LOCUS       NM_006496               9044 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens G protein subunit alpha i3 (GNAI3), mRNA.
ACCESSION   NM_006496
VERSION     NM_006496.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9044)
  AUTHORS   Guo,L., Sun,H. and Pu,J.
  TITLE     GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced
            inflammation and osteogenic differentiation in periodontal stem
            cells by mediating the NF-kappaB/NLRP3 inflammasome pathway
  JOURNAL   Arch Oral Biol 163, 105974 (2024)
   PUBMED   38636252
  REMARK    GeneRIF: GNAI3 mediated by Lin28A regulates
            lipopolysaccharide-induced inflammation and osteogenic
            differentiation in periodontal stem cells by mediating the
            NF-kappaB/NLRP3 inflammasome pathway.
REFERENCE   2  (bases 1 to 9044)
  AUTHORS   Duranti,C., Iorio,J., Bagni,G., Chioccioli Altadonna,G.,
            Fillion,T., Lulli,M., D'Alessandro,F.N., Montalbano,A.,
            Lastraioli,E., Fanelli,D., Coppola,S., Schmidt,T., Piazza,F.,
            Becchetti,A. and Arcangeli,A.
  TITLE     Integrins regulate hERG1 dynamics by girdin-dependent Galphai3:
            signaling and modeling in cancer cells
  JOURNAL   Life Sci Alliance 7 (1), e202302135 (2023)
   PUBMED   37923359
  REMARK    GeneRIF: Integrins regulate hERG1 dynamics by girdin-dependent
            Galphai3: signaling and modeling in cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9044)
  AUTHORS   Li,Y., Chai,J.L., Shi,X., Feng,Y., Li,J.J., Zhou,L.N., Cao,C. and
            Li,K.R.
  TITLE     Galphai1/3 mediate Netrin-1-CD146-activated signaling and
            angiogenesis
  JOURNAL   Theranostics 13 (7), 2319-2336 (2023)
   PUBMED   37153740
  REMARK    GeneRIF: Galphai1/3 mediate Netrin-1-CD146-activated signaling and
            angiogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9044)
  AUTHORS   Yanagi,K., Morimoto,N., Iso,M., Abe,Y., Okamura,K., Nakamura,T.,
            Matsubara,Y. and Kaname,T.
  TITLE     A novel missense variant of the GNAI3 gene and recognisable
            morphological characteristics of the mandibula in ARCND1
  JOURNAL   J Hum Genet 66 (10), 1029-1034 (2021)
   PUBMED   33723370
  REMARK    GeneRIF: A novel missense variant of the GNAI3 gene and
            recognisable morphological characteristics of the mandibula in
            ARCND1.
REFERENCE   5  (bases 1 to 9044)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 9044)
  AUTHORS   Jiang,M., Pandey,S., Tran,V.T. and Fong,H.K.
  TITLE     Guanine nucleotide-binding regulatory proteins in retinal pigment
            epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3907-3911 (1991)
   PUBMED   1902575
REFERENCE   7  (bases 1 to 9044)
  AUTHORS   Carty,D.J., Padrell,E., Codina,J., Birnbaumer,L., Hildebrandt,J.D.
            and Iyengar,R.
  TITLE     Distinct guanine nucleotide binding and release properties of the
            three Gi proteins
  JOURNAL   J Biol Chem 265 (11), 6268-6273 (1990)
   PUBMED   2108158
REFERENCE   8  (bases 1 to 9044)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
REFERENCE   9  (bases 1 to 9044)
  AUTHORS   Codina,J., Olate,J., Abramowitz,J., Mattera,R., Cook,R.G. and
            Birnbaumer,L.
  TITLE     Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G
            protein of receptor-regulated K+ channels
  JOURNAL   J Biol Chem 263 (14), 6746-6750 (1988)
   PUBMED   2452165
REFERENCE   10 (bases 1 to 9044)
  AUTHORS   Suki,W.N., Abramowitz,J., Mattera,R., Codina,J. and Birnbaumer,L.
