LOCUS       NM_002069              10083 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens G protein subunit alpha i1 (GNAI1), transcript variant
            1, mRNA.
ACCESSION   NM_002069
VERSION     NM_002069.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10083)
  AUTHORS   Ham,D., Shihoya,W., Nureki,O., Inoue,A. and Chung,K.Y.
  TITLE     Molecular mechanism of the endothelin receptor type B interactions
            with Gs, Gi, and Gq
  JOURNAL   Structure 32 (10), 1632-1639 (2024)
   PUBMED   39043181
  REMARK    GeneRIF: Molecular mechanism of the endothelin receptor type B
            interactions with Gs, Gi, and Gq.
REFERENCE   2  (bases 1 to 10083)
  AUTHORS   Hu,X., Chen,F., Jia,L., Long,A., Peng,Y., Li,X., Huang,J., Wei,X.,
            Fang,X., Gao,Z., Zhang,M., Liu,X., Chen,Y.G., Wang,Y., Zhang,H. and
            Wang,Y.
  TITLE     A gut-derived hormone regulates cholesterol metabolism
  JOURNAL   Cell 187 (7), 1685-1700 (2024)
   PUBMED   38503280
REFERENCE   3  (bases 1 to 10083)
  AUTHORS   Yin,D.P., Zhang,H., Teng,H., Zhang,D., Chen,P., Xie,L. and Liu,J.S.
  TITLE     Overexpressed Galphai1 exerts pro-tumorigenic activity in
            nasopharyngeal carcinoma
  JOURNAL   Cell Death Dis 14 (12), 792 (2023)
   PUBMED   38049415
  REMARK    GeneRIF: Overexpressed Galphai1 exerts pro-tumorigenic activity in
            nasopharyngeal carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10083)
  AUTHORS   Zhou,S., Wang,Z., Liu,Z., Mu,G., Xie,Q., Wang,Z., Xiang,Q., Gong,Y.
            and Cui,Y.
  TITLE     Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses
            for Platelet Reactivity and Clinical Outcomes of Repeat
            Revascularization After First PCI in Chinese Patients
  JOURNAL   Cardiovasc Drugs Ther 37 (3), 507-518 (2023)
   PUBMED   34860335
  REMARK    GeneRIF: Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway
            Analyses for Platelet Reactivity and Clinical Outcomes of Repeat
            Revascularization After First PCI in Chinese Patients.
REFERENCE   5  (bases 1 to 10083)
  AUTHORS   Li,Y., Chai,J.L., Shi,X., Feng,Y., Li,J.J., Zhou,L.N., Cao,C. and
            Li,K.R.
  TITLE     Galphai1/3 mediate Netrin-1-CD146-activated signaling and
            angiogenesis
  JOURNAL   Theranostics 13 (7), 2319-2336 (2023)
   PUBMED   37153740
  REMARK    GeneRIF: Galphai1/3 mediate Netrin-1-CD146-activated signaling and
            angiogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10083)
  AUTHORS   Bonkowski,E., Fathi,E. and Mefford,H.C.
  TITLE     GNAI1-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   39083633
REFERENCE   7  (bases 1 to 10083)
  AUTHORS   Gennity,J.M. and Siess,W.
  TITLE     Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of
            a novel soluble Gi-protein in human platelets
  JOURNAL   Biochem J 279 (Pt 3) (Pt 3), 643-650 (1991)
   PUBMED   1953657
REFERENCE   8  (bases 1 to 10083)
  AUTHORS   Jiang,M., Pandey,S., Tran,V.T. and Fong,H.K.
  TITLE     Guanine nucleotide-binding regulatory proteins in retinal pigment
            epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3907-3911 (1991)
   PUBMED   1902575
REFERENCE   9  (bases 1 to 10083)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
REFERENCE   10 (bases 1 to 10083)
  AUTHORS   Suki,W.N., Abramowitz,J., Mattera,R., Codina,J. and Birnbaumer,L.
  TITLE     The human genome encodes at least three non-allellic G proteins
            with alpha i-type subunits
  JOURNAL   FEBS Lett 220 (1), 187-192 (1987)
   PUBMED   2440724
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004159.1 and AC080066.6.
            
            On Nov 22, 2018 this sequence version replaced NM_002069.5.
