LOCUS       NM_053004               6642 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens G protein subunit beta 1 like (GNB1L), mRNA.
ACCESSION   NM_053004 NM_021169 NM_022446
VERSION     NM_053004.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6642)
  AUTHORS   Huang,M., Yao,F., Nie,L., Wang,C., Su,D., Zhang,H., Li,S., Tang,M.,
            Feng,X., Yu,B., Chen,Z., Wang,S., Yin,L., Mou,L., Hart,T. and
            Chen,J.
  TITLE     FACS-based genome-wide CRISPR screens define key regulators of DNA
            damage signaling pathways
  JOURNAL   Mol Cell 83 (15), 2810-2828 (2023)
   PUBMED   37541219
REFERENCE   2  (bases 1 to 6642)
  AUTHORS   Wang,Y.Y., Hsu,S.H., Tsai,H.Y. and Cheng,M.C.
  TITLE     Sequencing of the coding regions of GNBIL on chromosome 22q11.2 as
            a risk gene of schizophrenia
  JOURNAL   Psychiatry Res 300, 113943 (2021)
   PUBMED   33932639
  REMARK    GeneRIF: Sequencing of the coding regions of GNBIL on chromosome
            22q11.2 as a risk gene of schizophrenia.
REFERENCE   3  (bases 1 to 6642)
  AUTHORS   Sun,Y., Tao,Y., Wang,J. and Saffen,D.
  TITLE     The schizophrenia/bipolar disorder candidate gene GNB1L is
            regulated in human temporal cortex by a cis-acting element located
            within the 3'-region
  JOURNAL   Neurosci Bull 31 (1), 43-52 (2015)
   PUBMED   24831436
  REMARK    GeneRIF: mRNA expression results implies that the GNB1L
            high-expression allele is the risk allele for schizophrenia and
            bipolar disorder in the Han Chinese population.
REFERENCE   4  (bases 1 to 6642)
  AUTHORS   Li,Y., Zhao,Q., Wang,T., Liu,J., Li,J., Li,T., Zeng,Z., Feng,G.,
            He,L. and Shi,Y.
  TITLE     Association study between GNB1L and three major mental disorders in
            Chinese Han populations
  JOURNAL   Psychiatry Res 187 (3), 457-459 (2011)
   PUBMED   20538345
  REMARK    GeneRIF: The results of this study suggested that GNB1L is linked
            with bipolar disorder and schizophrenia and not with major
            depressive disorder.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 6642)
  AUTHORS   Dorr,M., Schmidt,C.O., Spielhagen,T., Bornhorst,A., Hentschel,K.,
            Franz,C., Empen,K., Kocher,T., Diehl,S.R., Kroemer,H.K., Volzke,H.,
            Ewert,R., Felix,S.B. and Rosskopf,D.
  TITLE     beta-blocker therapy and heart rate control during exercise testing
            in the general population: role of a common G-protein beta-3
            subunit variant
  JOURNAL   Pharmacogenomics 11 (9), 1209-1221 (2010)
   PUBMED   20860462
  REMARK    GeneRIF: Beta-blocker therapy and heart rate control during
            exercise testing in the general population: role of GNB1L variant.
REFERENCE   6  (bases 1 to 6642)
  AUTHORS   Sarbassov,D.D., Ali,S.M., Kim,D.H., Guertin,D.A., Latek,R.R.,
            Erdjument-Bromage,H., Tempst,P. and Sabatini,D.M.
  TITLE     Rictor, a novel binding partner of mTOR, defines a
            rapamycin-insensitive and raptor-independent pathway that regulates
            the cytoskeleton
  JOURNAL   Curr Biol 14 (14), 1296-1302 (2004)
   PUBMED   15268862
REFERENCE   7  (bases 1 to 6642)
  AUTHORS   Funke,B., Pandita,R.K. and Morrow,B.E.
  TITLE     Isolation and characterization of a novel gene containing WD40
            repeats from the region deleted in velo-cardio-facial/DiGeorge
            syndrome on chromosome 22q11
  JOURNAL   Genomics 73 (3), 264-271 (2001)
   PUBMED   11350118
REFERENCE   8  (bases 1 to 6642)
  AUTHORS   Hirosawa,M., Nagase,T., Murahashi,Y., Kikuno,R. and Ohara,O.
