LOCUS       NM_001243774            3532 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens G protein subunit gamma 2 (GNG2), transcript variant
            3, mRNA.
ACCESSION   NM_001243774
VERSION     NM_001243774.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3532)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3532)
  AUTHORS   Huang,S., Xu,P., Tan,Y., You,C., Zhang,Y., Jiang,Y. and Xu,H.E.
  TITLE     Structural basis for recognition of anti-migraine drug lasmiditan
            by the serotonin receptor 5-HT1F-G protein complex
  JOURNAL   Cell Res 31 (9), 1036-1038 (2021)
   PUBMED   34239069
REFERENCE   3  (bases 1 to 3532)
  AUTHORS   Chen,S., Huang,M. and Hu,X.
  TITLE     Interference with KCNJ2 inhibits proliferation, migration and EMT
            progression of apillary thyroid carcinoma cells by upregulating
            GNG2 expression
  JOURNAL   Mol Med Rep 24 (3) (2021)
   PUBMED   34212982
  REMARK    GeneRIF: Interference with KCNJ2 inhibits proliferation, migration
            and EMT progression of apillary thyroid carcinoma cells by
            upregulating GNG2 expression.
REFERENCE   4  (bases 1 to 3532)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3532)
  AUTHORS   Xu,P., Huang,S., Zhang,H., Mao,C., Zhou,X.E., Cheng,X., Simon,I.A.,
            Shen,D.D., Yen,H.Y., Robinson,C.V., Harpsoe,K., Svensson,B.,
            Guo,J., Jiang,H., Gloriam,D.E., Melcher,K., Jiang,Y., Zhang,Y. and
            Xu,H.E.
  TITLE     Structural insights into the lipid and ligand regulation of
            serotonin receptors
  JOURNAL   Nature 592 (7854), 469-473 (2021)
   PUBMED   33762731
REFERENCE   6  (bases 1 to 3532)
  AUTHORS   Stoyanov,B., Volinia,S., Hanck,T., Rubio,I., Loubtchenkov,M.,
            Malek,D., Stoyanova,S., Vanhaesebroeck,B., Dhand,R., Nurnberg,B. et
            al.
  TITLE     Cloning and characterization of a G protein-activated human
            phosphoinositide-3 kinase
  JOURNAL   Science 269 (5224), 690-693 (1995)
   PUBMED   7624799
REFERENCE   7  (bases 1 to 3532)
  AUTHORS   Pumiglia,K.M., LeVine,H., Haske,T., Habib,T., Jove,R. and
            Decker,S.J.
  TITLE     A direct interaction between G-protein beta gamma subunits and the
            Raf-1 protein kinase
  JOURNAL   J Biol Chem 270 (24), 14251-14254 (1995)
   PUBMED   7782277
REFERENCE   8  (bases 1 to 3532)
  AUTHORS   Tsukada,S., Simon,M.I., Witte,O.N. and Katz,A.
  TITLE     Binding of beta gamma subunits of heterotrimeric G proteins to the
            PH domain of Bruton tyrosine kinase
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 11256-11260 (1994)
   PUBMED   7972043
REFERENCE   9  (bases 1 to 3532)
  AUTHORS   Lambright,D.G., Noel,J.P., Hamm,H.E. and Sigler,P.B.
  TITLE     Structural determinants for activation of the alpha-subunit of a
            heterotrimeric G protein
  JOURNAL   Nature 369 (6482), 621-628 (1994)
   PUBMED   8208289
REFERENCE   10 (bases 1 to 3532)
  AUTHORS   Offermanns,S., Laugwitz,K.L., Spicher,K. and Schultz,G.
  TITLE     G proteins of the G12 family are activated via thromboxane A2 and
            thrombin receptors in human platelets
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 504-508 (1994)
   PUBMED   8290554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC318652.1, BE245271.1,
            AL358333.4 and BQ025819.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001243774.1.