            
            Summary: Guanine nucleotide binding proteins are heterotrimeric
            signal-transducing molecules consisting of alpha, beta, and gamma
            subunits. The alpha subunit binds guanine nucleotide, can hydrolyze
            GTP, and can interact with other proteins. The protein encoded by
            this gene represents the alpha subunit of an inhibitory complex.
            The encoded protein is part of a complex that responds to
            beta-adrenergic signals by inhibiting adenylate cyclase. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.205066.1,
                                           SRR1660803.118122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649796.2/ ENSP00000497260.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               AC004159.1         62953-63400
            449-491             AC080066.6         11234-11276
            492-633             AC080066.6         11373-11514
            634-791             AC080066.6         21508-21665
            792-920             AC080066.6         25987-26115
            921-1050            AC080066.6         33252-33381
            1051-1204           AC080066.6         34999-35152
            1205-10083          AC080066.6         39586-48464
FEATURES             Location/Qualifiers
     source          1..10083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.11"
     gene            1..10083
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /note="G protein subunit alpha i1"
                     /db_xref="GeneID:2770"
                     /db_xref="HGNC:HGNC:4384"
                     /db_xref="MIM:139310"
     exon            1..448
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /inference="alignment:Splign:2.1.0"
     exon            449..491
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /inference="alignment:Splign:2.1.0"
     exon            492..633
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /inference="alignment:Splign:2.1.0"
     exon            634..791
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /inference="alignment:Splign:2.1.0"
     exon            792..920
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1050
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1204
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..10083
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1919..1924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /note="hexamer: AATAAA"
     polyA_site      1943
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /note="major polyA site"
     regulatory      2082..2087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /note="hexamer: AATAAA"
     polyA_site      2101
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /note="major polyA site"
     regulatory      3281..3286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /note="hexamer: AATAAA"
     polyA_site      3310
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
     regulatory      7302..7307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /note="hexamer: AATAAA"
     polyA_site      7324
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
     regulatory      10061..10066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
