LOCUS       NM_006572               6249 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens G protein subunit alpha 13 (GNA13), transcript variant
            1, mRNA.
ACCESSION   NM_006572
VERSION     NM_006572.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6249)
  AUTHORS   Shi,L., Luo,B., Deng,L., Zhang,Q., Li,Y., Sun,D., Zhang,H. and
            Zhuang,L.
  TITLE     The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells
            through the regulation of P2RY10/GNA13
  JOURNAL   Scand J Gastroenterol 59 (6), 710-721 (2024)
   PUBMED   38357893
  REMARK    GeneRIF: The lncRNA TRG-AS1 promotes the growth of colorectal
            cancer cells through the regulation of P2RY10/GNA13.
REFERENCE   2  (bases 1 to 6249)
  AUTHORS   Hasan,S., White,N.F., Tagliatela,A.C., Durall,R.T., Brown,K.M.,
            McDiarmid,G.R. and Meigs,T.E.
  TITLE     Overexpressed Galpha13 activates serum response factor through
            stoichiometric imbalance with Gbetagamma and mislocalization to the
            cytoplasm
  JOURNAL   Cell Signal 102, 110534 (2023)
   PUBMED   36442589
  REMARK    GeneRIF: Overexpressed Galpha13 activates serum response factor
            through stoichiometric imbalance with Gbetagamma and
            mislocalization to the cytoplasm.
REFERENCE   3  (bases 1 to 6249)
  AUTHORS   Xia,Z., Zhang,X., Liu,P., Zhang,R., Huang,Z., Li,D., Xiao,X.,
            Wu,M., Ning,N., Zhang,Q., Zhang,J., Liu,M., Jiao,B. and Ren,R.
  TITLE     GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL
            cells to BCL2 inhibitors in a palmitoylation-dependent manner
  JOURNAL   Cell Death Dis 12 (1), 54 (2021)
   PUBMED   33423045
  REMARK    GeneRIF: GNA13 regulates BCL2 expression and the sensitivity of
            GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6249)
  AUTHORS   Castillo-Kauil,A., Garcia-Jimenez,I., Cervantes-Villagrana,R.D.,
            Adame-Garcia,S.R., Beltran-Navarro,Y.M., Gutkind,J.S.,
            Reyes-Cruz,G. and Vazquez-Prado,J.
  TITLE     Galphas directly drives PDZ-RhoGEF signaling to Cdc42
  JOURNAL   J Biol Chem 295 (50), 16920-16928 (2020)
   PUBMED   33023908
  REMARK    GeneRIF: Galphas directly drives PDZ-RhoGEF signaling to Cdc42.
REFERENCE   5  (bases 1 to 6249)
  AUTHORS   Maziarz,M., Federico,A., Zhao,J., Dujmusic,L., Zhao,Z., Monti,S.,
            Varelas,X. and Garcia-Marcos,M.
  TITLE     Naturally occurring hotspot cancer mutations in Galpha13 promote
            oncogenic signaling
  JOURNAL   J Biol Chem 295 (49), 16897-16904 (2020)
   PUBMED   33109615
  REMARK    GeneRIF: Naturally occurring hotspot cancer mutations in Galpha13
            promote oncogenic signaling.
REFERENCE   6  (bases 1 to 6249)
  AUTHORS   Offermanns,S., Hu,Y.H. and Simon,M.I.
  TITLE     Galpha12 and galpha13 are phosphorylated during platelet activation
  JOURNAL   J Biol Chem 271 (42), 26044-26048 (1996)
   PUBMED   8824244
REFERENCE   7  (bases 1 to 6249)
  AUTHORS   Laugwitz,K.L., Allgeier,A., Offermanns,S., Spicher,K., Van
            Sande,J., Dumont,J.E. and Schultz,G.
  TITLE     The human thyrotropin receptor: a heptahelical receptor capable of
            stimulating members of all four G protein families
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 116-120 (1996)
   PUBMED   8552586
REFERENCE   8  (bases 1 to 6249)
  AUTHORS   Kabouridis,P.S., Waters,S.T., Escobar,S., Stanners,J. and
            Tsoukas,C.D.
