LOCUS       NM_021629               6315 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens G protein subunit beta 4 (GNB4), mRNA.
ACCESSION   NM_021629
VERSION     NM_021629.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6315)
  AUTHORS   Zhao,Y., Zhao,L., Jin,H., Xie,Y., Chen,L., Zhang,W., Dong,L.,
            Zhang,L., Huang,Y., Wan,K., Yang,Q. and Wang,S.
  TITLE     Plasma methylated GNB4 and Riplet as a novel dual-marker panel for
            the detection of hepatocellular carcinoma
  JOURNAL   Epigenetics 19 (1), 2299044 (2024)
   PUBMED   38154055
  REMARK    GeneRIF: Plasma methylated GNB4 and Riplet as a novel dual-marker
            panel for the detection of hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 6315)
  AUTHORS   Liu,D., Liu,Y., Zhu,W., Lu,Y., Zhu,J., Ma,X., Xing,Y., Yuan,M.,
            Ning,B., Wang,Y. and Jia,Y.
  TITLE     Helicobacter pylori-induced aberrant demethylation and expression
            of GNB4 promotes gastric carcinogenesis via the Hippo-YAP1 pathway
  JOURNAL   BMC Med 21 (1), 134 (2023)
   PUBMED   37016382
  REMARK    GeneRIF: Helicobacter pylori-induced aberrant demethylation and
            expression of GNB4 promotes gastric carcinogenesis via the
            Hippo-YAP1 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6315)
  AUTHORS   Liu,B., Chen,L., Huang,H., Huang,H., Jin,H. and Fu,C.
  TITLE     Prognostic and Immunological Value of GNB4 in Gastric Cancer by
            Analyzing TCGA Database
  JOURNAL   Dis Markers 2022, 7803642 (2022)
   PUBMED   35756485
  REMARK    GeneRIF: Prognostic and Immunological Value of GNB4 in Gastric
            Cancer by Analyzing TCGA Database.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6315)
  AUTHORS   Chen,T.J., Dehghanian,S.Z., Chan,T.C., He,H.L., Li,W.S.,
            Abdollahi,S., Chen,N.Y., Li,C.F. and Shiue,Y.L.
  TITLE     High G protein subunit beta 4 protein level is correlated to poor
            prognosis of urothelial carcinoma
  JOURNAL   Med Mol Morphol 54 (4), 356-367 (2021)
   PUBMED   34398348
  REMARK    GeneRIF: High G protein subunit beta 4 protein level is correlated
            to poor prognosis of urothelial carcinoma.
REFERENCE   5  (bases 1 to 6315)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6315)
  AUTHORS   Downes,G.B. and Gautam,N.
  TITLE     The G protein subunit gene families
  JOURNAL   Genomics 62 (3), 544-552 (1999)
   PUBMED   10644457
  REMARK    Review article
REFERENCE   7  (bases 1 to 6315)
  AUTHORS   Huang,L., Shanker,Y.G., Dubauskaite,J., Zheng,J.Z., Yan,W.,
            Rosenzweig,S., Spielman,A.I., Max,M. and Margolskee,R.F.
  TITLE     Ggamma13 colocalizes with gustducin in taste receptor cells and
            mediates IP3 responses to bitter denatonium
  JOURNAL   Nat Neurosci 2 (12), 1055-1062 (1999)
   PUBMED   10570481
REFERENCE   8  (bases 1 to 6315)
  AUTHORS   Asano,T., Morishita,R., Ueda,H. and Kato,K.
  TITLE     Selective association of G protein beta(4) with gamma(5) and
            gamma(12) subunits in bovine tissues
  JOURNAL   J Biol Chem 274 (30), 21425-21429 (1999)
   PUBMED   10409705
REFERENCE   9  (bases 1 to 6315)
  AUTHORS   Pietruck,F., Moritz,A., Montemurro,M., Sell,A., Busch,S.,
            Rosskopf,D., Virchow,S., Esche,H., Brockmeyer,N., Jakobs,K.H. and
            Siffert,W.
  TITLE     Selectively enhanced cellular signaling by Gi proteins in essential
            hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are
            not mutated
  JOURNAL   Circ Res 79 (5), 974-983 (1996)
   PUBMED   8888689
REFERENCE   10 (bases 1 to 6315)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Hereditary Neuropathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007620.30.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021629.3.
            
            Summary: Heterotrimeric guanine nucleotide-binding proteins (G
            proteins), which integrate signals between receptors and effector
            proteins, are composed of an alpha, a beta, and a gamma subunit.