  TITLE     The human genome encodes at least three non-allellic G proteins
            with alpha i-type subunits
  JOURNAL   FEBS Lett 220 (1), 187-192 (1987)
   PUBMED   2440724
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355310.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 24, 2019 this sequence version replaced NM_006496.3.
            
            Summary: Guanine nucleotide-binding proteins (G proteins) are
            involved as modulators or transducers in various transmembrane
            signaling pathways. G proteins are composed of 3 units: alpha, beta
            and gamma. This gene encodes an alpha subunit and belongs to the
            G-alpha family. Mutation in this gene, resulting in a gly40-to-arg
            substitution, is associated with auriculocondylar syndrome, and
            shown to affect downstream targets in the G protein-coupled
            endothelin receptor pathway. [provided by RefSeq, Jun 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.156507.1,
                                           SRR1803617.43796.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369851.7/ ENSP00000358867.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AL355310.20        9668-9891
            225-267             AL355310.20        34790-34832
            268-409             AL355310.20        34949-35090
            410-567             AL355310.20        40257-40414
            568-696             AL355310.20        43490-43618
            697-826             AL355310.20        47269-47398
            827-980             AL355310.20        47782-47935
            981-1193            AL355310.20        53096-53308
            1194-9044           AL355310.20        53398-61248
FEATURES             Location/Qualifiers
     source          1..9044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..9044
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /note="G protein subunit alpha i3"
                     /db_xref="GeneID:2773"
                     /db_xref="HGNC:HGNC:4387"
                     /db_xref="MIM:139370"
     exon            1..224
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1171
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /note="guanine nucleotide-binding protein G(k) subunit
                     alpha; g(i) alpha-3; guanine nucleotide binding protein (G
                     protein), alpha inhibiting activity polypeptide 3; guanine
                     nucleotide-binding protein G(i) subunit alpha;
                     heterotrimeric guanine nucleotide-binding protein 1A"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(i) subunit
                     alpha-3"
                     /protein_id="NP_006487.1"
                     /db_xref="CCDS:CCDS802.1"
                     /db_xref="GeneID:2773"
                     /db_xref="HGNC:HGNC:4387"
                     /db_xref="MIM:139370"
                     /translation="MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGES
                     GKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARAD
                     DARQLFVLAGSAEEGVMTPELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLD
                     RISQSNYIPTQQDVLRTRVKTTGIVETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGV
                     TAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEE
