LOCUS       NM_004126               3019 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein subunit gamma 11 (GNG11), mRNA.
ACCESSION   NM_004126
VERSION     NM_004126.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3019)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3019)
  AUTHORS   Takauji,Y., Kudo,I., En,A., Matsuo,R., Hossain,M.N.,
            Nakabayashi,K., Miki,K., Fujii,M. and Ayusawa,D.
  TITLE     GNG11 (G-protein subunit gamma 11) suppresses cell growth with
            induction of reactive oxygen species and abnormal nuclear
            morphology in human SUSM-1 cells
  JOURNAL   Biochem Cell Biol 95 (4), 517-523 (2017)
   PUBMED   28380310
  REMARK    GeneRIF: expression of GNG11 induced the generation of reactive
            oxygen species (ROS) and abnormal nuclear morphology in SUSM-1
            cells but not in HeLa cells
REFERENCE   3  (bases 1 to 3019)
  AUTHORS   den Hoed,M., Eijgelsheim,M., Esko,T., Brundel,B.J., Peal,D.S.,
            Evans,D.M., Nolte,I.M., Segre,A.V., Holm,H., Handsaker,R.E.,
            Westra,H.J., Johnson,T., Isaacs,A., Yang,J., Lundby,A., Zhao,J.H.,
            Kim,Y.J., Go,M.J., Almgren,P., Bochud,M., Boucher,G.,
            Cornelis,M.C., Gudbjartsson,D., Hadley,D., van der Harst,P.,
            Hayward,C., den Heijer,M., Igl,W., Jackson,A.U., Kutalik,Z.,
            Luan,J., Kemp,J.P., Kristiansson,K., Ladenvall,C., Lorentzon,M.,
            Montasser,M.E., Njajou,O.T., O'Reilly,P.F., Padmanabhan,S., St
            Pourcain,B., Rankinen,T., Salo,P., Tanaka,T., Timpson,N.J.,
            Vitart,V., Waite,L., Wheeler,W., Zhang,W., Draisma,H.H.,
            Feitosa,M.F., Kerr,K.F., Lind,P.A., Mihailov,E., Onland-Moret,N.C.,
            Song,C., Weedon,M.N., Xie,W., Yengo,L., Absher,D., Albert,C.M.,
            Alonso,A., Arking,D.E., de Bakker,P.I., Balkau,B., Barlassina,C.,
            Benaglio,P., Bis,J.C., Bouatia-Naji,N., Brage,S., Chanock,S.J.,
            Chines,P.S., Chung,M., Darbar,D., Dina,C., Dorr,M., Elliott,P.,
            Felix,S.B., Fischer,K., Fuchsberger,C., de Geus,E.J., Goyette,P.,
            Gudnason,V., Harris,T.B., Hartikainen,A.L., Havulinna,A.S.,
            Heckbert,S.R., Hicks,A.A., Hofman,A., Holewijn,S.,
            Hoogstra-Berends,F., Hottenga,J.J., Jensen,M.K., Johansson,A.,
            Junttila,J., Kaab,S., Kanon,B., Ketkar,S., Khaw,K.T., Knowles,J.W.,
            Kooner,A.S., Kors,J.A., Kumari,M., Milani,L., Laiho,P.,
            Lakatta,E.G., Langenberg,C., Leusink,M., Liu,Y., Luben,R.N.,
            Lunetta,K.L., Lynch,S.N., Markus,M.R., Marques-Vidal,P., Mateo
            Leach,I., McArdle,W.L., McCarroll,S.A., Medland,S.E., Miller,K.A.,
            Montgomery,G.W., Morrison,A.C., Muller-Nurasyid,M., Navarro,P.,
            Nelis,M., O'Connell,J.R., O'Donnell,C.J., Ong,K.K., Newman,A.B.,
            Peters,A., Polasek,O., Pouta,A., Pramstaller,P.P., Psaty,B.M.,
            Rao,D.C., Ring,S.M., Rossin,E.J., Rudan,D., Sanna,S., Scott,R.A.,
            Sehmi,J.S., Sharp,S., Shin,J.T., Singleton,A.B., Smith,A.V.,
            Soranzo,N., Spector,T.D., Stewart,C., Stringham,H.M., Tarasov,K.V.,
            Uitterlinden,A.G., Vandenput,L., Hwang,S.J., Whitfield,J.B.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilson,J.F., Witteman,J.C.,
            Wong,A., Wong,Q., Jamshidi,Y., Zitting,P., Boer,J.M., Boomsma,D.I.,
            Borecki,I.B., van Duijn,C.M., Ekelund,U., Forouhi,N.G., Froguel,P.,
            Hingorani,A., Ingelsson,E., Kivimaki,M., Kronmal,R.A., Kuh,D.,
            Lind,L., Martin,N.G., Oostra,B.A., Pedersen,N.L., Quertermous,T.,
