LOCUS       NM_004297               2497 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens G protein subunit alpha 14 (GNA14), mRNA.
ACCESSION   NM_004297
VERSION     NM_004297.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2497)
  AUTHORS   Ren,J., Cui,Z., Jiang,C., Wang,L., Guan,Y., Ren,Y., Zhang,S.,
            Tu,T., Yu,J., Li,Y., Duan,W., Guan,J., Wang,K., Zhang,H., Xing,D.,
            Kahn,M.L., Zhang,H. and Hong,T.
  TITLE     GNA14 and GNAQ somatic mutations cause spinal and intracranial
            extra-axial cavernous hemangiomas
  JOURNAL   Am J Hum Genet 111 (7), 1370-1382 (2024)
   PUBMED   38917801
  REMARK    GeneRIF: GNA14 and GNAQ somatic mutations cause spinal and
            intracranial extra-axial cavernous hemangiomas.
REFERENCE   2  (bases 1 to 2497)
  AUTHORS   Xu,C., Li,Y.M., Sun,B., Zhong,F.J. and Yang,L.Y.
  TITLE     GNA14's interaction with RACK1 inhibits hepatocellular carcinoma
            progression through reducing MAPK/JNK and PI3K/AKT signaling
            pathway
  JOURNAL   Carcinogenesis 42 (11), 1357-1369 (2021)
   PUBMED   34657150
  REMARK    GeneRIF: GNA14's interaction with RACK1 inhibits hepatocellular
            carcinoma progression through reducing MAPK/JNK and PI3K/AKT
            signaling pathway.
REFERENCE   3  (bases 1 to 2497)
  AUTHORS   Wang,J., Teng,F., Chai,H., Zhang,C., Liang,X. and Yang,Y.
  TITLE     GNA14 stimulation of KLF7 promotes malignant growth of endometrial
            cancer through upregulation of HAS2
  JOURNAL   BMC Cancer 21 (1), 456 (2021)
   PUBMED   33892667
  REMARK    GeneRIF: GNA14 stimulation of KLF7 promotes malignant growth of
            endometrial cancer through upregulation of HAS2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2497)
  AUTHORS   Song,G., Zhu,X., Xuan,Z., Zhao,L., Dong,H., Chen,J., Li,Z.,
            Song,W., Jin,C., Zhou,M., Xie,H., Zheng,S. and Song,P.
  TITLE     Hypermethylation of GNA14 and its tumor-suppressive role in
            hepatitis B virus-related hepatocellular carcinoma
  JOURNAL   Theranostics 11 (5), 2318-2333 (2021)
   PUBMED   33500727
  REMARK    GeneRIF: Hypermethylation of GNA14 and its tumor-suppressive role
            in hepatitis B virus-related hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2497)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2497)
  AUTHORS   Rubio,J.P., Levy,E.R., Dobson-Stone,C. and Monaco,A.P.
  TITLE     Genomic organization of the human galpha14 and Galphaq genes and
            mutation analysis in chorea-acanthocytosis (CHAC)
  JOURNAL   Genomics 57 (1), 84-93 (1999)
   PUBMED   10191087
REFERENCE   7  (bases 1 to 2497)
  AUTHORS   Kuang,Y., Wu,Y., Jiang,H. and Wu,D.
  TITLE     Selective G protein coupling by C-C chemokine receptors
  JOURNAL   J Biol Chem 271 (8), 3975-3978 (1996)
   PUBMED   8626727
REFERENCE   8  (bases 1 to 2497)
  AUTHORS   Kleuss,C., Raw,A.S., Lee,E., Sprang,S.R. and Gilman,A.G.
  TITLE     Mechanism of GTP hydrolysis by G-protein alpha subunits
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9828-9831 (1994)
   PUBMED   7937899
REFERENCE   9  (bases 1 to 2497)
  AUTHORS   Wu,D., LaRosa,G.J. and Simon,M.I.
