFPSLLPRQLQVLAGIYPIAQIQEPYTAVGYLASR
                     IPVQALLHLRHPEAEDPSAEHPWCAWDICEAWAEKRGYKTAKAARNDVYRAANSLLRL
                     AVDGRLSLCFHPPGYSEQKGTWESHPETTELVVLQGRVGPAGDEEEEEEEELSSSCEE
                     EGEEDRDADEEGEGDEETPTSAPGSSLAGRNPYALLGEDEC"
     exon            360..525
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..662
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..814
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..886
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1094
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1190
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1385
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1564
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1727
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1868
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..6801
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2197..2202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /note="hexamer: AATAAA"
     polyA_site      2218
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /note="major polyA site"
     polyA_site      3832
                     /gene="GNL1"
                     /gene_synonym="HSR1"
     regulatory      6773..6778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNL1"
                     /gene_synonym="HSR1"
                     /note="hexamer: ATTAAA"
     polyA_site      6801
                     /gene="GNL1"
                     /gene_synonym="HSR1"
ORIGIN      
        1 cttcctcgcc gccggggcgc cctctcggtg ccactggctc tcacgtgcca gtagcccacc
       61 ccgcatcatc ctctcgcctc gctcctggag ggaagtgact atatctcccc cgtccgcctt
      121 ccatcgccgc cgcggcggta attctgtcgg gcccgcccgc tgacgtcacc tgctagcccc
      181 gcctcctcta gggtcccggg cccctgcggc gggggctgcc ccggggggca gtcagttgag
      241 gcggcgggag ctcggcggag ggcgggccag gtgactggtc cgggccatgc cgaggaagaa
      301 gccattcagc gtgaagcaga agaagaagca gttgcaggac aaacgggagc ggaagagagg
      361 gcttcaagat gggctgcgct ccagttccaa cagccgcagc gggagccggg agcggcgaga
      421 ggaacagacc gacacctcgg acggggagtc tgtgacccat catatccgca ggcttaacca
      481 gcagccttct caggggctgg gtccacgagg ctacgaccca aatcgatacc gactgcattt
      541 tgagagagac agcagggagg aggtagagag gagaaagaga gcagcccggg agcaagttct
      601 acagccggtc agtgctgagt tgttggagct ggacatccgg gaggtgtatc agcctggctc
      661 agttctggac tttcctcgac gtcctccttg gagctatgag atgtccaagg agcaactaat
      721 gagccaagag gaacggagct tccaagacta tcttgggaag attcatgggg cttactcctc
      781 tgagaaactc agctactttg agcacaatct ggagacatgg aggcagctgt ggcgggtgtt
      841 agagatgtct gacatcgtcc tgcttatcac tgatatccga catccagttg tgaatttccc
      901 gccagcactt tatgagtatg tgactggaga acttggactg gccctggtgc tggttttgaa
      961 caaggtggat ctggccccgc cagctcttgt ggttgcctgg aagcattatt tccatcaaca
     1021 ctatccccag ctccacgtcg tccttttcac ctcttttcct cgggaccccc gcaccccaca
     1081 ggaccctagt agtgtcttga agaagagtcg gaggcggggg agaggatgga ctcgggccct
     1141 ggggccagag cagttgctga gagcctgtga agccatcact gtggggaaag tggacttgag
     1201 cagctggcgg gagaagattg ctcgggatgt ggctggggcc acctggggta atggctctgg
     1261 ggaggaggag gaagaggagg atggcccagc agtcctggtg gagcagcaga ctgattcagc
     1321 aatggagcca actggcccaa cccaagagcg ctacaaggat ggggtggtga ccatcggctg
     1381 tgtgggtttc cctaatgtgg gaaagtcctc gctgatcaat gggctggtgg ggcggaaagt
     1441 cgtgagtgtc tccagaaccc cgggccatac ccgatacttt cagacctact ttcttacccc
