LOCUS       NM_005273               1664 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein subunit beta 2 (GNB2), mRNA.
ACCESSION   NM_005273
VERSION     NM_005273.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1664)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1664)
  AUTHORS   Zhang,L., Sahar,A.M., Li,C., Chaudhary,A., Yousaf,I., Saeedah,M.A.,
            Mubarak,A., Haris,M., Nawaz,M., Reem,M.A., Ramadan,F.A.,
            Mostafa,A.A.M., Feng,W. and Hameed,Y.
  TITLE     A detailed multi-omics analysis of GNB2 gene in human cancers
  JOURNAL   Braz J Biol 84, e260169 (2022)
   PUBMED   35730811
  REMARK    GeneRIF: A detailed multi-omics analysis of GNB2 gene in human
            cancers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1664)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   4  (bases 1 to 1664)
  AUTHORS   Fjaer,R., Marciniak,K., Sundnes,O., Hjorthaug,H., Sheng,Y.,
            Hammarstrom,C., Sitek,J.C., Vigeland,M.D., Backe,P.H., Oye,A.M.,
            Fosse,J.H., Stav-Noraas,T.E., Uchiyama,Y., Matsumoto,N., Comi,A.,
            Pevsner,J., Haraldsen,G. and Selmer,K.K.
  TITLE     A novel somatic mutation in GNB2 provides new insights to the
            pathogenesis of Sturge-Weber syndrome
  JOURNAL   Hum Mol Genet 30 (21), 1919-1931 (2021)
   PUBMED   34124757
  REMARK    GeneRIF: A novel somatic mutation in GNB2 provides new insights to
            the pathogenesis of Sturge-Weber syndrome.
REFERENCE   5  (bases 1 to 1664)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1664)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   7  (bases 1 to 1664)
  AUTHORS   Lovett,M., Kere,J. and Hinton,L.M.
  TITLE     Direct selection: a method for the isolation of cDNAs encoded by
            large genomic regions
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9628-9632 (1991)
   PUBMED   1946378
REFERENCE   8  (bases 1 to 1664)
  AUTHORS   Blatt,C., Eversole-Cire,P., Cohn,V.H., Zollman,S., Fournier,R.E.,
            Mohandas,L.T., Nesbitt,M., Lugo,T., Jones,D.T., Reed,R.R. et al.
  TITLE     Chromosomal localization of genes encoding guanine
            nucleotide-binding protein subunits in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 85 (20), 7642-7646 (1988)
   PUBMED   2902634
REFERENCE   9  (bases 1 to 1664)
  AUTHORS   Gao,B., Gilman,A.G. and Robishaw,J.D.
  TITLE     A second form of the beta subunit of signal-transducing G proteins
  JOURNAL   Proc Natl Acad Sci U S A 84 (17), 6122-6125 (1987)
   PUBMED   3114742
REFERENCE   10 (bases 1 to 1664)
  AUTHORS   Fong,H.K., Amatruda,T.T. 3rd, Birren,B.W. and Simon,M.I.
  TITLE     Distinct forms of the beta subunit of GTP-binding regulatory
            proteins identified by molecular cloning
  JOURNAL   Proc Natl Acad Sci U S A 84 (11), 3792-3796 (1987)
   PUBMED   3108879
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM763069.1, AL535249.3,
            CV569909.1, AK291592.1 and BC012348.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005273.3.
            
            Summary: Heterotrimeric guanine nucleotide-binding proteins (G
            proteins), which integrate signals between receptors and effector
            proteins, are composed of an alpha, a beta, and a gamma subunit.