                     KIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQF
                     VFDAVTDVIIKNNLKECGLY"
     exon            225..267
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /inference="alignment:Splign:2.1.0"
     exon            268..409
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /inference="alignment:Splign:2.1.0"
     exon            410..567
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /inference="alignment:Splign:2.1.0"
     exon            568..696
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /inference="alignment:Splign:2.1.0"
     exon            697..826
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /inference="alignment:Splign:2.1.0"
     exon            827..980
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1193
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..9044
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2339..2344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /note="hexamer: ATTAAA"
     polyA_site      2358
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /note="major polyA site"
     regulatory      3180..3185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /note="hexamer: AATAAT"
     polyA_site      3210
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
     polyA_site      4409
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
     regulatory      4638..4643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /note="hexamer: ATTAAA"
     polyA_site      4656
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
     regulatory      6935..6940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /note="hexamer: ATTAAA"
     polyA_site      6955
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
     regulatory      9011..9016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
                     /note="hexamer: AATAAA"
     polyA_site      9044
                     /gene="GNAI3"
                     /gene_synonym="87U6; ARCND1; ARCODS; HG1A"
ORIGIN      
        1 gacggagagg gccaccgccc agcaatagac ggtgcctcag cctgccgagc cgcagtttcc
       61 gtggtgtgag tgagtccggg cccgtgtccc ctctcccgcc gccgccatgg gctgcacgtt
      121 gagcgccgaa gacaaggcgg cagtggagcg aagcaagatg atcgaccgca acttacggga
      181 ggacggggaa aaagcggcca aagaagtgaa gctgctgcta ctcggtgctg gagaatctgg
      241 taaaagcacc attgtgaaac agatgaaaat cattcatgag gatggctatt cagaggatga
      301 atgtaaacaa tataaagtag ttgtctacag caatactata cagtccatca ttgcaatcat
      361 aagagccatg ggacggctaa agattgactt tggggaagct gccagggcag atgatgcccg
      421 gcaattattt gttttagctg gcagtgctga agaaggagtc atgactccag aactagcagg
      481 agtgattaaa cggttatggc gagatggtgg ggtacaagct tgcttcagca gatccaggga
      541 atatcagctc aatgattctg cttcatatta tctaaatgat ctggatagaa tatcccagtc
      601 taactacatt ccaactcagc aagatgttct tcggacgaga gtgaagacca caggcattgt
      661 agaaacacat ttcaccttca aagacctata cttcaagatg tttgatgtag gtggccaaag
      721 atcagaacga aaaaagtgga ttcactgttt tgagggagtg acagcaatta tcttctgtgt
      781 ggccctcagt gattatgacc ttgttctggc tgaggacgag gagatgaacc gaatgcatga
      841 aagcatgaaa ctgtttgaca gcatttgtaa taacaaatgg tttacagaaa cttcaatcat
      901 tctcttcctt aacaagaaag acctttttga ggaaaaaata aagaggagtc cgttaactat
      961 ctgttatcca gaatacacag gttccaatac atatgaagag gcagctgcct atattcaatg
     1021 ccagtttgaa gatctgaaca gaagaaaaga taccaaggag atctatactc acttcacctg