     1501 ctctgtgaag ctctgtgact gcccaggcct catcttccca tctcttctgc ctaggcagtt
     1561 gcaggttctg gcagggatct accctatcgc ccagatccag gagccctaca ctgctgtggg
     1621 ctacctggcc tcccgaattc ccgtgcaggc cctgctccac ctgcgccacc cagaggctga
     1681 ggacccctca gcggaacacc cctggtgtgc ctgggacatc tgtgaagcct gggcagagaa
     1741 acgtggttac aagacagcca aggcggctcg gaatgatgtg tacagagcag ccaacagtct
     1801 cttgcggctg gcagtggacg gccgcctcag cctgtgtttt catcccccag gctacagtga
     1861 acagaaaggc acctgggagt cccatccaga gaccacggag ctggtggttt tgcagggcag
     1921 ggtggggcca gcaggtgacg aggaggagga ggaagaggaa gagctgagca gctcctgtga
     1981 ggaggaggga gaggaggacc gggatgcgga tgaggaggga gaaggggatg aggagacccc
     2041 aacctcggct ccagggtcca gcctggctgg ccgaaaccct tatgccctgc tgggtgagga
     2101 tgagtgctga gttcctcgcc cagcgccatc ttccctccca gtatctttgc ttttggactg
     2161 acctgggggt atctcccctc tgccacccca attgtgaata aagattgttt gctttgtagc
     2221 cccttcccca gatgaactga ggtgagagcg gctgttccag gctaacagct gtgggaggct
     2281 tctctcctct tctcccttct tttttcatgc attctctttg caagggaaag ttctcttagg
     2341 agtttagtag gttctcagtc tctgaaacct gcttcctcta cccattctcc cactctgcac
     2401 cttaggaatc ccgttatcta catggggagg ggaggtctaa atccagctcc cttttggagt
     2461 ttgtgccatt ctccgatttg agcagcagcc ctgtgtgccc cctgccgcca gacctgctca
     2521 ttccaggagc ttctgggaga aggaacagta agagaggaac tgtgtcccaa gctgatgtct
     2581 cttaatgaga tttttacagg aattgttcaa attcagcaaa tatttattga gggtctattg
     2641 tgtgtcttga cctgtgctga gcaccaagca tataaggatg taccaccaga gcctgaccta
     2701 aatttgaagc ctggccatga tcaaaacccc accttcaggc acccaagttt ttggattaag
     2761 aagggtgaat gatgttctcc aaatcctggg ggctcatgca gtataattct aggacttcat
     2821 gttgatacaa atttttagtt aaggcaaaac gcttgtgaaa atgttgatta aatgtgtacg
     2881 agtagtttta attactggtg aacaactagc gtgcacattt atgatttgag cagaacagcc
     2941 ctttaagtac agtgttaagt ttcattgttt aaaagcttgg cagctacgag tatttgaggt
     3001 acataggggc gggcacagaa ccagcctcct gaattccatt tactctggtt tgggggtgga
     3061 acaaagatga tccagtgcag ggtctgagct agaacctagc aggtggccag aaccatttta
     3121 gggtttcacc tcagcatttc ggcagaaatc agctctctcg tgagtcaggg caccttaggc
     3181 tttgctgtat atccctttgt taagccagca gctagactcc tagattgaat tcttttagaa
     3241 atgggagaat gagctttttt attgactgcc agtgttgtct gtattggatg atagcaaaaa
     3301 gtgtagttgg acaggttgcc cactagatgg agtgagaagt accagactcc ttttttctct
     3361 aaagcagatc ctttcaggat ctgagtcact gggcagtttc tctaatgcga gcagacagac
     3421 cctgttaacc aaggagcaaa ggaaagtata tttaaagagg ctaaggtgtt tggccacata
     3481 ttgctttagg ttcatctcca ttggtctcag tgtggacata actcctggaa ttcactccag
     3541 tgcaaagttt aaataatacc agcatgagaa tgtacttgaa ggtttcccaa aatgtgctag
     3601 acaagaaaga gaaaaggtcc cagctgagag aaaaatccac ctgtctccca tctggggctc
     3661 tttggcctca ctgatagaaa aggaaaaggg gcccaagcta agcttacttt gagggttcat
     3721 gatgttcaga gatgctcagg ggacttctcc gctgcaggag gtggggtgag gacattggat
     3781 tcatttcctc aaaatatgga gagaaaggag aaaaatcaga attctatttg tacctctgct
     3841 tcctgtgctg tttatctttg cttgtcttta tctttttcca cctcaggggt ttcatcaggg
     3901 gtatttggga gagtctaggg gtggggatga agaattgact gggagctgag gaggggggat
     3961 ttttatgctg aagacctggc aggaggcaac tcctgacacc cccacagggt tagactgtaa
     4021 aacctcttcc atgacttgct gactctatag gataatagca acaggaaaag aactgaggga
     4081 cgtgcagatg aggatgaata gggccccaac accagtgcct gaggctgagg ttagaactga
