LOCUS       NM_016194               8934 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens G protein subunit beta 5 (GNB5), transcript variant 2,
            mRNA.
ACCESSION   NM_016194
VERSION     NM_016194.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8934)
  AUTHORS   Zhang,J., Pandey,M., Awe,A., Lue,N., Kittock,C., Fikse,E.,
            Degner,K., Staples,J., Mokhasi,N., Chen,W., Yang,Y., Adikaram,P.,
            Jacob,N., Greenfest-Allen,E., Thomas,R., Bomeny,L., Zhang,Y.,
            Petros,T.J., Wang,X., Li,Y. and Simonds,W.F.
  TITLE     The association of GNB5 with Alzheimer disease revealed by genomic
            analysis restricted to variants impacting gene function
  JOURNAL   Am J Hum Genet 111 (3), 473-486 (2024)
   PUBMED   38354736
  REMARK    GeneRIF: The association of GNB5 with Alzheimer disease revealed by
            genomic analysis restricted to variants impacting gene function.
REFERENCE   2  (bases 1 to 8934)
  AUTHORS   Pijuan,J., Vilanova-Adell,A., Casas-Alba,D., Campistol,J.,
            Hoenicka,J. and Palau,F.
  TITLE     Inheritance of c.628-6G>A GNB5 hypomorphic allele uncovers another
            challenge in the pathogenic prediction of genomic variants
  JOURNAL   Clin Genet 105 (3), 340-342 (2024)
   PUBMED   37994112
  REMARK    GeneRIF: Inheritance of c.628-6G>A GNB5 hypomorphic allele uncovers
            another challenge in the pathogenic prediction of genomic variants.
REFERENCE   3  (bases 1 to 8934)
  AUTHORS   Patil,D.N., Singh,S., Laboute,T., Strutzenberg,T.S., Qiu,X., Wu,D.,
            Novick,S.J., Robinson,C.V., Griffin,P.R., Hunt,J.F., Izard,T.,
            Singh,A.K. and Martemyanov,K.A.
  TITLE     Cryo-EM structure of human GPR158 receptor coupled to the
            RGS7-Gbeta5 signaling complex
  JOURNAL   Science 375 (6576), 86-91 (2022)
   PUBMED   34793198
  REMARK    GeneRIF: Cryo-EM structure of human GPR158 receptor coupled to the
            RGS7-Gbeta5 signaling complex.
REFERENCE   4  (bases 1 to 8934)
  AUTHORS   Jeong,E., Kim,Y., Jeong,J. and Cho,Y.
  TITLE     Structure of the class C orphan GPCR GPR158 in complex with
            RGS7-Gbeta5
  JOURNAL   Nat Commun 12 (1), 6805 (2021)
   PUBMED   34815401
  REMARK    GeneRIF: Structure of the class C orphan GPCR GPR158 in complex
            with RGS7-Gbeta5.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8934)
  AUTHORS   Shao,Z., Masuho,I., Tumber,A., Maynes,J.T., Tavares,E., Ali,A.,
            Hewson,S., Schulze,A., Kannu,P., Martemyanov,K.A. and Vincent,A.
  TITLE     Extended Phenotyping and Functional Validation Facilitate Diagnosis
            of a Complex Patient Harboring Genetic Variants in MCCC1 and GNB5
            Causing Overlapping Phenotypes
  JOURNAL   Genes (Basel) 12 (9), 1352 (2021)
   PUBMED   34573334
  REMARK    GeneRIF: Extended Phenotyping and Functional Validation Facilitate
            Diagnosis of a Complex Patient Harboring Genetic Variants in MCCC1
            and GNB5 Causing Overlapping Phenotypes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8934)
  AUTHORS   Jones,P.G., Lombardi,S.J. and Cockett,M.I.
  TITLE     Cloning and tissue distribution of the human G protein beta 5 cDNA
  JOURNAL   Biochim Biophys Acta 1402 (3), 288-291 (1998)
   PUBMED   9606987
REFERENCE   7  (bases 1 to 8934)
  AUTHORS   Gold,S.J., Ni,Y.G., Dohlman,H.G. and Nestler,E.J.