                     /note="hexamer: AATAAA"
     polyA_site      10083
                     /gene="GNAI1"
                     /gene_synonym="Gi; HG1B; NEDHISB"
ORIGIN      
        1 gagctcggct gggcttggcg aggctgcggc gcggccaccg gcgggagtgc agcggccact
       61 gtacccagag attcaaaacc ccaaacccgg gacttggggg cgctgagccg ggccgggaag
      121 cagagcctgg tcgtgaggaa cagccgcccg ttgctgtctg cccctttgcg gacagcgtct
      181 ccctcgactc cgcttaggaa gtggtggggg cggcgtggcc cccgtcggga ggcgttcgaa
      241 cgcccgctag gagagagaaa ggattcccct gtgcttggag cccgcactcg ggcgcggagg
      301 gagcggcggc aggctctcgc tttcggcacc atgggctgca cgctgagcgc cgaggacaag
      361 gcggcggtgg agcggagtaa gatgatcgac cgcaacctcc gtgaggacgg cgagaaggcg
      421 gcgcgcgagg tcaagctgct gctgctcggt gctggtgaat ctggtaaaag tacaattgtg
      481 aagcagatga aaattatcca tgaagctggt tattcagaag aggagtgtaa acaatacaaa
      541 gcagtggtct acagtaacac catccagtca attattgcta tcattagggc tatggggagg
      601 ttgaagatag actttggtga ctcagcccgg gcggatgatg cacgccaact ctttgtgcta
      661 gctggagctg ctgaagaagg ctttatgact gcagaacttg ctggagttat aaagagattg
      721 tggaaagata gtggtgtaca agcctgtttc aacagatccc gagagtacca gcttaatgat
      781 tctgcagcat actatttgaa tgacttggac agaatagctc aaccaaatta catcccgact
      841 caacaagatg ttctcagaac tagagtgaaa actacaggaa ttgttgaaac ccattttact
      901 ttcaaagatc ttcattttaa aatgtttgat gtgggaggtc agagatctga gcggaagaag
      961 tggattcatt gcttcgaagg agtgacggcg atcatcttct gtgtagcact gagtgactac
     1021 gacctggttc tagctgaaga tgaagaaatg aaccgaatgc atgaaagcat gaaattgttt
     1081 gacagcatat gtaacaacaa gtggtttaca gatacatcca ttatactttt tctaaacaag
     1141 aaggatctct ttgaagaaaa aatcaaaaag agccctctca ctatatgcta tccagaatat
     1201 gcaggatcaa acacatatga agaggcagct gcatatattc aatgtcagtt tgaagacctc
     1261 aataaaagaa aggacacaaa ggaaatatac acccacttca catgtgccac agatactaag
     1321 aatgtgcagt ttgtttttga tgctgtaaca gatgtcatca taaaaaataa tctaaaagat
     1381 tgtggtctct tttaagtttt gcagttcatg gtaaaatgca ttttcaaacc aaatgagtac
     1441 ttatatatgg atctctgtag actagagtct tgcagcaaca cagaatgtaa tataaggcaa
     1501 atgcatctgg gacttgacca aagttgttct gttttgtttt tttaactgaa agtaacagaa
     1561 ggacctttct taaatgtgac agatggtcct gcagtgtgaa actgaaggac agtgttaaag
     1621 ctgggctcta gtatattgat gatttctgca taagtgtaaa tatgcaaatg tatgtataca
     1681 tgtatttatg actttagttt tcgacattat ttttaggttt taagagtggc aacttaggat
     1741 tttagggtga tggctttgga aataacataa atataccttg tactgaatga cagactatta
     1801 ctacgtttgc cagttttaaa cagctttatt tatgttcatg tcctgtaaat ttttaagtac
     1861 agtaattaat attaggaaac attacagccc ttatctagat tatatgtata cttgtattaa
     1921 taaaaatgtt atttgtacaa acattgcaca gactatttta ataacatgat ttgttcttta
     1981 aattttatgt gttttattga aatgttctta agatgaatac acctgccttt ggatcaacta
     2041 tttaaacatt gtatgcattt tgatttttcc tactttaaga aaataaaata atttaatttt
     2101 acattagatt ccacgttaga tttggtttga aaaactaaaa tttcagattt ctgaggatat
     2161 actgtcttag acttattgta cacacttagt ttttattcac ttgttttcac tctgaatttt
     2221 aatatttggc tgatatgaat gcattgcctc aaaggtgatg tcatcttaat ttttattcac
     2281 tttaaataac tacatttttg tttataacta agtttggagg gatcctaaga gcatttttgt
     2341 gggtaaaaaa aaaacctgtg gacataatga attttgagac attgattggt gaggctttta