  TITLE     G protein-coupled signal transduction pathways for interleukin-8
  JOURNAL   Science 261 (5117), 101-103 (1993)
   PUBMED   8316840
REFERENCE   10 (bases 1 to 2497)
  AUTHORS   Berstein,G., Blank,J.L., Jhon,D.Y., Exton,J.H., Rhee,S.G. and
            Ross,E.M.
  TITLE     Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11,
            its physiologic regulator
  JOURNAL   Cell 70 (3), 411-418 (1992)
   PUBMED   1322796
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355535.14, AK312460.1,
            BC027886.1, AI629022.1, AL158159.14 and AI263118.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004297.3.
            
            Summary: This gene encodes a member of the guanine
            nucleotide-binding, or G protein family. G proteins are
            heterotrimers consisting of alpha, beta and gamma subunits. The
            encoded protein is a member of the alpha family of G proteins, more
            specifically the alpha q subfamily of G proteins. The encoded
            protein may play a role in pertussis-toxin resistant activation of
            phospholipase C-beta and its downstream effectors.[provided by
            RefSeq, Feb 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.91110.1,
                                           SRR1660807.57257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341700.7/ ENSP00000365807.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL355535.14        62660-62665         c
            7-15                AK312460.1         1-9
            16-1944             BC027886.1         1-1929
            1945-2292           AI629022.1         203-550             c
            2293-2300           AL158159.14        91192-91199         c
            2301-2497           AI263118.1         2-198               c
FEATURES             Location/Qualifiers
     source          1..2497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.2"
     gene            1..2497
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /note="G protein subunit alpha 14"
                     /db_xref="GeneID:9630"
                     /db_xref="HGNC:HGNC:4382"
                     /db_xref="MIM:604397"
     exon            1..653
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /inference="alignment:Splign:2.1.0"
     CDS             530..1597
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /note="guanine nucleotide-binding protein 14; guanine
                     nucleotide binding protein (G protein), alpha 14; g
                     alpha-14; heterotrimeric guanine nucleotide-binding
                     protein 1I"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     alpha-14"
                     /protein_id="NP_004288.1"
                     /db_xref="CCDS:CCDS6657.1"
                     /db_xref="GeneID:9630"
                     /db_xref="HGNC:HGNC:4382"
                     /db_xref="MIM:604397"
                     /translation="MAGCCCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTG
                     ESGKSTFIKQMRIIHGSGYSDEDRKGFTKLVYQNIFTAMQAMIRAMDTLRIQYVCEQN
                     KENAQIIREVEVDKVSMLSREQVEAIKQLWQDPGIQECYDRRREYQLSDSAKYYLTDI
                     DRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFES
                     VTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFLNSSVILFLNKKDLLE
                     EKIMYSHLISYFPEYTGPKQDVRAARDFILKLYQDQNPDKEKVIYSHFTCATDTDNIR
                     FVFAAVKDTILQLNLREFNLV"
     exon            654..838
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /inference="alignment:Splign:2.1.0"
     exon            839..993
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1122