  TITLE     Regulators of G-protein signaling (RGS) proteins: region-specific
            expression of nine subtypes in rat brain
  JOURNAL   J Neurosci 17 (20), 8024-8037 (1997)
   PUBMED   9315921
REFERENCE   8  (bases 1 to 8934)
  AUTHORS   Watson,A.J., Aragay,A.M., Slepak,V.Z. and Simon,M.I.
  TITLE     A novel form of the G protein beta subunit Gbeta5 is specifically
            expressed in the vertebrate retina
  JOURNAL   J Biol Chem 271 (45), 28154-28160 (1996)
   PUBMED   8910430
REFERENCE   9  (bases 1 to 8934)
  AUTHORS   Yan,K., Kalyanaraman,V. and Gautam,N.
  TITLE     Differential ability to form the G protein betagamma complex among
            members of the beta and gamma subunit families
  JOURNAL   J Biol Chem 271 (12), 7141-7146 (1996)
   PUBMED   8636150
REFERENCE   10 (bases 1 to 8934)
  AUTHORS   Poke,G., Sadleir,L.G., Merla,G., de Valles-Ibanez,G. and
            Skinner,J.R.
  TITLE     GNB5-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   34436834
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010674.11, AW967075.1,
            BC013997.2 and AC023906.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_016194.3.
            
            Summary: Heterotrimeric guanine nucleotide-binding proteins (G
            proteins), which integrate signals between receptors and effector
            proteins, are composed of an alpha, a beta, and a gamma subunit.
            These subunits are encoded by families of related genes. This gene
            encodes a beta subunit. Beta subunits are important regulators of
            alpha subunits, as well as of certain signal transduction receptors
            and effectors. Alternatively spliced transcript variants encoding
            different isoforms exist. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF300650.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261837.12/ ENSP00000261837.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC010674.11        61592-61615         c
            25-506              AW967075.1         1-482
            507-1828            BC013997.2         375-1696
            1829-3108           AC023906.7         73142-74421         c
            3109-8934           AC023906.7         67316-73141         c
FEATURES             Location/Qualifiers
     source          1..8934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..8934
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /note="G protein subunit beta 5"
                     /db_xref="GeneID:10681"
                     /db_xref="HGNC:HGNC:4401"
                     /db_xref="MIM:604447"
     exon            1..71
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            72..215
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1277
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /note="isoform b is encoded by transcript variant 2;
                     guanine nucleotide-binding protein subunit beta-5;
                     transducin beta chain 5; guanine nucleotide-binding
                     protein, beta subunit 5L; G protein, beta subunit 5L;
                     guanine nucleotide binding protein (G protein), beta 5;
                     heterotrimeric guanine nucleotide-binding protein 2E"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     beta-5 isoform b"