            These subunits are encoded by families of related genes. This gene
            encodes a beta subunit. Beta subunits are important regulators of
            alpha subunits, as well as of certain signal transduction receptors
            and effectors. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.177602.1,
                                           SRR1803614.226704.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000232564.8/ ENSP00000232564.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC007620.30        77855-77979         c
            126-224             AC007620.30        52653-52751         c
            225-263             AC007620.30        47398-47436         c
            264-370             AC007620.30        45908-46014         c
            371-434             AC007620.30        43002-43065         c
            435-597             AC007620.30        41394-41556         c
            598-664             AC007620.30        40224-40290         c
            665-866             AC007620.30        39921-40122         c
            867-1083            AC007620.30        31699-31915         c
            1084-6315           AC007620.30        22597-27828         c
FEATURES             Location/Qualifiers
     source          1..6315
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.33"
     gene            1..6315
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /note="G protein subunit beta 4"
                     /db_xref="GeneID:59345"
                     /db_xref="HGNC:HGNC:20731"
                     /db_xref="MIM:610863"
     exon            1..125
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            126..224
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1190
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /note="G protein beta-4 subunit; transducin beta chain 4;
                     guanine nucleotide binding protein (G protein), beta
                     polypeptide 4; heterotrimeric guanine nucleotide-binding
                     protein 2B"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     beta-4"
                     /protein_id="NP_067642.1"
                     /db_xref="CCDS:CCDS3230.1"
                     /db_xref="GeneID:59345"
                     /db_xref="HGNC:HGNC:20731"
                     /db_xref="MIM:610863"
                     /translation="MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQ
                     MRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMT
                     CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTS
                     SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMC
                     RQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSV
                     AFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS
                     FLRIWN"
     exon            225..263
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            264..370
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            371..434
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            435..597
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            598..664
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            665..866
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1083
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..6315
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6295..6300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /note="hexamer: AATAAA"
     polyA_site      6315
                     /gene="GNB4"
                     /gene_synonym="CMTD1F; HG2B"
                     /note="major polyA site"
ORIGIN      
        1 gtggccggcg gctctggtct cggctgtgag ctgcgctctc cacgccggct ccgcgctcca
       61 ggggctgctg agcgcccagc ggacaccggc agcgcgcggt cgacgcgggc ctgagctccc
      121 tccagctgtt ttcactcatt agctcctgag gtaaacaaat tgaaaaaatg agcgaactgg