     2401 tttcccttga ggagtctctt gtacctagca tacatgatag ctccttgttg ggaagataac
     2461 aagaaggatc tttgaatact ctattgctga tataatgcaa gatttaaatt tatacatata
     2521 actaatttca aatgtaatta tcacactatg ttaaaattac ttttttccct tagataattc
     2581 aaatttctcc acttgcttga gattatatca tttctttttc aattatacta ttatttctga
     2641 gaatgaaatg gacgattaca cttagaaaat gagtaatagt gtttaataag tcagtgatta
     2701 tatgtgtgct caaataagtg ttatgtatca gctagatact gagctttgat agaataattt
     2761 tcttttgatt attcatgatg tgtcatctct gaccttgttt cagcaaagta aacagcactc
     2821 cccaccccac cctccttttt ttactcatct tggaaaaggt tagtctttca gtacacgttg
     2881 ctggtaagta gtttccaagt tacgtgttgt cactgggttg aagtatattt gtgtgtgtgt
     2941 gtgtgtgtgt gtgtgtgtgt gtaaccataa actatattca tatctgtttc atttggagga
     3001 ttttcttctt tgtaatgtaa agaaattcaa agttatcaaa gttccttaaa tgtgttagtt
     3061 tagattcttt atgtgccttt catgaaagat atgttttcat taattttact ggtggacctg
     3121 taatatccac attgtgaagc tgtgtatgaa attcaactat aatatgaata aatttgaatc
     3181 atgagaatta tgggttaaaa agccacaaag aagcacatat tggtgaccat cattaatgaa
     3241 atcctgaact ttattctgtg taattgtgtt aataaatcct aataaattta aatttttaaa
     3301 attttacaaa cctattggct aagtacattt tggattagaa tttaagtatc agtctgttgt
     3361 ttcttcattt cttctttttc tatgctcttt ttacaatttc agctactcca gaagctcaga
     3421 ttttccctgt tccaagctat gagatgtgat gccacatttg gaattgcctt cttgatatcc
     3481 ccttctgaga atgcattgcc tgctttttaa ctcattatat tcaaaactaa attcatcatc
     3541 attctctcct tacaccagtt ctcaccctga ctttgccatt tttccttact aagtaccatc
     3601 atcatttatt ccttcaatgg ggaacttttt agtttaagtt ctgggatacg tgtgctgaac
     3661 atgcaggttg gttacatatg tatacatgtg ccatggtggt ttgctgcacc tatcaacctg
     3721 tcatctaagt tttaagccct gcatgcatta ggtggaactc ttctgattcc taatctccat
     3781 ttcaatttac tgacagttct acaaagcctt aaatctgttt tttgtttgtt ttcctttcta
     3841 ttcctactac tacctattca agtctttgct aaacttcctc ttaaaatggc attattagtt
     3901 aaattcccca cctcccattt ctctcttctc gaaaaaccca ggttagttat cctaatgtag
     3961 aactgtggcc ctatcacctt ctattccttg atctgcattg gctctgattt gtcaataaaa
     4021 ttaagtataa gttagcctgc catttaatgc tcttcatcac ctgaggcctg ttcctttcta
     4081 cactgtatcc aaatagtgtc ctgtgcataa cctgggcttt cctccaagta ctgtattact
     4141 tactacatgt gatatgctta gagcagtgcc tacaatgtgg gaagtgttca tttgtgtctg
     4201 tcaatgttat ttttattagc acttttaaaa tggtgtgtaa aatgtattgg cacttttaaa
     4261 tttggcactt ttaaatttgt ttgtgatacc tcttttagac tcctctggca tctgttcttc
     4321 agggtgccct tctgggaact acatgattct gatagagctg ccaatcgcat ttcttacttc
     4381 tccgtctcta ggcttagacc tgaccaatcc gagtcctcca gcattggacg agtgagccaa
     4441 tcattgtccc agttgccatt cttaaagtcc ctaaggcgct tgtggtttct aaaattctct
     4501 tcatttcagt aaccttctaa aagtctactt ttttatgcct aatctagttt aatcgaattc
     4561 agtttgttac tgaaaaagta ctgattaaaa tccatatgtt ctcattgaat actgacagta
     4621 actagagatc aaaaaaggct taaagaggtt aattaacttg agcaagacca gatgaaggtt
     4681 ttaaacctag agcttctgac tccatgtctg tcagaggacc ccaaagatgc taccttattt
     4741 ccagaaaatg tgtaagtagt gtttcgccta tccccactct gcccttgagt tcctctgagc
     4801 cataatagtt tttcagattt aaaaaaggag atacttatta atgtctttca tcagagctat
     4861 tttttactcc ttagatgtga agctacttaa gagcacagtt accatttttt acatcatttg
     4921 ccgtttgcag aaccacctta tgtaaatgaa tttagttgat actgtaatca ttattacaga