                     /protein_id="NP_057278.2"
                     /db_xref="CCDS:CCDS10149.1"
                     /db_xref="GeneID:10681"
                     /db_xref="HGNC:HGNC:4401"
                     /db_xref="MIM:604447"
                     /translation="MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLSYCSTCAEIMA
                     TEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK
                     GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGC
                     AIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT
                     CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA
                     FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFS
                     LSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLR
                     VWA"
     exon            216..327
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            328..464
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..506
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..583
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..716
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..860
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..952
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1001
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1098
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1265
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..8934
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3077..3082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /note="hexamer: AATAAA"
     polyA_site      3100
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /note="major polyA site"
     regulatory      8911..8916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /note="hexamer: AATAAA"
     polyA_site      8934
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
ORIGIN      
        1 acacctcaag ctgcgcgctg gtcctcacct ctcaccatct gctctgtggc tcccagtgct
       61 gactctggaa gctttatctt gggtaaaaga tgtgtgatca gacctttctc gttaatgtat
      121 ttggctcatg tgacaaatgt ttcaaacaac gagctctgag accagttttc aagaagtctc
      181 aacaactcag ctactgttca acatgtgcag aaattatggc aaccgagggg ctgcacgaga
      241 acgagacgct ggcgtcgctg aagagcgagg ccgagagcct caagggcaag ctggaggagg
      301 agcgagccaa gctgcacgat gtggagctgc accaggtggc ggagcgggtg gaggccctgg
      361 ggcagtttgt catgaagacc agaaggaccc tcaaaggcca cgggaacaaa gtcctgtgca
      421 tggactggtg caaagataag aggaggatcg tgagctcgtc acaggatggg aaggtgatcg
      481 tgtgggattc cttcaccaca aacaaggagc acgcggtcac catgccctgc acgtgggtga
      541 tggcatgtgc ttatgcccca tcgggatgtg ccattgcttg tggtggtttg gataataagt
      601 gttctgtgta ccccttgacg tttgacaaaa atgaaaacat ggctgccaaa aagaagtctg
      661 ttgctatgca caccaactac ctgtcggcct gcagcttcac caactctgac atgcagatcc
      721 tgacagcgag cggcgatggc acatgtgccc tgtgggacgt ggagagcggg cagctgctgc
      781 agagcttcca cggacatggg gctgacgtcc tctgcttgga cctggccccc tcagaaactg
      841 gaaacacctt cgtgtctggg ggatgtgaca agaaagccat ggtgtgggac atgcgctccg
      901 gccagtgcgt gcaggccttt gaaacacatg aatctgacat caacagtgtc cggtactacc
      961 ccagtggaga tgcctttgct tcagggtcag atgacgctac gtgtcgcctc tatgacctgc
     1021 gggcagatag ggaggttgcc atctattcca aagaaagcat catatttgga gcatccagcg