      181 aacagttgag gcaagaagca gaacaactgc ggaatcagat tcaggatgct cggaaagcat
      241 gtaatgatgc aacgcttgtt cagattacat caaatatgga ctctgtgggt cgaatacaaa
      301 tgcgaacaag acgtacactg aggggccacc tagctaaaat ctatgctatg cattggggat
      361 acgattccag gctgctagtc agtgcttctc aagatggaaa attaattatt tgggatagct
      421 atacaacaaa taagatgcat gctattcctt tgaggtcctc ctgggtgatg acctgtgctt
      481 atgctccctc tggtaattat gttgcctgtg gaggcttgga caacatctgc tctatatata
      541 acttaaagac cagagaggga aatgtgagag taagccgaga gttgccaggt cacacagggt
      601 acttgtcctg ctgtcgtttt ttagatgaca gccaaattgt tacaagttca ggagatacaa
      661 cttgtgcttt atgggacatc gaaactgccc agcagaccac cacattcact gggcattctg
      721 gagatgtgat gagtctttct ttgagtcctg acatgaggac ttttgtttct ggtgcttgtg
      781 atgcctcttc caaattatgg gatattcgag atggaatgtg tagacagtct ttcacgggac
      841 atgtctcaga tatcaatgct gtcagttttt tcccaaatgg atatgccttc gccactggct
      901 ctgatgatgc cacttgccgg ctctttgacc ttcgtgcaga tcaagagtta ttattgtatt
      961 ctcatgacaa tatcatctgt ggaatcactt ctgtagcctt ctcaaaaagt gggcgtctct
     1021 tgttggctgg ttacgatgac tttaattgta atgtatggga cacgctaaaa ggagatcgtg
     1081 caggtgtcct tgctggtcat gacaaccgtg tgagctgctt aggtgtaact gatgatggca
     1141 tggctgtggc aacaggctct tgggacagtt ttcttagaat ctggaattaa cagtgtcata
     1201 catatttgtt ctccattgat atatctggag aaatcaatgc tacagcctat agctgtgaaa
     1261 aaattctacc ttatatttgc aggtgaagat ttttctatta gattatctac aaaaacaagc
     1321 tttcagtaaa ctaccaaaaa aaaagtgggg gtggaggaaa aaaggcaaag gcgccttctg
     1381 agatcaaaag gaccagtgta ttaatttgag gggttgggtt attttaacct tggtgaattg
     1441 ttgtgtgtac tcagagtgta ttttctttgt gtagaacaga atgtacacat tatagcagct
     1501 cgccattgtg tttgcatttt ttaagaagta catttttaac tttgtataca caagaaatgt
     1561 catatttttg agttttgtaa tggaagaacc aggcacagaa acagacagaa atgatactgt
     1621 atgtgtgtgt atttatgtct gaagaaagtc cccttgaatt ctgatatctc tttgaatcta
     1681 agagatcctg atagcttcat gtttaagagc attgacaggt ggggcacctc tgaggggagt
     1741 tcattgtttc tcatgcatca tttgccatat actattaatc aaagtgcttg ctttcagtcc
     1801 tttgagggga cagataatct gaaggccaga gattagagat ttcactgata ttttggacat
     1861 acataagaaa catcattata attaataaaa agtaggtaat agcatataaa tggttcttga
     1921 cattttaaaa gcctggttat gatcagttga cactttgagt acccccctaa atagctggac
     1981 tttccttttc atttcatatt tggaactaag tttgtagcgt atactcatct ttcagaagtt
     2041 tggtaaacat tgggattgtc cctgcatctg aacatctttc ccagtgctat cagtatacat
     2101 ctagagagga aatgcaatgt gacagtgtta catttggaga gaagtgtgaa atctaaccaa
     2161 tcgctagcac atatttgttg taatacggtg gtttatttca tgtttgcata ctataaaatc
     2221 tgaattgatg tgaaatatct gtgcctttaa atttcttaaa cctttaagct ttttgttctg
     2281 ttttgcaaca ttttgtagta tttcttccct tccttagcac aaaatactgg tttctaagtg
     2341 gttttgcttc aaaggatgtc tagatgtaag tgattccact taaagccaaa ataaaaattc
     2401 ctaaagcagt tcttaaagga gttagagagc tatattaaac agtttttctg tggtataata
     2461 atgtgtctct tactagaagt cccccacgac caagttaaag atacttttcc tgttggattc
     2521 tcttttacaa ataagtctaa atgactgata atagaagatt gttagtcttg cttgatggta
     2581 aagtcttgga ttattctgat atatagacgt gcattgtttt gtaacttagt tacttttcag
     2641 ataggtctgt gttaactttt gaacatgtgt aacttaacct aaatactccc aaactttacc
     2701 tctaaatttt tgtttttatg ttgtgaatgt gctaatatgt gcatcaactg taaagatgta
     2761 tcagttttat taaaatcagt tgacaattag aataataaag tggataaagg caaattaaga
     2821 tataggacca aaacagaata ttgtagatgg cagttatgaa tgtatattta tattttgatt
     2881 aagatttcta ttaacttttt ggctgggcag agtggcttac acctataatc ccagcaattt
     2941 gggaggccaa ggtgggcaga tcacttgagg tcaggagttc gcgaccagcc tacccaacat
     3001 ggtgaaaccc catctcttct aaaaatacaa acattagccg ggcgtggtgg cacattcctg
     3061 taatcccagc tactcgggag gctgaggcag gagattcgcc tgaacccggg aggcagaggt
     3121 tgcagtgagc cgagattgtg ccactgcact ccagcctagg cgacagagtg agactccatc
     3181 tcaaattgga aaaaaaaaaa attatatgaa cttttgctat taatgtttat ttgtaggcta