            
            Summary: This gene encodes one of the gamma subunits of a guanine
            nucleotide-binding protein. Such proteins are involved in signaling
            mechanisms across membranes. Various subunits forms heterodimers
            which then interact with the different signal molecules. [provided
            by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (3) lacks an alternate exon in the
            5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.10530.1,
                                           SRR1660809.5635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               DC318652.1         309-416
            109-491             BE245271.1         110-492
            492-3107            AL358333.4         51116-53731         c
            3108-3532           BQ025819.1         23-447              c
FEATURES             Location/Qualifiers
     source          1..3532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..3532
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /note="G protein subunit gamma 2"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
     exon            1..179
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /inference="alignment:Splign:2.1.0"
     exon            180..295
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..424
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /EC_number="3.1.26.4"
                     /note="guanine nucleotide-binding protein G(I)/G(O)
                     gamma-2 subunit; guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2; heterotrimeric guanine
                     nucleotide-binding protein 3F1; guanine nucleotide binding
                     protein gamma 2; g gamma-I; guanine nucleotide binding
                     protein (G protein), gamma 2"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2 precursor"
                     /protein_id="NP_001230703.1"
                     /db_xref="CCDS:CCDS32082.1"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
                     /translation="MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAH
                     AKEDPLLTPVPASENPFREKKFFCAIL"
     exon            296..3532
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3510..3515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /note="hexamer: AATAAA"
     polyA_site      3532
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /note="major polyA site"
ORIGIN      
        1 agtccctggg ctgcagccgc tgctacacat actcacaacg ctgccgccgc gctccgtggg
       61 caactcctac tactgctggg ctgggctggg ctgggctggg ctgcgccgga gctcgcctgc
      121 acagatcagc tccggagagg ggaaaaccac gctcctcgga ccaagcctcg ggagctaagt
      181 gtttctgaaa gatctatcca gcactccgat ggccagcaac aacaccgcca gcatagcaca
      241 agccaggaag ctggtagagc agcttaagat ggaagccaat atcgacagga taaaggtgtc
      301 caaggcagct gcagatttga tggcctactg tgaagcacat gccaaggaag accccctcct
      361 gacccctgtt ccggcttcag aaaacccgtt tagggagaag aagtttttct gtgccatcct
      421 ttaagtcttt gagaggggcc tgaagagcct ccgggctcct gggacattga tgtagagttt
      481 ttagtgaagt gggcaccttt ctagtccacg gcatttgaag agagcgagga gaaccattct
      541 ggaaactcta ggctatgcat gtttaaagat ctggtcccct ttatgagaat gcaagccgat
      601 ccacatcctg acttaagaga tctgattctg acgaactgcc tggaggaggg gaatatataa
      661 aaataaaatt ggtgtcactt cttttctgct atcccccagc ccccccccca aaatcctcat
      721 gtttctgctt catattttga aaaataacaa ttaaaacaga cagctgtact gaggtaagat