     1081 tgccacagac acgaagaatg tgcagtttgt ttttgatgct gttacagatg tcatcattaa
     1141 aaacaactta aaggaatgtg gactttattg agaagcatgg atgttagtga aagttactac
     1201 agtgtggagt gttgagacca gacacctttt gctgtctcat ggggcagcta caagcatgaa
     1261 cgggaccagg gaatggcagc agcatgcaga atcttagcac tctttagcac aatattttgt
     1321 attagggaac ttttaattga catgagatgc taaagtcaga cattggaatt ggaagaacta
     1381 taaagtgtga ttcgatcgtc aagacatcac ttggatttct taatcttaaa tgcttatgga
     1441 agatgtgaag ttgaggtgct gcattctaga acttcaatat gtagcttact ctttttttcc
     1501 ccccttctta aaccaccagt ggttcatttt taaggttttt tcatcaagag aagaataact
     1561 ttactaaatt ttatttcttt atttgcaaaa gaatctttat taaaacaaac aatcttaact
     1621 atgcacatga tgtgaccaga tcatcttgaa aatattcctc tttagtagga actctttgtt
     1681 tttaactctt ggtatggtca gaatataata cttccataat tacttataat tctttccggt
     1741 tactggggct ataaatacaa ctttttaaat gaaatttatg ttattatcct gctcaaagta
     1801 ccattatggt ttccatatgg taattacatt ggaaagttct gcaataagat tctagttctc
     1861 tcttttcttt aagcttatgg ttgaaggtta accttgtttg tgcagattac caaattactg
     1921 ctgatgtagt atgataaagt cagcttcttg gatacagaca cacccagggc agctgccaat
     1981 cagaaatgca aattgctaaa ttccaaacag aaccagtgac tttgctgcta catatttact
     2041 aaattgacca ctttgattct tgcttgtttg tctcagttat agggagtttt gtacatggtg
     2101 cctcttgttt tccatcttca tggccttttc tgttgagaaa catctaaagt gtattaacag
     2161 tgcatgcttt tactttgtaa atgtggtgcc aaatccctgt ttgccatcgt ttttactgta
     2221 ccgatgttaa ctgtagtaat ccttagccag tatgttcttt tgctgaaact gttgcatttt
     2281 gggacttttt tccactttgt catgtgtaca tttttaatct gttatagttg gcggcagtat
     2341 taaaatggtg agtaaagagc ccaggtttgc tcctgtttgt aactagtctt ttctggaaat
     2401 actgtcttct gtttcctttt gcctttgcag aatgtgcttt agcctttgtc tgagaatggg
     2461 tttaggtaga agggtttcct gaaagtctag tcttttggtg taatagtatt gttgaacctt
     2521 aggttttatg ttatatctgc atatgagtga tatgtgatca tgattcattt tgcagattta
     2581 cattttgctt gtgtggaaag ttacgttcac ttcaacctac agaccctttt gtataatgta
     2641 cagcaaatgt cattaaatat tgaatgctct attgggggaa gacaaatgaa gagaatgcat
     2701 tttgagcatt tcaaatcagt agtttgggca gtgccttttg gggtccaatc tttttggatt
     2761 ggattctatt tcatcttttg atgtgacttt tcactagttt acaaaaaaaa ggttggtggt
     2821 caacaaaaaa agcaagtcat agcagttcag tgcctttgtt ggtagttttt aacttttttt
     2881 gtgattcttt ttggaaaatc atagcttaca gatggtataa ctgtattata taatggaatt
     2941 ttctttaggt gtgggaaaac ttgatctgaa agaaaattat cagcttcaat tggcgattga
     3001 ttcagtgccc acaatgtaaa cagggttggt agttgttact cattttgaat ataccttttc
     3061 cttattgtat tctgtaatat aggatcctgg aaatgagacc tggtggaata ttattttcaa
     3121 ctgtagtctt tctatactgt ggactaatga aatggtgttg ttgataatct aaaataacca
     3181 ataatccaaa aaagttcatt ttactttgaa tttgtatttt catttgaata tctatctgat
     3241 atgttaaatt tttagccctt ctgttaaaga aaaatagcag gtccccattt ttctgcctct
     3301 gtaccattta catttgctct ctgtttgtta acatgaagat cactcttatt tcaccatccc
     3361 aaataactta tctaaatgca cattccttga ggacacaggg agacaattta agtcagtagt
     3421 ttttaatatg acttaagtaa aaatcacttg gacccatcta agggattgac ttttggctgg
     3481 tgggctggca atcgattttt tttttttttt tttttttttg agacggagtc tcgctctgtc
     3541 gcccaggctg gagtgcagtg gcgcgatctc ggcttattgc aagctctgcc tcccgggttc
     3601 atgctattct cctgctggga ctaccaggtt cctgccacca cgcccagcta atttttttgt
     3661 atgtcttagt agagacgggg tttaaccgtg ttagccagga tggtcttgat cccctgacct