  TITLE     Identification of novel transcribed sequences on human chromosome
            22 by expressed sequence tag mapping
  JOURNAL   DNA Res 8 (1), 1-9 (2001)
   PUBMED   11258795
REFERENCE   9  (bases 1 to 6642)
  AUTHORS   Gong,L., Liu,M., Jen,J. and Yeh,E.T.
  TITLE     GNB1L, a gene deleted in the critical region for DiGeorge syndrome
            on 22q11, encodes a G-protein beta-subunit-like polypeptide
  JOURNAL   Biochim Biophys Acta 1494 (1-2), 185-188 (2000)
   PUBMED   11072084
REFERENCE   10 (bases 1 to 6642)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY007378.1, CA425124.1, AC000089.1 and AC000091.1.
            
            On Nov 22, 2018 this sequence version replaced NM_053004.2.
            
            Summary: This gene encodes a G-protein beta-subunit-like
            polypeptide which is a member of the WD repeat protein family. WD
            repeats are minimally conserved regions of approximately 40 amino
            acids typically bracketed by gly-his and trp-asp (GH-WD), which may
            facilitate formation of heterotrimeric or multiprotein complexes.
            Members of this family are involved in a variety of cellular
            processes, including cell cycle progression, signal transduction,
            apoptosis, and gene regulation. This protein contains 6 WD repeats
            and is highly expressed in the heart. The gene maps to the region
            on chromosome 22q11, which is deleted in DiGeorge syndrome,
            trisomic in derivative 22 syndrome and tetrasomic in cat-eye
            syndrome. Therefore, this gene may contribute to the etiology of
            those disorders. Transcripts from this gene share exons with some
            transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF301895.1, AY007378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329517.11/ ENSP00000331313.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1442              AY007378.1         66-1507
            1443-1454           CA425124.1         19-30               c
            1455-5514           AC000089.1         847-4906            c
            5515-6642           AC000091.1         43801-44928         c
FEATURES             Location/Qualifiers
     source          1..6642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..6642
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /note="G protein subunit beta 1 like"
                     /db_xref="GeneID:54584"
                     /db_xref="HGNC:HGNC:4397"
                     /db_xref="MIM:610778"
     exon            1..55
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /inference="alignment:Splign:2.1.0"
     exon            56..152
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /inference="alignment:Splign:2.1.0"
     exon            153..300
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1156
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /note="G-protein beta subunit-like protein; guanine
                     nucleotide binding protein beta-subunit-like polypeptide;
                     guanine nucleotide binding protein (G protein), beta
                     polypeptide 1-like; WD repeat-containing protein 14; g
                     protein subunit beta-like protein 1; WD40
                     repeat-containing protein deleted in VCFS"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     beta-like protein 1"
