LOCUS       NM_002068               2273 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens G protein subunit alpha 15 (GNA15), mRNA.
ACCESSION   NM_002068
VERSION     NM_002068.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2273)
  AUTHORS   Sun,Y. and Han,Y.
  TITLE     GNA15 facilitates the malignant development of thyroid carcinoma
            cells via the BTK-mediated MAPK signaling pathway
  JOURNAL   Histol Histopathol 39 (9), 1217-1227 (2024)
   PUBMED   38333922
  REMARK    GeneRIF: GNA15 facilitates the malignant development of thyroid
            carcinoma cells via the BTK-mediated MAPK signaling pathway.
REFERENCE   2  (bases 1 to 2273)
  AUTHORS   Zeng,B., Chen,Y., Chen,H., Zhao,Q., Sun,Z., Liu,D., Li,X.,
            Zhang,Y., Wang,J. and Xing,H.R.
  TITLE     Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and
            immune microenvironment of melanoma through GNA15
  JOURNAL   Pharmacol Res 188, 106660 (2023)
   PUBMED   36642112
  REMARK    GeneRIF: Exosomal miR-211-5p regulates glucose metabolism,
            pyroptosis, and immune microenvironment of melanoma through GNA15.
REFERENCE   3  (bases 1 to 2273)
  AUTHORS   Zanini,S., Giovinazzo,F., Alaimo,D., Lawrence,B., Pfragner,R.,
            Bassi,C., Modlin,I. and Kidd,M.
  TITLE     GNA15 expression in small intestinal neuroendocrine neoplasia:
            functional and signalling pathway analyses
  JOURNAL   Cell Signal 27 (5), 899-907 (2015)
   PUBMED   25701539
  REMARK    GeneRIF: GNA15 was not expressed in normal neuroendocrine cells but
            was overexpressed in gastroenteropancreatic neuroendocrine
            neoplasia cell lines.
REFERENCE   4  (bases 1 to 2273)
  AUTHORS   Avasarala,S., Bikkavilli,R.K., Van Scoyk,M., Zhang,W., Lapite,A.,
            Hostetter,L., Byers,J.T., Heasley,L.E., Sohn,J.W. and Winn,R.A.
  TITLE     Heterotrimeric G-protein, Galpha16, is a critical downstream
            effector of non-canonical Wnt signaling and a potent inhibitor of
            transformed cell growth in non small cell lung cancer
  JOURNAL   PLoS One 8 (10), e76895 (2013)
   PUBMED   24204697
  REMARK    GeneRIF: Data indicate the importance of Galpha16 as a downstream
            effector of the non-canonical Wnt signaling pathway and as a
            potential therapeutic target for the treatment of non small cell
            lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2273)
  AUTHORS   Giovinazzo,F., Malpeli,G., Zanini,S., Parenti,M., Piemonti,L.,
            Colombatti,M., Valenti,M.T., Dalle Carbonare,L., Scarpa,A.,
            Sinnett-Smith,J., Rozengurt,E., Bassi,C. and Innamorati,G.
  TITLE     Ectopic expression of the heterotrimeric G15 protein in pancreatic
            carcinoma and its potential in cancer signal transduction
  JOURNAL   Cell Signal 25 (3), 651-659 (2013)
   PUBMED   23200847
  REMARK    GeneRIF: G15 ectopic presence could functionally contribute to the
            transformation process since siRNA-induced depletion of Galpha15 in
            pancreatic carcinoma cell lines dramatically inhibited
            anchorage-independent growth and resistance to the lack of
            nutrients.
REFERENCE   6  (bases 1 to 2273)
  AUTHORS   Wu,D., Kuang,Y., Wu,Y. and Jiang,H.
  TITLE     Selective coupling of beta 2-adrenergic receptor to
            hematopoietic-specific G proteins
  JOURNAL   J Biol Chem 270 (27), 16008-16010 (1995)
   PUBMED   7608160
REFERENCE   7  (bases 1 to 2273)
  AUTHORS   Mapara,M.Y., Bommert,K., Bargou,R.C., Leng,C., Beck,C.,
            Ludwig,W.D., Gierschik,P. and Dorken,B.