            Rotter,J.I., van der Schouw,Y.T., Verschuren,W.M., Walker,M.,
            Albanes,D., Arnar,D.O., Assimes,T.L., Bandinelli,S., Boehnke,M., de
            Boer,R.A., Bouchard,C., Caulfield,W.L., Chambers,J.C., Curhan,G.,
            Cusi,D., Eriksson,J., Ferrucci,L., van Gilst,W.H., Glorioso,N., de
            Graaf,J., Groop,L., Gyllensten,U., Hsueh,W.C., Hu,F.B.,
            Huikuri,H.V., Hunter,D.J., Iribarren,C., Isomaa,B., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kiemeney,L.A., van der Klauw,M.M.,
            Kooner,J.S., Kraft,P., Iacoviello,L., Lehtimaki,T., Lokki,M.L.,
            Mitchell,B.D., Navis,G., Nieminen,M.S., Ohlsson,C., Poulter,N.R.,
            Qi,L., Raitakari,O.T., Rimm,E.B., Rioux,J.D., Rizzi,F., Rudan,I.,
            Salomaa,V., Sever,P.S., Shields,D.C., Shuldiner,A.R., Sinisalo,J.,
            Stanton,A.V., Stolk,R.P., Strachan,D.P., Tardif,J.C.,
            Thorsteinsdottir,U., Tuomilehto,J., van Veldhuisen,D.J.,
            Virtamo,J., Viikari,J., Vollenweider,P., Waeber,G., Widen,E.,
            Cho,Y.S., Olsen,J.V., Visscher,P.M., Willer,C., Franke,L.,
            Erdmann,J., Thompson,J.R., Pfeufer,A., Sotoodehnia,N.,
            Newton-Cheh,C., Ellinor,P.T., Stricker,B.H., Metspalu,A.,
            Perola,M., Beckmann,J.S., Smith,G.D., Stefansson,K., Wareham,N.J.,
            Munroe,P.B., Sibon,O.C., Milan,D.J., Snieder,H., Samani,N.J. and
            Loos,R.J.
  CONSRTM   Global BPgen Consortium; CARDIoGRAM Consortium; PR GWAS Consortium;
            QRS GWAS Consortium; QT-IGC Consortium; CHARGE-AF Consortium
  TITLE     Identification of heart rate-associated loci and their effects on
            cardiac conduction and rhythm disorders
  JOURNAL   Nat Genet 45 (6), 621-631 (2013)
   PUBMED   23583979
REFERENCE   4  (bases 1 to 3019)
  AUTHORS   Hossain,M.N., Sakemura,R., Fujii,M. and Ayusawa,D.
  TITLE     G-protein gamma subunit GNG11 strongly regulates cellular
            senescence
  JOURNAL   Biochem Biophys Res Commun 351 (3), 645-650 (2006)
   PUBMED   17092487
  REMARK    GeneRIF: Collectively, these results suggest a novel senescence
            pathway mediated by GNG11 in response to environmental cues.
REFERENCE   5  (bases 1 to 3019)
  AUTHORS   Ruiz-Ballesteros,E., Mollejo,M., Rodriguez,A., Camacho,F.I.,
            Algara,P., Martinez,N., Pollan,M., Sanchez-Aguilera,A.,
            Menarguez,J., Campo,E., Martinez,P., Mateo,M. and Piris,M.A.
  TITLE     Splenic marginal zone lymphoma: proposal of new diagnostic and
            prognostic markers identified after tissue and cDNA microarray
            analysis
  JOURNAL   Blood 106 (5), 1831-1838 (2005)
   PUBMED   15914563
REFERENCE   6  (bases 1 to 3019)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   7  (bases 1 to 3019)
  AUTHORS   Jiang,G. and Zhang,B.B.
  TITLE     Glucagon and regulation of glucose metabolism
  JOURNAL   Am J Physiol Endocrinol Metab 284 (4), E671-E678 (2003)
   PUBMED   12626323
  REMARK    Review article
REFERENCE   8  (bases 1 to 3019)
  AUTHORS   Cuello,F., Schulze,R.A., Heemeyer,F., Meyer,H.E., Lutz,S.,
            Jakobs,K.H., Niroomand,F. and Wieland,T.
  TITLE     Activation of heterotrimeric G proteins by a high energy phosphate
            transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta
            subunits. Complex formation of NDPK B with Gbeta gamma dimers and
            phosphorylation of His-266 IN Gbeta
  JOURNAL   J Biol Chem 278 (9), 7220-7226 (2003)
   PUBMED   12486123
REFERENCE   9  (bases 1 to 3019)
  AUTHORS   Downes,G.B. and Gautam,N.