                     /protein_id="NP_443730.1"
                     /db_xref="CCDS:CCDS13768.1"
                     /db_xref="GeneID:54584"
                     /db_xref="HGNC:HGNC:4397"
                     /db_xref="MIM:610778"
                     /translation="MTAPCPPPPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGS
                     QSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRS
                     AVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADA
                     KLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDS
                     QKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHR
                     IRVFHWRTMQPLAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLWSLYPRA"
     exon            301..426
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /inference="alignment:Splign:2.1.0"
     exon            427..589
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /inference="alignment:Splign:2.1.0"
     exon            590..688
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /inference="alignment:Splign:2.1.0"
     exon            689..904
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /inference="alignment:Splign:2.1.0"
     exon            905..6642
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1432..1437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /note="hexamer: AATAAA"
     polyA_site      1450
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /note="major polyA site"
     regulatory      6623..6628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
                     /note="hexamer: AATAAA"
     polyA_site      6642
                     /gene="GNB1L"
                     /gene_synonym="DGCRK3; FKSG1; GY2; WDR14; WDVCF"
ORIGIN      
        1 ctctggacgc tgcgcggcgc tcctaggagc aggcgttccc gactccggca agagggtggc
       61 gcctggactc tcgccctcag agggaggccc gtcccacggt ctgtggctac ggatcccagg
      121 accctcttcg cgggcgattc gcgtagcctc aggtaactgc atcctgccca gcatgacggc
      181 cccctgcccg ccgccacctc cagaccccca gtttgtcctc cgaggcaccc agtcaccggt
      241 gcatgcgctg cacttctgcg aaggagccca ggctcagggg cgcccgctcc tcttctcagg
      301 gtctcagagt ggcctggtac acatctggag cctgcagacg cggagagcgg ttaccaccct
      361 ggatggccac ggcggccagt gtgtgacctg gctgcagacg ctgccccagg ggcgccagct
      421 cctcagtcag ggccgggacc tgaagctgtg cctgtgggac ctcgcggagg gcaggagcgc
      481 tgtcgtggac tccgtgtgct tggagagtgt gggcttctgc cggagcagca tcctggccgg
      541 gggccagcca cgctggacgc ttgccgtgcc agggaggggc agcgacgagg ttcagattct
      601 ggagatgccc tccaagacgt cagtgtgcgc cctgaagccg aaggcagatg ccaagctggg
      661 catgcccatg tgcctgcggc tgtggcaggc cgactgcagc tcccgcccac tccttctggc
      721 cggctatgag gatggatcgg tggtcctgtg ggacgtctct gagcagaagg tgtgcagccg
      781 catcgcctgc catgaggagc ccgtcatgga ccttgacttt gactcccaga aggccagggg
      841 catctcaggc tccgcgggga aggcgctggc tgtctggagc ctggactggc agcaggccct
      901 gcaggtgcgt gggactcatg aactcaccaa tcccgggatc gccgaggtca cgatccggcc
      961 agatcgcaag atcctggcca ccgcaggctg ggaccaccgc atccgcgtgt tccactggcg
     1021 gacgatgcag ccactggccg tgctggcctt ccacagcgcc gctgtccagt gcgtggcctt
     1081 caccgccgat ggcttgctgg ccgcgggctc caaggatcag cggatcagcc tctggtcact
     1141 ctacccacgc gcatgactca cccactccct tcccgggaga cgaggagggc gggcagggag
     1201 gtgggcatca ggccccagcc ttggcctgaa acctcaaggg cctctgagga ccagcaagtc