  TITLE     Expression of GTP-binding protein alpha subunits in human
            thymocytes
  JOURNAL   Mol Cell Biochem 144 (1), 45-51 (1995)
   PUBMED   7791744
REFERENCE   9  (bases 1 to 6249)
  AUTHORS   Kleuss,C., Raw,A.S., Lee,E., Sprang,S.R. and Gilman,A.G.
  TITLE     Mechanism of GTP hydrolysis by G-protein alpha subunits
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9828-9831 (1994)
   PUBMED   7937899
REFERENCE   10 (bases 1 to 6249)
  AUTHORS   Offermanns,S., Laugwitz,K.L., Spicher,K. and Schultz,G.
  TITLE     G proteins of the G12 family are activated via thromboxane A2 and
            thrombin receptors in human platelets
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 504-508 (1994)
   PUBMED   8290554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC335364.1, AF493902.1, AC037487.12 and AW298099.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006572.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.241084.1,
                                           SRR1803615.57429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439174.7/ ENSP00000400717.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               DC335364.1         63-209
            148-1281            AF493902.1         1-1134
            1282-5707           AC037487.12        46683-51108
            5708-6249           AW298099.1         16-557              c
FEATURES             Location/Qualifiers
     source          1..6249
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.1"
     gene            1..6249
                     /gene="GNA13"
                     /gene_synonym="G13; HG1N"
                     /note="G protein subunit alpha 13"
                     /db_xref="GeneID:10672"
                     /db_xref="HGNC:HGNC:4381"
                     /db_xref="MIM:604406"
     exon            1..430
                     /gene="GNA13"
                     /gene_synonym="G13; HG1N"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1281
                     /gene="GNA13"
                     /gene_synonym="G13; HG1N"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanine nucleotide-binding protein subunit alpha-13; g
                     alpha-13; guanine nucleotide binding protein (G protein),
                     alpha 13; heterotrimeric guanine nucleotide-binding
                     protein 1N"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     alpha-13 isoform 1"
                     /protein_id="NP_006563.2"
                     /db_xref="CCDS:CCDS11661.1"
                     /db_xref="GeneID:10672"
                     /db_xref="HGNC:HGNC:4381"
                     /db_xref="MIM:604406"
                     /translation="MADFLPSRSVLSVCFPGCLLTSGEAEQQRKSKEIDKCLSREKTY
                     VKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDA
                     REKLHIPWGDNSNQQHGDKMMSFDTRAPMAAQGMVETRVFLQYLPAIRALWADSGIQN
                     AYDRRREFQLGESVKYFLDNLDKLGEPDYIPSQQDILLARRPTKGIHEYDFEIKNVPF
                     KMVDVGGQRSERKRWFECFDSVTSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIV