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1252
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1406
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..2497
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2478..2483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /note="hexamer: AATATA"
     polyA_site      2497
                     /gene="GNA14"
                     /gene_synonym="HG1I"
                     /note="major polyA site"
ORIGIN      
        1 ccactcagtc ttagtctgcg gtcactgctg aggttttcag aactttccag gcaaaggcca
       61 gccaggtcct ttgcctccaa cccactccgc gcctacctcc cgcctgggga cacccctagg
      121 cccaggagat cctactctcc cccgagcacc gacgttccaa ctcgtctgcg cccccgactg
      181 ctgtccggct cctgtgccaa ggggcgcgcg catcttcccg gggccagcaa cgctcccaac
      241 ttctcgactc gccctcctcc tccccagagc gagagtgggg cgggctgagc ccggatccgg
      301 ggtgcactcg agcgttccca gcgctcggca ttcaccccgc ctcagagccg actttcgaag
      361 ggggattgag cctcggaggt ccaggcgtct tactccaaag ctcaagtcgg cccccgtctt
      421 ttctttccac acccctgtgc ccgtcgcatg ctggccgggt gagcggccgg gccgaggatt
      481 cgggtgcccg gggccgcgtc gccccgtcgg gtactgagct gagcgcacca tggccggctg
      541 ctgctgcctg tccgcggagg agaaggagtc gcagcgcatc agcgcggaga tcgagcgaca
      601 gcttcgtcgg gacaagaagg acgcgcgccg tgagcttaag ctgctgctgc tgggaactgg
      661 tgaaagtggg aaaagcacct ttatcaagca gatgagaatt atccatgggt ctggttacag
      721 cgacgaagac agaaaggggt tcacgaagct ggtttaccaa aacatattca ccgccatgca
      781 agccatgatc agagcgatgg acacgctaag gatacagtat gtgtgtgaac agaataagga
      841 aaatgcccag ataatcagag aagtggaagt ggacaaggtc tccatgctct ccagggagca
      901 ggtggaggcc atcaagcagc tctggcaaga tccaggcatc caggagtgtt acgacaggag
      961 gagggagtac cagctgtcgg actctgccaa atattacctg actgacattg accgcatcgc
     1021 cacaccatca ttcgtgccta cccaacaaga tgtgcttcgc gtccgagtgc ccaccaccgg
     1081 catcattgag tatccatttg acttggaaaa catcatcttt cggatggtgg atgttggtgg
     1141 ccaacgatcg gaaagacgga agtggattca ctgctttgag agtgtcacct ccattatttt
     1201 cttggttgct ctgagtgaat atgaccaggt cctggctgag tgtgacaacg agaatcgcat
     1261 ggaagagagc aaagccttat ttaaaaccat catcacctac ccctggtttc tgaattcgtc
     1321 tgtgatttta ttcttgaaca agaaggatct tttggaagag aaaatcatgt actctcatct
     1381 aattagctat ttcccagaat acacaggacc gaaacaggat gtcagagctg ccagagactt
     1441 tatcctgaag ctttaccaag atcagaatcc tgacaaagag aaagtcatct actctcactt
     1501 cacatgtgct acagatacag acaatattcg ctttgtgttt gctgctgtca aagacacaat
     1561 tctacagcta aacctaaggg aattcaacct tgtctaaaag ctgctgccca ctcctcccct
     1621 ataacagaag atgtgatttg caaactcctt gttttatttg caagtgcttc tgacatcacc
     1681 agagccagcc ccatgccagg aactaaggat gtcatgtaga tcgtggggac agagatgggt
     1741 gatggaactt ggaagatatt tgagtttacc aacatacttt aaaagtcctt acatcccaaa
     1801 ttgtgtttat aattattttc ttgacttttg gctataagat tttgtgtaat ttttgaattt
     1861 ggtgttttct agaattttta aaagccactt tgatttagtt ttaaatatgt ttaaaaatag
     1921 cgattaaaat tatgtaagca aggagcctgt tagtttatag atcatgcctt caaacctcta
     1981 gagttaattt gggtgacttt tttaaaaata agaatgttaa tgggtttgaa gctttttatt
     2041 aaaccttgta atttagagac atttttaatt gtgtttctca cctcatgctg aagggtgact
     2101 cctttaacat gccaccaaag atttttttta aacacttggt tctttttgtg tgttaacttt
     2161 ctaagccaaa ttaatggata tataagtata tctaatttag ctttgccaca gtttgatcac
     2221 caagaagcca aagctgacat agagtaaatg ggctctagat agcatatatg ttttattggt
     2281 gaaaaatgtg tgtgtgtgca cgtgtgtgtg tgtgtacatt tttaccccca atgtatatga
     2341 ccagatctta aaaatgtatg aaatggctag aagtccacat tgtttgacaa atgttacgta
     2401 accctgccaa agttctgatg gccaccacag atttgctgtt tgaattatgt atgctgtgcc
     2461 tttctgagga ggctaagaat ataccattct gctatta
//
