LOCUS       NM_012202                864 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens G protein subunit gamma 3 (GNG3), mRNA.
ACCESSION   NM_012202
VERSION     NM_012202.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 864)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 864)
  AUTHORS   Wagnon,J.L., Barker,B.S., Hounshell,J.A., Haaxma,C.A., Shealy,A.,
            Moss,T., Parikh,S., Messer,R.D., Patel,M.K. and Meisler,M.H.
  TITLE     Pathogenic mechanism of recurrent mutations of SCN8A in epileptic
            encephalopathy
  JOURNAL   Ann Clin Transl Neurol 3 (2), 114-123 (2015)
   PUBMED   26900580
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 864)
  AUTHORS   Bhatnagar,A., Unal,H., Jagannathan,R., Kaveti,S., Duan,Z.H.,
            Yong,S., Vasanji,A., Kinter,M., Desnoyer,R. and Karnik,S.S.
  TITLE     Interaction of G-protein betagamma complex with chromatin modulates
            GPCR-dependent gene regulation
  JOURNAL   PLoS One 8 (1), e52689 (2013)
   PUBMED   23326349
  REMARK    GeneRIF: Findings suggest a wide-ranging mechanism by which direct
            interaction of Gbetagamma with specific chromatin bound
            transcription factors regulates functional gene networks in
            response to GPCR activation in cells including the angiotensin II
            type 1 receptor.
            Erratum:[PLoS One. 2016 May 4;11(5):e0155198. doi:
            10.1371/journal.pone.0155198.. PMID: 27144543]
REFERENCE   4  (bases 1 to 864)
  AUTHORS   Saini,D.K., Karunarathne,W.K., Angaswamy,N., Saini,D., Cho,J.H.,
            Kalyanaraman,V. and Gautam,N.
  TITLE     Regulation of Golgi structure and secretion by receptor-induced G
            protein betagamma complex translocation
  JOURNAL   Proc Natl Acad Sci U S A 107 (25), 11417-11422 (2010)
   PUBMED   20534534
  REMARK    GeneRIF: Golgi structure and secretion is regulated by
            receptor-induced G protein betagamma complex translocation
REFERENCE   5  (bases 1 to 864)
  AUTHORS   Fowler,C.E., Aryal,P., Suen,K.F. and Slesinger,P.A.
  TITLE     Evidence for association of GABA(B) receptors with Kir3 channels
            and regulators of G protein signalling (RGS4) proteins
  JOURNAL   J Physiol 580 (Pt 1), 51-65 (2007)
   PUBMED   17185339
REFERENCE   6  (bases 1 to 864)
  AUTHORS   Bell,B., Xing,H., Yan,K., Gautam,N. and Muslin,A.J.
  TITLE     KSR-1 binds to G-protein betagamma subunits and inhibits beta
            gamma-induced mitogen-activated protein kinase activation
  JOURNAL   J Biol Chem 274 (12), 7982-7986 (1999)
   PUBMED   10075696
REFERENCE   7  (bases 1 to 864)
  AUTHORS   Morishita,R., Saga,S., Kawamura,N., Hashizume,Y., Inagaki,T.,
            Kato,K. and Asano,T.
  TITLE     Differential localization of the gamma 3 and gamma 12 subunits of G
            proteins in the mammalian brain
  JOURNAL   J Neurochem 68 (2), 820-827 (1997)
   PUBMED   9003074
REFERENCE   8  (bases 1 to 864)
  AUTHORS   Yan,K., Kalyanaraman,V. and Gautam,N.
  TITLE     Differential ability to form the G protein betagamma complex among
            members of the beta and gamma subunit families
  JOURNAL   J Biol Chem 271 (12), 7141-7146 (1996)
   PUBMED   8636150
REFERENCE   9  (bases 1 to 864)
  AUTHORS   Garcia-Higuera,I., Thomas,T.C., Yi,F. and Neer,E.J.
  TITLE     Intersubunit surfaces in G protein alpha beta gamma heterotrimers.
            Analysis by cross-linking and mutagenesis of beta gamma
  JOURNAL   J Biol Chem 271 (1), 528-535 (1996)
   PUBMED   8550614
REFERENCE   10 (bases 1 to 864)
  AUTHORS   Wedegaertner,P.B., Wilson,P.T. and Bourne,H.R.