      781 atgtgtgacc ttcttggaat gaatattgtc tttagaatac cctttgataa gctgagctgt
      841 cccgtgtaga tgcaattcgg tttaatggca ttgatgtata gtcactgtgc ctttcttttt
      901 ctttcttcct tctcctctac ccctccttcc acccctcccc attagagtag tgtggagata
      961 aggctggact ggtctatcag attgaactcc aagaatgatc acacaaaatg tttagggaga
     1021 tgttccccgt ggtgtatcct catggtaaca acgacaaaaa atgccggttg tctgtgttct
     1081 cttttcacta ttcctaacat gtgtacatga tagctttgat tctgcaagta aaagtaaatc
     1141 ctgtgttgtg actggtgctt tcatatattt gtgacaattt ttgagtaata ttgcatgaaa
     1201 atgtccctat gttacatcca ttcagaagtt ttgttgtttt actctaaagc tgggaaagga
     1261 aatgagaggg aaaagacccc ggagagggaa gaaaatctca gtattttgaa aattgagatt
     1321 acttcagagc cttagccaca cctaaaatac ctcctagtta atagtggtat aaatgcctct
     1381 tcaatacgtt ttccagaatc caaagcattt tggtttatcc aggacccagg gcagcacagc
     1441 tgtcaccaag caggagagtt aaggattcac catgagctgg gaaatgcttt tgccatgagt
     1501 atgagcaaat tccctctttc cctgaatcat ggacattcta gattaaaaga acattttttt
     1561 gtgctcttaa caagaaaacc atggccctcc tttgttcaag tatcagaaga aataaaccca
     1621 cagctccaga gaaggtgacc attctcagaa ctccagctat tcactctcca gggagaagga
     1681 cctcaaatcg ccactctttg ggcggcaggt gcggtcccca cggccggctc tacgaggaag
     1741 agttctggct cttttgtcca ctgagatggt cttggttttt cacttaacaa attttttaat
     1801 ggaatctttg tttttgttct ccatcttgtt tgttagagtc tctcggcctt tatttacaaa
     1861 ttccttgcaa ctagagcgct ccttccccaa gatatggtag tgagagtaat ttttcattgt
     1921 agctgtagtc tccatcagta acagcaggcc ctggaagact tgatcacctt tttctgtgtc
     1981 attttcagtc aaagagggcc tctcttacat cttgtttgct ttcaaatccc caaatatcat
     2041 ctccatctcc caattaattt tattgtctct ttcctctcta ttcgctttct cctgtttttt
     2101 ttttaaaaaa aaagcatgaa aaaggaagag aaaaagtttg atatgccaag gacagatttt
     2161 gaaacagact tggtaaatgt tttccttagc tccttcatgg gcatgctggt gaaagaataa
     2221 atacatccaa ttaaagctca tgctggggtc ggggagaaga ggatactgaa acatttgtga
     2281 aatgtatgaa tgcacttctg taaccagata cttctgttct tctgttcaaa ttgtggggtt
     2341 tttgttacag ttaggacgcc catgaagatt taggggtgaa aaaaacagca gagtatttat
     2401 taaactacag cattgtacaa ttagcttagt aacactatgg aataagctaa aacatatcac
     2461 agtttttaca tgggccaaaa catgaattga gtatgtggtc acatgaaaac acggatgaat
     2521 gaataaaaca ctctttggtg gtgactgagg catcattaga aggcccagac gatttccact
     2581 attcacagca tttccttttc tcagaaggac tctttatatt tccatgtaaa tctagatctt
     2641 tggagcaatt aagatggaat tacaatttct agggagcatt ttaaggaaaa tgttttggct
     2701 ttttcataat tttatgtctt acagtatgga attataatac gaaaatcttt atatgagttt
     2761 tggcttcttg gtatttgtac ttattcaggg gaaaaagtct ttcgattact tatgcctcta
     2821 tagagcttaa tttcttgaga aattcaacag tcattttcac cagcataatt ttatcttaag
     2881 gaataactaa taggaaaagt cagcttaatt atttaaggcc ctagtttcta catataatat
     2941 attcgataga aatgaaaatc tgccgtggaa ttaactaata agtagtaaca ataaacttca
     3001 tatttagaat gcaaagtcta taaagaataa ttttacatga tcctcaatat caactccagt
     3061 ttaaaaagtg ttatttttaa aacatttgaa accaagtact gtttaatttc aatcagaaga
     3121 tgcaaataca tactttgatc tatgtttgat tttgctaata atatttgaag gagattgcct
     3181 accaaggaca aaacaataaa tttaaaaatc aaacgatttc tccatacgct catagtcaca
     3241 tatggaattt tgagaaaata aagcatgctg tctttaggaa tttttatact tctttgtctt
     3301 tcttccttaa tatttgcttc tagctgctct tggcaatgat gaattgttat gtatgcatta
     3361 atgttttgca gcccaaaagt tgttcacatt tttcctatat aagatctgtg gagtgtgtgt
     3421 ttcaaagaga gaactacaga aatgttaaag caggaaaacc tgaatgtgat gtgcacattt
     3481 tcatcccaca tggacaatgt atgtgtttta ataaatggaa ttttcagatt ca
//