  TITLE     G protein subunit G alpha 16 expression is restricted to progenitor
            B cells during human B-cell differentiation
  JOURNAL   Blood 85 (7), 1836-1842 (1995)
   PUBMED   7703490
REFERENCE   8  (bases 1 to 2273)
  AUTHORS   Berstein,G., Blank,J.L., Jhon,D.Y., Exton,J.H., Rhee,S.G. and
            Ross,E.M.
  TITLE     Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11,
            its physiologic regulator
  JOURNAL   Cell 70 (3), 411-418 (1992)
   PUBMED   1322796
REFERENCE   9  (bases 1 to 2273)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   10 (bases 1 to 2273)
  AUTHORS   Amatruda,T.T. 3rd, Steele,D.A., Slepak,V.Z. and Simon,M.I.
  TITLE     G alpha 16, a G protein alpha subunit specifically expressed in
            hematopoietic cells
  JOURNAL   Proc Natl Acad Sci U S A 88 (13), 5587-5591 (1991)
   PUBMED   1905813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005262.1, BC013585.1 and BQ015560.1.
            
            On May 17, 2019 this sequence version replaced NM_002068.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.434304.1,
                                           DRR138509.55800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262958.4/ ENSP00000262958.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AC005262.1         42705-42937
            234-2269            BC013585.1         1-2036
            2270-2273           BQ015560.1         38-41               c
FEATURES             Location/Qualifiers
     source          1..2273
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2273
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /note="G protein subunit alpha 15"
                     /db_xref="GeneID:2769"
                     /db_xref="HGNC:HGNC:4383"
                     /db_xref="MIM:139314"
     exon            1..563
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..1543
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /note="g alpha-15; g alpha-16; G-protein subunit alpha-16;
                     guanine nucleotide-binding protein subunit alpha-16;
                     epididymis tissue protein Li 17E; guanine nucleotide
                     binding protein (G protein), alpha 15 (Gq class);
                     epididymis secretory sperm binding protein; heterotrimeric
                     guanine nucleotide-binding protein 1L"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     alpha-15"
                     /protein_id="NP_002059.3"
                     /db_xref="CCDS:CCDS12104.1"
                     /db_xref="GeneID:2769"
                     /db_xref="HGNC:HGNC:4383"
                     /db_xref="MIM:139314"
                     /translation="MARSLTWRCCPWCLTEDEKAAARVDQEINRILLEQKKQDRGELK
                     LLLLGPGESGKSTFIKQMRIIHGAGYSEEERKGFRPLVYQNIFVSMRAMIEAMERLQI
                     PFSRPESKHHASLVMSQDPYKVTTFEKRYAAAMQWLWRDAGIRACYERRREFHLLDSA
                     VYYLSHLERITEEGYVPTAQDVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKK
                     WIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTILELPWFKSTSVILFL
                     NKTDILEEKIPTSHLATYFPSFQGPKQDAEAAKRFILDMYTRMYTGCVDGPEGSKKGA
                     RSRRLFSHYTCATDTQNIRKVFKDVRDSVLARYLDEINLL"
     exon            564..748
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            749..903
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1032