     4981 tggtagcatc atcattgctt agtgtgttat gttggaagta gaaagtgatg gtgaaaatcc
     5041 taggctctgg caccccgtct ggcttcaaat cctggctcaa tttcttatta actgggaaaa
     5101 tctgggcaaa taatttagtt ttgctctgcc tccatttata tcatctgaaa ataaataagg
     5161 attaaataat ccattaattt taatggttgt tgtcagcatt aaataagttc acagtacatg
     5221 ttaagtacct agaggggagt gtggaatgta taagccgtca atacaatttg ctgttatttg
     5281 attataaata atagttttaa ggtgccttta aaatcataat cagtgcttaa caaatggttg
     5341 ttgatacgtg ctttgaatga aatgcctcaa aaacaaaact ctcataattc gttttcataa
     5401 tgaaaactaa gtgtctcaca tattgatact ggaaaatgag aaaatgcaat ctctaatcaa
     5461 cttgaggaca cttctgtcgt tttaatgtaa ccaatagtat gagagagttt atattttaat
     5521 gttaggttgg aaattttctt tttttttttt tttttttttt tttggtatgg agtcttgctc
     5581 cttcaccagg ctggagtgca gtcgtgcaat ctccactctc tgcaacctcc aactccatgg
     5641 ttcaagcaat tgtcctgcct cagcctcccg agtagctggg attacaggca tgcgccacta
     5701 cacccagcta atttttgtat ttttagtaaa ggggggtttc accatgttgg ccaggatggt
     5761 cttgatcacc tgaccttgtg atctgaccgc ctcggcctcc caaagtgctg ggattacaga
     5821 cgtgagccac tgcgcccagc cagttttctt ttttagttct tttcaaaacc ctttcttaac
     5881 agttgaaatg catttatata aagaagttta cgtttcacaa tcccactggc ctgtttccca
     5941 ggcatttttt taaaccaatt actgtttgct ttggtgtctg ttgtgatttc tcttatttag
     6001 ttggattttg tagttacttt aaaagttacg aaatttcaca tttcatcaag tccagaggcc
     6061 agagacaccc aaatatgcac agacaggaat cagctgcaat tgtccaagcc agagctgatt
     6121 aggcctcaac tggaatagtc ccaccatgta ataaatcttc ctgagtattg tgtataaggt
     6181 caaatatttc cagcttcttt gattttactg cccgtcttcc taggtctcca tccgtaaagt
     6241 ggatggaaac actgtcattg aaggagctag ttcttcaaat ttaatttttt tttttttttt
     6301 tttcctgaga cagagtttcg ttcttgtttc ccaggctgga gcgcaatggt gcgatctcgg
     6361 ctcaccgcaa catccgcctc ccgggtacaa gcaattctcc tgcctcaggt tcccgagtag
     6421 ctgggattac aggcatgcga cactacaccc aactaatctt gtatttttag tagagacggg
     6481 gtttctccat gtcggtcggg ctggtctcga actcctgacc tcaggtaatc cgcccacctc
     6541 ggccgcccaa agtgctggga ttacaggtgt gagccaccgc acctggccaa aatattttta
     6601 attgattaaa aatgagataa tttgaggaaa catgcataga atactagaca gagactattt
     6661 tagcagataa gagtgccact tttagtaaaa gaagttgtca cctagaagaa agtacaggtg
     6721 ctccttgact taccgtgggt taagtcctga aaagcccact gtaagttgat aataccttat
     6781 tttgaaaatg catttaatac acctaaccta ccaaatgtag cttagcctgg cctaacttaa
     6841 aggtgctcag aacacttaga ttagcataca gttggacaag atagcataaa gcctatttta
     6901 caataaagga tatctcatgt aattttcttg gatactgtac tgaaaatgaa aaacagattg
     6961 attgcatggg tacttgaaat atggtttcta actgaatgca taccagtttc gcaccaatgt
     7021 aaagttgaaa aattgttaag ttggaccatc atacgttggg gaccatctgt acatagagta
     7081 ggactcttga gagcctaagg gccacagaaa ttccttttcc aactgcagtg tctatggagg
     7141 gattcttata attaatttta ttcctgtgca aacacactat ctgtgtattc tctattttac
     7201 caggattttt tgtttttgct aaattagaca tacaattttg cagttatttt ttactaagtt
     7261 gacaaatgtt tgtacaattt cagtgtaaag ctagtcttca aaataaacca ctgtgaagat
     7321 tggatattac cttggatttt ctgttgtgca ctcttgaatt ttaattatgt tctgtggaaa
     7381 cttcacagag ttttagcttt gatccttcct tcacttttga aaatcaagag taaagttaag
     7441 tcaaagctac ttctaaacag ctctatcttt aatttctatt aaatagtact gaggtatcaa
     7501 ttttgtagct tgtggaatgc ggactatccc agcagcaaat tcattaatat ggtttgtata
