LOCUS       NM_016541                985 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein subunit gamma 13 (GNG13), mRNA.
ACCESSION   NM_016541
VERSION     NM_016541.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 985)
  AUTHORS   Liu,Y., Gu,S., Wu,T., Xu,Y., Meng,Q., Guan,Z., Zhang,X., Sun,X.,
            Shen,Y., Fan,H., Gu,C. and Feng,J.
  TITLE     High GNG13 expression is associated with poor survival in
            epithelial ovarian cancer and breast cancer
  JOURNAL   Neoplasma 69 (1), 183-192 (2022)
   PUBMED   34734529
  REMARK    GeneRIF: High GNG13 expression is associated with poor survival in
            epithelial ovarian cancer and breast cancer.
REFERENCE   2  (bases 1 to 985)
  AUTHORS   Sanfilippo,C., Musumeci,G., Kazakova,M., Mazzone,V.,
            Castrogiovanni,P., Imbesi,R. and Di Rosa,M.
  TITLE     GNG13 Is a Potential Marker of the State of Health of Alzheimer's
            Disease Patients' Cerebellum
  JOURNAL   J Mol Neurosci 71 (5), 1046-1060 (2021)
   PUBMED   33057964
  REMARK    GeneRIF: GNG13 Is a Potential Marker of the State of Health of
            Alzheimer's Disease Patients' Cerebellum.
REFERENCE   3  (bases 1 to 985)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 985)
  AUTHORS   Fushan,A.A., Simons,C.T., Slack,J.P. and Drayna,D.
  TITLE     Association between common variation in genes encoding sweet taste
            signaling components and human sucrose perception
  JOURNAL   Chem Senses 35 (7), 579-592 (2010)
   PUBMED   20660057
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 985)
  AUTHORS   Li,Z., Benard,O. and Margolskee,R.F.
  TITLE     Ggamma13 interacts with PDZ domain-containing proteins
  JOURNAL   J Biol Chem 281 (16), 11066-11073 (2006)
   PUBMED   16473877
  REMARK    GeneRIF: Ggamma13 interacts with PDZ domain-containing proteins
REFERENCE   6  (bases 1 to 985)
  AUTHORS   Cuello,F., Schulze,R.A., Heemeyer,F., Meyer,H.E., Lutz,S.,
            Jakobs,K.H., Niroomand,F. and Wieland,T.
  TITLE     Activation of heterotrimeric G proteins by a high energy phosphate
            transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta
            subunits. Complex formation of NDPK B with Gbeta gamma dimers and
            phosphorylation of His-266 IN Gbeta
  JOURNAL   J Biol Chem 278 (9), 7220-7226 (2003)
   PUBMED   12486123
REFERENCE   7  (bases 1 to 985)
  AUTHORS   Huang,L., Max,M., Margolskee,R.F., Su,H., Masland,R.H. and Euler,T.
  TITLE     G protein subunit G gamma 13 is coexpressed with G alpha o, G beta
            3, and G beta 4 in retinal ON bipolar cells
  JOURNAL   J Comp Neurol 455 (1), 1-10 (2003)
   PUBMED   12454992
REFERENCE   8  (bases 1 to 985)
  AUTHORS   Blake,B.L., Wing,M.R., Zhou,J.Y., Lei,Q., Hillmann,J.R., Behe,C.I.,
            Morris,R.A., Harden,T.K., Bayliss,D.A., Miller,R.J. and
            Siderovski,D.P.
  TITLE     G beta association and effector interaction selectivities of the
            divergent G gamma subunit G gamma(13)
  JOURNAL   J Biol Chem 276 (52), 49267-49274 (2001)
   PUBMED   11675383
REFERENCE   9  (bases 1 to 985)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   10 (bases 1 to 985)
  AUTHORS   Huang,L., Shanker,Y.G., Dubauskaite,J., Zheng,J.Z., Yan,W.,
            Rosenzweig,S., Spielman,A.I., Max,M. and Margolskee,R.F.
  TITLE     Ggamma13 colocalizes with gustducin in taste receptor cells and
            mediates IP3 responses to bitter denatonium
  JOURNAL   Nat Neurosci 2 (12), 1055-1062 (1999)
   PUBMED   10570481
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031033.5, DA111448.1 and BM931126.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016541.2.