     1081 tggacttctc cctcagtggt cgcctgctgt ttgctggata caatgattac actatcaacg
     1141 tctgggatgt tctcaaaggg tcccgggtct ccatcctgtt tggacatgaa aaccgcgtta
     1201 gcactctacg agtttccccc gatgggactg ctttctgctc tggatcatgg gatcataccc
     1261 tcagagtctg ggcctaatca tcttctgaca gtgcactcat gtatacctga gaatttgaaa
     1321 tcttcacatg taaatagata ttacttctag aggagcttag agtttattgc agtgtagctt
     1381 aggggagcaa cccatggctc acaggtcact aagcgtctcc aatatgacta ttaaaactgt
     1441 cacctctgga aatacactag tgtgagcctt cagcactgcg agaatacctt caagtacagt
     1501 atttttcttt tggaacactt tttaaaatgt atctgttttt aaggttattc taaattatag
     1561 tagcctcaac tcattctgtc accagtagaa ttcagcagtt aatatattcc atattatttc
     1621 tttgaatcaa ttcattttca gagcacttta aagtctgata tttctcgatg tgcactgtga
     1681 tgcctggaac cttcctctgg aagtgctgat tttatggact gaggactggt gactggtctg
     1741 tgatagaagc aaattccaat tccaaatgta attagacaaa aatcattttt ttagaatgtg
     1801 tttttattgt aaaagtatct ttttcagctt cctgttctat tgtctttttt cagatacaac
     1861 atttttgtct atggtgaact gctgtaaatg acgcagagaa atgcctaaaa aggacaggtg
     1921 gtttgactca tggatgatga tgatgtcact gtgccacttg gacagggcgt tttctctgaa
     1981 ttgaagggaa agccaatggt gtttgtaaac aaatgcttct gagagcaaag aaaagtcttc
     2041 tgtgtgggaa cacaagatag taaacttatt taaaaaccta ttagtagaat tagtggaaac
     2101 acttaggtta aagtgaatct tgtccatata aattatattc atggccgggc gcggtggctc
     2161 acgcttgtaa tcccagcact ttgggaggcc gaggcgggcg gatcacgagg tcaggagttc
     2221 gagaccacgg tgaaaccctg tctctactaa aaaatacaaa aaattagccg ggcgtggtgg
     2281 cgggcgcctg tagtcccagc tactcggaga ggctgaggca ggagaatggc gtgaacccgg
     2341 gaggtggagc ttgcagtgag ccgaggtcga gccactgcag cctgggtgac aaagcgagac
     2401 tccgtctcaa aaaaaaaaaa aaattatatt catatgtatt gcattgcaat tataattaca
     2461 tatgcagatt gattgatagt catgaataat aacgtctgct cctcttacat agaaaaacga
     2521 tattaaaaga agatcttctc tttatttgag actcagaatt ccttctagaa gaaggaagtg
     2581 ctttttgtta taggatccct tcttttcctt tttttgtttt tttgtaagat gtagatgctt
     2641 attctttgct ttagaaaact tctcacttaa aaagatggca tgcacctagg ggaataaaag
     2701 gtcacctcag acaccaggtg tcattcctgg tgaggcctgc ctcgtcggtg gcctggggtc
     2761 tgccggcagg ttctggctgc acctgaaggc tgcgtgcacc ttgtcccctg gacaggtctc
     2821 ctttcctggc cctgctccag cccagccctt cttctagtgg tagctctggc tttgcaggcc
     2881 cagctccagg ccctgctcct cagagagact cttccagagc tggagctggg cacagccata
     2941 agacaggact ggaccagatg ctcctgtaaa catccagggg tgtgccaggc ccaccctcac
     3001 aactgcttgt tcaggtatcg tgatgggcca ctcggtccaa aatcagccag gccatctttt
     3061 ccatcatctc acttcaaata aacataataa ttatatttga tcatttgcag agcagttact
     3121 ggtggtttta ttgtacactg gggtctgggg tagagagaga aaaatgaagg gcctctgcct
     3181 tcctccaggg agcccagaga gagtgctttt tagtcccagt agattccagt ctgggcaggg
     3241 gctcaggaaa tgggcccagt gtctggccag ctcctgccag gtgctgaagg ggtcagggca
     3301 ccatgggatt cctgagctct gctccagaat gtcccacagt ggcccctggt gcagctggcc
     3361 tccttgtggt ggcatcccca accctctctc ccacagccat tttttttttt gtctctgcac
     3421 tgtgccttcc ggctcccaga agtgcaggaa ggcacgagaa aggaaggaaa ggtggcccag
     3481 ggaagcacat tccaggttcc atgtttggag aggtggagag catcttcagg atatgtgcaa
     3541 agtagactgt gactttccaa tccaaaaagc cactttaagg gcccagggaa agtattccag
     3601 agaatgcttc cactccccgc atgggcagga agcctccttc gctgtgagca tgcgctctcg
     3661 cagtgggtgc tgtcgggatt tgctgatgag atacttgatt tggactatgt gacagcatgt
