LOCUS       NM_052847               4193 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein subunit gamma 7 (GNG7), mRNA.
ACCESSION   NM_052847 NM_005145
VERSION     NM_052847.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4193)
  AUTHORS   Duan,H., Chen,B., Wang,W. and Luo,H.
  TITLE     Identification of GNG7 as a novel biomarker and potential
            therapeutic target for gastric cancer via bioinformatic analysis
            and in vitro experiments
  JOURNAL   Aging (Albany NY) 15 (5), 1445-1474 (2023)
   PUBMED   36863706
  REMARK    GeneRIF: Identification of GNG7 as a novel biomarker and potential
            therapeutic target for gastric cancer via bioinformatic analysis
            and in vitro experiments.
REFERENCE   2  (bases 1 to 4193)
  AUTHORS   Zou,C., Lv,X., Wei,H., Wu,S., Song,J., Tang,Z., Liu,S., Li,X. and
            Ai,Y.
  TITLE     Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma
            via miR-4311/GNG7 axis
  JOURNAL   Bioengineered 13 (3), 6371-6382 (2022)
   PUBMED   35240924
  REMARK    GeneRIF: Long non-coding RNA LINC00472 inhibits oral squamous cell
            carcinoma via miR-4311/GNG7 axis.
REFERENCE   3  (bases 1 to 4193)
  AUTHORS   Zhao,X., Zhang,X.C., Zang,K. and Yu,Z.H.
  TITLE     MicroRNA miR-19b-3p mediated G protein gamma subunit 7 (GNG7) loss
            contributes lung adenocarcinoma progression through activating
            Hedgehog signaling
  JOURNAL   Bioengineered 12 (1), 7849-7858 (2021)
   PUBMED   34635014
  REMARK    GeneRIF: MicroRNA miR-19b-3p mediated G protein gamma subunit 7
            (GNG7) loss contributes lung adenocarcinoma progression through
            activating Hedgehog signaling.
REFERENCE   4  (bases 1 to 4193)
  AUTHORS   Zhang,Y., Yang,J., Wang,X. and Li,X.
  TITLE     GNG7 and ADCY1 as diagnostic and prognostic biomarkers for
            pancreatic adenocarcinoma through bioinformatic-based analyses
  JOURNAL   Sci Rep 11 (1), 20441 (2021)
   PUBMED   34650124
  REMARK    GeneRIF: GNG7 and ADCY1 as diagnostic and prognostic biomarkers for
            pancreatic adenocarcinoma through bioinformatic-based analyses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4193)
  AUTHORS   Zheng,H., Tian,H., Yu,X., Ren,P. and Yang,Q.
  TITLE     G protein gamma 7 suppresses progression of lung adenocarcinoma by
            inhibiting E2F transcription factor 1
  JOURNAL   Int J Biol Macromol 182, 858-865 (2021)
   PUBMED   33864871
  REMARK    GeneRIF: G protein gamma 7 suppresses progression of lung
            adenocarcinoma by inhibiting E2F transcription factor 1.
REFERENCE   6  (bases 1 to 4193)
  AUTHORS   Ohta,M., Mimori,K., Fukuyoshi,Y., Kita,Y., Motoyama,K.,
            Yamashita,K., Ishii,H., Inoue,H. and Mori,M.
  TITLE     Clinical significance of the reduced expression of G protein gamma
            7 (GNG7) in oesophageal cancer
  JOURNAL   Br J Cancer 98 (2), 410-417 (2008)
   PUBMED   18219292
  REMARK    GeneRIF: GNG7 suppression represents a new prognostic indicator in
            cases of oesophageal cancer.
REFERENCE   7  (bases 1 to 4193)
  AUTHORS   Fowler,C.E., Aryal,P., Suen,K.F. and Slesinger,P.A.
  TITLE     Evidence for association of GABA(B) receptors with Kir3 channels
            and regulators of G protein signalling (RGS4) proteins
  JOURNAL   J Physiol 580 (Pt 1), 51-65 (2007)
   PUBMED   17185339
REFERENCE   8  (bases 1 to 4193)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   9  (bases 1 to 4193)
  AUTHORS   Jiang,G. and Zhang,B.B.
  TITLE     Glucagon and regulation of glucose metabolism
  JOURNAL   Am J Physiol Endocrinol Metab 284 (4), E671-E678 (2003)
   PUBMED   12626323
  REMARK    Review article
REFERENCE   10 (bases 1 to 4193)
  AUTHORS   Shibata,K., Mori,M., Tanaka,S., Kitano,S. and Akiyoshi,T.
  TITLE     Identification and cloning of human G-protein gamma 7,
            down-regulated in pancreatic cancer
  JOURNAL   Biochem Biophys Res Commun 246 (1), 205-209 (1998)
   PUBMED   9600093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC014466.1, DA247608.1, AC005512.1 and BC053630.1.