                     NNRVFSNVSIILFLNKTDLLEEKVQIVSIKDYFLEFEGDPHCLRDVQKFLVECFRNKR
                     RDQQQKPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLMLQ"
     exon            431..657
                     /gene="GNA13"
                     /gene_synonym="G13; HG1N"
                     /inference="alignment:Splign:2.1.0"
     exon            658..708
                     /gene="GNA13"
                     /gene_synonym="G13; HG1N"
                     /inference="alignment:Splign:2.1.0"
     exon            709..6249
                     /gene="GNA13"
                     /gene_synonym="G13; HG1N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4804..4809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNA13"
                     /gene_synonym="G13; HG1N"
                     /note="hexamer: AATAAA"
     polyA_site      4823
                     /gene="GNA13"
                     /gene_synonym="G13; HG1N"
                     /note="major polyA site"
     regulatory      6226..6231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GNA13"
                     /gene_synonym="G13; HG1N"
                     /note="hexamer: AATAAA"
     polyA_site      6249
                     /gene="GNA13"
                     /gene_synonym="G13; HG1N"
ORIGIN      
        1 agttcgctgg ttccctccct ccctgggcgc gctcgggccg ccgccgcgct ccccgccctc
       61 gagcctcggt gccggagccg cccgccgccg gaggaggagg tggagggagc cggaggggcc
      121 cgccgaggcg gcggcggcgg cggcaagatg gcggacttcc tgccgtcgcg gtccgtgctg
      181 tccgtgtgct tccccggctg cctgctgacg agtggcgagg ccgagcagca acgcaagtcc
      241 aaggagatcg acaaatgcct gtctcgggaa aagacctatg tgaagcggct ggtgaagatc
      301 ctgctgctgg gcgcgggcga gagcggcaag tccaccttcc tgaagcagat gcggatcatc
      361 cacgggcagg acttcgacca gcgcgcgcgc gaggagttcc gccccaccat ctacagcaac
      421 gtgatcaaag gtatgagggt gctggttgat gctcgagaga agcttcatat tccctgggga
      481 gacaactcaa accaacaaca tggagataag atgatgtcgt ttgatacccg ggcccccatg
      541 gcagcccaag gaatggtgga aacaagggtt ttcttacaat atcttcctgc tataagagca
      601 ttatgggcag acagcggcat acagaatgcc tatgaccggc gtcgagaatt tcaactgggt
      661 gaatctgtaa aatatttcct ggataacttg gataaacttg gagaaccaga ttatattcca
      721 tcacaacaag atattctgct tgccagaaga cccaccaaag gcatccatga atacgacttt
      781 gaaataaaaa atgttccttt caaaatggtt gatgtaggtg gtcagagatc agaaaggaaa
      841 cgttggtttg aatgtttcga cagtgtgaca tcaatacttt tccttgtttc ctcaagtgaa
      901 tttgaccagg tgcttatgga agatcgactg accaatcgcc ttacagagtc tctgaacatt
      961 tttgaaacaa tcgtcaataa ccgggttttc agcaatgtct ccataattct gttcttaaac
     1021 aagacagact tgcttgagga gaaggtgcaa attgtgagca tcaaagacta tttcctagaa
     1081 tttgaagggg atccccactg cttaagagac gtccaaaaat tcctggtgga atgtttccgg
     1141 aacaaacgcc gggaccagca acagaagccc ttataccacc acttcaccac tgctatcaac
     1201 acggagaaca tccgccttgt tttccgtgac gtgaaggata ctattctgca tgacaacctc
     1261 aagcagctta tgctacagtg atgtacaaaa gacttgctgt tttaatatct ttttgtgttt
     1321 ttgatgtttt ctgtttgttt tgttttttaa aatagcagtt tacaaccaga attagaacaa