  TITLE     The G protein subunit gene families
  JOURNAL   Genomics 62 (3), 544-552 (1999)
   PUBMED   10644457
  REMARK    Review article
REFERENCE   10 (bases 1 to 3019)
  AUTHORS   Ray,K., Kunsch,C., Bonner,L.M. and Robishaw,J.D.
  TITLE     Isolation of cDNA clones encoding eight different human G protein
            gamma subunits, including three novel forms designated the gamma 4,
            gamma 10, and gamma 11 subunits
  JOURNAL   J Biol Chem 270 (37), 21765-21771 (1995)
   PUBMED   7665596
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002076.2 and BC009709.1.
            
            On May 17, 2019 this sequence version replaced NM_004126.3.
            
            Summary: This gene is a member of the guanine nucleotide-binding
            protein (G protein) gamma family and encodes a lipid-anchored, cell
            membrane protein. As a member of the heterotrimeric G protein
            complex, this protein plays a role in this transmembrane signaling
            system. This protein is also subject to carboxyl-terminal
            processing. Decreased expression of this gene is associated with
            splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.62543.1,
                                           SRR1660803.252836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248564.6/ ENSP00000248564.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               AC002076.2         138200-138698
            500-916             AC002076.2         142556-142972
            917-923             BC009709.1         864-870
            924-3019            AC002076.2         142980-145075
FEATURES             Location/Qualifiers
     source          1..3019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..3019
                     /gene="GNG11"
                     /gene_synonym="GNGT11; HG3H1"
                     /note="G protein subunit gamma 11"
                     /db_xref="GeneID:2791"
                     /db_xref="HGNC:HGNC:4403"
                     /db_xref="MIM:604390"
     exon            1..499
                     /gene="GNG11"
                     /gene_synonym="GNGT11; HG3H1"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..625
                     /gene="GNG11"
                     /gene_synonym="GNGT11; HG3H1"
                     /note="guanine nucleotide-binding protein G(I)/G(S)/G(O)
                     subunit gamma-11; guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) gamma-11 subunit; G protein gamma-11
                     subunit; guanine nucleotide binding protein (G protein),
                     gamma 11; heterotrimeric guanine nucleotide-binding
                     protein 3H1"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-11 precursor"
                     /protein_id="NP_004117.1"
                     /db_xref="CCDS:CCDS5634.1"
                     /db_xref="GeneID:2791"
                     /db_xref="HGNC:HGNC:4403"
                     /db_xref="MIM:604390"
                     /translation="MPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYI
                     EERSGEDPLVKGIPEDKNPFKEKGSCVIS"
     exon            500..3019
                     /gene="GNG11"
                     /gene_synonym="GNGT11; HG3H1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      903..908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG11"
                     /gene_synonym="GNGT11; HG3H1"
                     /note="hexamer: AATAAA"
     polyA_site      923
                     /gene="GNG11"
                     /gene_synonym="GNGT11; HG3H1"
                     /note="major polyA site"
     regulatory      2804..2809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG11"
                     /gene_synonym="GNGT11; HG3H1"
                     /note="hexamer: AATAAA"
     polyA_site      2826
                     /gene="GNG11"
                     /gene_synonym="GNGT11; HG3H1"
     regulatory      2999..3004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG11"