            
            Summary: Heterotrimeric G proteins, which consist of alpha (see MIM
            139320), beta (see MIM 139380), and gamma subunits, function as
            signal transducers for the 7-transmembrane-helix G protein-coupled
            receptors. GNG13 is a gamma subunit that is expressed in taste,
            retinal, and neuronal tissues and plays a key role in taste
            transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM,
            Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB030207.1, SRR3476690.1027708.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248150.5/ ENSP00000248150.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL031033.5         16462-16462         c
            2-563               DA111448.1         2-563
            564-985             BM931126.1         112-533
FEATURES             Location/Qualifiers
     source          1..985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..985
                     /gene="GNG13"
                     /gene_synonym="G(gamma)13; h2-35; HG3J"
                     /note="G protein subunit gamma 13"
                     /db_xref="GeneID:51764"
                     /db_xref="HGNC:HGNC:14131"
                     /db_xref="MIM:607298"
     exon            1..69
                     /gene="GNG13"
                     /gene_synonym="G(gamma)13; h2-35; HG3J"
                     /inference="alignment:Splign:2.1.0"
     exon            70..201
                     /gene="GNG13"
                     /gene_synonym="G(gamma)13; h2-35; HG3J"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..307
                     /gene="GNG13"
                     /gene_synonym="G(gamma)13; h2-35; HG3J"
                     /note="guanine nucleotide binding protein 13, gamma; G
                     gamma subunit, clone:h2-35; guanine nucleotide binding
                     protein (G protein), gamma 13; heterotrimeric guanine
                     nucleotide-binding protein 3J"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-13"
                     /protein_id="NP_057625.1"
                     /db_xref="CCDS:CCDS10427.1"
                     /db_xref="GeneID:51764"
                     /db_xref="HGNC:HGNC:14131"
                     /db_xref="MIM:607298"
                     /translation="MEEWDVPQMKKEVESLKYQLAFQREMASKTIPELLKWIEDGIPK
                     DPFLNPDLMKNNPWVEKGKCTIL"
     exon            202..985
                     /gene="GNG13"
                     /gene_synonym="G(gamma)13; h2-35; HG3J"
                     /inference="alignment:Splign:2.1.0"
     regulatory      976..981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG13"
                     /gene_synonym="G(gamma)13; h2-35; HG3J"
                     /note="hexamer: TATAAA"
     polyA_site      985
                     /gene="GNG13"
                     /gene_synonym="G(gamma)13; h2-35; HG3J"
                     /note="major polyA site"
ORIGIN      
        1 acttggccct cgctctcact cgcggtcgcc tggccgttgt cattgtccct ccgctgtcac
       61 cttttcaagc cccaggctgg ctgcttcaga agcccctgac cccatggagg agtgggacgt
      121 gccacagatg aagaaagagg tggagagcct caagtaccag ctggccttcc agcgggagat
      181 ggcgtccaag accatccccg agctgctgaa gtggatcgag gacgggatcc ccaaggaccc
      241 cttcctgaac cccgacctga tgaagaacaa cccatgggtg gaaaagggca aatgcaccat
      301 cctgtgagcc ccgcacccgg cccctctcac accatcctgt gagaccacgc ccggccccac
      361 tcccaccatc ttgtaagact gtgcccagcc ccactcactc catcctgtga gtcccactcc
      421 cagccccact cccaccatcc tgtgagccca tgcccggccc cactcacacc aacctgtgag
      481 ccccactccc ggccccactc actccatctt gtaagactat gcccagcccc attcactcca
      541 tcctgtgagt cccactccca gccccactcc caccatcctg tgagccccac ttccagcccc
      601 actcccacca tcctgtgagc cccactccca gccccactcc caccatcctg tgagccccac
      661 tcccggcccc actcactcca tcctgtgagc cccactccca gccccactca caccaacctg
      721 tgagccccac tcccggcccc actcacaaca tcttgtaaga ctgtgcccgg ccccattcac
      781 tccatcctgt gagaccacgc ccggccccac tcactctatc ctgtgagacc acgcctggcc
      841 ccactcccac catcctgtga gccccactcc tggccccact cacaccatcc tatgagccca
      901 cgcccggccc cactcccacc atcctgtgaa ccccactcca ctcgcacgtg attacagtct
      961 gtaaaggtgt gactttataa agaca
//
