LOCUS       NM_001098722            4897 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens G protein subunit gamma 4 (GNG4), transcript variant
            1, mRNA.
ACCESSION   NM_001098722
VERSION     NM_001098722.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4897)
  AUTHORS   Wang,J., Wang,Y., Zhou,J., Cai,M., Guo,P., Du,T. and Zhang,H.
  TITLE     GNG4, as a potential predictor of prognosis, is correlated with
            immune infiltrates in colon adenocarcinoma
  JOURNAL   J Cell Mol Med 27 (17), 2517-2532 (2023)
   PUBMED   37448185
  REMARK    GeneRIF: GNG4, as a potential predictor of prognosis, is correlated
            with immune infiltrates in colon adenocarcinoma.
REFERENCE   2  (bases 1 to 4897)
  AUTHORS   Duan,L., Liu,X., Luo,Z., Zhang,C., Wu,C., Mu,W., Zuo,Z., Pei,X. and
            Shao,T.
  TITLE     G-Protein Subunit Gamma 4 as a Potential Biomarker for Predicting
            the Response of Chemotherapy and Immunotherapy in Bladder Cancer
  JOURNAL   Genes (Basel) 13 (4), 693 (2022)
   PUBMED   35456499
  REMARK    GeneRIF: G-Protein Subunit Gamma 4 as a Potential Biomarker for
            Predicting the Response of Chemotherapy and Immunotherapy in
            Bladder Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4897)
  AUTHORS   Tanaka,H., Kanda,M., Miwa,T., Umeda,S., Sawaki,K., Tanaka,C.,
            Kobayashi,D., Hayashi,M., Yamada,S., Nakayama,G., Koike,M. and
            Kodera,Y.
  TITLE     G-protein subunit gamma-4 expression has potential for detection,
            prediction and therapeutic targeting in liver metastasis of gastric
            cancer
  JOURNAL   Br J Cancer 125 (2), 220-228 (2021)
   PUBMED   33854208
  REMARK    GeneRIF: G-protein subunit gamma-4 expression has potential for
            detection, prediction and therapeutic targeting in liver metastasis
            of gastric cancer.
REFERENCE   4  (bases 1 to 4897)
  AUTHORS   Zhao,H., Sheng,D., Qian,Z., Ye,S., Chen,J. and Tang,Z.
  TITLE     Identifying GNG4 might play an important role in colorectal cancer
            TMB
  JOURNAL   Cancer Biomark 32 (4), 435-450 (2021)
   PUBMED   34275892
  REMARK    GeneRIF: Identifying GNG4 might play an important role in
            colorectal cancer TMB.
REFERENCE   5  (bases 1 to 4897)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4897)
  AUTHORS   Cuello,F., Schulze,R.A., Heemeyer,F., Meyer,H.E., Lutz,S.,
            Jakobs,K.H., Niroomand,F. and Wieland,T.
  TITLE     Activation of heterotrimeric G proteins by a high energy phosphate
            transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta
            subunits. Complex formation of NDPK B with Gbeta gamma dimers and
            phosphorylation of His-266 IN Gbeta
  JOURNAL   J Biol Chem 278 (9), 7220-7226 (2003)
   PUBMED   12486123
REFERENCE   7  (bases 1 to 4897)
  AUTHORS   Downes,G.B. and Gautam,N.
  TITLE     The G protein subunit gene families
  JOURNAL   Genomics 62 (3), 544-552 (1999)
   PUBMED   10644457
  REMARK    Review article
REFERENCE   8  (bases 1 to 4897)
  AUTHORS   Yan,K., Kalyanaraman,V. and Gautam,N.
  TITLE     Differential ability to form the G protein betagamma complex among
            members of the beta and gamma subunit families
  JOURNAL   J Biol Chem 271 (12), 7141-7146 (1996)
   PUBMED   8636150
REFERENCE   9  (bases 1 to 4897)
  AUTHORS   Ray,K., Kunsch,C., Bonner,L.M. and Robishaw,J.D.