            These subunits are encoded by families of related genes. This gene
            encodes a beta subunit. Beta subunits are important regulators of
            alpha subunits, as well as of certain signal transduction receptors
            and effectors. This gene contains a trinucleotide (CCG) repeat
            length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012348.1, SRR1163655.99858.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303210.9/ ENSP00000305260.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BM763069.1         1-11
            12-158              AL535249.3         7-153
            159-738             CV569909.1         35-614
            739-1662            AK291592.1         614-1537
            1663-1664           BC012348.1         1648-1649
FEATURES             Location/Qualifiers
     source          1..1664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1664
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /note="G protein subunit beta 2"
                     /db_xref="GeneID:2783"
                     /db_xref="HGNC:HGNC:4398"
                     /db_xref="MIM:139390"
     exon            1..184
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /inference="alignment:Splign:2.1.0"
     exon            185..330
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1296
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /note="G protein, beta-2 subunit; heterotrimeric guanine
                     nucleotide-binding protein 2C1; guanine nucleotide-binding
                     protein G(I)/G(S)/G(T) beta subunit 2; signal-transducing
                     guanine nucleotide-binding regulatory protein beta
                     subunit; transducin beta chain 2; g protein subunit
                     beta-2; guanine nucleotide binding protein (G protein),
                     beta polypeptide 2; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(T) subunit beta-2"
                     /protein_id="NP_005264.2"
                     /db_xref="CCDS:CCDS5703.1"
                     /db_xref="GeneID:2783"
                     /db_xref="HGNC:HGNC:4398"
                     /db_xref="MIM:139390"
                     /translation="MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQ
                     MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT
                     CAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS
                     SGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMC
                     RQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSV
                     AFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS
                     FLKIWN"
     exon            331..369
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /inference="alignment:Splign:2.1.0"
     exon            370..476
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /inference="alignment:Splign:2.1.0"
     exon            477..540
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /inference="alignment:Splign:2.1.0"
     exon            541..703
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /inference="alignment:Splign:2.1.0"
     exon            704..770
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /inference="alignment:Splign:2.1.0"
     exon            771..972
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1189
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1664
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1638..1643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /note="hexamer: CATAAA"
     polyA_site      1664
                     /gene="GNB2"
                     /gene_synonym="HG2C1; NEDHYDF; SSS4"
                     /note="major polyA site"
ORIGIN      
        1 actggcgggc gggatccctc cgctctgggg aggcagcgct ggcggcgggg ctggggccac
       61 tgaggaaatc catccgcgcc gccgccgccg ccgccgccgc cgccgccgcc gcctccgccg
      121 cggaggaaga cagcgccgcc cgcgcaccgc cagcgacctc cgccgcagag tcccaccgcc
      181 acaggcctcg ggccagcggc caggagctgc ctcccccagc ccccgtcccg cggcccccag
      241 ccgcccccaa ccctgcccca cgggcccggc gccatgagtg agctggagca actgagacag
      301 gaggccgagc agctccggaa ccagatccgg gatgcccgaa aagcatgtgg ggactcaaca
      361 ctgacccaga tcacagctgg gctggaccca gtggggagaa tccagatgag gacccggagg
      421 accctccgtg ggcacctggc aaagatctat gccatgcact gggggaccga ctcaaggctg
      481 ctggtcagcg cctcccagga tgggaagctc atcatctggg acagctacac caccaacaag
      541 gtccacgcca tcccgctgcg ctcctcctgg gtaatgacct gtgcctacgc gccctcaggg
      601 aactttgtgg cctgtggggg gttggacaac atctgctcca tctacagcct caagacccgc
      661 gagggcaacg tcagggtcag ccgggagctg cctggccaca ctgggtacct gtcgtgttgc
      721 cgcttcctgg atgacaacca aatcatcacc agctctgggg ataccacctg tgccctgtgg
      781 gacattgaga caggccagca gacagtgggt tttgctggac acagtgggga tgtgatgtcc
      841 ctgtccctgg cccccgatgg ccgcacgttt gtgtcaggcg cctgtgatgc ctctatcaag
      901 ctgtgggacg tgcgggattc catgtgccga cagaccttca tcggccatga atccgacatc
      961 aatgcagtgg ctttcttccc caacggctac gccttcacca ccggctctga cgacgccacg
     1021 tgccgcctct tcgacctgcg ggccgatcag gagctcctca tgtactccca tgacaacatc
     1081 atctgtggca tcacctctgt tgccttctcg cgcagcggac ggctgctgct cgctggctac
     1141 gacgacttca actgcaacat ctgggatgcc atgaagggcg accgtgcagg agtcctcgct
     1201 ggccacgaca accgcgtgag ctgcctcggg gtcaccgacg atggcatggc tgtggccacg
     1261 ggctcctggg actccttcct caagatctgg aactaatggc cccaccccca ctgggcccag
     1321 gccaggaggg gccctgccca tgcccacact acaggccagg gctgcggggc tggcgcaatc
     1381 ccagccccct tccccgggcc acggggcctt gggtccctgc cctcccaccc aggtttggtt
     1441 cctcccgggg cccccactgt ggagataaga aggggatgga atgggggaag aggaggagca
     1501 ggaggccctc atccttctgc tgccctgggg ttggggcctc acccctctgg agggccggag
     1561 gcaggaggtg gaaaccccag gggctggctt ttttaaaact ggttttattt taatttttat
     1621 tatattttca gtttttccat aaaggagcca attccaactc tgta
//