     3721 ggagactcag gggtaagctc catgggatag attgtatttt gcagattgaa aataatgctg
     3781 agtgcatttt ataatcagct tttctttttt ccagaggact tggggataaa cctaccaaac
     3841 caattgtggt gaaggggcca aacagatggg cccccagggg tgtagagcct tgggcagccc
     3901 cctcctgggc cagaaaaaag aaagttcagg cagaaaggtg tgggtgatgg gtatttatgg
     3961 gaaatatctg tgacatgaag ccaagtccag tgctttagaa tgcgcggtca gcctctcacc
     4021 ggtggggccc tggcagccgt ccctcttctc ccaggcgagc cagaggtggg catcccgttg
     4081 ccactgccct cttcccgctc ttctacctcc tttgcaccct tctctaggtt ataagtggct
     4141 taaaacagca cagggttgta agggcctttg tgtcccgggc tctcatagtt gccaggccag
     4201 ctggctgaaa ggtggcacca ccgatactgg gactcctctg tgagttagag ggatgccttg
     4261 gtgacataag agggctggcc ttcattcaca cccacctctg tcacggtcac agaatatatg
     4321 ataatatctg agtttttctc agcctcagtt tccccatttg taacatggga tgggactaaa
     4381 atatgtaaag tgcctacctc agcctttagc acatcttcag gaagggttag ttcccagctt
     4441 ctccctgtgt cctcctcagt ccccttccta tttgcccccc tcccttctcc ctccacctat
     4501 cttccctctt tctcttccct tcccctcctc ctccctctct cctccctctc tcccatttcc
     4561 ccctccctcc ctcccatctc ctcctccctc cctcccatct cctcctcctc cctcccatct
     4621 cctccctccc atctcctcct ccctcccatc tcctcctccc tcccatctcc tcctccctcc
     4681 catctcctcc tcccttcctc ctgtcacccc tcctccctcc ctctcatcac ctcctccctc
     4741 cctcccatcg cctcctctct ccttcctatc tcctctttcc tcttctctgc cccctccccc
     4801 tctcctcatt catccggact cctttttcta acccttctca atcttccccc attcctcatc
     4861 tcctcttcct ctgtctccct gttccacctc tctcctggtc tccttccttc cccttctgct
     4921 gtttctccct ccctcctcct cccttcccat tccccttccc ccagcacttc cttttctccc
     4981 catctcctcc ccattcccct tcccccagct ctttcttttc tccccatctc ctccccatcc
     5041 ataggcagcc cccactcata tagcaaatta gtaattctca tcagttagag cttcgtctgg
     5101 gctagtggtt ctcaaacttt ttggtcttag gatctctgta cacttttttt tttttttttt
     5161 ttttacgtgg agttttgctc ttgttgccca ggctggagtg cagtggcgcg atctcgggct
     5221 cacttcaacc tccgcctcct gggttcaagc gattctcctg cctcagcctc ccgagtagct
     5281 gggattacaa ggcatgcacc accacgcccg gctaattttg tatttttagt agagaccagg
     5341 tttctccatg ttggtcacac tggtctcgaa ctcccaacct caggtgatcc tcccaccttg
     5401 gcctcccaaa gtgctgggat tacaggtgta agccaccgtg cccagcctac acccttaaaa
     5461 gttattgagg accccaaata acttgctcat tgtggattgt atctatccat atttattgta
     5521 ttagaaatta agactgagaa aaagttataa aacacaagaa tacagatgca cacgttccat
     5581 tagccatcaa ggtgatcttt ctcccatgcc agtagtctct ggaaaattcc tgagaggatg
     5641 aaaataaaaa aatcacccat acaaaaaaaa aaagtgtcaa tattattatg aaaatagttt
     5701 tgaccgtgag gaccccctga aagggtctca gggaccctcg ggggccctgg atcttgcttt
     5761 gagaacagct gatctgggct aatgagccct tttccagccc ctctgtgtga gacctcccag
     5821 aaaccactaa gggccttgga agagcttggc aaagaaagag gtgacaggat gattgaggag
     5881 agccacccta gggaaagcct tcagaggagg ctttgggaca gccccggtcg gtggaggaag
     5941 tcccagagag gcagtcggaa gggctaggga ccagctgagg cctgtgacct gaaaatcctt
     6001 tcaaaagagg acgcctggaa gcctggggaa ggcacagtgg gtggggtaga agactggggc
     6061 tgaggcccag gccattccca agcctggaag agctgattga gtggggattt gtagatcttc
     6121 atttcccaaa cttgcctgct gagaagaatc gtcccaccca tggcaggttc ctgcactgcg
     6181 ccttcagggc cctgccctga gatctggact gggcgggcct gaggtgggcc aggaaatctg
     6241 agccggaggc ccactgggga ggccgcgagt gaatcttgtc tctgtggatc ctttgtaagg
