LOCUS       NM_053064               3573 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens G protein subunit gamma 2 (GNG2), transcript variant
            1, mRNA.
ACCESSION   NM_053064 XM_495987
VERSION     NM_053064.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3573)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3573)
  AUTHORS   Huang,S., Xu,P., Tan,Y., You,C., Zhang,Y., Jiang,Y. and Xu,H.E.
  TITLE     Structural basis for recognition of anti-migraine drug lasmiditan
            by the serotonin receptor 5-HT1F-G protein complex
  JOURNAL   Cell Res 31 (9), 1036-1038 (2021)
   PUBMED   34239069
REFERENCE   3  (bases 1 to 3573)
  AUTHORS   Chen,S., Huang,M. and Hu,X.
  TITLE     Interference with KCNJ2 inhibits proliferation, migration and EMT
            progression of apillary thyroid carcinoma cells by upregulating
            GNG2 expression
  JOURNAL   Mol Med Rep 24 (3) (2021)
   PUBMED   34212982
  REMARK    GeneRIF: Interference with KCNJ2 inhibits proliferation, migration
            and EMT progression of apillary thyroid carcinoma cells by
            upregulating GNG2 expression.
REFERENCE   4  (bases 1 to 3573)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3573)
  AUTHORS   Xu,P., Huang,S., Zhang,H., Mao,C., Zhou,X.E., Cheng,X., Simon,I.A.,
            Shen,D.D., Yen,H.Y., Robinson,C.V., Harpsoe,K., Svensson,B.,
            Guo,J., Jiang,H., Gloriam,D.E., Melcher,K., Jiang,Y., Zhang,Y. and
            Xu,H.E.
  TITLE     Structural insights into the lipid and ligand regulation of
            serotonin receptors
  JOURNAL   Nature 592 (7854), 469-473 (2021)
   PUBMED   33762731
REFERENCE   6  (bases 1 to 3573)
  AUTHORS   Stoyanov,B., Volinia,S., Hanck,T., Rubio,I., Loubtchenkov,M.,
            Malek,D., Stoyanova,S., Vanhaesebroeck,B., Dhand,R., Nurnberg,B. et
            al.
  TITLE     Cloning and characterization of a G protein-activated human
            phosphoinositide-3 kinase
  JOURNAL   Science 269 (5224), 690-693 (1995)
   PUBMED   7624799
REFERENCE   7  (bases 1 to 3573)
  AUTHORS   Pumiglia,K.M., LeVine,H., Haske,T., Habib,T., Jove,R. and
            Decker,S.J.
  TITLE     A direct interaction between G-protein beta gamma subunits and the
            Raf-1 protein kinase
  JOURNAL   J Biol Chem 270 (24), 14251-14254 (1995)
   PUBMED   7782277
REFERENCE   8  (bases 1 to 3573)
  AUTHORS   Tsukada,S., Simon,M.I., Witte,O.N. and Katz,A.
  TITLE     Binding of beta gamma subunits of heterotrimeric G proteins to the
            PH domain of Bruton tyrosine kinase
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 11256-11260 (1994)
   PUBMED   7972043
REFERENCE   9  (bases 1 to 3573)
  AUTHORS   Lambright,D.G., Noel,J.P., Hamm,H.E. and Sigler,P.B.
  TITLE     Structural determinants for activation of the alpha-subunit of a
            heterotrimeric G protein
  JOURNAL   Nature 369 (6482), 621-628 (1994)
   PUBMED   8208289
REFERENCE   10 (bases 1 to 3573)
  AUTHORS   Offermanns,S., Laugwitz,K.L., Spicher,K. and Schultz,G.
  TITLE     G proteins of the G12 family are activated via thromboxane A2 and
            thrombin receptors in human platelets
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 504-508 (1994)
   PUBMED   8290554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC318652.1, DA785895.1,
            AL358333.4 and BQ025819.1.
            
            On Jun 2, 2019 this sequence version replaced NM_053064.4.