            
            On Nov 23, 2018 this sequence version replaced NM_052847.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.411482.1,
                                           SRR1660805.188960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153031, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382159.8/ ENSP00000371594.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               BC014466.1         16-168
            154-597             DA247608.1         152-595
            598-3040            AC005512.1         26399-28841         c
            3041-4192           BC053630.1         3006-4157
            4193-4193           AC005512.1         25246-25246         c
FEATURES             Location/Qualifiers
     source          1..4193
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4193
                     /gene="GNG7"
                     /gene_synonym="HG3B"
                     /note="G protein subunit gamma 7"
                     /db_xref="GeneID:2788"
                     /db_xref="HGNC:HGNC:4410"
                     /db_xref="MIM:604430"
     exon            1..49
                     /gene="GNG7"
                     /gene_synonym="HG3B"
                     /inference="alignment:Splign:2.1.0"
     exon            50..106
                     /gene="GNG7"
                     /gene_synonym="HG3B"
                     /inference="alignment:Splign:2.1.0"
     exon            107..146
                     /gene="GNG7"
                     /gene_synonym="HG3B"
                     /inference="alignment:Splign:2.1.0"
     exon            147..264
                     /gene="GNG7"
                     /gene_synonym="HG3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..390
                     /gene="GNG7"
                     /gene_synonym="HG3B"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma 7; heterotrimeric guanine nucleotide-binding protein
                     3B"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-7"
                     /protein_id="NP_443079.1"
                     /db_xref="CCDS:CCDS12091.1"
                     /db_xref="GeneID:2788"
                     /db_xref="HGNC:HGNC:4410"
                     /db_xref="MIM:604430"
                     /translation="MSATNNIAQARKLVEQLRIEAGIERIKVSKAASDLMSYCEQHAR
                     NDPLLVGVPASENPFKDKKPCIIL"
     exon            265..4193
                     /gene="GNG7"
                     /gene_synonym="HG3B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      962
                     /gene="GNG7"
                     /gene_synonym="HG3B"
     regulatory      4169..4174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG7"
                     /gene_synonym="HG3B"
                     /note="hexamer: AATAAA"
     polyA_site      4193
                     /gene="GNG7"
                     /gene_synonym="HG3B"
                     /note="major polyA site"
ORIGIN      
        1 gggttcggct gcgcggcggg gctgaggcgg ccgcggggcc cgagcgcagg gagtggagct
       61 tggtttcggg atctcggtgc tgcagacggc gagacctcct gcacagggtg tacagcaagc
      121 tgtgattcct gggaaaacta aaaaagctct ctgaacaacg gggcccagag ctgatggcag
      181 acaatgtcag ccactaacaa catagcccag gcccggaagc tggtggaaca gctacgcata
      241 gaagccggga ttgagcgcat caaggtctcc aaagcggcgt ctgacctcat gagctactgt
      301 gagcaacatg cccggaacga ccccctgctg gtcggagtcc ctgcctcgga gaaccccttt
      361 aaggacaaga aaccttgtat tattttataa ctgtgttctc atatgttctc tctctctctc
      421 tctctttctc tctctctctc tctgtctctg tctctgtctc aggcagggca tcattcagta
      481 attagctcaa acaaaacatc tcaagtcccc aaaaccttta attccaaaag aaatcccccc
      541 tctccccgcc aaaaaaggcg ttcccaccgc ccggatgggg tagaatggac cttgtaggtg
      601 gagatgaatt ttcaggtccg accccatggc cctctcagtt tgggccaaaa gggatggagg
      661 ctttacggcc acttcccgtt cggaataact gaaatccccc agcgatgggg taacaatttt
      721 ttaaaactct cgattgccgt ttcaattgtg gaccggcgcc gagggggaaa gggaggtgac
      781 ttcgcccggt ggcaatagtt ccgggagaat tggccattgg taaaaagact tcatagggtc
      841 actggaatgc tttgtgttgt ttttaagtag aggtaaaatt gagatggggg gcgggaggtg
      901 acatcatgaa gttttttgga aatatctctt tatttaaaaa attgttactc catacggcta
