LOCUS       NM_001102386            1239 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein subunit alpha transducin 3 (GNAT3), mRNA.
ACCESSION   NM_001102386 XM_294370
VERSION     NM_001102386.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Zhou,S., Wang,Z., Liu,Z., Mu,G., Xie,Q., Wang,Z., Xiang,Q., Gong,Y.
            and Cui,Y.
  TITLE     Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses
            for Platelet Reactivity and Clinical Outcomes of Repeat
            Revascularization After First PCI in Chinese Patients
  JOURNAL   Cardiovasc Drugs Ther 37 (3), 507-518 (2023)
   PUBMED   34860335
  REMARK    GeneRIF: Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway
            Analyses for Platelet Reactivity and Clinical Outcomes of Repeat
            Revascularization After First PCI in Chinese Patients.
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Wooding,S.P. and Ramirez,V.A.
  TITLE     Worldwide diversity, association potential, and natural selection
            in the superimposed taste genes, CD36 and GNAT3
  JOURNAL   Chem Senses 47 (2022)
   PUBMED   34972209
  REMARK    GeneRIF: Worldwide diversity, association potential, and natural
            selection in the superimposed taste genes, CD36 and GNAT3.
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Le Gleau,L., Rouault,C., Osinski,C., Prifti,E., Soula,H.A.,
            Debedat,J., Busieau,P., Amouyal,C., Clement,K., Andreelli,F.,
            Ribeiro,A. and Serradas,P.
  TITLE     Intestinal alteration of alpha-gustducin and sweet taste signaling
            pathway in metabolic diseases is partly rescued after weight loss
            and diabetes remission
  JOURNAL   Am J Physiol Endocrinol Metab 321 (3), E417-E432 (2021)
   PUBMED   34338041
  REMARK    GeneRIF: Intestinal alteration of alpha-gustducin and sweet taste
            signaling pathway in metabolic diseases is partly rescued after
            weight loss and diabetes remission.
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Esberg,A., Haworth,S., Hasslof,P., Lif Holgerson,P. and
            Johansson,I.
  TITLE     Oral Microbiota Profile Associates with Sugar Intake and Taste
            Preference Genes
  JOURNAL   Nutrients 12 (3), 681 (2020)
   PUBMED   32138214
  REMARK    GeneRIF: Oral Microbiota Profile Associates with Sugar Intake and
            Taste Preference Genes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Tizzano,M., Grigereit,L., Shultz,N., Clary,M.S. and Finger,T.E.
  TITLE     Immunohistochemical Analysis of Human Vallate Taste Buds
  JOURNAL   Chem Senses 40 (9), 655-660 (2015)
   PUBMED   26400924
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Li,X., Staszewski,L., Xu,H., Durick,K., Zoller,M. and Adler,E.
  TITLE     Human receptors for sweet and umami taste
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4692-4696 (2002)
   PUBMED   11917125
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Caricasole,A., Sala,C., Roncarati,R., Formenti,E. and
            Terstappen,G.C.
  TITLE     Cloning and characterization of the human phosphoinositide-specific
            phospholipase C-beta 1 (PLC beta 1)
  JOURNAL   Biochim Biophys Acta 1517 (1), 63-72 (2000)
   PUBMED   11118617
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Wall,M.A., Coleman,D.E., Lee,E., Iniguez-Lluhi,J.A., Posner,B.A.,
            Gilman,A.G. and Sprang,S.R.
  TITLE     The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma
            2
  JOURNAL   Cell 83 (6), 1047-1058 (1995)
   PUBMED   8521505
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Lambright,D.G., Noel,J.P., Hamm,H.E. and Sigler,P.B.
  TITLE     Structural determinants for activation of the alpha-subunit of a
            heterotrimeric G protein
  JOURNAL   Nature 369 (6482), 621-628 (1994)
   PUBMED   8208289
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   Takami,S., Getchell,T.V., McLaughlin,S.K., Margolskee,R.F. and
            Getchell,M.L.
  TITLE     Human taste cells express the G protein alpha-gustducin and
            neuron-specific enolase
  JOURNAL   Brain Res Mol Brain Res 22 (1-4), 193-203 (1994)
   PUBMED   8015379
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073182.4, BC147016.1 and
            AC004862.1.
            
            On May 17, 2019 this sequence version replaced NM_001102386.2.
