LOCUS       NM_033258                435 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens G protein subunit gamma 8 (GNG8), mRNA.
ACCESSION   NM_033258 XM_017027503
VERSION     NM_033258.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 435)
  AUTHORS   Krishnan,A., Mustafa,A., Almen,M.S., Fredriksson,R., Williams,M.J.
            and Schioth,H.B.
  TITLE     Evolutionary hierarchy of vertebrate-like heterotrimeric G protein
            families
  JOURNAL   Mol Phylogenet Evol 91, 27-40 (2015)
   PUBMED   26002831
REFERENCE   2  (bases 1 to 435)
  AUTHORS   El-Haibi,C.P., Sharma,P., Singh,R., Gupta,P., Taub,D.D., Singh,S.
            and Lillard,J.W. Jr.
  TITLE     Differential G protein subunit expression by prostate cancer cells
            and their interaction with CXCR5
  JOURNAL   Mol Cancer 12, 64 (2013)
   PUBMED   23773523
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 435)
  AUTHORS   Cuello,F., Schulze,R.A., Heemeyer,F., Meyer,H.E., Lutz,S.,
            Jakobs,K.H., Niroomand,F. and Wieland,T.
  TITLE     Activation of heterotrimeric G proteins by a high energy phosphate
            transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta
            subunits. Complex formation of NDPK B with Gbeta gamma dimers and
            phosphorylation of His-266 IN Gbeta
  JOURNAL   J Biol Chem 278 (9), 7220-7226 (2003)
   PUBMED   12486123
REFERENCE   4  (bases 1 to 435)
  AUTHORS   Hurowitz,E.H., Melnyk,J.M., Chen,Y.J., Kouros-Mehr,H., Simon,M.I.
            and Shizuya,H.
  TITLE     Genomic characterization of the human heterotrimeric G protein
            alpha, beta, and gamma subunit genes
  JOURNAL   DNA Res 7 (2), 111-120 (2000)
   PUBMED   10819326
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093503.2.
            
            On or before Jan 12, 2021 this sequence version replaced
            XM_017027503.1, NM_033258.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.2253448.1,
                                           SRR1163658.386480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000693335.1/ ENSP00000508424.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC093503.2         77323-77378         c
            57-183              AC093503.2         75775-75901         c
            184-435             AC093503.2         75129-75380         c
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..435
                     /gene="GNG8"
                     /gene_synonym="HG3E"
                     /note="G protein subunit gamma 8"
                     /db_xref="GeneID:94235"
                     /db_xref="HGNC:HGNC:19664"
     exon            1..56
                     /gene="GNG8"
                     /gene_synonym="HG3E"
                     /inference="alignment:Splign:2.1.0"
     exon            57..183
                     /gene="GNG8"
                     /gene_synonym="HG3E"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..312
                     /gene="GNG8"
                     /gene_synonym="HG3E"
                     /note="gamma-9; guanine nucleotide binding protein (G
                     protein), gamma 8; heterotrimeric guanine
                     nucleotide-binding protein 3E"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-8"
                     /protein_id="NP_150283.1"
                     /db_xref="CCDS:CCDS12687.1"
                     /db_xref="GeneID:94235"
                     /db_xref="HGNC:HGNC:19664"
                     /translation="MSNNMAKIAEARKTVEQLKLEVNIDRMKVSQAAAELLAFCETHA
                     KDDPLVTPVPAAENPFRDKRLFCVLL"
     exon            184..435
                     /gene="GNG8"
                     /gene_synonym="HG3E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      355..360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG8"
                     /gene_synonym="HG3E"
                     /note="hexamer: AATAAA"
     polyA_site      373
                     /gene="GNG8"
                     /gene_synonym="HG3E"
     polyA_site      435
                     /gene="GNG8"
                     /gene_synonym="HG3E"
                     /note="major polyA site"
ORIGIN      
        1 agacgctgcc tcccagcctc tgtcaccgcc gcgagcccgg cccagagcag caacagcccc
       61 cactcccgcg cgtcttttaa ccccttcccc gccgcaacca tgtccaacaa catggccaag
      121 attgccgagg cccgcaagac ggtggaacag ctgaagctgg aggtgaacat cgaccgcatg
      181 aaggtgtcgc aggcagcagc ggaactcctg gctttctgcg agacgcatgc caaagatgac
      241 ccgctggtga cgccagtacc cgccgcggag aaccccttcc gcgacaagcg cctcttttgt
      301 gttctgctct gagccctccg gacagcttac cctcccctgc caaagtatgg atccaataaa
      361 cttggtaact gtggtggtgc ctgtgctttc agggagactg aggcacgcac agagcttggg
      421 gccaccgtag gggaa
//