            
            Summary: This gene encodes one of the gamma subunits of a guanine
            nucleotide-binding protein. Such proteins are involved in signaling
            mechanisms across membranes. Various subunits forms heterodimers
            which then interact with the different signal molecules. [provided
            by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.223454.1,
                                           SRR1803611.165638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000556766.6/ ENSP00000451231.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               DC318652.1         309-573
            266-708             DA785895.1         139-581
            709-3148            AL358333.4         51116-53555         c
            3149-3573           BQ025819.1         23-447              c
FEATURES             Location/Qualifiers
     source          1..3573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..3573
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /note="G protein subunit gamma 2"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
     exon            1..179
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /inference="alignment:Splign:2.1.0"
     exon            180..220
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..336
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..465
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /EC_number="3.1.26.4"
                     /note="guanine nucleotide-binding protein G(I)/G(O)
                     gamma-2 subunit; guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2; heterotrimeric guanine
                     nucleotide-binding protein 3F1; guanine nucleotide binding
                     protein gamma 2; g gamma-I; guanine nucleotide binding
                     protein (G protein), gamma 2"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2 precursor"
                     /protein_id="NP_444292.1"
                     /db_xref="CCDS:CCDS32082.1"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
                     /translation="MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAH
                     AKEDPLLTPVPASENPFREKKFFCAIL"
     exon            337..3573
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3551..3556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /note="hexamer: AATAAA"
     polyA_site      3573
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /note="major polyA site"
ORIGIN      
        1 agtccctggg ctgcagccgc tgctacacat actcacaacg ctgccgccgc gctccgtggg
       61 caactcctac tactgctggg ctgggctggg ctgggctggg ctgcgccgga gctcgcctgc
      121 acagatcagc tccggagagg ggaaaaccac gctcctcgga ccaagcctcg ggagctaagc
      181 cagatctgcc agtgagcctc aggctttagg aactgaagag tgtttctgaa agatctatcc
      241 agcactccga tggccagcaa caacaccgcc agcatagcac aagccaggaa gctggtagag
      301 cagcttaaga tggaagccaa tatcgacagg ataaaggtgt ccaaggcagc tgcagatttg
      361 atggcctact gtgaagcaca tgccaaggaa gaccccctcc tgacccctgt tccggcttca
      421 gaaaacccgt ttagggagaa gaagtttttc tgtgccatcc tttaagtctt tgagaggggc
      481 ctgaagagcc tccgggctcc tgggacattg atgtagagtt tttagtgaag tgggcacctt
      541 tctagtccac ggcatttgaa gagagcgagg agaaccattc tggaaactct aggctatgca
      601 tgtttaaaga tctggtcccc tttatgagaa tgcaagccga tccacatcct gacttaagag
      661 atctgattct gacgaactgc ctggaggagg ggaatatata aaaataaaat tggtgtcact
      721 tcttttctgc tatcccccag cccccccccc aaaatcctca tgtttctgct tcatattttg