     1261 atggcccaag gaccatggag tccccgctgt cttcatgagg ttggtatttc cttttgtgga
     1321 gtgcctcatc acaggacggt gactctgggg gccagccaga gccctggccg tccgaggcct
     1381 gcaggagacg ttggcttggg cctgctgtgt tgccagctga gggtatttta taataaattt
     1441 ccattgccaa gttgcaggct tgaggtggga gctccctgag gaggccctgg tcccccactt
     1501 agcatcagtg ccctcagacc cccaccaggc aggatgctca gccccaccct cacacctgct
     1561 gttgaatggg ccaccccgag tgtgggtttc ctgggccagg cctcaggaga tgataggccc
     1621 caaccatagc tgcgtcgatg tccacatgac ccctcacccc gaggaggcca ggagctccca
     1681 acacacaggt tgaggccagg atcaggatca ggaagtaact gaactcccta aagagtgaag
     1741 cagagaaagg tgcctgtgag ggacggcaag gggggcttgc agcgcacagg gccaggccag
     1801 atgtgggatc cgggagggca cgcctgcccg cagagggtgc agtggggaag gcgcacaggg
     1861 tgcacctcca ggtgagtgct gggcagaagg cacgagagca gcaagggagt gtgacaagca
     1921 ccgcctcaca gtggccaagg ccacagtcac agctgcggct gcacacaggg tggcccccag
     1981 ggcacaacac agcaagagca ggacttagca gccagagcct cacactgcat gcagccgggc
     2041 ccagcctggc cggtcgtctc ctcctaaaag cgggtgttga ttgggaaaga accatgaccc
     2101 tgaatattgg agtggggccc atgggcagat ccagagaagc tgggaccaca cacgcctgtg
     2161 tctgcccgga ttgccggaag agcccctcta gctgaaggcc cggggtggcc tcccttgagg
     2221 cagttgccct gcaaggccct gccgatgctc cttgggaccc ccacctgggc ttctagtcct
     2281 agaactagac tcgagtccag cagaccccca ggatgagata cagagggtga ccctgagagt
     2341 ggcaccagcc tcctgcagga ccacatggca tttccaggtt tccaggcaga aatctgaaca
     2401 tgtgtgggac ggatcggaag ggtgtgggat ccaggtggcc ggagcagggg tggatcaggg
     2461 gagttcccgg aacagacctg ccaaacggag ggctggactg ggcgctgcag cttggggcca
     2521 ggaaggctcc agtgccgggc tgggggtggg ggctggatta cagcctgagg gtggctgcac
     2581 tgagtgaagt ggacatggcc agccgccgtg gggtacagcc gaggagggct tccaaggcct
     2641 ggggatgggg gtgttggatt tgtcagtgag acctgtgcac ccactgcagg gggtcccaag
     2701 gccgtgcctc cccaacccca ctgtgaggaa catggttgct ggggggcccg gagtccttga
     2761 ggagtcctgt gaccacactt ctctgttggt cagaggtacc atggggaccg ttccatcaaa
     2821 cgggaatgtc agtgctggcc gggaaagcgg cccctggccc aagcttggag accacctggc
     2881 tcgggtactg gcctggctcc gttggacaag ggtggccacc aggtgcccag gacctttgga
     2941 gaggggggcc ctgctgcttt tcctcgagtg tcctatagcc gccaggatgc gtagggcact
     3001 ccgggaggta ttttcatatc actgaggtgt cagggagggg aagggtcctg ggtttaggct
     3061 gcagtgactg caggtgctga gggagctgtg ccctgggtgc tcatcacagg ctgtcacagt
     3121 gagggaaggt gtcaggttct gacatcccca tgacagcggc agggtaggtg gagtgggaat
     3181 tggctttgca gtttccctgc atgcccttga cagccttgcc aaaggcacat ctgccccgcc
     3241 tcagctccca ccctgagggt tctgggcctc taccccttcc cctgtttatg tccctgtcat
     3301 ctttggcatc atcactgtag ttacaaaact ccctacgtcc cacagccacg aggtgggtat
     3361 cccacatgag ggcccaggtg tgcatgccag catgaggttg gcgagtggca ctgcctgctg
     3421 atgtcttaca tagaggccat gaagagctgt gggcagggtg tacagaccct gagttggccc
     3481 ctggccctcg tgctttcagt caaaggcaca agcagggtgg atggcaggcg gctgccccct
     3541 agcctggcct tgagctccct gccccaggcc atgtggcgtt gagcagtgtc caggcacatc
     3601 ttgttctgaa tctcagtgtg cagggatgga gtcgggacag cgtgagtcct gcatgcctaa
     3661 cacagccctc acccctccag tgcacaacgg ggccacgtgc ccgcatctgg gtggctaggc
     3721 agatagggcc ccccttgcca ggcagatcca gcttctgagg ccttatagac gtcctgtgga
     3781 gggcaggccc aggactttca ttcacctggc tgagctgcct gggagagcag cagaaccggt
     3841 gctggggtcc aagccggcca agagcagtgc agccctcctg gtcctgttcc tctcttgagc
     3901 tgctccgtgg tgtccacagc agagccatgt ggctctggac aggtcggcct ttgtgtcaac