      961 aactcggatt gtgatggttg aacccgtcgc taaactgcac gatcctgcaa tgaatgcacg
     1021 atggagtgtg ggggtctgga gggggcttcg tctatgaaaa gttgccaagt gtgactcccc
     1081 tgcatgatgt tagccatggg tcctttctgc agggtcccct ctgtgccaga aatgggtttt
     1141 cgggacttgc cccagggaag ccgtcaccgg cccggcccat catgtttttg gatttttttt
     1201 ttttttcttt ttttgagatg gagtttcatt cttgttaccc aggctggagt gcagctgcat
     1261 gatttcagct caccgcaacc tctgcctccc cggttcaagc gattctcctg cctcagcctc
     1321 ccgagtagct gagactacag gcgtgtgcca ctacgcccgg ctaattgttg tatttttagt
     1381 agagacgggg tttcaccgta ttggccaggc cgctctcaaa ctcctgacct cgggatccgc
     1441 ccacctcggc ctcccaaagt gctgggatta caggcatgag ccaccgcgcc cagtgtgttt
     1501 taagcatgag gcatccgcgt ggctgggaga ggctttgacc atccttggct cttccaggtt
     1561 gtcctaccct ctggcatcca ccatagacgt ttttcaaaca gaaaatgcag gctggggagc
     1621 cgcggcaggg cgggtggggc taccctgtgc tgctgtgtgt acaaaattgt tccatgatct
     1681 tggagtgact ctgaaggact ctgggaggtg agacgttgtc ccggagatca aaacgtccgc
     1741 tcaaaacgtt accctgtcgc tcgaacccga tctttttgct tttccacccc cgtgcaaccc
     1801 aggacggctg tctgaggccg ggagatgcct tagacgcagg atgggccact cctcccagcg
     1861 gcaagtggaa atcgaagatg tcatggggtc ggggggaggc ttctgaaaga tgactgcgtc
     1921 ctcctctgcg gcacggacgg gagcaggtgc agccacatct tccagggcct gccggcatca
     1981 cctgcggcca cacctgagat ggaccccacg cagccctgat cgcaggaggc ctggccgccc
     2041 cgaccccctc cacggggctg gcctagaagc aagtagtaga ataaaactag cctagtcctg
     2101 tccctccggc cccagtggag acaggcgtct aagaacccgt gccgagaggg ttcctggacg
     2161 gccgcccagg tcctccgtgc aggcccgtga ggcggggatc cctgcttggc tcacttcctg
     2221 agctggtgac tgccagggtt cccacctcgc caaggctaga gggctccggg tgtgtgtgca
     2281 ggtgtcgggg gagtgacctc cactcctcaa cctcgggcag ctcccacagg ccacagccgg
     2341 gctccccacc cccggcaccc agctctctac ggcaggtccg ggagggctgg ggcttcgggg
     2401 agccctaccc gccaaacctg ctgttggccc gggagagccc cagaggctcc cggagactgc
     2461 agcctcctgt ggttgggctg ggagccggca gggtttgggg tgtgggcgtc cccaccacgc
     2521 atagcaggaa tggcaggaag ggacaaaagc ctgttccaga gaccctggga ggaccccagg
     2581 cagggagagc ccgcctgcct ccaccctttc caacaagcca tcttggtaac tgggaacaaa
     2641 cacaccccac cccgtttttc cttaaaagag gccttaatcc ccgagccccc gctgccaggg
     2701 cagagggagg agggggcaca gctgtgccaa gcccggcccc actggtgtgt cctcacaatg
     2761 tgaccccaga aatgccagca gggaacggag gctgctgcag agacgcagcc ccaggcagcc
     2821 ggggctccta ggctggtgca gatggtgggg ttaaacgggc tgagcgttcc aggtaaactg
     2881 aggctcgggg aggggaagga caggctggcc tctccttcac tgtccacagg gccttgggtt
     2941 ccctgagctg tccagacccc accatctccc ggaccccagg gaggtggcca ttgccagaag
     3001 cctgtgggtt tctttctagc ttgggggatt aaaaaaaaaa ttctccactt ttttttttct
     3061 tgagtagact tcagtgacca cactgtggaa aatacctttg cagacgtggc acccgagtgc
     3121 acacaccgac cgccacatgt gcttttctgc cgggaatccc tggggtgaac gcatgtttta
     3181 tgggcgtttc caggagcgcg cgtgcacctc cagacgggga gctggcgggc gggggtggca
     3241 gcagcagctc tagccttggg gggacaagcc tctctcagct acgccagggg aaaagagagt
     3301 taaggacact cacccccacc cacgcacaca cacaaggcag cgtcgggtgg gagagagaag
     3361 gccgtttctc cttctgtagc ctgggtctcc cacgggcctt ccccgctgct gagcgagaca
     3421 ccagtagcca ggtgaagggc cacagcgggc caggccccga ccctgttgtg acccacctgg
     3481 gcaccttccc ggaccagctc cgcctcccct gccctcctct ctccaggaag gagccagaac
     3541 cctcacccct ctcccaccct ccccaggggt aaccccaggc caagcacaga tagctcagct
     3601 gcgacctctg gcctctgggg acataaacgg ggcggctggg ccagggcgga aggtgctcct
     3661 gtttccctcc ttctgcgtgg tccctttgac gggccggcca ccgtgtccga ggcgcaacgc
     3721 taggcctcca ggccacgcat ccatctccaa gttaacagcc cgtcctgccc aagttctggg
     3781 gcaggtagga gagggccgtc acacacctgt ccgcccgtga gtgacccggg ggggcttccg
     3841 ggtggaggtg gagccaccac gcccttcctc aaggggtcac ttattaaaaa gtccacggcc
     3901 tgaggccagg ccctctgcac agaagccata tgccggccag ccgcgcctcc tcctctgtcc
     3961 acggaaccgc tgcccatcta accttcgtaa agacctgtct cctgtttcca gccgccgcct
     4021 gtggttctag caggttctat gccatctgca ttgggatgtc tggttgtttt tatttctgac
     4081 ttttttaaaa ttccaggtgt gccgcaccca ctttctcgca gtgttttaat attgtgtgga
     4141 gttgtcgata ccacgtgaat tcatacacaa taaaaagcct cactctccct ttt
//