      781 aaaaataaca attaaaacag acagctgtac tgaggtaaga tatgtgtgac cttcttggaa
      841 tgaatattgt ctttagaata ccctttgata agctgagctg tcccgtgtag atgcaattcg
      901 gtttaatggc attgatgtat agtcactgtg cctttctttt tctttcttcc ttctcctcta
      961 cccctccttc cacccctccc cattagagta gtgtggagat aaggctggac tggtctatca
     1021 gattgaactc caagaatgat cacacaaaat gtttagggag atgttccccg tggtgtatcc
     1081 tcatggtaac aacgacaaaa aatgccggtt gtctgtgttc tcttttcact attcctaaca
     1141 tgtgtacatg atagctttga ttctgcaagt aaaagtaaat cctgtgttgt gactggtgct
     1201 ttcatatatt tgtgacaatt tttgagtaat attgcatgaa aatgtcccta tgttacatcc
     1261 attcagaagt tttgttgttt tactctaaag ctgggaaagg aaatgagagg gaaaagaccc
     1321 cggagaggga agaaaatctc agtattttga aaattgagat tacttcagag ccttagccac
     1381 acctaaaata cctcctagtt aatagtggta taaatgcctc ttcaatacgt tttccagaat
     1441 ccaaagcatt ttggtttatc caggacccag ggcagcacag ctgtcaccaa gcaggagagt
     1501 taaggattca ccatgagctg ggaaatgctt ttgccatgag tatgagcaaa ttccctcttt
     1561 ccctgaatca tggacattct agattaaaag aacatttttt tgtgctctta acaagaaaac
     1621 catggccctc ctttgttcaa gtatcagaag aaataaaccc acagctccag agaaggtgac
     1681 cattctcaga actccagcta ttcactctcc agggagaagg acctcaaatc gccactcttt
     1741 gggcggcagg tgcggtcccc acggccggct ctacgaggaa gagttctggc tcttttgtcc
     1801 actgagatgg tcttggtttt tcacttaaca aattttttaa tggaatcttt gtttttgttc
     1861 tccatcttgt ttgttagagt ctctcggcct ttatttacaa attccttgca actagagcgc
     1921 tccttcccca agatatggta gtgagagtaa tttttcattg tagctgtagt ctccatcagt
     1981 aacagcaggc cctggaagac ttgatcacct ttttctgtgt cattttcagt caaagagggc
     2041 ctctcttaca tcttgtttgc tttcaaatcc ccaaatatca tctccatctc ccaattaatt
     2101 ttattgtctc tttcctctct attcgctttc tcctgttttt tttttaaaaa aaaagcatga
     2161 aaaaggaaga gaaaaagttt gatatgccaa ggacagattt tgaaacagac ttggtaaatg
     2221 ttttccttag ctccttcatg ggcatgctgg tgaaagaata aatacatcca attaaagctc
     2281 atgctggggt cggggagaag aggatactga aacatttgtg aaatgtatga atgcacttct
     2341 gtaaccagat acttctgttc ttctgttcaa attgtggggt ttttgttaca gttaggacgc
     2401 ccatgaagat ttaggggtga aaaaaacagc agagtattta ttaaactaca gcattgtaca
     2461 attagcttag taacactatg gaataagcta aaacatatca cagtttttac atgggccaaa
     2521 acatgaattg agtatgtggt cacatgaaaa cacggatgaa tgaataaaac actctttggt
     2581 ggtgactgag gcatcattag aaggcccaga cgatttccac tattcacagc atttcctttt
     2641 ctcagaagga ctctttatat ttccatgtaa atctagatct ttggagcaat taagatggaa
     2701 ttacaatttc tagggagcat tttaaggaaa atgttttggc tttttcataa ttttatgtct
     2761 tacagtatgg aattataata cgaaaatctt tatatgagtt ttggcttctt ggtatttgta
     2821 cttattcagg ggaaaaagtc tttcgattac ttatgcctct atagagctta atttcttgag
     2881 aaattcaaca gtcattttca ccagcataat tttatcttaa ggaataacta ataggaaaag
     2941 tcagcttaat tatttaaggc cctagtttct acatataata tattcgatag aaatgaaaat
     3001 ctgccgtgga attaactaat aagtagtaac aataaacttc atatttagaa tgcaaagtct
     3061 ataaagaata attttacatg atcctcaata tcaactccag tttaaaaagt gttattttta
     3121 aaacatttga aaccaagtac tgtttaattt caatcagaag atgcaaatac atactttgat
     3181 ctatgtttga ttttgctaat aatatttgaa ggagattgcc taccaaggac aaaacaataa
     3241 atttaaaaat caaacgattt ctccatacgc tcatagtcac atatggaatt ttgagaaaat
     3301 aaagcatgct gtctttagga atttttatac ttctttgtct ttcttcctta atatttgctt
     3361 ctagctgctc ttggcaatga tgaattgtta tgtatgcatt aatgttttgc agcccaaaag
     3421 ttgttcacat ttttcctata taagatctgt ggagtgtgtg tttcaaagag agaactacag
     3481 aaatgttaaa gcaggaaaac ctgaatgtga tgtgcacatt ttcatcccac atggacaatg
     3541 tatgtgtttt aataaatgga attttcagat tca
//