     3241 tttatatcac ttcataaaga acagttcttt gagaaaagaa taaaggaatg tattcatttc
     3301 cagaaaaaga gggttgggga aagtttgcca tgtaggttag tcagaagaaa gcaattctat
     3361 tatgcataaa aataacctta aatatgtaag agagtatctc ctctacttaa aagttattat
     3421 agtagtcaca ggcatacaga ccacaggaat tctatggtct taacatattt taaaattaca
     3481 tttattttaa tgttcttaaa gtttatgaag aggagtttaa agcaattccc ataattaaat
     3541 atttactcgg caactaaaaa ctatttaaca cttgtggtta attatacaca taaacaaatg
     3601 gcgacagagt agcctcacta ccacaattac ttcatggtta cacctttgct ttctaataat
     3661 aggggctcca gttgctaaat atatttgttt acttacagtt taagttgagc tgattgttga
     3721 attctgttat tgttcctgaa ttcaatgagt atataatttg tagagatgtt gaatagtttg
     3781 gatcttagtt tttaaggctg aaaaatctgg ctggatttag tttttaaaaa tttgcatcat
     3841 caagaatatt gcagttaatg ttcctttttt ttttttttta aagacagagt ctcactctgt
     3901 cacccaggct ggagtgtaca gtggtgtgat tttggctcat tgcaacctca acctctgcct
     3961 cctgggttca agcaattctt gtgcctcagc ctcccaagta gctgggacta taggcatgtg
     4021 ccaccatgcc cggctaattt ttgtattttt agtagagatg gggtttcacc atcttggcca
     4081 gtctgatctc gtactcctgg cctcaagtga tccaccagcc tcagcctccc aaagtgctgg
     4141 gattacagac gtgagccacc gtgcccagcc aggtttcctt ctttaccttc taagaaacat
     4201 ttaaacataa tgtgcctgag aaggttaatt tgttgactct gtagcatgtc aagaagagta
     4261 gttttttgag atctggcaag aatattttag agatacatat tcttttctaa gtatgttatc
     4321 accctgtggt gttgagcata tcgtcccaaa aacctgcttc agcaagcagt tcttggccag
     4381 gcatggtggc tcacacctgt aatcccagca ctttgggagg ccgaggcagg tggatcacga
     4441 ggtcaggagt tcaagaccag cctggccaag atggtgaaac cccatctcta ctaaaaatac
     4501 aaaaattagc cgggcgtgga ggtgggcgcc tgtcagctac tcgtgaggct gaggcagaga
     4561 attacttgaa ctcaggaggt ggaggttttg gtgagctgag atggcgccac tgcactccaa
     4621 cccgagcgac agagcaagat tccgtcccaa aaagaaaaag cagtttttgc catcagcaag
     4681 gatatctcct ccactttaat ggacaggcct catttttggc agctatgctg tttgagatgt
     4741 agactgaata tccaaggttc ctccctagct caagttttta cttgtgatta cacacaccac
     4801 attgaattcc gtcttcagag gcaaagattt gggcttcata tctcaacagc aaaagggcct
     4861 gttcagcaat tcccttcatt ttagactcat atgacctcag cgattgcatg atagtagtaa
     4921 actagtctcc tggaaataat ggatgtaggt gcttctagaa tatgttacag aatttcagac
     4981 ttaacctatt aatagataaa tggatcttga cttaaggtga caaaatgaaa cttttattat
     5041 tgcttaaaaa tgctgtgcca atattgtata actagctcct ctaatacttt tggtattttg
     5101 gatttaataa taagacctta agcattttaa atgtgaacat gttcagggaa gtatgctttg
     5161 atgtaaatgt ctcagatcta agttgtaaca caattgaata cttgtggctt attcttggtt
     5221 taacttagga aaactggtta aacaatcccc catttgggcc tgtcatcatt ttaatagtga
     5281 cgatgttctt tctgaaatct tcagggtcgg agtcaggctg aattttttta aaaattaaat
     5341 attatgttca aattctttcc tttttgccat tgtgaaaaag caaaatttta aatgatttct
     5401 cctgttagaa tttttaaaaa tacccacagg ttggaccatc tttcttatgg gttgcacaat
     5461 gaatttatat tttaaattag attaagtaga atgtgaagta catttcagat ttactagttt
     5521 tctttccatt gttcattttg ggttgcctca gattcagtgt atattttaaa atattggtta
     5581 cataataggt actcaatgaa atggtttata gtagaatatc taagctagca ctttatttta
     5641 aaaagtaact tattaattaa tcacacattg atggtacacc ttgtatttag caaatgtttg
     5701 catgttgata aaatctccta tgtcttcttt cttaaatcca gttgctgatt ttgtaaaata
     5761 cagttgtgat aaagcagcat tacggggggg aaaaagctat attccaactg gtgttaaatg
     5821 tattcaacaa aatcttacat catacagtat ttatttctta attaatagaa cttcagtgat
     5881 atacttggta gatatctcaa gccttttgtc ttttacacaa tggtgctcta tcctattgtt
     5941 ttcttttcaa agaagcatct gaacacttgc atttctattt tcctatccaa aggcatccac
     6001 atctaagtgt gtttttaaag ttgattaaaa ttatttttct gttaaagcat tctgaaagtg
     6061 tttgtcttta cctagaatga tttgtacaca ctcgtggtca actgaacatg aatgtcagta
     6121 gtagtctaat tatgggaagg gtaaacgtgt tagattaagg ctcttaaagc tctaaaccat
     6181 ataaactatg gacttgtatc atgatttaac tgttcttaga tctttcttac acagtgattc
     6241 attcctctat ttgtacagtg gctttatgaa atgttgtgaa ttgatactgt aatcaataaa
     6301 gtgcttttaa ccaga
//
