LOCUS       NM_021955                661 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens G protein subunit gamma transducin 1 (GNGT1),
            transcript variant 1, mRNA.
ACCESSION   NM_021955
VERSION     NM_021955.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 661)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 661)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 661)
  AUTHORS   Khan,S.M., Min,A., Gora,S., Houranieh,G.M., Campden,R.,
            Robitaille,M., Trieu,P., Petrin,D., Jacobi,A.M., Behlke,M.A.,
            Angers,S. and Hebert,T.E.
  TITLE     Gbeta4gamma1 as a modulator of M3 muscarinic receptor signalling
            and novel roles of Gbeta1 subunits in the modulation of cellular
            signalling
  JOURNAL   Cell Signal 27 (8), 1597-1608 (2015)
   PUBMED   25916507
  REMARK    GeneRIF: Suggest Gbeta4gamma1 as a modulator of M3 muscarinic
            receptor signaling.
REFERENCE   4  (bases 1 to 661)
  AUTHORS   Plimpton,R.L., Cuellar,J., Lai,C.W., Aoba,T., Makaju,A.,
            Franklin,S., Mathis,A.D., Prince,J.T., Carrascosa,J.L.,
            Valpuesta,J.M. and Willardson,B.M.
  TITLE     Structures of the Gbeta-CCT and PhLP1-Gbeta-CCT complexes reveal a
            mechanism for G-protein beta-subunit folding and Gbetagamma dimer
            assembly
  JOURNAL   Proc Natl Acad Sci U S A 112 (8), 2413-2418 (2015)
   PUBMED   25675501
  REMARK    GeneRIF: PhLP1 binding stabilizes the Gbeta fold, disrupting
            interactions with CCT and releasing a PhLP1-Gbeta dimer for
            assembly with Ggamma.
REFERENCE   5  (bases 1 to 661)
  AUTHORS   Yeh,C., Li,A., Chuang,J.Z., Saito,M., Caceres,A. and Sung,C.H.
  TITLE     IGF-1 activates a cilium-localized noncanonical Gbetagamma
            signaling pathway that regulates cell-cycle progression
  JOURNAL   Dev Cell 26 (4), 358-368 (2013)
   PUBMED   23954591
  REMARK    GeneRIF: During corticogenesis, a cilium-transduced, noncanonical
            IGF-1R-Gbetagamma-phospho(T94)Tctex-1 signaling pathway promotes
            the proliferation of neural progenitors through modulation of
            ciliary resorption and G1 length.
REFERENCE   6  (bases 1 to 661)
  AUTHORS   Scherer,S.W., Feinstein,D.S., Oliveira,L., Tsui,L.C. and
            Pittler,S.J.
  TITLE     Gene structure and chromosome localization to 7q21.3 of the human
            rod photoreceptor transducin gamma-subunit gene (GNGT1)
  JOURNAL   Genomics 35 (1), 241-243 (1996)
   PUBMED   8661128
REFERENCE   7  (bases 1 to 661)
  AUTHORS   Ray,K., Kunsch,C., Bonner,L.M. and Robishaw,J.D.
  TITLE     Isolation of cDNA clones encoding eight different human G protein
            gamma subunits, including three novel forms designated the gamma 4,
            gamma 10, and gamma 11 subunits
  JOURNAL   J Biol Chem 270 (37), 21765-21771 (1995)
   PUBMED   7665596
REFERENCE   8  (bases 1 to 661)
  AUTHORS   Tao,L., Pandey,S., Simon,M.I. and Fong,H.K.
  TITLE     Structure of the bovine transducin gamma subunit gene and analysis
            of promoter function in transgenic mice
  JOURNAL   Exp Eye Res 56 (4), 497-507 (1993)
   PUBMED   8500562
REFERENCE   9  (bases 1 to 661)
  AUTHORS   Simonds,W.F., Butrynski,J.E., Gautam,N., Unson,C.G. and
            Spiegel,A.M.
  TITLE     G-protein beta gamma dimers. Membrane targeting requires subunit
            coexpression and intact gamma C-A-A-X domain
  JOURNAL   J Biol Chem 266 (9), 5363-5366 (1991)
   PUBMED   1706334
REFERENCE   10 (bases 1 to 661)
  AUTHORS   Hurley,J.B., Fong,H.K., Teplow,D.B., Dreyer,W.J. and Simon,M.I.