     3961 agaacctggg tcgtgatgaa tcaccatgcg tctgaccagc cttgaaaccc ccacaacaga
     4021 agaagaaacg gtctcagctc cagacatcca gcttggaaaa gatgcacctg aacattggca
     4081 ttctcttcct agcaaacagc cacttcctgt aggctggcag gaacgccaac agagccagca
     4141 gtgaaggcat taagtgggga ggaggggtgg cccggaggca gcacgcgaag gtcagcatgc
     4201 agctcctggg atgaacctga gaggcgactc ctggcagcat ggctggtcgc tgccatcacg
     4261 cccctggcca acccaccaac tgggagaggc agcccttcca catcttcctc cataatgctc
     4321 ttgggtagca gtgaggcctc tcaagccaga gagaacttgg tgtttggaaa caacggcgga
     4381 catttcttgc cattttcagt gccaactcag gtaggtgtgt tctaccatcc tgtgtttttg
     4441 gggtgttttt ttttttgagt cagagtctca ctctgtcccc caggctggag tgcaatggag
     4501 cagtctcggc tcactgcaac ctctgattcc caggttcaag cgattctcct gcctcagcct
     4561 cccgagaagc tcaggaccac ccacataggt gcaggccatc atgcccagct aattttttat
     4621 ttttttttat agagaaggag tctcgctatg ttgcccaggc tggtttcgaa ctcctgggct
     4681 caagcgatcg atcctcccgc ctctagcctc ccaaagcact agaattatag gcctgagcca
     4741 ctgcgcccgg cccaccatcc tgttcttatt ggaagaattt ccatgtgtcg aggcacgggc
     4801 acaacgtagc tggtcctctg ctcagggccc cacaaggctg cgtcagggtg gcagcgcggc
     4861 tgggggcttt ttctgttcaa atccagattc tcgtggctgt gagccccagc cctgggcact
     4921 gtccgcctgg tggtgtcttc acagccagca ggggtggcct tggggtgttc tgtggagtaa
     4981 ctttcacggc ccagagtggg atcctgagtg gctggagccg tatgctccag catccccagc
     5041 cgctgcctcc ggtgcaggtg gagtgggccc ctctgattac caggagctgt cagaggggca
     5101 gcaggtccca ctccactggc cggtgggcag ctgtgtgcag ggacgcgggt cctggcacgt
     5161 ctgcctggtg aggccctgcc tccagtgcca aggggcctcc cctctcgacg gtgggcgcca
     5221 ccatgtgctg acctctgtgc agccccactt tacaaggtag gttcggccag caccccatcc
     5281 gcgggcgggc agcactcacc cagcgttgcg ccgccaacag ggtccctctt agacaagcag
     5341 ctgtgcctag agccttttcc ttcctccctg cgtgttacct gcaggccaac agacggccct
     5401 gggtctggga ccaggagaac ctgcctccgc ctctggcagt gggtgtccct gcaggcagat
     5461 tgggcttggc acgtagacac cgaggggtca gccgatgccg ggagatgatc ccgggaaggg
     5521 ctccggagca cagcccagga cccgccgccg ctgctgggcg ctccatgttg acgtgctgtg
     5581 cgtgtctcca ctccccaggc aatgatgttc aatcaggtgt ttcccacctg tgtctctgcc
     5641 aagaagccac agaacaccct ctgcacaaaa ggagtgtttg cacaaagaaa aacaaccctc
     5701 cgggggttct ttagaaatgc ttatactcaa ttagctagaa cttcatgtga aatcccagcg
     5761 tggaagacaa caagccggca ccggtgaaaa ctttgctgtg cacctgccct ctaccaagct
     5821 gccagcccca ccagccctgt ggtcctaggt gggcacagct gctgcacggt cccccaggcc
     5881 tgcctctcct cggggtctca accttcatac cagatttgcc agcatcccca ttcccgcctt
     5941 gtgggtggag agtccttgag accctctgtc actctgtcag cttccccagg tcagcgagct
     6001 gtggcttggc tcccacgcat cagcttttat gggaggccca ttaggagctg ggcaggaggg
     6061 acagagggga ggccaggcag ccactgctga gtgggacggg tagcccagcc catgaggctg
     6121 gccagcccta caggggaggt cccacagcac tggccgggaa gtccacatag gaaagcatca
     6181 gttgagggat gaagccacgg acgatgggga caacggccac agggtgtgct aagctgagga
     6241 aattagtagg aggtgctcat aagctgtttt gttttttggt ttgtttgttt gttttttctt
     6301 ttaagagacc agggacagtg ggggtctcac tctgtcaccc aggctggagt gcagtggcat
     6361 gatcatagct tactgcagcc tccaactaat aggctcaagt gatcctcctg cctcagcctc
     6421 ccgagtaact catggccttt aagtgaactg cttccaccat ccagctgtgc aggtggcctg
     6481 ggaacagcag cacatctgtc ccctgccacc tcttgcatgc acacttgacc tcctgacttg
     6541 ggctctgaaa cctgtaaaat gtggggtgta gagaaatcga gtcatttggc ctcatcctgg
     6601 tgccattatc tcttgctaca ttaataaacc acctcaaaca ga
//