     7561 ggactcactt tgcagcattc aattttagta taacatgttt tcctgtttac aaatataagt
     7621 aattaccttt ccgttttaag tgaccaattg tcctagcaat ctacttcaca aggcaattta
     7681 cctgtaataa atataacttt tttgcagact tgagcatacg tttaaaccat ttaaccattc
     7741 ttgaatttct taacatagta agttacaaat tttaactatg aatcttcttc ttcgaaagga
     7801 atcttgtcta aatctaataa agcatttttc tggctgaagc tgcaatggaa agcttcagta
     7861 tgaagctggc ataaggaaag ccagtaaaaa gtgccctttc ttctttctga gagccccacc
     7921 tctgatcctc ctacacttaa ggcttctaga tgcagattta tacaatagtg ctaaatcaag
     7981 accttgaaaa atgtactcat atagtaagat ttactcaaaa ccacgaactc ctccattatt
     8041 taaaatatgt tagagataca taaatatata gagaaaatgc atacatacat aatttattga
     8101 gtgcctactg tgtgctaggt acttttctgg gtaccttact aatgctctca tttagtcatc
     8161 agagcagtcc tgcaatattg gtaaaatttc cattttctat ataaggaaac acatttaaga
     8221 gaggttagta ttttgtgcaa tgttggctat ctaggaagtg gcagagctgg gtgtaaaatc
     8281 tagagttaag acctttgtta gccatatctt caaaatccag tgtcatttct tagccatatc
     8341 ttcaaaatcc agtgtcattt cttagccata tcttcaaaat ccagtgtcat ttcttagcca
     8401 tatcttcaaa atccaatggc ataaagaagt ttttcacaag ggtgccacat ggtgtagtgc
     8461 agcatgtcca acagcattgc ctgaacagat gttaataagt atgcatgatg cacattagca
     8521 tgtcaatggc tgtgaaaagc cagtgcagta aagaagtaaa gagctctctg tgtgttaacc
     8581 ctccatttca caaacatagg aactgcacag acacagcagc cactacccag gtgtgaatgc
     8641 agagcactta aaacgtagct agtccaaagt gagttggcct attagtgtaa aatacaagag
     8701 ttcagataca cagaatttaa aaattacatg ttgaactgat ttgtgatata ttgggttata
     8761 taattttaaa attctacttt tttttacatt tttaatgtgg ttttggaaaa taggtactca
     8821 tgtgtctttg cattatattt gtatttggga aatgaaatgc tttatttttc ttccacaaca
     8881 actctatttg cattgcatgg aaatgttccc aagttttaga gaaacacata caaaaactaa
     8941 aaaggataga atgctaaaat ttgaatgtgg aagatgtggg tcttggtgtc ttgaataaat
     9001 cacaccttca gtgactttct tgggaaatgg tgggcctcag taaagacttg gactattcca
     9061 gttttaaatg ctatcgtttg gtttggtgta atatagcctt tcctgtgggg ggaaaaccca
     9121 tctcattttc actttaaata tgtcagctat aataaaagag agacatacac attttaagat
     9181 ctatactcta aaacagggtt ttgaaattag cagctctctt tatttttagt tccaatacat
     9241 ggagggggag ttgacccttc aagatactgg aaaattatta aatccagttt acagactcat
     9301 ctctttagtc tgcagccaaa tcaaaagatt agtggggttt tttttaatgt tgttattgtg
     9361 ttgtgttttg tttttttaat atgtttcaat tcccctagcc aaattccttt ctttctccac
     9421 acctcccaca ggactgggct gagcacagtc atgcattaaa aaagcttctg aacttatttt
     9481 ggaaagagta gctccctgga gtgtggagga ggacaggaat ttgctatctg caggacttaa
     9541 atcaggatag agtatcaaat attccaaggc cttacatgca tgttttgttt tttgataaag
     9601 acagaagatt gcaaatggtt tgctctttaa cagtcaataa aatcatatct actaatcaat
     9661 acatttgaag tttactagat tctcaaactt tccataagat ttgagttcat tagtttaatg
     9721 ggatcgatct gagaaaaatt agatttatgt gcagatttta gctacccttg tccttggaat
     9781 gtgtatgcac acacacacac atctgtgaga atgattattt tctacttgat acagtgtgca
     9841 tcaaataaaa gtttactata ttggaatatg ggaataaatt catttataat tagttgaaat
     9901 tgtccagaca catattttag aaaagtatgt tatttttgtt ttaagtttgg aagaacctga
     9961 atgattaaac ctgatttaag tccctctaac aattatgaag aaaaaaaaag actagatttt
    10021 atatcaactt aattgtcttt tggtttaaaa ttatgtatcc aataaagaca tttaaaaagt
    10081 aaa
//