  TITLE     Isolation of cDNA clones encoding eight different human G protein
            gamma subunits, including three novel forms designated the gamma 4,
            gamma 10, and gamma 11 subunits
  JOURNAL   J Biol Chem 270 (37), 21765-21771 (1995)
   PUBMED   7665596
REFERENCE   10 (bases 1 to 4897)
  AUTHORS   Pumiglia,K.M., LeVine,H., Haske,T., Habib,T., Jove,R. and
            Decker,S.J.
  TITLE     A direct interaction between G-protein beta gamma subunits and the
            Raf-1 protein kinase
  JOURNAL   J Biol Chem 270 (24), 14251-14254 (1995)
   PUBMED   7782277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX784976.1, AK311781.1, FO393422.1 and AK074383.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001098722.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.297756.1,
                                           SRR1803613.82635.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391854.7/ ENSP00000375727.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CX784976.1         159-160
            3-358               AK311781.1         1-356
            359-4894            FO393422.1         140082-144617       c
            4895-4897           AK074383.1         2013-2015
FEATURES             Location/Qualifiers
     source          1..4897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.3"
     gene            1..4897
                     /gene="GNG4"
                     /gene_synonym="HG3C"
                     /note="G protein subunit gamma 4"
                     /db_xref="GeneID:2786"
                     /db_xref="HGNC:HGNC:4407"
                     /db_xref="MIM:604388"
     exon            1..123
                     /gene="GNG4"
                     /gene_synonym="HG3C"
                     /inference="alignment:Splign:2.1.0"
     exon            124..235
                     /gene="GNG4"
                     /gene_synonym="HG3C"
                     /inference="alignment:Splign:2.1.0"
     exon            236..344
                     /gene="GNG4"
                     /gene_synonym="HG3C"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..473
                     /gene="GNG4"
                     /gene_synonym="HG3C"
                     /note="guanine nucleotide binding protein 4;
                     heterotrimeric guanine nucleotide-binding protein 3C;
                     guanine nucleotide binding protein (G protein), gamma 4"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-4"
                     /protein_id="NP_001092192.1"
                     /db_xref="CCDS:CCDS1607.1"
                     /db_xref="GeneID:2786"
                     /db_xref="HGNC:HGNC:4407"
                     /db_xref="MIM:604388"
                     /translation="MKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAAADLLAY
                     CEAHVREDPLIIPVPASENPFREKKFFCTIL"
     exon            345..4897
                     /gene="GNG4"
                     /gene_synonym="HG3C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1732..1737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG4"
                     /gene_synonym="HG3C"
                     /note="hexamer: AATAAA"
     polyA_site      1750
                     /gene="GNG4"
                     /gene_synonym="HG3C"