     1381 tcttaattct acgtttaact tcttgaaaat cttagtactt tttctgcggc ctttggtttg
     1441 tggctgaaag ctgttgagtg actcatcgcc aagatttgct gtaatgcagg ctttgatctg
     1501 tttcaccatg gcttctattc aagtccagtt aaaacctccc agctgacctc agactaggca
     1561 tatttcaggc tttaaattat tctactttcc aaactgaatt ctcctgcagt gccaagtatc
     1621 aaaggtgtcc ttaaatactt gtagggatga ggttaggaat attcagttcc aaaacaagat
     1681 atcttctgtc cgccttacat atagcagtga cacttgttgc ctaactttat ggtgacctcc
     1741 tattttgtaa gggctgttag aagttctatc taagaaatgg cattctgtag gtttatagaa
     1801 ggtttagcct tcatatttta attgcttgta tacacaacag ctgttttgct tttagatttc
     1861 tgtgtttctg aaggtaatgt tcttcctgtt ttcaagttta cataaggatc tttggtctga
     1921 tgctgatgaa gagttcacag gtggtatggg agagcaaaag gcaagctaat gctgtttacc
     1981 gtgttttggt caaacgtaac gagtgaaata gaatttgcct ttctcatatt taattatcat
     2041 gtagtttaat gtaccatatg tgaaacattc tggccatagc agcaactaaa aactgcaagc
     2101 aacttggtaa cagaactttc taaataaact taacctgttc cagaatgtca tgtatttgac
     2161 ttttaagccc tatctcagtt ggtcagtaaa gaccaatcct tactgtagga aatcattgtt
     2221 gtatcatcac aaacatctat cttttgctgt cctgtccagt cccatcaact ccacactgtg
     2281 ccatttgtgg catcgttttg tttatttgga gtttgctaag ggcagtattt ttctgtcaag
     2341 actattcaag aaggcattat ttgagattcc tgttcattct tggtgtgtct ctaacagata
     2401 cagtatgtat acatttgtat aattgttgtt gttgaaagtc cagctttttt gaggtatatt
     2461 ttaaatgttt taaggatgct tctaaggatc agtagtaatt tttttagttc gcacctaaag
     2521 atgattacat tgacctcccc cgactgctta ccaaattaaa atgtgtccac gaagtagctt
     2581 tgtgatcgca gatacattca tagtgaactc atcagaatgg ctggtttgca gtactgaaat
     2641 actatcttct aggctgtatg tagtgctaca attagagaaa cagaagtcca aggctggcga
     2701 cagcttgaaa agtctgacag cttttctact tttcctgaaa attttaagac tgtgatatct
     2761 gtcattttac tgtatagctg actgtgtact caggtatttt attggtcctt gaaagattgg
     2821 tcgttatgga tcacccagcc tttccaagtc agtggctgtt gttctgtctt gctgtctgat
     2881 acgagagtgg ggcttttcag tgaactaacc agggattgtt cttgacatac ctgacttttc
     2941 tcacatttga acttccacta tcattgtatc catataactt ctagcatttt catgccatgg
     3001 taatccatga gctacacata cgtagcccgg caccgtgatg caagttcatg gtatcgtgca
     3061 tgttcgtggt atcatggtat cattcatgcg tgtttgaata gttctacatc tagtgcttct
     3121 tgccaaaaag aatacattgt ttaaattcac aaaattagca taattgcagt gctaatgaat
     3181 atcggaatat gtgcacagta acatttggac tattcattgg agagtttacc catacattta
     3241 gcaaattgaa tggccaaaac atttgactcc agtgagggct caagttagat ccctatagaa
     3301 agaggacact tcatcttact taagtcatag ttaagatctg tgatacgaac catagatatt
     3361 gcctgacaaa gcagaaatca ccaagtttcc cccttttgaa ttaccaccaa gaagtgttga
     3421 aacaccaaat agatatcatg ttattttggg catttgcagt tttcttccct gctgcatgta
     3481 atgtctcaga atcaacattc ttttaaaatc tagactatat tttgaggcaa tgaattactt
     3541 atattcaact taggcttgtt ttgacattca gtagaacttt aagttcaatc taaaggcttc
     3601 agtccacatt tttttatacg ttgtatttta aaaacgtttg aaaggagtct tacacctgta
     3661 tcatgaaaac tgaatccttt tgaaatacca ctatatgaag agagagatga aatttagtga
     3721 acagaattga aaaggtgctc ataatttcac tatgcaaact taccccagtc tctaaaaaag
     3781 taatttagat ttaaagttct ttgatgtatt tgattttcta aatctttatg gttatgattt