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1162
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1316
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..2273
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2252..2257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /note="hexamer: ATTAAA"
     polyA_site      2273
                     /gene="GNA15"
                     /gene_synonym="GNA16; HG1L"
                     /note="major polyA site"
ORIGIN      
        1 agaaggagga agaagggccc tgctggtcac acaggaccca gtctgcggtg ggggttttcc
       61 cgccaccgcc ccgccctccc tggggccccc acctcaccct ctcctggcac ccttcaccgt
      121 caacctgtcg ggccgggtct gagcaggtct ggaggtgggc ggggagccct ggcctcccca
      181 cctcctcccg tccccaccct gttcccagca ctcaagcctt gccaccgccg agccgggctt
      241 cctgggtgtt tcaggcaagg aagtctaggt ccctgggggg tgacccccaa ggaaaaggca
      301 gcctccctgc gcacccggtt gcccggagcc ctctccaggg ccggctgggc tgggggttgc
      361 cctggccagc aggggcccgg gggcgatgcc acccggtgcc gactgaggcc accgcaccat
      421 ggcccgctcg ctgacctggc gctgctgccc ctggtgcctg acggaggatg agaaggccgc
      481 cgcccgggtg gaccaggaga tcaacaggat cctcttggag cagaagaagc aggaccgcgg
      541 ggagctgaag ctgctgcttt tgggcccagg cgagagcggg aagagcacct tcatcaagca
      601 gatgcggatc atccacggcg ccggctactc ggaggaggag cgcaagggct tccggcccct
      661 ggtctaccag aacatcttcg tgtccatgcg ggccatgatc gaggccatgg agcggctgca
      721 gattccattc agcaggcccg agagcaagca ccacgctagc ctggtcatga gccaggaccc
      781 ctataaagtg accacgtttg agaagcgcta cgctgcggcc atgcagtggc tgtggaggga
      841 tgccggcatc cgggcctgct atgagcgtcg gcgggaattc cacctgctcg attcagccgt
      901 gtactacctg tcccacctgg agcgcatcac cgaggagggc tacgtcccca cagctcagga
      961 cgtgctccgc agccgcatgc ccaccactgg catcaacgag tactgcttct ccgtgcagaa
     1021 aaccaacctg cggatcgtgg acgtcggggg ccagaagtca gagcgtaaga aatggatcca
     1081 ttgtttcgag aacgtgatcg ccctcatcta cctggcctca ctgagtgaat acgaccagtg
     1141 cctggaggag aacaaccagg agaaccgcat gaaggagagc ctcgcattgt ttgggactat
     1201 cctggaacta ccctggttca aaagcacatc cgtcatcctc tttctcaaca aaaccgacat
     1261 cctggaggag aaaatcccca cctcccacct ggctacctat ttccccagtt tccagggccc
     1321 taagcaggat gctgaggcag ccaagaggtt catcctggac atgtacacga ggatgtacac
     1381 cgggtgcgtg gacggccccg agggcagcaa gaagggcgca cgatcccgac gcctcttcag
     1441 ccactacaca tgtgccacag acacacagaa catccgcaag gtcttcaagg acgtgcggga
     1501 ctcggtgctc gcccgctacc tggacgagat caacctgctg tgacccaggc cccacctggg
     1561 gcaggcggca ccggcgggcg ggtgggaggt gggagtggct gcagggaccc ctagtgtccc
     1621 tggtctatct ctccagcctc ggcccacacg caagggagtc gggggacgga cggcccgctg
     1681 ctggccgctc tcttctctgc ctctcaccag gacagccgcc ccccagggta ctcctgccct
     1741 tgcttgactc agtttccctc ctttgaaagg gaaggagcaa aacggccatt tgggatgcca
     1801 gggtggatga aaaggtgaag aaatcagggg attgaggact tgggtgggtg ggcatctctc
     1861 aggagcccca tctccgggcg tgtcacctcc tgggcagggt tctgggaccc tctgtgggtg
     1921 acgcacaccc tgggatgggg ctagtagagc cttcaggcgc cttcgggcgt ggactctggc
     1981 gcactctagt ggacaggaga aggaacgcct tccaggaacc tgtggactag gggtgcaggg
     2041 acttcccttt gcaaggggta acagaccgct ggaaaacact gtcactttca gagctcggtg
     2101 gctcacagcg tgtcctgccc cggtttgcgg acgagagaaa tcgcggccca caagcatccc
     2161 cccatccctt gcaggctggg ggctgggcat gctgcatctt aaccttttgt atttattccc
     2221 tcaccttctg cagggctccg tgcgggctga aattaaagat ttcttagagg ctg
//