     6301 attgccatgc taaaccactt gccctctcat ccgtgaccgg agagaattgg gtcactcttc
     6361 cagacatacc acagactcct gcttctagac agcacttggc tggagccagg ctggccttca
     6421 gggttggtca gtctccacag gggactctgg cctcccgtgg gctgccacag ggccaacccc
     6481 agtgaaagaa atgaaatgac tgaatatgtt catgtcatta gaaaaaggat gcagcagggg
     6541 gtggggagga gttggttaat ggaatcaaat ttgcagcaag ataggagtct agtgtttggc
     6601 ggcactgtag ggtgactatc gctaacaata atttactgtg tattttcaag tagctagaag
     6661 agagaatttt gaatgttcct gtcaacctaa ataacaaaga caggctcgct aaagatattt
     6721 aatcaaaagt agggcattgc aacaggaata tgtgtgctgt agtaaactgt gtgcatattc
     6781 caggaggtaa agaaaaacaa aggtgactgg gcgcggtggc tcacgcctgt aatcccagca
     6841 ctttgggagg ccgaggcggg tggatcacga ggtcaggaga tcgagaccat cctggctaac
     6901 acggtgaaac cctgtctgta ctaaaaaaaa atatatatat atattagctg ggcgtggtgg
     6961 caggtgcctg tagtcccagc tgctcgggag gctggggcag gagaatggca tgaacccagg
     7021 aggtagagct tgcagtgagc cgagatggca ccactgcact ccagcctggg cgacagagcg
     7081 agactctgac tcaaaaaaac aaagaaaaaa aaaaagaaaa acaaaggttt ttaaaggaaa
     7141 aaatgaggag gattacataa tggttttgaa ataattatcc ttggctacaa atatcaataa
     7201 caaaggtcac accagtccga ggttggacag gcagttgcta ggcagatgtc tttgcagaag
     7261 taatttttgt gtgaggttgc agcagcctat gtgcaaggtt gtaatttttg cagaatcttt
     7321 tgtgatcatt tttggtatta ggcatacaag catgagaatc ccctcttcat ggcctcccca
     7381 gctctatttg tcatggtttg tttttttaaa acactagtga ctctatttga attctaacaa
     7441 ctttcacatt cccaacacaa atgatagaca tttaagggat taatatgcta attaccctga
     7501 tcattacaca ttgtatacat gtatcaaaat aacacactgt accccataaa tacatacaat
     7561 tatgtgtcaa ttaaagatca ttatttttaa aaataggacc agaaaaaaag atgcagaccc
     7621 tctagtaagg agatgggatc aggagtgatt ccatggttaa tttaacccac ataaacaact
     7681 aatcgtaagt atggtatgag cgtttatgta aagactgtga caacaggaaa tgtctgtctt
     7741 tgaacccaag gttatctaac cagcacacca atggtgaaag attaactttg tcagaaacca
     7801 ggaaccatga agcagaggtc actgtttcca acctgtgtgt tttccacggt aattggcagc
     7861 ctccccaagg gaaattaaaa catatgtcca cacagaaatt tgaatgcaaa tgttcatagc
     7921 agcattactc ataatagccc aaagctgaaa cagccccaat gttccacagt ggatgaatcg
     7981 atgaacaaaa tatggcgcat ccacagaatg gaatacaaag aaagaaagcg tggacacatg
     8041 ctgcaacatg gatgaacctt gaaaatattg tgccagggga aagaaaccag agacaaagag
     8101 ccacatgttg taggattcca tgtatatgaa aggtcctaat aagcaaactc ataaagacaa
     8161 aaagcagatt ggtggtcact tagggctagg gtgaggagtg acggttagtg ggcactgagt
     8221 ttctccgggg ggaactgaat tagatggtgg tgattgcaca attctgtgaa tagactaaaa
     8281 accactggac tgtaagaggg tgaatttttt ggtatatgaa ttacatctca ataaagctgt
     8341 tacttaaaac gtggaaaaaa taataagcag tcactagcta ttctcaataa aacagaaacc
     8401 acataggtaa gaccaatatt gtcacatttt ggttttggct gataatgggg caagtgagca
     8461 tagtcaccgt tgccagagga tttaccattt acaaataaaa gtttctgtgg agtgacaacc
     8521 ttttactgtg tgccaggtac tgtgctaagc actttgtata taccgattca tgtaatcctt
     8581 gtgacagccc cgtgatgccc catttttaga tggggagatt gaggttagga gagttgaata
     8641 acttgcccat agctgcacag cttccaagtt gcagagacag gattttcacc gagtcttatt
     8701 acaaactgcc tcatattgtg tggactggaa attctatgtt gaggttaatt tattcatttg
     8761 ttgtttagtt cttttcatca ttgttgagtt accaatggca gttccagagg atttatcatt
     8821 taccccaaag ctactgcaaa tctaagagaa aacaatgttc ttgctgctaa agtttaatgt
     8881 acaaaaaggt aaaatcatga ctgtcttgca aataaaacat gaacatgtat ccaa
//