                     /note="major polyA site"
     regulatory      4869..4874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG4"
                     /gene_synonym="HG3C"
                     /note="hexamer: AATAAA"
     polyA_site      4897
                     /gene="GNG4"
                     /gene_synonym="HG3C"
                     /note="major polyA site"
ORIGIN      
        1 gcacgaggcg cgcgtttgca cccgagcccg gcccgcgccc cgatgcggag cgatgccgct
       61 cggcctggcc gccccccgcg agcaccgcgc tgcagacgaa gcccgcgcgt gatcccgctc
      121 cgggtgacct caaagcagaa gctctgaatt cacctctcat ctgacgactg acagctgctg
      181 ccaccgccag cctctgtccc ttgcccaggc ctgtcacacg gctgcctctc agcaggggca
      241 gtagaatgaa agagggcatg tctaataaca gcaccactag catctcccaa gccaggaaag
      301 ctgtggagca gctaaagatg gaagcctgta tggacagggt caaggtctcc caggcagctg
      361 cggacctcct ggcctactgt gaagctcacg tgcgggaaga tcctctcatc attccagtgc
      421 ctgcatcaga aaaccccttt cgcgagaaga agttcttttg taccattctc taactccgtg
      481 tgtgatgaaa acgcctcctt ttctgacctt caaagtcccc tgtagagacc atgcatgctc
      541 taagccttag ggagtgagac caacacccat ccctgcccag ccaacagtgg ccggggcttg
      601 tcttatgttt ccatctgttt tcttcgtggc attcaatttc atttttttcc ttttcatttt
      661 catgttattt tcattattgg caaagaaaat caaaatgttt atagccaaat aacaaatgtg
      721 ccatgtaaaa gtaagtctgg acttaagagt ttaaaatttt taaacatcag tttccaagtt
      781 tatatcatat taatacattt cagtggataa tttattttaa aaaaaaaact atgcctaaat
      841 atcccttatt tgcaatattc agtatcaaat tagagcattt tgaccaactg aaacatataa
      901 cgttttcatc tcctttcctg gagaaagcag ctgcagaggt tctgtatttc ctgcatttcc
      961 atcatcctag taaaaagaca acaacccaca ggattggaat ggttttcttt tgtttttttt
     1021 ttgttgttgt tgttgttttg agatggagtc tcgctctgtc acccaggctg gagtgcaatg
     1081 gcgtgacctc agctcactgc gacctccacc tcctgggttc aagcgattct cctgcctcag
     1141 cctcctgagt agctgggatc ataggcacgc gccaccacac ccagctaatt ttttgtattt
     1201 ttagtaaaga cggggtttca ccatgttggt caggctggtc tcaaactcct gacctcgtga
     1261 tccacccgcc tcggcctccc aaagcgctgg gattacaggc gtgagccacc acacccggcc
     1321 gtggaatggt tttcttagca tatcctcctg gggccgtggc gccccggctg tgggccgtgg
     1381 tggatgtccc ttgtttcagt ggtcctacaa aggtagatgg tgggcggaca ccgaagtcaa
     1441 cttgactgta aaagtacccc ataccgttga cgcgctgtgg cagacctgtg ggtgcggtct
     1501 cccctctcca aatgccacct cttcctgctc cctcctcttt tggctcctac tcagtagttc
     1561 cattgtgggc tgcagtaata taaggacctg ttctggacac agcactgggc ccgctggggt
     1621 tttagtaggg cagccccttc cctgcaggag tgaggcatgg tgacagcagt cccctatgtg
     1681 cccccaagtc atctgagcat tggtgtgcat taaggtactc aatcttccaa caataaatac
     1741 cataagtgca tgtctgtttt attttattta tttatctttt tgagacagag tcttgctctg
     1801 tcgcccgggc tggaatgcaa tggcacaatc tcagctcacc gcaacctcca ctcgcaggtt
     1861 caagtgatcc tcatgtctca gcctccctag tagctgggat gacaagcaca cgccaacatg
     1921 cctggctcat ttttgtattt ttagtagaga cggggtttca ccatgtcggc caggctggtc
     1981 tccaactact ggcctcgagt gatctgccca ccttggcctc ccaaagtgct gggattgcag
     2041 gtgtgagcca gtgcacccgg ccgtatgtct tagagtgagg ggaaactgag gcacaaagcg
     2101 tttatgtagt ttgcccaagg ttacacatgg taagcagaaa aactgggatt tgagggcagg
     2161 cagcccggcc ccagagttcc cttagccccc tgaactgtgc taccttccag gtctacctgt
     2221 ttgcaggtag ggagacccac aaactatcat aactgcacac cgtgaagcaa acacctttgt