     3721 cgtgatctgc ctgcctcagc ctcccaaagt gctgggatta caggcgtgag ccaccgcacc
     3781 tggctggcaa tttataattt ttaaaaggtg attctgatta ccagccaggc ttgcaaatca
     3841 ctggtttgta ttgaaataaa agatattttc ttgtagcagg gctaaaatgt gggatgaaac
     3901 attaaatcta ctagcctgaa aaaaaacttt ggcatttgta atcaaagaag ctgaaagttg
     3961 ccttgtgtgt ttcctctgaa gaatgctgga gatttgtgat ggataatgtt tcagaattca
     4021 ggtgcctatg ctttggacca tcaaagaagc cattagtctc tgtgtaaaga agaagtattc
     4081 ttaatggaca gtccccccta accttataaa ttcagctttg caacagattt cacctcctag
     4141 catgaaaatt ccaaaaactt taacaattac tcataagtgg atcttgagat gacattttca
     4201 tcttggacag tttgaattct aaatctctag ttcacagtga atcgtttttt aaatttttac
     4261 tgatggatcg ttatttttca caaggtacta cattcttaca atgtaagact agatggacca
     4321 aaattttaaa aaaaacttct tgccttgttt ttttaatttt catatatatt ctatttgttg
     4381 tatatacaca ttagactatt ttaaaataac agctggtttt tgtaattcat tcattcaccc
     4441 tatattctta tattctgctc attattctct catttatagc tgtgacattc tttggacatt
     4501 acttgcctgg cctgattagt tacttaatat aatttattca tttgcttagc atgtgtgaca
     4561 tagttctgga atttcctgtt gcagaactcc ttgctgtatt gcagtcatat ataaggtaaa
     4621 gtcagtctct tgttcctatt aaaaagctac cattgattat tttccctttt tacatgttca
     4681 aaaaaaaaaa aataagcaac cctctactca tttgtataaa cctaaaacgt cactgttttc
     4741 cttgagcgtt agtacttgtg ggttctttcc ttttcatgtg taatactgat tttaagagca
     4801 atgatcttag tttgccagtg ccaggtaatt attgtgttct actttaggct tcgtagtgca
     4861 aatcagggat ctgacctgga tcagcctcag ctctttacat agctttatga tcatcatatt
     4921 ttgttgtatt gctcccaaca agcacaagag aaaaaggcag gcttcctaga gacctcaagt
     4981 tgaaagttga ttttgctgac aactatcagg gagtaaaaga aagccttttt caggcactgg
     5041 agaactaact ttaatgatga tcaaggtctt tatgccttta tcttttagtt tttaagatca
     5101 tttctctccc tcctttcccc ccagttttct caacatttat gagttagttc tgctgagaac
     5161 aacatacttc agaacatgtc aggatagggc agttttttct tgtttttctt ttttcttttt
     5221 ttgagacagt cttgctctgt tgcccaggct ggagtacagt ggcacgatct ctgctcactg
     5281 caacctttgc ctcttaggtt caagcgattc ttgtgcctca gcctcccaag tagctgtgat
     5341 tacaggcatg tgccaccaca tctggctaac ttttgtattt ctagtagaga cagggtttca
     5401 ccatgttagc caggctggtc tcaaactcct gacctcaagt gatttgcctg ccttggcctc
     5461 ccaaagtgct gagattacag atgtgaacca ctccacccac tcagggcagt tttttttctg
     5521 ataccatatc aggcctaggc ctgggctgac tcaaatcttc tcaggaataa gaggtaagaa
     5581 ggaatgttaa acagcagtag ttacctgggg tacatggtta atttgattta gcagattctt
     5641 tggctaaacc ctagtaaatt aaaatgtctg agccaggtca tgggaatata catgttttta
     5701 atacattcct taggtgattt tgatgtagcc aatctgggcc aacatttggg gacaactgag
     5761 taggacctaa tacaggttga atagccctta tccaaatctc ttgggaccag aagtgtttga
     5821 gagttcagat ttttgtgagg ttttgaaata tttgcattat atacttattg gttcgggatt
     5881 ccaaatccaa aaatctgaaa tccaaaatgc cccagtgtgt gcttcctttg agtgttatgt
     5941 tgttacccaa aaagcttttg attttggagc attttagatt ttggattttc agatttgaaa
     6001 tgctcaatct atattaaaga tcaacacagg ctgagcacag tggctcatgt ctgtaatccc
     6061 agcactttgg gaggccgagg taagcagatc acttgaggtc aggagtttga gaccagcttg
     6121 gccaacatgg tgaaaccccg tctttactaa aaatacaaaa attagccagg catggtggtg
     6181 gatgcctgta atcctagcta ctcgggaggc tgaggcagga gaatcgcttg aacctgggag
     6241 gcagaggttg cagtgagccg agatcgcacc actgaattcc agcctgggcg acagagtgag
     6301 tctgtttttt ttttgttttt ttttaaagtc aacacaaata ttgaaaataa gcaacttcag