     4141 ctacaaagac acaggaaacc aagggcccag tctcccctcc acgctgaaat acgcaccctc
     4201 ttgtctgggt catgtctact atgtgaatac ttgaccatgg aggtctgggg ctctggtggc
     4261 ttccatagct ggctagtctc ttgatggaga gaaatcaggg cttctctcat ccatgctgga
     4321 atttcattta gatgtcaact tccaagtttc cctttttcca gatgggatta tagtcctgct
     4381 tctggaacag ggtagctgtg tgtggtccag gatagttcaa ttatctggcc ctttgttcac
     4441 ttcttacaat cattgataca gtcaacaaaa attggttaaa aacaatatat gccagacata
     4501 tatccctgag ttctgggaca ataaccaaaa ttgaataagg caatatccta ctctcaagca
     4561 atagagggta ggaatagaat aataataata taatacaata gctctatagc agtatgtaaa
     4621 ctataaaagc attattttac gtgtttctat tgaactgtca taactaaata agatggttag
     4681 tactataatt atcccaagga ttcattcact catagaacat ttgttgagca attactacct
     4741 gccagtcact tccaagtggt aagtgagata gaaatggttc tttgtggcgc tcacaattta
     4801 ttggagaatg gaaacacaat tacaaaaaaa aagtgtgata agttctggga gaagggtggt
     4861 acaggatcct gtggggtagt ggtggctcca tataggaggg acattgggat actgatcagg
     4921 aaggagtggg ggacagggct agaagctgca ttagtataaa gttatgtcag actgccaaaa
     4981 caaaacaaac acaaaaaatc agtagtctgt ggtaaagaat tgctatagga acagccagta
     5041 ggggcagtta agctggtctt ggtgaatcag gggaagcgtc ctagaggaac agatgtccat
     5101 gctgaggcca aatgctggac aggagttagc cagacaggga aattgcattc tgggcagagg
     5161 agacagcaaa ggtcaagaaa catgacaact ttggaagact gtaacttgtt cagaggcaga
     5221 gggtgcaaag gagaaatgag gaaaggtgaa gctggagagg tgggcttggt ccagctcttg
     5281 ctgggccttt tcagccgtgt taaagattta gactgtatcc agagggatgt tgaactttaa
     5341 gcctaagact gaaaaggtga gaattgtgcc ttagatcact atggttgcag tgtggagact
     5401 ggtttggaaa ggggagaaat cagaggcttt tacagccatc ccagggagag agaatgaaca
     5461 ccagaattag ggtaatggaa gatggaaaga agagaaatcg ttttatgggt tgctcaggag
     5521 atagaattga catgtcttgg gattgttttg ctgtgtaggg gagagagaca agtcaagagt
     5581 atacatcctg tttctgactt ggcaactggg tgggtcatgg gtctgtttcc tgagacagtt
     5641 gtctacagcc ataccaccgt aagcgcccta aatctcatca gagacagttt atgcaaatgg
     5701 agcttgggga aagagaggtc gtggctggag acagagattt gggcatcatc aacatatagg
     5761 tgtggggagc agagaaggct gaggaagaaa gcaggaaaca tataaaaagg agagcaggga
     5821 aaggagccag tgagacagga aaaacctagt aacgtggtgt gatgaagcta ggggaggaag
     5881 gaaggaagga agggcggcgt ggaacgctgc tgatgggtgg tggcggggaa aatgaacgag
     5941 tatccaccag caacgagagg ggcctccatg gtcttggtgg gagcatttct ttggagaggt
     6001 ggaatcagaa gccccagatg tcagagggtt aaggaataat ttggaggaaa agcgtaaagg
     6061 cagtggaggt gaggagagaa ttttcaaaat gtttggcagt gattgcaatg aaagaaaaaa
     6121 atggagggag cagagtatat gcagttgagg aactttttta gtttggagtg tgttaacacg
     6181 atgttaggaa gaaggatcaa gtgaaggaga aaggtgaaaa tgctggaagg tggggcttag
     6241 tgatgaaaca aaccttgggg acaggtgggc gtggtactga gagtcccagt gaggggagtg
     6301 ccctcaggca ggcgccggtg gcttctgtca caggagggaa cagcgctgac attcagctgg
     6361 ttcgcactga tacggctcaa ccagtttgtt aaaacatgtc tgttccagtg tcagtaatat
     6421 acgagtaact gcaatatgca gtaaaaatta taaattctaa tacaaactca gttcaagcta
     6481 attaagagat cgcaacagcc gttggtaaat ggacttcccg ctgcatttga gaagctttgc
     6541 agcgccatct gccggtgtcg tagcatcact gcaggctgag aggctgcttt gcgccttcat
     6601 cttgaagcac tctgaaattg cctgtttaaa ttaccttgga atcatggagt tgctactgct
     6661 tctgaatagt ttagcttcta ctttgatttt attgttagtg cattgtcgtt cttgtgtcag
     6721 tagcaagttt cagtgtttta atatttacaa atacaaaaat ttttaataaa atattaaagc
     6781 caaacttgaa tgaagagaca a
//