     3841 ggaataaaat gtgcctaatc ctgtgttaca ttctgttctt aaatctgaat gccttctcat
     3901 ttaattctga ggaaatatca cacaagtgtc ttcattgacc ttgaagaaat gtatatacag
     3961 ttgccttata aaacaacata aatttagacc ataactttta tagagaaagg gttttgtcaa
     4021 atgttttctg aaaatctgag taattcaaag catgcctctg cccctttaat atttttaata
     4081 acctgcattg ttgctgtctg ccaaatatta aattgaaatc ttcatttcaa ttttattatc
     4141 tggaaagggc actggattgc tctgcaacca aagaaagcaa tatggaatga aaaaactcat
     4201 tcacttttgt cttattttct tttaaggtgt attggcatgt aatttgcata gagaaggtcc
     4261 tctggttagt ctctcaaatt gaggctgttt agggaaatcc ttattcagtt ggtggcagtg
     4321 gttggtttaa agtagaagga aataagatcg ccttaatacc agaaatgatt agaagtgctg
     4381 atttagattc aacaaatacc atatgtcctt atcatttttt gtaagaagaa attggttaag
     4441 tcctaacttt caatgtgtac ccaaatactt gtatttatgc ttttgataaa atgtattttc
     4501 agcattaata cacatccgat tatgccttat ttatatatga agaataaagt taccatgtta
     4561 cactgttatg tcctaaaatt caaatcacta tttgagaaac cctcaaattg gtgctttcat
     4621 tatataatga tacatttaga caaaacccca aactaagcca tttgaaacaa gattctctcc
     4681 attgcagttt gtagcaatgt tatttctgtg tatgtcatga gaaggctaaa tatcagtgtt
     4741 aatttcttgt ttgaatccgt gaaatcatgc ctgtaaagcc caaacatttg taacaaactc
     4801 cctaataaat ttagagaaag tcactctgtt accatttcat ttattttagt tttatttgag
     4861 aaattaagac cagaagtttt gctcatgtct ttttcacttg gaaatctgac ttagtaccta
     4921 gttaatttgt ctctctccca tcattttaag gcgttcgctt ctgttaatca cagatgatct
     4981 gtccttgtgt tgtgctgctt gactaaaagc actgttttgt tttgttttgt tttgtttttt
     5041 aatgatagga tacagggtgg cttttcagtc tagtaaacat gaggagggga gagattgtgg
     5101 gtgggtgtgg gtgtgtccgc atgtcccaaa tacagcacat gcccattttt ttatggtacg
     5161 aggttagggc ttattaataa atgtatacta gatcttgaag tgtaagtcta agtctgaaca
     5221 ttttaaacaa gttggacttt atggcttttt caagttccat caagtagata ctagtcttag
     5281 gctggtaggt gattaacaac atcatttgga gtacagtgtt tgtaccacta gcattcttat
     5341 gtctgtactt gaacgtgtag ttagcattta agttatgttc actcttgtag cattcaggtc
     5401 ttaccatctg gtttcaaatg cgagagctta tatgaacatt gttttgaaag catgaatgat
     5461 atggcaatat tttatgtctt gataaggaga gttttgtgac atatacaaat ctgctgttga
     5521 tgatgaaagt ttacaggtgg atcagagtat gctggaactc agtgtgcata aaatttcagt
     5581 cagtgaatat cactgaacgt catatactac ttggtatgtg actttggttt gtgttaagaa
     5641 agcttgtata taatattttt tgccatagta agtgagaaat tgtccttaat catgcctgtt
     5701 tgatggtact aggaaagaaa ggggtagaga ttaattcttg cacagtataa gcaacagtgc
     5761 aacaaactat gccatttacc ttttacctct tacttgaagg cagaatcgca aaacgtttga
     5821 aatggctttt ctaaactact ctactctggt gagagctcat ttaccacaag aagccttata
     5881 aaaaagtata ttttgtaata accccgtaga tactgtacct aacaaaacat gactcgtatt
     5941 agctctataa aatatttgtg gcttaggatt ttttttttac atatatcttt ttataacttt
     6001 ccaggaacta agcacattat ctgataattg ttgtaaattt ttttgtcagt gctttagttc
     6061 aggatgggca ataaattatt tctaaaggag gtctaaaagt ggaaagaatg gtttgatttt
     6121 ataaaatgag ttgctagttc attacagctt tttacttttg tacatatttt gcaaaacatt
     6181 tgcctcttgc tattaatatt tgctttgtaa aaattactga catttaataa acatttgtaa
     6241 acaattcaa
//