                     /gene_synonym="GNGT11; HG3H1"
                     /note="hexamer: ATTAAA"
     polyA_site      3019
                     /gene="GNG11"
                     /gene_synonym="GNGT11; HG3H1"
ORIGIN      
        1 agtcctgcag ccccagccca gccgtccccc gcgggcgtgg caggtcctga gtcagggcct
       61 gtccgtggcc agcatccctg ctgggcgatt gagcagcggg aagctgcttg gacccagtct
      121 caaacttaac cctcatctag cacccgggca ggcctcctgg gttgcaggga cttgagaaaa
      181 ggcagagttc tcaggtccta ggaagctggg gcacgctggc gtgacaagcg tcccggagaa
      241 agccaagccc tcggggagct ggggaccgca gcagggctgc agtcacatcc tgcgcgggtg
      301 ggcggcgggc caggccttca gttgtttcgg gacgcgccga gcttcgccgc tcttccagcg
      361 gctccgctgc cagagctagc ccgagcccgg ttctggggcg aaaatgcctg cccttcacat
      421 cgaagatttg ccagagaagg aaaaactgaa aatggaagtt gagcagcttc gcaaagaagt
      481 gaagttgcag agacaacaag tgtctaaatg ttctgaagaa ataaagaact atattgaaga
      541 acgttctgga gaggatcctc tagtaaaggg aattccagaa gacaagaacc cctttaaaga
      601 aaaaggcagc tgtgttattt cataaataac ttgggagaaa ctgcatccta agtggaagaa
      661 ctagtttgtt ttagttttcc cagataaaac caacatgctt tttaaggaag gaagaatgaa
      721 attaaaagga gactttctta agcaccatat agatagggtt atgtataaaa gcatatgtgc
      781 tactcatctt tgctcactat gcagtctttt ttaagagagc agagagtatc agatgtacaa
      841 ttatggaaat aagaacatta cttgagcatg acacttcttt cagtatattg cttgatgctt
      901 caaataaagt tttgtcttgg gaagatgagt gttggtgatt taagaagaca cttttcatgc
      961 attaactttt atatttctcc ccgtaatctt ttgggtgtgg agtatgattg ggtttggaat
     1021 atgattcaga aggttaggtg gttcgacaga tcacatctcc aaaccctgcg tcaatggttt
     1081 agagtgctga gttctgacct ctggaacgtg tttgatctaa ccttaactat taagaaactg
     1141 agcaggtaga attcctataa cattgacaga agtcagatta tctgagtcag gaacaaggcc
     1201 aagccacatc tatgttagta cttccctagt ttatcatcat ttagatcttc ttaatagtgt
     1261 tcctgtagta gtagccttga agaaaatact gagttggggt tcaggaagag tgccctgcct
     1321 ctctgccgtg tagtggccag gccagccctg gctttgagag ccagtactta ttcctgcaca
     1381 gagctacatc tcccatgtgc tctccaggtc ttgggcatgg cactactcca gttctgtggc
     1441 attggtgcag acacttggac ctctgcactc atgcttgcca gcattttcca gcaggcctgg
     1501 gccaaacatg cctttttttc ttctcctcca aaggaaccag tgaatctttg cccactttaa
     1561 agattagttg gtctttttct tactgatttg taggaattct tcatatattc tggccattta
     1621 ttcgtgtttg gtgatatgtg ttgcgaatac cttctcccag tctgtggctt accttttcac
     1681 agtgaccttc ccttcagtgg ttttatcctg cagggcaaca cgtcagagta taactcctgc
     1741 tcaagttcat aacaaaggta cctgaagccc aaacctcaca aaaagggacc tttctttctc
     1801 accttgagca ttctcccgct tcttctccgt cttttgggtc aaaattgctc caagtttgag
     1861 ccaaaagaaa aacgtggaaa aacccttgct ggttagctct agctcaaatg gacttagtca
     1921 ttaacttgac ctgcaatttt caatgtggca ccagaagcca atgtttctcc ttgactagct
     1981 cttttctccc acttacacat gtaggtatac cttactatca agcgagagag gcgcctgtaa
     2041 cctgtagcag ctttctaaag tatatcagca tcctcgttct gaaattcctt tcctttccct
     2101 ctctgggaaa gaacagaata ccccaggctt ttgaaaaata gtttacacag accaaaagca
     2161 gaaactattt ccttcagttt cctgacactg tccaagtgat gacatcaatt ggcattactg
     2221 agagcccagg gataatttta gcccaaaact actactccta ggaaggagta gtatgatcta
     2281 ctactcttag gaaggattta ggaatagtaa aggtgtattt cttccaaaca gcatagaact
     2341 attagtacta ttagtcattt aacatttaac atggcatggg attttagagc tttggtgcct
     2401 gtaaagtttt acttctatta gctgtttcat ttctttgcac ttataaagtt ttcttctgtt
     2461 gcctatgaaa gcaaacattt attccggtta ctggcaaggc agtttaaatc acctgcttct
     2521 ttcatgaaag gccaagacaa tacatttatt ccctaacttg ttgggagttg cgattacaag
     2581 tctatatcct gatttctatt agcacattca gctatccatt tgtgtacact cccaagtcct
     2641 agcttttgct cttcatgtct ctttcaacca tatgatcaat cagttggacg acttctggtt
     2701 tttcctgaat aaatatctaa tcttataggt gcttctatta aatataattc tgtttctttt
     2761 tcttaccatt tatcattata acccagccaa catgtagaag tgcaataaaa atattttaat
     2821 tttcaactgt tcaactgcta aaattattag cttgtaatta aaaaagaaaa aatacatcca
     2881 ctatatattt agatatattg taaatgtaac ctttggtgac tgataatttg ttaagtagaa
     2941 tttaaattat gtatccaatt tattcaaagt gtatagttgt gtaattattt actatttgat
     3001 taaaaatagt tatcatgca
//