     2281 tgcagtaacc cgtggcacac ttcacttccc acattctcca ggaggaagcc gtattctggt
     2341 agtttaagga aggtgattca tggatgcccc aaggaaaggc tagacatcga tgaattagct
     2401 cttggattgt ctaagatcaa cctgaaggtc ctacctaaac caaactcata tgatcccgat
     2461 gaaagaggag aatacacagt gggagcagag ctctttgtgt aagtttgttc tattctgttt
     2521 atttggaaac tgcctctctc cctagttctg aaagagactt gctgtgtgat agagaacagg
     2581 ccatttgtgc ctgaaatgtt ctaacctgca aattgggttt aatggtaatt atcctgcctt
     2641 tctgtctggg aggaaacaga gatgctacat agatgaaagc tctgattatc atttaaaaca
     2701 aataaatgta ctaaatgccg tggtataata tagggaagaa tggatgactt caaagagacc
     2761 atggttccgt tggaggcata aaattgcctg caaagaggca aatgtaattt ccagaccaat
     2821 taatgacttg ctgccctcgt aaatggattt aggacatctt tgttccttgc ttcttttgtt
     2881 aaaactcatt cttagtttca ttatcagctc actaataata ccagtgttgt taagatgctc
     2941 aaactagagc agaattgtat gctggatgtg acgctaggac ctcagatcct ttgatagtgc
     3001 agttatgacc aggatctctt tattctgtgc ttcacgtcaa catcattaac ccgatgaagc
     3061 gaagcacaag tcataaaggc acatcagaga agccgagaaa gcggggccgt acagagagca
     3121 tcaaaatcag gtcagaaaaa tgctgctttc ctcttccacc aaaccttctc cctgttgttt
     3181 ttacatgccc cgtccctcca gattcagcct ccgttttgtt ctctctcctt ttccttttcc
     3241 tcctctcttc cttaccttcc cctgtgagat gcttttctgt ccttttactg cacctcttcc
     3301 agacctatgg catttgggga cgggtcaccc ttcctagagt gatcctgaat ccagctgcct
     3361 cttctttttt tgtttttgtt tttgtttttg agacagagtc tctttctgtc gtccaggctg
     3421 gagtgcagta gcgcaatctt ggctcactgc aacctctgcc tcctgggttc aagcgattct
     3481 tgtgcctcaa cctcacgagg agctgggatt gcaggcgccc gccaccacac ccggctaatt
     3541 tttgtatttt tagtagagac ggagtttcac catgttggcc acgctggtct tgaagcccag
     3601 acctcaagtg atccgcccgc cttggcctcc caaagtgctg ggattacagg catgagccac
     3661 cgcgcctggc ctagttccct cttcttagat ggagatttct gcacatgagc tgtgagatcc
     3721 acagacatgt cactgagctc ccccactctg tcagtggaag atgaatggaa taaagcctgc
     3781 ttgcattgtg gagtgcagct gtggggacag ttgtcatttt tgtgttttca gcttaactgt
     3841 ccagcatctc ccctcccttc ctacagcagg gacatcatgc cttagatata aacttagtgg
     3901 tgtgcagtac ccaccgtgga agctgaagaa gggaagtatt tcctgtctct caggcacacc
     3961 ccgcttccag ccccatacca gtcgggaagt ggtcattgac ctggggtgga ctacctggac
     4021 ccttgcttgg ggctatgagc ctggagaatg tgacacaaat gaagggatgc tgagactcat
     4081 ttcaaggaag ccaccgtggt ccggggttgg tagtcataca gcaaggcagg tgggtagggc
     4141 tggcaggctg cagggatggt gtgtccactg gtagcaatgt ccagggatgg cagcgtcctg
     4201 ggaatgtcat ttctgctcca ctccttggac tcgctgagct gtctccgcct ccacctatct
     4261 tcctacagac ctcccttcta gttttctgtc aattctttga gccagcaaac tccatccagt
     4321 acattctttc ttctttcatg aaagagcttg agttggatgt aaatatatat gacctaacaa
     4381 ttccacccct aggtgtatac cctacagaaa tgtgtacatg tgttcatcca gagacatgct
     4441 ctaaatcttc acaaaaacac tctccataat aaccccgaac aggaaagcac cccaatgccc
     4501 atgttggctg gataagcaca ttagggtata ttcacacgat ggaatcccag actgcaatgg
     4561 gaatgagctg caactccacc cccaacttgg agtgtattca ccaaccctag tgttgaacga
     4621 gataaggcaa aaatgcacca taggattcca tttatataaa gtttaaaacc cagcaaaatt
     4681 catccatgcg gttgcaagta gagatcagtc ctaagaagac agtaaccaga agcgggcatg
     4741 aggtggtgct tctggggtgt tctgtttctt gatctggttg ccggttacct gggtgctttc
     4801 cgtttgtgaa cattcttgga gctgtacact tttgatctgg gcacttttct gtgtgtatgt
     4861 tatacttcaa taaaaagttg ggctttgtga ctagcaa
//
