LOCUS       NM_005274                806 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens G protein subunit gamma 5 (GNG5), mRNA.
ACCESSION   NM_005274 XM_005270763
VERSION     NM_005274.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 806)
  AUTHORS   Liang,S., Zhu,L., Yang,F. and Dong,H.
  TITLE     Transcription factor YY1-activated GNG5 facilitates glioblastoma
            cell growth, invasion, stemness and glycolysis through
            Wnt/beta-catenin pathway
  JOURNAL   Sci Rep 14 (1), 25234 (2024)
   PUBMED   39448763
  REMARK    GeneRIF: Transcription factor YY1-activated GNG5 facilitates
            glioblastoma cell growth, invasion, stemness and glycolysis through
            Wnt/beta-catenin pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 806)
  AUTHORS   Peng,J., Li,S., Li,B., Hu,W. and Ding,C.
  TITLE     Exosomes derived from M1 macrophages inhibit the proliferation of
            the A549 and H1299 lung cancer cell lines via the
            miRNA-let-7b-5p-GNG5 axis
  JOURNAL   PeerJ 11, e14608 (2023)
   PUBMED   36643646
  REMARK    GeneRIF: Exosomes derived from M1 macrophages inhibit the
            proliferation of the A549 and H1299 lung cancer cell lines via the
            miRNA-let-7b-5p-GNG5 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 806)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 806)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 806)
  AUTHORS   Yang,B., Han,Z.Y., Wang,W.J., Ma,Y.B. and Chu,S.H.
  TITLE     GNG5 is an unfavourable independent prognostic indicator of gliomas
  JOURNAL   J Cell Mol Med 24 (21), 12873-12878 (2020)
   PUBMED   33000557
  REMARK    GeneRIF: GNG5 is an unfavourable independent prognostic indicator
            of gliomas.
REFERENCE   6  (bases 1 to 806)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
REFERENCE   7  (bases 1 to 806)
  AUTHORS   Yan,K., Kalyanaraman,V. and Gautam,N.
  TITLE     Differential ability to form the G protein betagamma complex among
            members of the beta and gamma subunit families
  JOURNAL   J Biol Chem 271 (12), 7141-7146 (1996)
   PUBMED   8636150
REFERENCE   8  (bases 1 to 806)
  AUTHORS   Ahmad,W., Li,S., Chen,H., Tuck-Muller,C.M., Pittler,S.J. and
            Aronson,N.N. Jr.
  TITLE     Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5)
            genes co-localize to human chromosome 1p22
  JOURNAL   Cytogenet Cell Genet 71 (1), 44-46 (1995)
   PUBMED   7606925
REFERENCE   9  (bases 1 to 806)
  AUTHORS   Fisher,K.J. and Aronson,N.N. Jr.
  TITLE     Characterization of the cDNA and genomic sequence of a G protein
            gamma subunit (gamma 5)
  JOURNAL   Mol Cell Biol 12 (4), 1585-1591 (1992)
   PUBMED   1549114
REFERENCE   10 (bases 1 to 806)
  AUTHORS   Gilman,A.G.
  TITLE     G proteins: transducers of receptor-generated signals
  JOURNAL   Annu Rev Biochem 56, 615-649 (1987)
   PUBMED   3113327
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359762.24, BM834854.1, BC003563.1 and BM809260.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005274.2.
            
            Summary: G proteins are trimeric (alpha-beta-gamma)
            membrane-associated proteins that regulate flow of information from
            cell surface receptors to a variety of internal metabolic
            effectors. Interaction of a G protein with its activated receptor
            promotes exchange of GTP for GDP that is bound to the alpha
            subunit. The alpha-GTP complex dissociates from the beta-gamma
            heterodimer so that the subunits, in turn, may interact with and
            regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary
            by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.612147.1,
                                           SRR5189661.2416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370645.9/ ENSP00000359679.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL359762.24        16825-16826         c
            3-273               BM834854.1         1-271
            274-802             BC003563.1         1-529
            803-806             BM809260.1         540-543
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..806
                     /gene="GNG5"
                     /note="G protein subunit gamma 5"
                     /db_xref="GeneID:2787"
                     /db_xref="HGNC:HGNC:4408"
                     /db_xref="MIM:600874"
     exon            1..146
                     /gene="GNG5"
                     /inference="alignment:Splign:2.1.0"
     exon            147..437
                     /gene="GNG5"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..563
                     /gene="GNG5"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma 5"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-5"
                     /protein_id="NP_005265.1"
                     /db_xref="CCDS:CCDS696.1"
                     /db_xref="GeneID:2787"
                     /db_xref="HGNC:HGNC:4408"
                     /db_xref="MIM:600874"
                     /translation="MSGSSSVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAQ
                     HDPLLTGVSSSTNPFRPQKVCSFL"
     exon            438..582
                     /gene="GNG5"
                     /inference="alignment:Splign:2.1.0"
     exon            583..806
                     /gene="GNG5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      784..789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG5"
                     /note="hexamer: AATAAA"
     polyA_site      806
                     /gene="GNG5"
                     /note="major polyA site"
ORIGIN      
        1 ctcacttccc tcaacccttc ccacaaactg ggaggaaaac tgagacctcc tggtcacccg
       61 ccgccgggcc ttttagaaac tcccacaagc tctgccttcc ctccctggtc ctcttcagac
      121 cccctcttag ttcttcgcgg ctaacggctc gcgctcgggg ccgggtgtgg agctggaaca
      181 gagggctggc aaggcgcgca tgcgcaccga gggtggagcc gctgagcaca gaaccggaaa
      241 cttagagaca aagttcggag ccccgccccc gccgcgcgcc gctgagttgt ctggccccgc
      301 cgacccacgg cccacgaccc accgacccac gaatcggccc ggccgtcgcg tgcaccatgt
      361 ctggctcctc cagcgtcgcc gctatgaaga aagtggttca acagctccgg ctggaggccg
      421 gactcaaccg cgtaaaagtt tcccaggcag ctgcagactt gaaacagttc tgtctgcaga
      481 atgctcaaca tgaccctctg ctgactggag tatcttcaag tacaaatccc ttcagacccc
      541 agaaagtctg ttcctttttg tagtaaaatg aatctttcaa aggtttccca aaccactcct
      601 tatgatccag tgaatattca agagagctac atttgaagcc tgtacaaaag cttatccctg
      661 taacacatgt gccataatat acaaacttct actttcgtca gtccttaaca tctacctctc
      721 tgaattttca tgaatttcta tttcacaagg gtaattgttt tatatacact ggcagcagca
      781 tacaataaaa cttagtatga aacttt
//