            
            Summary: Sweet, bitter, and umami tastes are transmitted from taste
            receptors by a specific guanine nucleotide binding protein. The
            protein encoded by this gene is the alpha subunit of this
            heterotrimeric G protein, which is found not only in the oral
            epithelium but also in gut tissues. Variations in this gene have
            been linked to metabolic syndrome. [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2153733
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398291.4/ ENSP00000381339.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC073182.4         18983-19037         c
            56-1148             BC147016.1         1-1093
            1149-1149           AC004862.1         146890-146890       c
            1150-1208           BC147016.1         1095-1153
            1209-1209           AC004862.1         146830-146830       c
            1210-1239           BC147016.1         1155-1184
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.11"
     gene            1..1239
                     /gene="GNAT3"
                     /gene_synonym="GDCA; HG1E"
                     /note="G protein subunit alpha transducin 3"
                     /db_xref="GeneID:346562"
                     /db_xref="HGNC:HGNC:22800"
                     /db_xref="MIM:139395"
     exon            1..256
                     /gene="GNAT3"
                     /gene_synonym="GDCA; HG1E"
                     /inference="alignment:Splign:2.1.0"
     exon            257..299
                     /gene="GNAT3"
                     /gene_synonym="GDCA; HG1E"
                     /inference="alignment:Splign:2.1.0"
     exon            300..441
                     /gene="GNAT3"
                     /gene_synonym="GDCA; HG1E"
                     /inference="alignment:Splign:2.1.0"
     exon            442..599
                     /gene="GNAT3"
                     /gene_synonym="GDCA; HG1E"
                     /inference="alignment:Splign:2.1.0"
     exon            600..728
                     /gene="GNAT3"
                     /gene_synonym="GDCA; HG1E"
                     /inference="alignment:Splign:2.1.0"
     exon            729..858
                     /gene="GNAT3"
                     /gene_synonym="GDCA; HG1E"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1012
                     /gene="GNAT3"
                     /gene_synonym="GDCA; HG1E"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1239
                     /gene="GNAT3"
                     /gene_synonym="GDCA; HG1E"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatcttag agcattaggg aatggactgc taggtacttc agcagagcat tactcttgcc
       61 tcctatgtcc aaaccacagc tgtgctcaac atttgaaaaa tctgaacata taaactgaca
      121 agtatctacc accacaagat gggaagtgga attagttcag agagcaagga gtcagccaaa
      181 agatcaaaag aactggagaa aaagcttcag gaggatgctg agcgagatgc aagaaccgta
      241 aagctgctac tattaggagc aggagaatct gggaaaagta ctattgttaa acaaatgaag
      301 atcatccata agaatggtta cagtgagcaa gaatgcatgg agttcaaagc agtaatttac
      361 agtaatacat tgcaatccat cctagctatt gtgaaagcca tgactaccct tggaattgat
      421 tatgtaaatc ccagaagtgc agaggaccaa cgacaacttt atgcaatggc aaataccctg
      481 gaagatggtg gcatgacacc tcaactggct gaggtaataa aacggctgtg gagagatcca
      541 ggaattcagg cctgctttga aagggcatct gaatatcagc tcaatgactc agcagcttac
      601 taccttaatg atttagatag aataacagca tctgggtatg tgccaaatga acaagatgtt
      661 ctccattctc gagtgaaaac gactggaatc attgaaactc aattctcctt taaagacttg
      721 cacttcagga tgtttgatgt aggtggacag agatctgaga gaaagaagtg gattcactgc
      781 tttgaaggag ttacatgcat tatattttgt gctgcactta gtgcctatga catggtcctc
      841 gtggaagacg aagaagtgaa tagaatgcat gaaagccttc acctgttcaa cagtatctgt
      901 aatcacaagt atttttcaac aacctccatt gtcctgttcc tcaacaaaaa agatatcttt
      961 caagaaaagg taaccaaggt gcatcttagt atctgctttc cagaatacac tgggccaaat
     1021 acatttgaag atgcaggaaa ctacatcaag aaccagtttc tagacctgaa tttaaaaaaa
     1081 gaagataagg aaatttattc ccacatgacc tgtgctactg acacccaaaa tgtcaagttt
     1141 gtgtttgacg cagttacaga tataataatc aaagagaatc taaaagactg tgggcttttc
     1201 taatcaacta ttttctcttc cactcttgct catgtatgc
//