  TITLE     Isolation and characterization of a cDNA clone for the gamma
            subunit of bovine retinal transducin
  JOURNAL   Proc Natl Acad Sci U S A 81 (22), 6948-6952 (1984)
   PUBMED   6438626
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC029367.1 and BQ637754.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_021955.4.
            
            Summary: This gene encodes the gamma subunit of transducin, a
            guanine nucleotide-binding protein (G protein) that is found in rod
            outer segments. Transducin, also known as GMPase, mediates the
            activation of a cyclic GTP-specific (guanosine monophosphate)
            phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ637754.1, BX509917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248572.10/ ENSP00000248572.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-431               BC029367.1         60-490
            432-661             BQ637754.1         390-619
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..661
                     /gene="GNGT1"
                     /gene_synonym="GNG1; HG3G1"
                     /note="G protein subunit gamma transducin 1"
                     /db_xref="GeneID:2792"
                     /db_xref="HGNC:HGNC:4411"
                     /db_xref="MIM:189970"
     exon            1..78
                     /gene="GNGT1"
                     /gene_synonym="GNG1; HG3G1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..185
                     /gene="GNGT1"
                     /gene_synonym="GNG1; HG3G1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..314
                     /gene="GNGT1"
                     /gene_synonym="GNG1; HG3G1"
                     /note="guanine nucleotide-binding protein G(T) subunit
                     gamma-T1; transducin gamma chain; guanine nucleotide
                     binding protein (G protein), gamma transducing activity
                     polypeptide 1; heterotrimeric guanine nucleotide-binding
                     protein 3G1"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(T) subunit
                     gamma-T1 precursor"
                     /protein_id="NP_068774.1"
                     /db_xref="CCDS:CCDS5633.1"
                     /db_xref="GeneID:2792"
                     /db_xref="HGNC:HGNC:4411"
                     /db_xref="MIM:189970"
                     /translation="MPVINIEDLTEKDKLKMEVDQLKKEVTLERMLVSKCCEEVRDYV
                     EERSGEDPLVKGIPEDKNPFKELKGGCVIS"
     exon            186..661
                     /gene="GNGT1"
                     /gene_synonym="GNG1; HG3G1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      450..455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNGT1"
                     /gene_synonym="GNG1; HG3G1"
                     /note="hexamer: AATAAA"
     polyA_site      471
                     /gene="GNGT1"
                     /gene_synonym="GNG1; HG3G1"
                     /note="major polyA site"
     regulatory      529..534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNGT1"
                     /gene_synonym="GNG1; HG3G1"
                     /note="hexamer: AATAAA"
     polyA_site      560
                     /gene="GNGT1"
                     /gene_synonym="GNG1; HG3G1"
ORIGIN      
        1 agaattgtta agagagagag ctcatatgaa attggttatc gtgggatatt taaaataaaa
       61 caaagaacag tttactttca ggcaaaaaga tgccagtaat caatattgag gacctgacag
      121 aaaaggacaa attgaagatg gaagttgacc agctcaagaa agaagtgaca ctggaaagaa
      181 tgctagtttc caaatgttgt gaagaagtaa gagattacgt tgaagaacga tctggcgagg
      241 atccactggt aaagggcatc ccagaggaca aaaatccctt caaggagctc aaaggaggct
      301 gtgtgatttc ataatacaaa caaaaagaaa aaaaattaaa caaattcttg gaaatatctc
      361 aaatgttaat aacaatatga atttttctca tgcatactat tactactaag catgtacgtg
      421 aatttttaaa tttatagatg taaactttta ataaaaattg gggtgtggta acccatcatt
      481 ctatgttttt cttaacatag ctggcacagg gtttaacaca taattgccaa taaatattgc
      541 ttaaagttct ttaaaaagaa ctatgtttta taaatgattc tatattattc tgagttgtca
      601 gcatatattt actgttttat gttttttcac ttccctttca acacttacaa ttttctaccc
      661 a
//