  TITLE     Lipid modifications of trimeric G proteins
  JOURNAL   J Biol Chem 270 (2), 503-506 (1995)
   PUBMED   7822269
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA123305.1, AP001458.6,
            AF092129.1 and AF087900.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012202.4.
            
            Summary: Guanine nucleotide binding proteins are heterotrimeric
            signal-transducing molecules consisting of alpha, beta, and gamma
            subunits. The gamma subunit determines the specificity of which
            signaling pathways will be affected by this particular complex. The
            protein encoded by this gene represents the gamma subunit of both
            inhibitory and stimulatory complexes. [provided by RefSeq, Jan
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.192929.1,
                                           SRR5189652.193201.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294117.6/ ENSP00000294117.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               DA123305.1         83-187
            106-106             AP001458.6         115048-115048
            107-861             AF092129.1         126-880
            862-864             AF087900.1         882-884
FEATURES             Location/Qualifiers
     source          1..864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..864
                     /gene="GNG3"
                     /gene_synonym="HG3D"
                     /note="G protein subunit gamma 3"
                     /db_xref="GeneID:2785"
                     /db_xref="HGNC:HGNC:4405"
                     /db_xref="MIM:608941"
     exon            1..240
                     /gene="GNG3"
                     /gene_synonym="HG3D"
                     /inference="alignment:Splign:2.1.0"
     exon            241..340
                     /gene="GNG3"
                     /gene_synonym="HG3D"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..469
                     /gene="GNG3"
                     /gene_synonym="HG3D"
                     /note="guanine nucleotide-binding protein gamma-3 subunit;
                     NBP gamma-3; guanine nucleotide binding protein (G
                     protein), gamma 3; heterotrimeric guanine
                     nucleotide-binding protein 3D"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-3"
                     /protein_id="NP_036334.1"
                     /db_xref="CCDS:CCDS8032.1"
                     /db_xref="GeneID:2785"
                     /db_xref="HGNC:HGNC:4405"
                     /db_xref="MIM:608941"
                     /translation="MKGETPVNSTMSIGQARKMVEQLKIEASLCRIKVSKAAADLMTY
                     CDAHACEDPLITPVPTSENPFREKKFFCALL"
     exon            341..864
                     /gene="GNG3"
                     /gene_synonym="HG3D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      843..848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG3"
                     /gene_synonym="HG3D"
                     /note="hexamer: AATAAA"
     polyA_site      864
                     /gene="GNG3"
                     /gene_synonym="HG3D"
                     /note="major polyA site"
ORIGIN      
        1 cttctagcat ccttcatcct tcaggtacca gccatccaga cagtgcttga gctgcagaaa
       61 ctgagaccag acctctggcc tggccctccc caggggcctc ctttcgtata gtcactgctt
      121 ctgcatcaga tactttcagc tgcaactccc tactgggtgg ggcacccatt tcaggcagaa
      181 ggttttggta ccctccactg accctacacc cagggctgct actgccgctt gtggcttcag
      241 gatgaaaggt gagaccccgg tgaacagcac tatgagtatt gggcaagcac gcaagatggt
      301 ggaacagctt aagattgaag ccagcttgtg tcggataaag gtgtccaagg cagcagcaga
      361 cctgatgact tactgtgatg cccacgcctg tgaggatccc ctcatcaccc ctgtgcccac
      421 ttcggagaac cccttccggg agaagaagtt cttctgtgct ctcctctgag ctcccctgtc
      481 ccttctcaca actcctccct tttccctctc ctgggccctt ccttaggtca gtaattgttg
      541 tgagcccctt aggctccttg catcccatcc ctaacccttg cctgaccatg tgaggttatc
      601 tgaagcacaa ggcccaccct cacctatctg tcgaccccat ttcctaccac ctttgtggcc
      661 gaccccaagc accccagaga tatgaggcac cctttgctcc acccacagca gggccccgtc
      721 agactctgcc agcgcgtcct gcccgcttcc ctcggtgacc tgctcagaca atggagaggg
      781 atgggccagg ttcttgctct cagtctcacc tggagctact gggagggtaa agccatttga
      841 agaataaagt catccagagc ctca
//