     6361 tgcacaaata agctcaaaat cactagtgag tgatctattt tttgccaata agaagtacca
     6421 tttgtacatg acttaaagtg ccttccacca agaaaattat tgaaaactgt tgggtcacat
     6481 aacattccta cactttggat acagagtatt tagttttata caaaattaag acaacaagaa
     6541 acctaggatg tccaaacatt catttcattt attttactgc atttatttat gcagtgaaaa
     6601 ttgaaagata caccaaatta aagataaaac cctgtgacag ataacagtat atgtaataac
     6661 atgaatattt atttacactt ggtagagaaa gcaaagctag ctagctctaa actagaatga
     6721 aagtcgtttt gaaatgggta cgggggtata taaggggaat gattgagtca catgtaaaag
     6781 cctttgtatg cccagtgcta gtgttttcct gaaatctagt gagaatcaca aggtaccaga
     6841 aataatcaaa taataaatat taatacactg ctgggataga agtatctcag tgtaccagca
     6901 ttcactaagc tataaaatct gtgacagcag gaatattaaa ttatgaacaa cctggtttat
     6961 ctgtctcctc ttatctttta cctctcccta cgcccaaaat tctccttagg ttatccagac
     7021 atttttacta agatgcttat ttatatgtaa gagagatttc cagtagatac aacaaaacac
     7081 aagaaatcac ctgttctgtt tattcttgct catgtaggat aaaggtcctg agacctctca
     7141 gaatcttacg aggttggaga gttgtttgga atgctgggtt ctggtcttgt ctctgcttcc
     7201 aaccagctat ggaatcttgt gtattctttc agtcttaaat cactcatctg ttatctaaag
     7261 atggactaaa ttattccttc ctgctgtgat attctgtggt tctcatcaga tagaaataac
     7321 atatttgaaa atgctttgta aatgttatga tactcaggat tatactgcac agaaaaaaaa
     7381 aaatcctaag gcagcaccaa caaaggtatt caacgtagtg ggtggtcttt tacagcatta
     7441 ctttgcccat attcattttg aagacctgaa atgaagttga actataaatt gctctaaaat
     7501 tcgtgaagca gggtgaaaag gtctttgctt tgttttacat ttaaatccag ctgtctattt
     7561 tctgcttata ctagtgcttt ttcatggcaa aaagacagaa aagttccctt ctgcagtctc
     7621 cagtgtcttc tgacctcaca gaaatgtttt catgctttta cctagcagga ccaccagagg
     7681 ctctgtcaca cttgcagtcc ctggcccaac accgaaatcc ttctggaatc tgtgctctgg
     7741 gggctgtgcc gggtagagag ggcagtggga ggtaagagct cttcaccctt caccaccttc
     7801 tccacccagc atggccggca cactttggtc tacggcacat ctccaagtat agagtgggtt
     7861 ttgaatgctg ttatgtctca ccgtggggat gggaaggaat actctgtttt ggactatttg
     7921 gaggtacatg tgagtggatt ttattaccag agtaggaact gtttcaagtt aatgtgtctt
     7981 ttatgttgct tttaagacaa cttttgtgcc gcttttatcc attcttcctt ttatccacag
     8041 aaatacaaat ttctaattat agtatatttt ttctattttt aaaattgtga taaagcatat
     8101 ataacaaaat ttgccatctt aagtgtacag ttcagtggca ttaagtacat tcacactgtt
     8161 gcacagccat caccaccatc catttccaga acttgttttc atcttcctga actgaaactc
     8221 tgtacctgtt aaacagtaac tccccatgcc ccaccttctt tcagcccctg gtaaccagca
     8281 ttttcctttg tctctatgaa tttgactatt ttagatacct catataagtg gaatcatagt
     8341 atttgtcctt ttgtgtcaat catattgtat ttttgtctaa aaaaggaaaa ctatcagatt
     8401 tatgtgaaat gtaacgtaat ttacatttga tttactgtta gtaatgtctc tttaatcatg
     8461 ctatgctagg gaagtacatt atggtctctc cctctaagaa tatgaagagg aaattttacc
     8521 ttcaacaaac aagcaaactt agttatattt ttgtgatttt atgctgtttt catattctat
     8581 tttgagatct atttgtctta gcttggaggt ggttttgtta aatgtccacg atttagagac
     8641 ggcataatga aaaaatgacc aagaatttgg ttgggaatgg gaggagctta gaagaacaag
     8701 aaattggctt tgattttata gtgtatggtg ctctgttggt agctggacat catcacaggc
     8761 tttggattga gaagacctgt tctggagttc tagttctgct actgcctagc gttgtgatct
     8821 tgatgaagat actcttcctt cctgggcttc agtttttgat ctataaattg ctagtgatgg
     8881 ggctggacta tttttaagtt tgttctaact ttagcagtct taagaattaa ggttgcatgc
     8941 cagaaaatag ggttaaatat ttgtttctga tctggttaca aaaaaaaaaa aaacttgatg
     9001 gcttaaagta aataaaaatt caacagtacg gtgtaaattt aaaa
//
