LOCUS       NM_001017998            1201 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens G protein subunit gamma 10 (GNG10), transcript variant
            1, mRNA.
ACCESSION   NM_001017998
VERSION     NM_001017998.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1201)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1201)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1201)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 1201)
  AUTHORS   Cardenas-Navia,L.I., Cruz,P., Lin,J.C., Rosenberg,S.A. and
            Samuels,Y.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Novel somatic mutations in heterotrimeric G proteins in melanoma
  JOURNAL   Cancer Biol Ther 10 (1), 33-37 (2010)
   PUBMED   20424519
  REMARK    GeneRIF: GNG10 mutations are associated with melanoma.
REFERENCE   5  (bases 1 to 1201)
  AUTHORS   Fowler,C.E., Aryal,P., Suen,K.F. and Slesinger,P.A.
  TITLE     Evidence for association of GABA(B) receptors with Kir3 channels
            and regulators of G protein signalling (RGS4) proteins
  JOURNAL   J Physiol 580 (Pt 1), 51-65 (2007)
   PUBMED   17185339
REFERENCE   6  (bases 1 to 1201)
  AUTHORS   Jiang,G. and Zhang,B.B.
  TITLE     Glucagon and regulation of glucose metabolism
  JOURNAL   Am J Physiol Endocrinol Metab 284 (4), E671-E678 (2003)
   PUBMED   12626323
  REMARK    Review article
REFERENCE   7  (bases 1 to 1201)
  AUTHORS   Ray,K., Kunsch,C., Bonner,L.M. and Robishaw,J.D.
  TITLE     Isolation of cDNA clones encoding eight different human G protein
            gamma subunits, including three novel forms designated the gamma 4,
            gamma 10, and gamma 11 subunits
  JOURNAL   J Biol Chem 270 (37), 21765-21771 (1995)
   PUBMED   7665596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB504443.1, BC107574.1 and AW583403.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001017998.3.
            
            Transcript Variant: This variant (1) represent the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279834.4834.1,
                                           SRR5189655.187991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374293.5/ ENSP00000363411.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DB504443.1         35-38
            5-1122              BC107574.1         6-1123
            1123-1201           AW583403.1         35-113              c
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..1201
                     /gene="GNG10"
                     /note="G protein subunit gamma 10"
                     /db_xref="GeneID:2790"
                     /db_xref="HGNC:HGNC:4402"
                     /db_xref="MIM:604389"
     exon            1..111
                     /gene="GNG10"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..237
                     /gene="GNG10"
                     /note="guanine nucleotide binding protein 10; guanine
                     nucleotide binding protein (G protein), gamma 10"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-10"
                     /protein_id="NP_001017998.1"
                     /db_xref="CCDS:CCDS35107.1"
                     /db_xref="GeneID:2790"
                     /db_xref="HGNC:HGNC:4402"
                     /db_xref="MIM:604389"
                     /translation="MSSGASASALQRLVEQLKLEAGVERIKVSQAAAELQQYCMQNAC
                     KDALLVGVPAGSNPFREPRSCALL"
     exon            112..243
                     /gene="GNG10"
                     /inference="alignment:Splign:2.1.0"
     exon            244..1201
                     /gene="GNG10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNG10"
                     /note="hexamer: AATAAA"
     polyA_site      1201
                     /gene="GNG10"
                     /note="major polyA site"
ORIGIN      
        1 agcagcccct aggagcccag cgccgccgcc atgtcctccg gggctagcgc gagcgccctg
       61 cagcgcttgg tagagcagct caagttggag gctggcgtgg agaggatcaa ggtctctcag
      121 gcagctgcag agcttcaaca gtactgtatg cagaatgcct gcaaggatgc cctgctggtg
      181 ggtgttccag ctggaagtaa ccccttccgg gagcctagat cctgtgcttt actctgaaga
      241 ctctaggaga gaagtttgct gaggaatgcc ttcaagcaca aagtgatgaa tgactgcctt
      301 caagtctcaa gaaaacactt ttccctaact tttagagata tttcagccct ttcctgtggc
      361 ctggtcctat agccaaaatc acagatattc atgagtttct acttgagtga gaaaactggg
      421 tgaaggaata gaattttaaa tagtaataac tgcttgtttt ttttgtgcaa gtacttttat
      481 acataagata aacaaaaacc ttaccaccaa acataccaaa atgcacctct ttcataagtg
      541 agttactaag atttctatac ctggaatatc atgtatgttt catttactgg atgtttacat
      601 tttaggaagg aaaatagttt tgtttattta aacaactgaa tacttataaa ctgttgttcc
      661 tggaagttat ttattccata aaaaatttgt tcttttgtca tgaatttata attcctaaat
      721 gaagaccaga aagtacaaat tgctgggagg aagaataggc tttattaatc aactgatgtc
      781 ttgatttttc taaatgggaa gattgcttta tttttaacac taattatggg agcagattct
      841 tagcaaactt ctttggaaaa gttaatgtta tgatgtgcat taggctgccc catcgtgtat
      901 ataaatgaag cagatttgat ttttgtattc ttacgtttct ctgctttgta gttgtggctg
      961 tacttaaaga aatacagaat ttcatatatt taaaaatgtt taaaatgtga cccacagaac
     1021 attgtaaatg attaaaaact aacatgaaaa tattacaacc taaaagaatt cttaacttca
     1081 caagtgtttt acttcgacga tgtgcctttg atttaatttg ggacactttt ttagaaggat
     1141 acattattcg tgtttgcaac ggtctttgaa gagcttggaa ataaaatttc tgcttaatta
     1201 a
//
